Aloin (BioDeep_00000000537)

 

Secondary id: BioDeep_00000003341

natural product PANOMIX_OTCML-2023


代谢物信息卡片


(10S)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]-10H-anthracen-9-one;Aloin

化学式: C21H22O9 (418.1263762)
中文名称: 芦荟苷A, 芦荟甙 B, 芦荟苷 B, 芦荟素 B, 芦荟苷B, 芦荟提取液, 芦荟甙
谱图信息: 最多检出来源 Viridiplantae(plant) 0.51%

分子结构信息

SMILES: C1=CC2=C(C(=C1)O)C(=O)C3=C(C2C4C(C(C(C(O4)CO)O)O)O)C=C(C=C3O)CO
InChI: InChI=1S/C21H22O9/c22-6-8-4-10-14(21-20(29)19(28)17(26)13(7-23)30-21)9-2-1-3-11(24)15(9)18(27)16(10)12(25)5-8/h1-5,13-14,17,19-26,28-29H,6-7H2

描述信息

C78276 - Agent Affecting Digestive System or Metabolism > C29697 - Laxative
D005765 - Gastrointestinal Agents > D002400 - Cathartics
Aloin A is a C-glycosyl compound that is beta-D-glucopyranose in which the anomeric hydroxy group is replaced by a 4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl moiety (the 9S diastereoisomer). It has a role as a metabolite and a laxative. It is a C-glycosyl compound, a member of anthracenes, a cyclic ketone and a member of phenols.
Barbaloin is a natural product found in Aloe africana, Aloe castanea, and other organisms with data available.
See also: Aloe Vera Leaf (part of); Frangula purshiana Bark (part of).
A C-glycosyl compound that is beta-D-glucopyranose in which the anomeric hydroxy group is replaced by a 4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl moiety (the 9S diastereoisomer).
Aloin B is a C-glycosyl compound that is beta-D-glucopyranose in which the anomeric hydroxy group is replaced by a 4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl moiety (the 9R diastereoisomer). It has a role as a metabolite and a laxative. It is a C-glycosyl compound, a member of anthracenes, a cyclic ketone and a member of phenols.
Aloin is a natural product found in Aloe africana, Aloe castanea, and other organisms with data available.
See also: Aloe Vera Leaf (part of); Frangula purshiana Bark (part of).
A C-glycosyl compound that is beta-D-glucopyranose in which the anomeric hydroxy group is replaced by a 4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl moiety (the 9R diastereoisomer).
IPB_RECORD: 1881; CONFIDENCE confident structure
Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity.
Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity.
Aloin B is an isomer of aloin, a physiologically active anthraquinone compound in aloe.
Aloin B is an isomer of aloin, a physiologically active anthraquinone compound in aloe.
Aloin (mixture of A&B) is anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) has diverse biological activities such as anti-inflammatory, immunity, antidiabetic, antioxidant, antibacterial, antifungal, and antitumor activities. Aloin (mixture of A&B) also an effective inhibitor of stimulated granulocyte matrix metalloproteinases (MMPs)[1][2].

