Buthionine sulfoximine (BioDeep_00000005561)
Secondary id: BioDeep_00001868159
human metabolite blood metabolite
代谢物信息卡片
2-amino-4-[butyl(imino)oxo-lambda6-sulfanyl]butanoic acid
化学式: C8H18N2O3S (222.1038)
中文名称: D,L-蛋氨酸-(S,R)-亚磺酰亚胺, 丁硫氨酸亚砜胺
谱图信息:
最多检出来源 Homo sapiens(blood) 98.85%
Reviewed
Last reviewed on 2024-09-04.
Cite this Page
Buthionine sulfoximine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/buthionine_sulfoximine (retrieved
2024-12-22) (BioDeep RN: BioDeep_00000005561). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: CCCCS(=N)(=O)CCC(C(=O)O)N
InChI: InChI=1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)
描述信息
Buthionine Sulfoximine is a synthetic amino acid. Buthionine sulfoximine irreversibly inhibits gamma-glutamylcysteine synthase, thereby depleting cells of glutathione, a metabolite that plays a critical role in protecting cells against oxidative stress, and resulting in free radical-induced apoptosis. Elevated glutathione levels are associated with tumor cell resistance to alkylating agents and platinum compounds. By depleting cells of glutathione, this agent may enhance the in vitro and in vivo cytotoxicities of various chemotherapeutic agents in drug-resistant tumors. Buthionine sulfoximine may also exhibit antiangiogenesis activity. (NCI04)
D020011 - Protective Agents > D011837 - Radiation-Protective Agents
D009676 - Noxae > D000963 - Antimetabolites
D011838 - Radiation-Sensitizing Agents
D000970 - Antineoplastic Agents
D004791 - Enzyme Inhibitors
Buthionine sulfoximine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=5072-26-4 (retrieved 2024-09-04) (CAS RN: 5072-26-4). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
同义名列表
29 个代谢物同义名
2-amino-4-[butyl(imino)oxo-lambda6-sulfanyl]butanoic acid; (2Rs)-2-Amino-4-(S-butylsulphonimidoyl)butanoic acid; (2Rs)-2-Amino-4-(S-butylsulfonimidoyl)butanoic acid; (2Rs)-2-Amino-4-(S-butylsulphonimidoyl)butyric acid; (2Rs)-2-Amino-4-(S-butylsulfonimidoyl)butyric acid; (2Rs)-2-Amino-4-(S-butylsulphonimidoyl)butanoate; (2Rs)-2-Amino-4-(S-butylsulfonimidoyl)butanoate; (2Rs)-2-Amino-4-(S-butylsulphonimidoyl)butyrate; 2-amino-4-(S-Butylsulphonimidoyl)butanoic acid; (2Rs)-2-Amino-4-(S-butylsulfonimidoyl)butyrate; 2-amino-4-(S-Butylsulphonimidoyl)butyric acid; 2-amino-4-(S-Butylsulfonimidoyl)butanoic acid; 2-amino-4-(S-Butylsulfonimidoyl)butyric acid; 2-amino-4-(S-Butylsulphonimidoyl)butanoate; S-Butyl-DL-homocysteine (S,R)-sulphoximine; S-Butyl-DL-homocysteine-[S,R]-sulphoximine; 2-amino-4-(S-Butylsulfonimidoyl)butanoate; S-Butyl-DL-homocysteine-[S,R]-sulfoximine; 2-amino-4-(S-Butylsulphonimidoyl)butyrate; 2-amino-4-(S-Butylsulfonimidoyl)butyrate; DL-Butathionine-(S,R)-sulphoximine; DL-Butathionine-(S,R)-sulfoximine; D,L-Buthionine-(S,R)-sulfoximine; DL-Buthionine sulphoximine; DL-Buthionine sulfoximine; Buthionine sulphoximine; Sulfoximine, buthionine; BUTHIONINE SULFOXIMINE; Buthionine sulfoximine
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:176510
- ChEBI: CHEBI:28714
- KEGG: C04543
- PubChem: 21157
- HMDB: HMDB0249462
- Metlin: METLIN66203
- DrugBank: DB12870
- ChEMBL: CHEMBL1627290
- ChEMBL: CHEMBL1256575
- Wikipedia: Buthionine_sulfoximine
- MeSH: Buthionine Sulfoximine
- chemspider: 19896
- CAS: 71765-30-5
- CAS: 5072-26-4
- PMhub: MS000018388
- NIKKAJI: J128.583A
- PubChem: 7149
- KNApSAcK: 28714
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Feng-Juan Li, Shouzhi Fu, Hua Ye, Yi-Han Hu, Jianxin Chen, Jamie R Privratsky, Wei Yu, Feng Dong, Russel J Reiter, Maolong Dong, Jun Guo, Jun Ren. Metallothionein Alleviates Glutathione Depletion-Induced Oxidative Cardiomyopathy through CISD1-Dependent Regulation of Ferroptosis in Murine Hearts.
