Classification Term: 170107

大环内酯类抗生素 (ontology term: 96c51b0f34dd8b0cad349251d80f781f)

found 3 associated metabolites at no_class-level_20 metabolite taxonomy ontology rank level.

Child Taxonomies: There is no child term of current ontology term.

Dolastatin 10

(2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-N-[(3R,4S,5S)-3-methoxy-1-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide

C42H68N6O6S (784.4920788)

Dolastatin 10 is a tetrapeptide that is isolated from the sea hare Dolabella auricularia. It is a potent anticancer agent which inhibits tubulin polymerization. It has a role as an animal metabolite, a marine metabolite, an antineoplastic agent, an apoptosis inducer and a microtubule-destabilising agent. It is a member of 1,3-thiazoles and a tetrapeptide. It is functionally related to a L-valine. Dolastatin 10 has been used in trials studying the treatment of Sarcoma, Leukemia, Lymphoma, Liver Cancer, and Kidney Cancer, among others. Dolastatin 10 is a natural product found in Symploca, Caldora penicillata, and other organisms with data available. Dolastatin 10 is a pentapeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity. Binding to tubulin, Dolastatin 10 inhibits microtubule assembly, resulting in the formation of tubulin aggregates and inhibition of mitosis. This agent also induces tumor cell apoptosis through a mechanism involving bcl-2, an oncoprotein that is overexpressed in some cancers. (NCI04) C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C273 - Antimitotic Agent D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization.

Madurmycin

Maduramicin ammonium

C47H83NO17 (933.5660708)

C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents Maduramicin ammonium (Maduramycin ammonium) is isolated from the actinomycete?Actinomadura rubra. Maduramicin ammonium (Maduramycin ammonium) is an anticoccidial agent for the the treatment of Eimeria spp., E. adenoeides, E. gallopavonis, and E. dispersa infection[1]. Maduramicin ammonium (Maduramycin ammonium) induces cell apoptosis in chicken myocardial cells via intrinsic and extrinsic pathways[2].

Calicheamicin

S-[6-[[5-[5-(ethylamino)-4-methoxyoxan-2-yl]oxy-4-hydroxy-6-[[(5E,13Z)-9-hydroxy-12-(methoxycarbonylamino)-13-[2-(methyltrisulfanyl)ethylidene]-11-oxo-2-bicyclo[7.3.1]trideca-1(12),5-dien-3,7-diynyl]oxy]-2-methyloxan-3-yl]amino]oxy-4-hydroxy-2-methyloxan-3-yl] 4-(3,5-dihydroxy-4-methoxy-6-methyloxan-2-yl)oxy-5-iodo-2,3-dimethoxy-6-methylbenzenecarbothioate

C55H74IN3O21S4 (1367.2742224)

Enediyne aminoglycosides derived from the bacterium MICROMONOSPORA ECHINOSPORA that are used as antineoplastic antibiotics. They bind to DNA in both healthy and tumor cells, resulting in strand scission and cell death. Calicheamicin is a naturally occurring organic compound that belongs to the class of macrocyclic lactones. It is renowned for its potent antitumor activity and was originally isolated from soil as an antibiotic. The compound's distinctive feature is its ability to bind to DNA and induce double-strand DNA breaks, which is a highly effective mechanism for inhibiting the proliferation of tumor cells. Due to its significant cytotoxicity, Calicheamicin and its derivatives have been the subject of research and development for antitumor drugs. However, the clinical application of Calicheamicin is limited by its strong toxicity. It is often used in combination with other treatments to reduce side effects and enhance its therapeutic efficacy. D000970 - Antineoplastic Agents > D000903 - Antibiotics, Antineoplastic > D000080084 - Calicheamicins