同义名列表

75 个代谢物同义名

aloin B; Aloin; (10S)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]-10H-anthracen-9-one;Aloin; (S)-1,8-dihydroxy-3-(hydroxymethyl)-10-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)anthracen-9(10H)-one; (10S)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]-10H-anthracen-9-one; (10S)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-9,10-dihydroanthracen-9-one; (10S)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-10H-anthracen-9-one; (1S)-1,5-anhydro-1-[(9S)-4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl]-D-glucitol; (1S)-1,5-anhydro-1-((9S)-4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl)-D-glucitol; 9(10H)-Anthracenone, 10-.beta.-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-, (10S)-; 10-.BETA.-D-Glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone-, 10(S)-; 9(10H)-Anthracenone, 10-.beta.-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-, (S)-; 9(10H)-Anthracenone, 10-beta-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-, (10S)-; 1,8-Dihydroxy-3-hydroxymethyl-10-(6-hydroxymethyl-3,4,5-trihydroxy-2-pyranyl)anthrone; 9(10H)-ANTHRACENONE, 10-beta-D-GLUCOPYRANOSYL-1,8-DIHYDROXY-3-(HYDROXYMETHYL)-, (S)-; (10S)-10-.BETA.-D-GLUCOPYRANOSYL-1,8-DIHYDROXY-3-(HYDROXYMETHYL)-9(10H)-ANTHRACENONE; (10S)-10-beta-D-GLUCOPYRANOSYL-1,8-DIHYDROXY-3-(HYDROXYMETHYL)-9(10H)-ANTHRACENONE; (R)-10-beta-D-Glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)anthracen-9(10H)-one; 1,8-Dihydroxy-10-(beta-D-glucopyranosyl)-3-(hydroxymethyl)-9(10H)-anthracenone; 10-beta-D-Glucopyranosyl-1,8-dihydroxy-3-hydroxymethyl-9(10H)-anthrone,(R)-; 10-Glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone; Aloin, United States Pharmacopeia (USP) Reference Standard; Aloin, from Aloe barbadensis Miller leaves, >=97\\%; Aloin, from Curacao aloe, ~50\\%; Aloin, analytical standard; barbaloin, monoglucoside; barbaloin, beta-D-isomer; barbaloin, (S)-isomer; Aloin (Barbaloin); Barbaloin,(S); Tox21_113216; ALOIN A [MI]; Isobarbaloin; Tox21_111495; Aloin [BAN]; Barbaloin-A; Barbaloin A; Barbaloin; Barbalin; Aloin-A; aloin A; Aloinum; (R)-1,8-dihydroxy-3-(hydroxymethyl)-10-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)anthracen-9(10H)-one; (10R)-1,8-DIHYDROXY-3-(HYDROXYMETHYL)-10-[(2S,3R,4R,5S,6R)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)OXAN-2-YL]-9,10-DIHYDROANTHRACEN-9-ONE; (10R)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-10H-anthracen-9-one; (1S)-1,5-anhydro-1-[(9R)-4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl]-D-glucitol; (1S)-1,5-anhydro-1-((9R)-4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl)-D-glucitol; 9(10H)-ANTHRACENONE, 10-.BETA.-D-GLUCOPYRANOSYL-1,8-DIHYDROXY-3-(HYDROXYMETHYL)-, (10R)-; 9(10H)-ANTHRACENONE, 10-beta-D-GLUCOPYRANOSYL-1,8-DIHYDROXY-3-(HYDROXYMETHYL)-, (10R)-; 9(10H)-Anthracenone, 10-beta-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-, (R)-; (10R)-10-.BETA.-D-GLUCOPYRANOSYL-1,8-DIHYDROXY-3-(HYDROXYMETHYL)-9(10H)-ANTHRACENONE; (10R)-10-beta-D-GLUCOPYRANOSYL-1,8-DIHYDROXY-3-(HYDROXYMETHYL)-9(10H)-ANTHRACENONE; 9(10H)-Anthracenone,10-b-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-,(10R)-; 10R-beta-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone; 1,8-Dihydroxy-10-(ss-D-glucopyranosyl)-3-(hydroxymethyl)-9(10H)-anthracenone; 10-ss-D-Glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone; AFHJQYHRLPMKHU-WEZNYRQKSA-N; Aloin B; Isobarbaloin; Aloin-B;Isobarbaloin; UNII-69VIB0J2WK; |A-Barbaloin; ALOIN B [MI]; BARBALOIN B; 69VIB0J2WK; alloin; 10-beta-D-Glucopyranosyl-1,8-dihydro-3-(hydroxymethyl)-9(10H)-anthracenone; 1,8-dihydroxy-3-(hydroxymethyl)-10-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-9,10-dihydroanthracen-9-one; 10-b-D-Glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone, 9CI; 10-(1',5'-Anhydroglucosyl)aloe-emodin-9-anthrone; Ugandaloin; Socaloin; Cafaloin; Jafaloin; Aloin-B; Aloin(mixture of A&B)



数据库引用编号

65 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

5 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(4)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