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Blood advances.
2023 Oct; ?(?):. doi:
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10.1007/s11095-016-2051-9. [PMID: 27738951] - Cody S Shirriff, John J Heikkila. Characterization of cadmium chloride-induced BiP accumulation in Xenopus laevis A6 kidney epithelial cells.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2017 Jan; 191(?):117-128. doi:
10.1016/j.cbpc.2016.10.003. [PMID: 27746171] - Dongju Lin, Kai Wang, Xiucai Guo, Huiyuan Gao, Ying Peng, Jiang Zheng. Lysine- and cysteine-based protein adductions derived from toxic metabolites of 8-epidiosbulbin E acetate.
Toxicology letters.
2016 Dec; 264(?):20-28. doi:
10.1016/j.toxlet.2016.10.007. [PMID: 27816466] - Renata Colla, Alberto Izzotti, Chiara De Ciucis, Daniela Fenoglio, Silvia Ravera, Andrea Speciale, Roberta Ricciarelli, Anna Lisa Furfaro, Alessandra Pulliero, Mario Passalacqua, Nicola Traverso, Maria Adelaide Pronzato, Cinzia Domenicotti, Barbara Marengo. Glutathione-mediated antioxidant response and aerobic metabolism: two crucial factors involved in determining the multi-drug resistance of high-risk neuroblastoma.
Oncotarget.
2016 Oct; 7(43):70715-70737. doi:
10.18632/oncotarget.12209. [PMID: 27683112] - Dan Zhu, Yudong Mei, Yujian Shi, Dekun Hu, Yong Ren, Quan Gu, Wenbiao Shen, Xin Chen, Lingxi Xu, Liqin Huang. Involvement of glutathione in β-cyclodextrin-hemin complex-induced lateral root formation in tomato seedlings.
Journal of plant physiology.
2016 Oct; 204(?):92-100. doi:
10.1016/j.jplph.2016.07.015. [PMID: 27543888] - Sudip Banerjee, Nukhet Aykin-Burns, Kimberly J Krager, Sumit K Shah, Stepan B Melnyk, Martin Hauer-Jensen, Snehalata A Pawar. Loss of C/EBPδ enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction.
Free radical biology & medicine.
2016 10; 99(?):296-307. doi:
10.1016/j.freeradbiomed.2016.08.022. [PMID: 27554969] - Yasuaki Uematsu, Sho Akai, Tomoaki Tochitani, Shingo Oda, Toru Yamada, Tsuyoshi Yokoi. MicroRNA-mediated Th2 bias in methimazole-induced acute liver injury in mice.
Toxicology and applied pharmacology.
2016 09; 307(?):1-9. doi:
10.1016/j.taap.2016.07.008. [PMID: 27421576] - Atsushi Iwamura, Katsuhito Watanabe, Sho Akai, Tsubasa Nishinosono, Koichi Tsuneyama, Shingo Oda, Toshiyuki Kume, Tsuyoshi Yokoi. Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice.
Drug metabolism and disposition: the biological fate of chemicals.
