Chemical Formula: C21H28O4
Chemical Formula C21H28O4
Found 159 metabolite its formula value is C21H28O4
11-Dehydrocorticosterone
11-Dehydrocorticosterone is a mineral corticosteroid. The conversion of inactive 11-ketoglucocorticoids such as 11-dehydrocorticosterone) into active 11b-hydroxyglucocorticoids (such as corticosterone) is catalyzed by 11beta-hydroxysteroid dehydrogenase (11b-HSD1, EC 1.1.1.146), which is expressed in many tissues and plays an important role in metabolically relevant tissues such as the liver, adipose tissue, skeletal muscles and possibly kidney. Chronically elevated local glucocorticoid action as a result of increased 11beta-HSD1 activity rather than elevated systemic glucocorticoid levels has been associated with metabolic syndrome, which is characterized by obesity, insulin resistance, type 2 diabetes and cardiovascular complications. Recent studies indicate that compounds inhibiting 11beta-HSD1 activity ameliorate the adverse effects of excessive glucocorticoid concentrations on metabolic processes, providing promising opportunities for the development of therapeutic interventions. 11-dehydrocorticosterone and corticosterone display antinatriuretic activity, although 11-dehydrocorticosterone is generally a more potent sodium retainer than corticosterone. (PMID: 17584152, Endocr Metab Immune Disord Drug Targets. 2007 Jun;7(2):125-40.) [HMDB] 11-Dehydrocorticosterone is a mineral corticosteroid. The conversion of inactive 11-ketoglucocorticoids such as 11-dehydrocorticosterone) into active 11b-hydroxyglucocorticoids (such as corticosterone) is catalyzed by 11beta-hydroxysteroid dehydrogenase (11b-HSD1, EC 1.1.1.146), which is expressed in many tissues and plays an important role in metabolically relevant tissues such as the liver, adipose tissue, skeletal muscles and possibly kidney. Chronically elevated local glucocorticoid action as a result of increased 11beta-HSD1 activity rather than elevated systemic glucocorticoid levels has been associated with metabolic syndrome, which is characterized by obesity, insulin resistance, type 2 diabetes and cardiovascular complications. Recent studies indicate that compounds inhibiting 11beta-HSD1 activity ameliorate the adverse effects of excessive glucocorticoid concentrations on metabolic processes, providing promising opportunities for the development of therapeutic interventions. 11-dehydrocorticosterone and corticosterone display antinatriuretic activity, although 11-dehydrocorticosterone is generally a more potent sodium retainer than corticosterone. (PMID: 17584152, Endocr Metab Immune Disord Drug Targets. 2007 Jun;7(2):125-40.).
11-nor-9-carboxy-Delta(9)-tetrahydrocannabinol
11-nor-9-carboxy-Delta(9)-tetrahydrocannabinol, also known as delta(1)-Tetrahydrocannabinol-7-Oic acid or delta-9-11-Carboxytetrahydrocannabinol, is classified as a member of the 2,2-dimethyl-1-benzopyrans. 2,2-dimethyl-1-benzopyrans are organic compounds containing a 1-benzopyran moiety that carries two methyl groups at the 2-position. 11-nor-9-carboxy-Delta(9)-tetrahydrocannabinol is considered to be practically insoluble (in water) and acidic
(E,E)-Boviquinone 3
(E,E)-Boviquinone 3 is found in mushrooms. (E,E)-Boviquinone 3 is a pigment from Chroogomphus rutilus (pine spike cap Pigment from Chroogomphus rutilus (pine spike cap). (E,E)-Boviquinone 3 is found in mushrooms.
Neotussilagolactone
Neotussilagolactone is found in tea. Neotussilagolactone is a constituent of Tussilago farfara (coltsfoot) Constituent of Tussilago farfara (coltsfoot). Neotussilagolactone is found in tea.