83 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Junjie Bai, Baolin Qian, Tianying Cai, Yifan Chen, Tongxi Li, Yonglang Cheng, Ziming Wu, Chen Liu, Mingxin Ye, Yichao Du, Wenguang Fu. Aloin Attenuates Oxidative Stress, Inflammation, and CCl4-Induced Liver Fibrosis in Mice: Possible Role of TGF-β/Smad Signaling. Journal of agricultural and food chemistry. 2023 Dec; 71(49):19475-19487. doi: 10.1021/acs.jafc.3c01721. [PMID: 38038700]
  • Meng Yu, Xin-Yu Kong, Tong-Tong Chen, Zhong-Mei Zou. In vivo metabolism combined network pharmacology to identify anti-constipation constituents in Aloe barbadensis Mill. Journal of ethnopharmacology. 2023 Sep; 319(Pt 1):117200. doi: 10.1016/j.jep.2023.117200. [PMID: 37726070]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Shreya Sikdar Mitra, Mimosa Ghorai, Samapika Nandy, Nobendu Mukherjee, Manoj Kumar, Radha, Arabinda Ghosh, Niraj Kumar Jha, Jarosław Proćków, Abhijit Dey. Barbaloin: an amazing chemical from the 'wonder plant' with multidimensional pharmacological attributes. Naunyn-Schmiedeberg's archives of pharmacology. 2022 12; 395(12):1525-1536. doi: 10.1007/s00210-022-02294-4. [PMID: 36173445]
  • Xin-Yu Kong, Tong-Tong Chen, Hong-Wu Zhang, Hong-Mei Jia, Meng Yu, Zhong-Mei Zou. Characterization of the metabolism of aloin A/B and aloesin in rats using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Biomedical chromatography : BMC. 2022 Dec; 36(12):e5483. doi: 10.1002/bmc.5483. [PMID: 35975594]
  • Hui Jiang, Gao-Feng Shi, Yu-Xi Fang, You-Qian Liu, Qi Wang, Xian Zheng, Dong-Jian Zhang, Jian Zhang, Zhi-Qi Yin. Aloin A prevents ulcerative colitis in mice by enhancing the intestinal barrier function via suppressing the Notch signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Nov; 106(?):154403. doi: 10.1016/j.phymed.2022.154403. [PMID: 36075180]
  • Yu Yang, Jiao-Jiao Wu, Jia Xia, Yan Wan, Jin-Feng Xu, Li Zhang, Dong Liu, Lu Chen, Fei Tang, Hui Ao, Cheng Peng. Can aloin develop to medicines or healthcare products?. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Sep; 153(?):113421. doi: 10.1016/j.biopha.2022.113421. [PMID: 36076485]
  • Gong Zhang, Rong Bai, Jianlin Huang, Yafeng Gao, Xiuli Yun, Akber Aisa Haji. Barbaloin attenuates pulmonary fibrosis through TGF-β1/Smads/p38 pathway. The Journal of pharmacy and pharmacology. 2022 Aug; 74(8):1160-1169. doi: 10.1093/jpp/rgac023. [PMID: 35666278]
  • A Wallace Hayes, Roger A Clemens, Peter Pressman. The absence of genotoxicity of a mixture of aloin A and B and a commercial aloe gel beverage. Toxicology mechanisms and methods. 2022 Jun; 32(5):385-394. doi: 10.1080/15376516.2021.2023828. [PMID: 34979868]
  • Magdalena Westermann, Amma G Adomako-Bonsu, Solveig Thiele, Serhat Sezai Çiçek, Hans-Jörg Martin, Edmund Maser. Inhibition of human carbonyl reducing enzymes by plant anthrone and anthraquinone derivatives. Chemico-biological interactions. 2022 Feb; 354(?):109823. doi: 10.1016/j.cbi.2022.109823. [PMID: 35065925]
  • Devin S M Lewis, Joanna Ho, Savannah Wills, Anasha Kawall, Avini Sharma, Krishna Chavada, Maximilian C C J C Ebert, Stefania Evoli, Ajay Singh, Srujana Rayalam, Vicky Mody, Shashidharamurthy Taval. Aloin isoforms (A and B) selectively inhibits proteolytic and deubiquitinating activity of papain like protease (PLpro) of SARS-CoV-2 in vitro. Scientific reports. 2022 02; 12(1):2145. doi: 10.1038/s41598-022-06104-y. [PMID: 35140265]