2016 07; 44(7):888-96. doi:
10.1124/dmd.116.069575. [PMID: 27112166] - Thotegowdanapalya C Mohan, Gabriel Castrillo, Cristina Navarro, Sonia Zarco-Fernández, Eswarayya Ramireddy, Cristian Mateo, Angel M Zamarreño, Javier Paz-Ares, Riansares Muñoz, Jose M García-Mina, Luis E Hernández, Thomas Schmülling, Antonio Leyva. Cytokinin Determines Thiol-Mediated Arsenic Tolerance and Accumulation.
Plant physiology.
2016 06; 171(2):1418-26. doi:
10.1104/pp.16.00372. [PMID: 27208271] - Sho Akai, Yasuaki Uematsu, Koichi Tsuneyama, Shingo Oda, Tsuyoshi Yokoi. Kupffer cell-mediated exacerbation of methimazole-induced acute liver injury in rats.
Journal of applied toxicology : JAT.
2016 May; 36(5):702-15. doi:
10.1002/jat.3202. [PMID: 26177832] - Weiwei Li, Dongju Lin, Huiyuan Gao, Youjun Xu, Dongya Meng, Charles Vincent Smith, Ying Peng, Jiang Zheng. Metabolic activation of furan moiety makes Diosbulbin B hepatotoxic.
Archives of toxicology.
2016 Apr; 90(4):863-72. doi:
10.1007/s00204-015-1495-8. [PMID: 25851819] - Dirleise Colle, Danúbia Bonfanti Santos, Juliana Montagna Hartwig, Marcelo Godoi, Daiane Fátima Engel, Andreza Fabro de Bem, Antonio L Braga, Marcelo Farina. Succinobucol, a Lipid-Lowering Drug, Protects Against 3-Nitropropionic Acid-Induced Mitochondrial Dysfunction and Oxidative Stress in SH-SY5Y Cells via Upregulation of Glutathione Levels and Glutamate Cysteine Ligase Activity.
Molecular neurobiology.
2016 Mar; 53(2):1280-1295. doi:
10.1007/s12035-014-9086-x. [PMID: 25619973] - Dan-Chu Chin, Chia-Chi Hsieh, Hsin-Yi Lin, Kai-Wun Yeh. A Low Glutathione Redox State Couples with a Decreased Ascorbate Redox Ratio to Accelerate Flowering in Oncidium Orchid.
Plant & cell physiology.
2016 Feb; 57(2):423-36. doi:
10.1093/pcp/pcv206. [PMID: 26738548] - Amany K Elshorbagy, Fredrik Jernerén, Cheryl L Scudamore, Fiona McMurray, Heather Cater, Tertius Hough, Roger Cox, Helga Refsum. Exploring the Lean Phenotype of Glutathione-Depleted Mice: Thiol, Amino Acid and Fatty Acid Profiles.
PloS one.
2016; 11(10):e0163214. doi:
10.1371/journal.pone.0163214. [PMID: 27788147] - Varanavasiappan Shanmugam, Yi-Wen Wang, Munkhtsetseg Tsednee, Krithika Karunakaran, Kuo-Chen Yeh. Glutathione plays an essential role in nitric oxide-mediated iron-deficiency signaling and iron-deficiency tolerance in Arabidopsis.
The Plant journal : for cell and molecular biology.
2015 Nov; 84(3):464-77. doi:
10.1111/tpj.13011. [PMID: 26333047] - Clarke P Anderson, Katherine K Matthay, John P Perentesis, Joseph P Neglia, Howard H Bailey, Judith G Villablanca, Susan Groshen, Beth Hasenauer, John M Maris, Robert C Seeger, C Patrick Reynolds. Pilot study of intravenous melphalan combined with continuous infusion L-S,R-buthionine sulfoximine for children with recurrent neuroblastoma.
Pediatric blood & cancer.
2015 Oct; 62(10):1739-46. doi:
10.1002/pbc.25594. [PMID: 26153194] - Wei Li, Ronald E Maloney, Tak Yee Aw. High glucose, glucose fluctuation and carbonyl stress enhance brain microvascular endothelial barrier dysfunction: Implications for diabetic cerebral microvasculature.
