5-Aminoimidazole (BioDeep_00000005752)
Secondary id: BioDeep_00001869482
human metabolite Endogenous
代谢物信息卡片
化学式: C3H5N3 (83.0483)
中文名称: 4-氨基咪唑
谱图信息:
最多检出来源 Homo sapiens(blood) 30.78%
分子结构信息
SMILES: C1=C(NC=N1)N
InChI: InChI=1S/C3H5N3/c4-3-1-5-2-6-3/h1-2H,4H2,(H,5,6)
描述信息
Because of its ability to mimic a low energy status of the cell, the cell-permeable nucleoside 5-aminoimidazole-4-carboxamide (AICA) riboside was proposed as an antineoplastic agent switching off major energy-consuming processes associated with the malignant phenotype (lipid production, DNA synthesis, cell proliferation, cell migration, etc.). Key to the antineoplastic action of AICA riboside is its conversion to ZMP, an AMP mimetic that at high concentrations activates the AMP-activated protein kinase (AMPK). (PMID: 16985054) [HMDB]
Because of its ability to mimic a low energy status of the cell, the cell-permeable nucleoside 5-aminoimidazole-4-carboxamide (AICA) riboside was proposed as an antineoplastic agent switching off major energy-consuming processes associated with the malignant phenotype (lipid production, DNA synthesis, cell proliferation, cell migration, etc.). Key to the antineoplastic action of AICA riboside is its conversion to ZMP, an AMP mimetic that at high concentrations activates the AMP-activated protein kinase (AMPK). (PMID: 16985054).
同义名列表
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:16607
- KEGG: C05239
- PubChem: 484
- HMDB: HMDB0003929
- Metlin: METLIN6989
- MetaCyc: CPD-54
- foodb: FDB023250
- chemspider: 470
- CAS: 4919-03-3
- PMhub: MS000018617
- PubChem: 7633
- 3DMET: B00762
- NIKKAJI: J507.002C
- RefMet: 5-Aminoimidazole
- KNApSAcK: 16607
分类词条
相关代谢途径
Reactome(0)
BioCyc(2)
PlantCyc(0)
代谢反应
2 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(2)
- purine nucleobases degradation I (anaerobic):
3,5-dihydro-4H-imidazol-4-one + H2O ⟶ N-formimino-glycine - purine nucleobases degradation II (anaerobic):
3,5-dihydro-4H-imidazol-4-one + H2O ⟶ N-formimino-glycine
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Maria Rapala-Kozik, Natalia Wolak, Marta Kujda, Agnieszka K Banas. The upregulation of thiamine (vitamin B1) biosynthesis in Arabidopsis thaliana seedlings under salt and osmotic stress conditions is mediated by abscisic acid at the early stages of this stress response.
BMC plant biology.
2012 Jan; 12(?):2. doi:
10.1186/1471-2229-12-2. [PMID: 22214485] - Benjamin T Bikman, Donghai Zheng, Melissa A Reed, Robert C Hickner, Joseph A Houmard, G Lynis Dohm. Lipid-induced insulin resistance is prevented in lean and obese myotubes by AICAR treatment.
American journal of physiology. Regulatory, integrative and comparative physiology.
2010 Jun; 298(6):R1692-9. doi:
10.1152/ajpregu.00190.2009. [PMID: 20393162] - Cadence E Minge, Brenton D Bennett, Robert J Norman, Rebecca L Robker. Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone reverses the adverse effects of diet-induced obesity on oocyte quality.
Endocrinology.
2008 May; 149(5):2646-56. doi:
10.1210/en.2007-1570. [PMID: 18276752] - Shalaka Samant, Hyunwoo Lee, Mahmood Ghassemi, Juan Chen, James L Cook, Alexander S Mankin, Alexander A Neyfakh. Nucleotide biosynthesis is critical for growth of bacteria in human blood.
PLoS pathogens.
2008 Feb; 4(2):e37. doi:
10.1371/journal.ppat.0040037. [PMID: 18282099] - Ji-Ming Ye, Nick Dzamko, Andrew J Hoy, Miguel A Iglesias, Bruce Kemp, Edward Kraegen. Rosiglitazone treatment enhances acute AMP-activated protein kinase-mediated muscle and adipose tissue glucose uptake in high-fat-fed rats.
Diabetes.
2006 Oct; 55(10):2797-804. doi:
10.2337/db05-1315. [PMID: 17003345] - Dongying Wu, Sean C Daugherty, Susan E Van Aken, Grace H Pai, Kisha L Watkins, Hoda Khouri, Luke J Tallon, Jennifer M Zaborsky, Helen E Dunbar, Phat L Tran, Nancy A Moran, Jonathan A Eisen. Metabolic complementarity and genomics of the dual bacterial symbiosis of sharpshooters.
PLoS biology.
2006 Jun; 4(6):e188. doi:
10.1371/journal.pbio.0040188. [PMID: 16729848] - X Yu, S McCorkle, M Wang, Y Lee, J Li, A K Saha, R H Unger, N B Ruderman. Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition.
Diabetologia.
2004 Nov; 47(11):2012-21. doi:
10.1007/s00125-004-1570-9. [PMID: 15578153] - N B Ruderman, H Park, V K Kaushik, D Dean, S Constant, M Prentki, A K Saha. AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise.
Acta physiologica Scandinavica.
2003 Aug; 178(4):435-42. doi:
10.1046/j.1365-201x.2003.01164.x. [PMID: 12864749] - . .
.
. doi:
. [PMID: 17064924]
