Bryostatins (BioDeep_00000005733)
natural product Marine Natural Products Chemicals and Drugs
代谢物信息卡片
[(1S,3S,5Z,7R,8E,11S,12S,13E,15S,21R,23R,25S)-25-acetyloxy-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl] (2E,4E)-octa-2,4-dienoate
化学式: C47H68O17 (904.4456)
中文名称: 草苔虫素
谱图信息:
最多检出来源 Homo sapiens(not specific) 50%
Reviewed
Last reviewed on 2024-12-16.
Cite this Page
Bryostatins. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/bryostatins (retrieved
2024-12-22) (BioDeep RN: BioDeep_00000005733). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: CCCC=CC=CC(=O)OC1C(=CC(=O)OC)CC2CC(C(C)O)OC(=O)CC(O)CC3CC(OC(C)=O)C(C)(C)C(O)(CC4CC(=CC(=O)OC)CC(C=CC(C)(C)C1(O)O2)O4)O3
InChI: InChI=1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35-,36+,37?,38+,43+,46+,47-/m1/s1
描述信息
Bryostatin 1 is a macrocyclic lactone isolated from the bryozoan Bugula neritina with antineoplastic activity. Bryostatin 1 binds to and inhibits the cell-signaling enzyme protein kinase C, resulting in the inhibition of tumor cell proliferation, the promotion of tumor cell differentiation, and the induction of tumor cell apoptosis. This agent may act synergistically with other chemotherapeutic agents. (NCI04)
Bryostatin 1. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=83314-01-6 (retrieved 2024-12-16) (CAS RN: 83314-01-6). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
同义名列表
3 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- PubChem: 44277532
- Metlin: METLIN66296
- ChEMBL: CHEMBL281926
- MeSH: Bryostatins
- KNApSAcK: C00038654
- PMhub: MS000018588
- ChEBI: CHEBI:88353
- NIKKAJI: J91.917I
- KEGG: C05149
- CAS: 83314-01-6
- KNApSAcK: 88353
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 10212 - Bugula neritina: 10.1016/0145-2126(95)00037-O
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Felix Becker, Linus Kebschull, Constantin Rieger, Annika Mohr, Barbara Heitplatz, Veerle Van Marck, Uwe Hansen, Junaid Ansari, Stefan Reuter, Benjamin Strücker, Andreas Pascher, Jens G Brockmann, Trevor Castor, J Steve Alexander, Felicity N E Gavins. Bryostatin-1 Attenuates Ischemia-Elicited Neutrophil Transmigration and Ameliorates Graft Injury after Kidney Transplantation.
Cells.
2022 03; 11(6):. doi:
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Journal of biomolecular structure & dynamics.
2022; 40(24):14160-14175. doi:
10.1080/07391102.2021.2001375. [PMID: 34779746] - Lingyan Wang, Yue Zhang, Eden Anderson, Adam Lamble, Rimas J Orentas. Bryostatin Activates CAR T-Cell Antigen-Non-Specific Killing (CTAK), and CAR-T NK-Like Killing for Pre-B ALL, While Blocking Cytolysis of a Burkitt Lymphoma Cell Line.
Frontiers in immunology.
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Biochemistry.
2019 07; 58(27):3016-3030. doi:
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Acta parasitologica.
2018 Mar; 63(1):198-209. doi:
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Journal of cellular physiology.
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Leukemia research.
2011 Jan; 35(1):87-94. doi:
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Molecular pharmacology.
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European journal of pharmacology.
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2006 Dec; 12(23):7059-62. doi:
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Molecular cancer therapeutics.
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Analytical biochemistry.
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Gynecologic oncology.
2004 Apr; 93(1):144-8. doi:
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Experimental hematology.
2004 Jan; 32(1):76-86. doi:
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Molecular pharmacology.
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Blood.
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Lung cancer (Amsterdam, Netherlands).
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Molecular pharmacology.
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Leukemia.
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Anti-cancer drugs.
1996 May; 7(3):299-306. doi:
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Cancer research.
1996 Feb; 56(4):802-8. doi:
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Cancer chemotherapy and pharmacology.
1996; 37(3):271-8. doi:
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British journal of cancer.
1995 Aug; 72(2):461-8. doi:
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Anti-cancer drugs.
1995 Jun; 6(3):384-91. doi:
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The Journal of biological chemistry.
1995 May; 270(18):10777-83. doi:
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Molecular pharmacology.
1994 Aug; 46(2):374-9. doi:
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Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
1994 Jun; 5(6):677-86. doi:
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Biochemistry.
1994 Jan; 33(2):542-51. doi:
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Advances in enzyme regulation.
1994; 34(?):257-68. doi:
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Experimental dermatology.
1993 Dec; 2(6):247-56. doi:
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Journal of the National Cancer Institute.
1993 Nov; 85(22):1812-8. doi:
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Cancer research.
1993 Jun; 53(12):2810-5. doi:
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The Journal of biological chemistry.
1993 Mar; 268(8):5543-9. doi:
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Cancer research.
1992 Jan; 52(1):101-7. doi:
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British journal of cancer.
1991 Oct; 64(4):671-6. doi:
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International journal of cancer.
1991 Apr; 47(6):929-32. doi:
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European journal of immunology.
1990 May; 20(5):1119-23. doi:
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The Journal of biological chemistry.
1988 Jun; 263(17):8253-60. doi:
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Biochemical and biophysical research communications.
1987 Jul; 146(1):208-15. doi:
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