Formebolone
Formebolone is a synthetic anabolic steroid. It is suspected of misuse in sports and therefore tested for in regular screening of athletes. The desire to artificially enhance physical performance in order to increase the chances to win in sports competition is supposedly as old as mankind itself. Already during the ancient Olympic Games, in approximately 200 B.C., athletes used concoctions of mushrooms and plant seeds, as well as special diets including bovine and canine testicles, as reported by Philostratos and Galen. The attempt to improve the power and strength of racing animals also has a long history, as it has been reported that the ancient Romans fed their horses so-called Hydromel, a mixture of honey and water, in order to increase endurance. The manipulation of the capacities of an athlete or animal has been referred to as doping since 1889, when this term, originating from a dialect spoken in the south-eastern region of Africa, was included in a British dictionary. With the athlete Linton, the first authentic doping-related death occurred in 1886 during a cycle race (Paris-Bordeaux), caused by an overdose of caffeine. (For a more complete review on doping see PMID: 15808003) [HMDB] Formebolone is a synthetic anabolic steroid. It is suspected of misuse in sports and therefore tested for in regular screening of athletes. The desire to artificially enhance physical performance in order to increase the chances to win in sports competition is supposedly as old as mankind itself. Already during the ancient Olympic Games, in approximately 200 B.C., athletes used concoctions of mushrooms and plant seeds, as well as special diets including bovine and canine testicles, as reported by Philostratos and Galen. The attempt to improve the power and strength of racing animals also has a long history, as it has been reported that the ancient Romans fed their horses so-called Hydromel, a mixture of honey and water, in order to increase endurance. The manipulation of the capacities of an athlete or animal has been referred to as doping since 1889, when this term, originating from a dialect spoken in the south-eastern region of Africa, was included in a British dictionary. With the athlete Linton, the first authentic doping-related death occurred in 1886 during a cycle race (Paris-Bordeaux), caused by an overdose of caffeine. (For a more complete review on doping see PMID: 15808003). C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C2360 - Anabolic Steroid
19-Oxo-deoxycorticosterone
19-oxo-deoxycorticosterone (19-oxo-DOC) is a steroid recently isolated from the rat adrenal gland.19-Oxo-Deoxycorticosterone Binds to the Renal Mineralocorticoid Receptor and Produces Sodium Retention but Not Potassium Excretion.19-oxo-DOC both binds to type I renal mineralocor-ticoid receptors and produces the expected antinatriuretic effect of maximal doses of mineralocorticoids. This lack of a kaliuretic effect suggests that either 1) the kaliuretic effect of steroids such as aldosterone is mediated by a binding site other than the type I receptors, or 2) that potassium secretion mediated by aldoster-one-type I receptor interactions in discrete nephron target segments can be influenced by a steroid-sensitive potassium-recycling system in a more distal nephron site. 19-hydroxydeoxycorticosterone (19,21-dihydroxy-4-pregnen-3,20-dione), 19-oxo-deoxycorticosterone (21-hydroxy-4-pregnen-3,19,20-trione), and 19-oic-deoxycorticosterone (19-oic-21-hydroxy-4-pregnen-3,20-dione)are formed from precursor deoxycorticosterone by adrenal glands obtained from intact rats and from rats undergoing adrenal regeneration.rat adrenals have the enzymes required to convert deoxycorticosterone to 19-hydroxydeoxycorticosterone, 19-oxo-deoxycorticosterone, and 19-oic-deoxycorticosterone; however, rat adrenals do not convert deoxycorticosterone or any of the oxygenated metabolites to 19-nor-deoxycorticosterone (21-hydroxy-19-nor-4-pregnen-3,20-dione). It is possible, however, that 19-nor-deoxycorticosterone is formed at peripheral sites from the oxygenated deoxycorticosterone precursors. 19-oxo-deoxycorticosterone (19-oxo-DOC) is a steroid recently isolated from the rat adrenal gland.19-Oxo-Deoxycorticosterone Binds to the Renal Mineralocorticoid Receptor and Produces Sodium Retention but Not Potassium Excretion.19-oxo-DOC both binds to type I renal mineralocor-ticoid receptors and produces the expected antinatriuretic effect of maximal doses of mineralocorticoids. This lack of a kaliuretic effect suggests that either 1) the kaliuretic effect of steroids such as aldosterone is mediated by a binding site other than the type I receptors, or 2) that potassium secretion mediated by aldoster-one-type I receptor interactions in discrete nephron target segments can be influenced by a steroid-sensitive potassium-recycling system in a more distal nephron site
(6Ar,10ar)-1-hydroxy-6,6-dimethyl-3-pentyl-6a,7,10,10a-tetrahydro-6h-benzo[c]chromene-9-carboxylic acid
7-Oxodehydroepiandrosterone 3-acetate
21-Deoxycortisone
4-Acetoxy-4-androstene-3,17-dione
[(8S,9S,13S,14S,17R)-3,17-Dihydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-1-yl] propanoate
15,16-Epoxy-20-oxo-8(17),13(16),14-labdatrien-19-oic acid methyl ester
[4S-[4alpha(E),4aalpha,5alpha,8abeta]]-4,4a,5,6,7,8,8a,9-Octahydro-3,4a,5-trimethyl-9-oxonaphtho[2,3-b]furan-4-yl ester 3-methyl-2-pentenoic acid
12-Methyl-5-dehydrohorminone
An abietane diterpenoid that is 5-dehydrohorminone in which the hydroxy group at position 12 is replaced by a methoxy group. Isolated from the roots of Salvia multicaulis, it exhibits antitubercular activity.
6,12-dihydroxy-11-methoxyabieta-5,8,11,13-tetraen-7-one
3beta-acetoxy-12-methoxy-13-methyl-podocarpa-8,11,13-trien-7-one|3beta-acetoxy-12-methoxy-13-methyl-podocarpane-8,11,13-trien-7-one|3beta-acetoxy-12-methoxy-13-methylpodocarpa-8,11,13-trien-7-one|3??-Acetoxy-12-methoxy-13-methyl-podocarpa-8,11,13-trien-7-one.