Redox biology.
2015 Aug; 5(?):80-90. doi:
10.1016/j.redox.2015.03.005. [PMID: 25867911] - H Schoeneberger, K Belz, B Schenk, S Fulda. Impairment of antioxidant defense via glutathione depletion sensitizes acute lymphoblastic leukemia cells for Smac mimetic-induced cell death.
Oncogene.
2015 Jul; 34(31):4032-43. doi:
10.1038/onc.2014.338. [PMID: 25381820] - Yi Chen, Katie L Moore, Anthony J Miller, Steve P McGrath, Jian Feng Ma, Fang-Jie Zhao. The role of nodes in arsenic storage and distribution in rice.
Journal of experimental botany.
2015 Jul; 66(13):3717-24. doi:
10.1093/jxb/erv164. [PMID: 25922485] - Patrizia Brunetti, Letizia Zanella, Angelo De Paolis, Davide Di Litta, Valentina Cecchetti, Giuseppina Falasca, Maurizio Barbieri, Maria Maddalena Altamura, Paolo Costantino, Maura Cardarelli. Cadmium-inducible expression of the ABC-type transporter AtABCC3 increases phytochelatin-mediated cadmium tolerance in Arabidopsis.
Journal of experimental botany.
2015 Jul; 66(13):3815-29. doi:
10.1093/jxb/erv185. [PMID: 25900618] - Azumi Iida, Eita Sasaki, Azusa Yano, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima, Tsuyoshi Yokoi. Carbamazepine-Induced Liver Injury Requires CYP3A-Mediated Metabolism and Glutathione Depletion in Rats.
Drug metabolism and disposition: the biological fate of chemicals.
2015 Jul; 43(7):958-68. doi:
10.1124/dmd.115.063370. [PMID: 25870103] - Xuan Wang, Lijie Jiang, Lan Ge, Min Chen, Guang Yang, Fang Ji, Laifu Zhong, Yingjie Guan, Xiaofang Liu. Oxidative DNA damage induced by di-(2-ethylhexyl) phthalate in HEK-293 cell line.
Environmental toxicology and pharmacology.
2015 May; 39(3):1099-106. doi:
10.1016/j.etap.2015.03.016. [PMID: 25899473] - Małgorzata Wójcik, Sławomir Dresler, Andrzej Plak, Anna Tukiendorf. Naturally evolved enhanced Cd tolerance of Dianthus carthusianorum L. is not related to accumulation of thiol peptides and organic acids.
Environmental science and pollution research international.
2015 May; 22(10):7906-17. doi:
10.1007/s11356-014-3963-8. [PMID: 25510617] - Ana Angela Romero-Haro, Carlos Alonso-Alvarez. The level of an intracellular antioxidant during development determines the adult phenotype in a bird species: a potential organizer role for glutathione.
The American naturalist.
2015 Mar; 185(3):390-405. doi:
10.1086/679613. [PMID: 25674693] - Haiyan Yuan, Yongxia Zhang, Suzhen Huang, Yongheng Yang, Chunsun Gu. Effects of exogenous glutathione and cysteine on growth, lead accumulation, and tolerance of Iris lactea var. chinensis.
Environmental science and pollution research international.
2015 Feb; 22(4):2808-16. doi:
10.1007/s11356-014-3535-y. [PMID: 25212813] - Zhen Wang, Jie-Li Mao, Ying-Jun Zhao, Chuan-You Li, Cheng-Bin Xiang. L-Cysteine inhibits root elongation through auxin/PLETHORA and SCR/SHR pathway in Arabidopsis thaliana.
Journal of integrative plant biology.
2015 Feb; 57(2):186-97. doi:
10.1111/jipb.12213. [PMID: 24798139] - ZhengLin Zhao, Sang Mi Park, LiXin Guan, YiYan Wu, Jong Rok Lee, Sang Chan Kim, Young Woo Kim, RongJie Zhao. Isoliquiritigenin attenuates oxidative hepatic damage induced by carbon tetrachloride with or without buthionine sulfoximine.
