1,2-Epoxy-3-(p-nitrophenoxy)propane (BioDeep_00000005460)
Secondary id: BioDeep_00001868754
human metabolite blood metabolite
代谢物信息卡片
化学式: C9H9NO4 (195.0532)
中文名称: 1,2-环氧-3-(4-硝基苯氧基)丙烷, 1,2-环氧-3-（对硝基苯氧基）丙烷
谱图信息:
最多检出来源 Homo sapiens(not specific) 50%
分子结构信息
SMILES: C1C(O1)COC2=CC=C(C=C2)[N+](=O)[O-]
InChI: InChI=1S/C9H9NO4/c11-10(12)7-1-3-8(4-2-7)13-5-9-6-14-9/h1-4,9H,5-6H2
描述信息
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:508
- KEGG: C04274
- PubChem: 21327
- HMDB: HMDB0246908
- Metlin: METLIN66149
- ChEMBL: CHEMBL33775
- chemspider: 20045
- CAS: 5255-75-4
- PMhub: MS000018276
- PubChem: 6937
- NIKKAJI: J39.054B
- KNApSAcK: 508
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Edwin J Squirewell, Marci G Smeltz, Laura Rowland-Faux, Lloyd P Horne, Peter W Stacpoole, Margaret O James. Effects of Multiple Doses of Dichloroacetate on GSTZ1 Expression and Activity in Liver and Extrahepatic Tissues of Young and Adult Rats.
Drug metabolism and disposition: the biological fate of chemicals.
2020 11; 48(11):1217-1223. doi:
10.1124/dmd.120.000142. [PMID: 32873593] - Kazunori Fujimoto, Shingo Arakawa, Toshiyuki Watanabe, Hiroaki Yasumo, Yosuke Ando, Wataru Takasaki, Sunao Manabe, Takashi Yamoto, Sen-Ichi Oda. Generation and functional characterization of mice with a disrupted glutathione S-transferase, theta 1 gene.
Drug metabolism and disposition: the biological fate of chemicals.
2007 Dec; 35(12):2196-202. doi:
10.1124/dmd.107.017905. [PMID: 17827337] - Mümtaz Işcan, Ahmet O Ada, Tülay Coban, Nilgün Kapucuoğlu, Ahmet Aydin, Aşkin Isimer. Combined effects of cadmium and nickel on testicular xenobiotic metabolizing enzymes in rats.
Biological trace element research.
2002 Nov; 89(2):177-90. doi:
10.1385/bter:89:2:177. [PMID: 12449241] - Jianxia Guo, Ludwika Zimniak, Piotr Zimniak, John L Orchard, Shivendra V Singh. Cloning and expression of a novel Mu class murine glutathione transferase isoenzyme.
The Biochemical journal.
2002 Sep; 366(Pt 3):817-24. doi:
10.1042/bj20020041. [PMID: 12069689] - Marjorie Coggan, Jack U Flanagan, Michael W Parker, Vanicha Vichai, William R Pearson, Philip G Board. Identification and characterization of GSTT3, a third murine Theta class glutathione transferase.
The Biochemical journal.
2002 Aug; 366(Pt 1):323-32. doi:
10.1042/bj20011878. [PMID: 12038961] - Mumtaz Iscan, Tulay Coban, Ismet Cok, Dilek Bulbul, Benay C Eke, Sema Burgaz. The organochlorine pesticide residues and antioxidant enzyme activities in human breast tumors: is there any association?.
Breast cancer research and treatment.
2002 Mar; 72(2):173-82. doi:
10.1023/a:1014828705281. [PMID: 12038708] - A Whittington, V Vichai, G Webb, R Baker, W Pearson, P Board. Gene structure, expression and chromosomal localization of murine theta class glutathione transferase mGSTT1-1.
The Biochemical journal.
1999 Jan; 337 ( Pt 1)(?):141-51. doi:
. [PMID: 9854036] - R Thier, F A Wiebel, A Hinkel, A Burger, T Brüning, K Morgenroth, T Senge, M Wilhelm, T G Schulz. Species differences in the glutathione transferase GSTT1-1 activity towards the model substrates methyl chloride and dichloromethane in liver and kidney.
Archives of toxicology.
1998 Oct; 72(10):622-9. doi:
10.1007/s002040050552. [PMID: 9851677] - J M Veitch, G M Hawksworth, V Rodilla. Conjugation of 1,2-epoxy-3-(p-nitrophenoxy)-propane and 1-menaphthyl sulfate with glutathione in human renal cortex and renal carcinomas.
Biochemical Society transactions.
1997 Nov; 25(4):S606. doi:
10.1042/bst025s606. [PMID: 9450034] - H Dai, F W Edens, R M Roe. Glutathione S-transferases in the Japanese quail: tissue distribution and purification of the liver isozymes.
Journal of biochemical toxicology.
1996; 11(2):85-96. doi:
10.1002/(sici)1522-7146(1996)11:2<85::aid-jbt6>3.0.co;2-q. [PMID: 8884469] - S K Ackerman, L Matter, S D Douglas. Effects of acid proteinase inhibitors on human neutrophil chemotaxis and lysosomal enzyme release. II. Bromphenacyl bromide and 1,2-epoxy-3-(p-nitrophenoxy)propane.
Clinical immunology and immunopathology.
1983 Feb; 26(2):213-22. doi:
10.1016/0090-1229(83)90139-3. [PMID: 6872342] - P Kraus, H D Kloft. The activity of glutathione-S-transferases in various organs of the rat.
Enzyme.
1980; 25(3):158-60. doi:
10.1159/000459242. [PMID: 6156823]