(4R,9R)-10-hydroxy-13-methoxy-9-methyl-15-oxo-20-norkaur-16-en-18-oic acid gamma-lactone
2,11beta-Dimethoxy-3-hydoxo-D-homoestra-1,3,5(10)trien-17a-on
(2E)-1,4-diacetoxy-2-(3,7-dimethylocta-2,6-dienyl)-6-methylbenzene
6beta-hydroxy-3beta-<4-methylsenecioyloxy>-euryopsin
Methyl 15,16-epoxy-12-oxo-8(17),13(16),14-ent-labdatrien-19-oate
15-desmethoxy-16-oxo-15,16H-seco-nidoresedic acid methyl ester|15-desmethoxy-16-oxo-15,16H-strictic acid methyl ester|methyl ester of 16-oxo-15,16H-strictic acid
5alpha-Hydroxyconyscabrasaeure-methylester|methyl 5alpha-hydroxyconyscabroate
4beta-hydroxy-5beta,6beta-epoxypregn-2-ene-1,20-dione
(6aR,8R,9aR)-8-methoxy-6a-methyl-8-pentyl-3-((E)-prop-1-enyl)-6a,8,9,9atetrahydro-6H-furo[2,3-h]-isochromen-6-one|monapurone C
12-methylcoleon U|6,11-dihydro-12-methoxy-5,8,11,13-abietatetraen-7-one
16-methoxy-6-oxo-7,11,13-labdatrien-16,15-olide|spicatanol methyl ether
5alpha-hydroxy-1,2-dehydro-5,10-dihydroprintzianic acid methyl ester|5alpha-Hydroxy-1,2-dehydro-5,10-dihydroprintziasaeure-methylester
4a.alpha.,4b.beta.-Gibbane-1.alpha.,10.beta.-dicarboxylic acid, 4a-(hydroxymethyl)-1-methyl-8-methylene-, 1,4a-lactone, methyl ester
8beta-hydroxy-14(17)-ene-18alpha-methoxycarbonyl-18-norvouacapene|mimosol A
15-oxo-14,16H-seco-nidoresedic acid methyl ester|15-oxo-14,16H-strictic acid methyl ester
methyl 14beta-hydroxy-12-oxo-3,4-secopimara-7,9(11),13,15,19(4)-tetraen-3-oate|trigonoheterene
7beta-methoxy-8,11,13-triene-18,6alpha-abietanolide|liquidambolide A
15beta,17alpha-dihydroxypregna-4,6-diene-3,20-dione
4-O-[6,7-dihydro-5,6E-dehydro-7(9)-dehydrogeranyl]-sinapyl alcohol
4-O-geranyl-sinapyl aldehyde|4-O-geranylsinapyl aldehyde|geranyloxy sinapyl aldehyde|Nelumal A
5-methoxy-11.14-dioxo-abiata-8,12,15-triene|bractealine
13-dehydroxysarcoglaucol-16-one|2,5,6,9,10,13,14,16-octahydro-4,12,15-trimethyl-16-oxocyclotetradeca[b]furan-8-carboxylic acid methyl ester
Triptonoditerpenic acid
(E,E)-1,11-bis(furan-3-yl)-4,8-dimethylundeca-7,10-diene-4,6-diol|Untenospongin A
4-[4-(3,4-Dimethoxyphenyl)-2,3-dimethylbutyl]-2-methoxyphenol
11-DEHYDROCORTICOSTERONE
An 11-oxo steroid that is corticosterone in which the hydroxy substituent at the 11beta position has been oxidised to give the corresponding ketone. D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
(E,E)-Boviquinone 3
Neotussilagolactone
Formebolone
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C2360 - Anabolic Steroid
ST 21:4;O4
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
Anecortave
S - Sensory organs > S01 - Ophthalmologicals > S01L - Ocular vascular disorder agents > S01LA - Antineovascularisation agents D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones D006133 - Growth Substances > D043924 - Angiogenesis Modulating Agents D000970 - Antineoplastic Agents > D020533 - Angiogenesis Inhibitors D006133 - Growth Substances > D006131 - Growth Inhibitors
Triptobenzene H
An abietane diterpenoid with formula C21H28O4, originally isolated from Tripterygium wilfordii.
[(8S,9S,13S,14S,17R)-3,17-Dihydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-1-yl] propanoate
4-[(2S,3R)-4-(3,4-dimethoxyphenyl)-2,3-dimethylbutyl]-2-methoxyphenol
19-Oxo-deoxycorticosterone
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
(6aR)-1-hydroxy-6,6-dimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c][1]benzopyran-9-carboxylic acid
11-nor-9-carboxy-Delta(9)-tetrahydrocannabinol
A phytocannabinoid that is Delta(9)-tetrahydrocannabinol in which the C-11 methyl has been fully oxidised to a carboxy group. Further enzymatic oxidation product of 11-hydroxy-Delta(9)-tetrahydrocannabinol.
21-deoxycortisone
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
(-)-(8R,8S)-3,3,4-trimethoxy-4-hydroxylignan
A lignan that is 2,3-dimethylbutane substituted by a 4-hydroxy-3-methoxyphenyl group at position 1 and a 3,4-dimethoxyphenyl group at position 4. It has been isolated from the bark of Machilus robusta.