Chemico-biological interactions.
2015 Jan; 225(?):13-20. doi:
10.1016/j.cbi.2014.10.030. [PMID: 25450236] - Da Wang, Lin Lin, Xin Li, Gui-Fan Sun. Effects of glutathione on the in vivo metabolism and oxidative stress of arsenic in mice.
The Journal of toxicological sciences.
2015; 40(5):577-83. doi:
10.2131/jts.40.577. [PMID: 26354374] - Toru Takeda, Yuki Fukui. Possible role of NAD-dependent glyceraldehyde-3-phosphate dehydrogenase in growth promotion of Arabidopsis seedlings by low levels of selenium.
Bioscience, biotechnology, and biochemistry.
2015; 79(10):1579-86. doi:
10.1080/09168451.2015.1045826. [PMID: 25988618] - Ebtihal H Mustafa, Huda T Mahmoud, Mariam Y Al-Hudhud, Maher Y Abdalla, Iman M Ahmad, Salem R Yasin, Ali Z Elkarmi, Lubna H Tahtamouni. 2-deoxy-D-Glucose Synergizes with Doxorubicin or L-Buthionine Sulfoximine to Reduce Adhesion and Migration of Breast Cancer Cells.
Asian Pacific journal of cancer prevention : APJCP.
2015; 16(8):3213-22. doi:
10.7314/apjcp.2015.16.8.3213. [PMID: 25921122] - Claudia Di Giacomo, Rosa Santangelo, Valeria Sorrenti, Giovanni L Volti, Rosaria Acquaviva. Neuroprotective effects of a glutathione depletor in rat post-ischemic reperfusion brain damage.
CNS & neurological disorders drug targets.
2015; 14(1):41-8. doi:
10.2174/1871527314666150116113647. [PMID: 25613502] - Qi Shen, Minjuan Zuo, Li Ma, Ye Tian, Lu Wang, Huidi Jiang, Quan Zhou, Hui Zhou, Lushan Yu, Su Zeng. Demethylation of neferine in human liver microsomes and formation of quinone methide metabolites mediated by CYP3A4 accentuates its cytotoxicity.
Chemico-biological interactions.
2014 Dec; 224(?):89-99. doi:
10.1016/j.cbi.2014.10.014. [PMID: 25451576] - Maryam Madadkar Haghjou, Louise Colville, Nicholas Smirnoff. The induction of menadione stress tolerance in the marine microalga, Dunaliella viridis, through cold pretreatment and modulation of the ascorbate and glutathione pools.
Plant physiology and biochemistry : PPB.
2014 Nov; 84(?):96-104. doi:
10.1016/j.plaphy.2014.08.024. [PMID: 25240268] - Ana C Liaudat, Luciana P Bohl, Nori G Tolosa de Talamoni, Belkys Maletto, María C Pistoresi-Palencia, Gabriela Picotto. Oxidative stress, cell cycle arrest and differentiation contribute toward the antiproliferative action of BSO and calcitriol on Caco-2 cells.
Anti-cancer drugs.
2014 Aug; 25(7):810-8. doi:
10.1097/cad.0000000000000109. [PMID: 24681551] - Fuying Du, Zhaohua Liu, Xinxiu Li, Jie Xing. Metabolic pathways leading to detoxification of triptolide, a major active component of the herbal medicine Tripterygium wilfordii.
Journal of applied toxicology : JAT.
2014 Aug; 34(8):878-84. doi:
10.1002/jat.2906. [PMID: 23836259] - Ahmed Nadeem, Nahid Siddiqui, Naif O Alharbi, Mohammad M Alharbi, Faisal Imam, Mohamed M Sayed-Ahmed. Glutathione modulation during sensitization as well as challenge phase regulates airway reactivity and inflammation in mouse model of allergic asthma.
Biochimie.
2014 Aug; 103(?):61-70. doi:
10.1016/j.biochi.2014.04.001. [PMID: 24742380] - Yan Wang, Weiwei Zhao, Junran Hao, Wentao Xu, Yunbo Luo, Weihong Wu, Zhuojun Yang, Zhihong Liang, Kunlun Huang. Changes in biosynthesis and metabolism of glutathione upon ochratoxin A stress in Arabidopsis thaliana.
Plant physiology and biochemistry : PPB.
2014 Jun; 79(?):10-8. doi:
10.1016/j.plaphy.2014.03.001. [PMID: 24662377] - Ellen Klauser, Michael Gülden, Edmund Maser, Sabine Seibert, Hasso Seibert. Additivity, antagonism, and synergy in arsenic trioxide-induced growth inhibition of C6 glioma cells: effects of genistein, quercetin and buthionine-sulfoximine.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2014 May; 67(?):212-21. doi:
10.1016/j.fct.2014.02.039. [PMID: 24632069] - L R Nigmatullina, N I Rumiantseva, Iu A Kostiukova. [Effect of D,L-buthionine-S,R-sulfoximine on the ratio of glutathione forms and the growth of tatar buckwheat calli].
Ontogenez.
2014 Jan; 45(1):50-62. doi:
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Clinical and experimental hypertension (New York, N.Y. : 1993).
2014; 36(6):367-73. doi:
10.3109/10641963.2014.943402. [PMID: 25198883] - Rola Barhoumi, Youssef Mouneimne, Robert S Chapkin, Robert C Burghardt. Effects of fatty acids on benzo[a]pyrene uptake and metabolism in human lung adenocarcinoma A549 cells.
PloS one.
2014; 9(3):e90908. doi:
10.1371/journal.pone.0090908. [PMID: 24651647] - Floriane Larras, Nicole Regier, Sébastien Planchon, John Poté, Jenny Renaut, Claudia Cosio. Physiological and proteomic changes suggest an important role of cell walls in the high tolerance to metals of Elodea nuttallii.
Journal of hazardous materials.
2013 Dec; 263 Pt 2(?):575-83. doi:
10.1016/j.jhazmat.2013.10.016. [PMID: 24225582] - Hsien-Jung Chen, Chin-Shu Huang, Guan-Jhong Huang, Te-Jin Chow, Yaw-Huei Lin. NADPH oxidase inhibitor diphenyleneiodonium and reduced glutathione mitigate ethephon-mediated leaf senescence, H2O2 elevation and senescence-associated gene expression in sweet potato (Ipomoea batatas).
Journal of plant physiology.
2013 Nov; 170(17):1471-83. doi:
10.1016/j.jplph.2013.05.015. [PMID: 23834930] - Eita Sasaki, Kentaro Matsuo, Azumi Iida, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima, Tsuyoshi Yokoi. A novel mouse model for phenytoin-induced liver injury: involvement of immune-related factors and P450-mediated metabolism.
Toxicological sciences : an official journal of the Society of Toxicology.
2013 Nov; 136(1):250-63. doi:
10.1093/toxsci/kft184. [PMID: 23986454] - Susanne Ramm, Angela Mally. Role of drug-independent stress factors in liver injury associated with diclofenac intake.
Toxicology.
2013 Oct; 312(?):83-96. doi:
10.1016/j.tox.2013.08.002. [PMID: 23939143] - Wen Hua Yang, Zhen Zhang, Yang Hu Sima, Jian Zhang, Jian Wen Wang. Glaucocalyxin A and B-induced cell death is related to GSH perturbation in human leukemia HL-60 cells.
Anti-cancer agents in medicinal chemistry.
2013 Oct; 13(8):1280-90. doi:
10.2174/18715206113139990200. [PMID: 23796245] - Hideaki Yamaguchi, Yumi Kidachi, Katsuyoshi Kamiie, Toshiro Noshita, Hironori Umetsu, Yoko Fuke, Kazuo Ryoyama. Utilization of 6-(methylsulfinyl)hexyl isothiocyanate for sensitization of tumor cells to antitumor agents in combination therapies.
Biochemical pharmacology.
2013 Aug; 86(4):458-68. doi:
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