  • Mostafa M Abdel-Moniem, Azza M Hassan, Mahmoud M Said, Amr Y Esmat. Iron supplementation ameliorates aloin-induced iron deficiency anemia in rats. Experimental and molecular pathology. 2022 02; 124(?):104740. doi: 10.1016/j.yexmp.2021.104740. [PMID: 34998864]
  • Jianbin Xiao, Siyuan Chen, Youqiang Chen, Jingqian Su. The potential health benefits of aloin from genus Aloe. Phytotherapy research : PTR. 2022 Feb; 36(2):873-890. doi: 10.1002/ptr.7371. [PMID: 35040198]
  • Dazhi Fu, Qiang Ji, Chunxiao Wang, Lei Yu, Rui Yu. Aloin decelerates the progression of hepatocellular carcinoma through circ_0011385/miR-149-5p/WT1 axis. Cell cycle (Georgetown, Tex.). 2021 12; 20(23):2476-2493. doi: 10.1080/15384101.2021.1988227. [PMID: 34720052]
  • Hanyi Hua, Jie Sheng, Yan Cui, Wenyi Zhang, Bin Hu, Yuliang Cheng, Yahui Guo, He Qian. The Intervention and Mechanism of Action for Aloin against Subchronic Aflatoxin B1 Induced Hepatic Injury in Rats. International journal of molecular sciences. 2021 Oct; 22(21):. doi: 10.3390/ijms222111620. [PMID: 34769051]
  • Hao Yuan, Hong Wan, Yi-Kao Hu, Emmanuel Ayodeji Ayeni, Qiang Chang, Chao Ma, Xun Liao. Fishing of α-Glucosidase's Ligands from Aloe vera by α-Glucosidase Functionalized Magnetic Nanoparticles. Molecules (Basel, Switzerland). 2021 Sep; 26(19):. doi: 10.3390/molecules26195840. [PMID: 34641385]
  • Kamil Pawłowicz, Dominika Ludowicz, Marta Karaźniewicz-Łada, Kamil Wdowiak, Judyta Cielecka-Piontek. Analysis of the Composition of Lyophilisates Obtained from Aloe arborescens Gel of Leaves of Different Ages from Controlled Crops. Molecules (Basel, Switzerland). 2021 May; 26(11):. doi: 10.3390/molecules26113204. [PMID: 34071863]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Eleftheria H Kaparakou, Charalabos D Kanakis, Maria Gerogianni, Matina Maniati, Kostas Vekrellis, Efstathia Skotti, Petros A Tarantilis. Quantitative determination of aloin, antioxidant activity, and toxicity of Aloe vera leaf gel products from Greece. Journal of the science of food and agriculture. 2021 Jan; 101(2):414-423. doi: 10.1002/jsfa.10650. [PMID: 32643805]
  • Qiushi Xu, Yunhui Fan, Juan J Loor, Yusheng Liang, Hongming Lv, Xudong Sun, Hongdou Jia, Chuang Xu. Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling. Food & function. 2021 Jan; 12(2):696-705. doi: 10.1039/d0fo02684k. [PMID: 33410857]
  • Chenxi Zhang, Zhenxuan Shao, Xiaofen Hu, Zhengtai Chen, Baolong Li, Renhao Jiang, Najeeb Bsoul, Jiaoxiang Chen, Cong Xu, Weiyang Gao. Inhibition of PI3K/Akt/NF-κB signaling by Aloin for ameliorating the progression of osteoarthritis: In vitro and in vivo studies. International immunopharmacology. 2020 Dec; 89(Pt B):107079. doi: 10.1016/j.intimp.2020.107079. [PMID: 33096361]
  • Lalit Birari, Shivani Wagh, Kalpesh R Patil, Umesh B Mahajan, Banappa Unger, Sateesh Belemkar, Sameer N Goyal, Shreesh Ojha, Chandragouda R Patil. Aloin alleviates doxorubicin-induced cardiotoxicity in rats by abrogating oxidative stress and pro-inflammatory cytokines. Cancer chemotherapy and pharmacology. 2020 09; 86(3):419-426. doi: 10.1007/s00280-020-04125-w. [PMID: 32812061]
  • Chang Peng, WeiJia Zhang, Xue Shen, YueMei Yuan, Yan Li, Wei Zhang, MeiCun Yao. Post-transcriptional regulation activity through alternative splicing involved in the effects of Aloe vera on the Wnt/β-catenin and Notch pathways in colorectal cancer cells. Journal of pharmacological sciences. 2020 Jul; 143(3):148-155. doi: 10.1016/j.jphs.2020.03.006. [PMID: 32268968]
  • Zahra Mehrani, Homeira Ebrahimzadeh, Ebrahim Moradi. Use of aloin-based and rosin-based electrospun nanofibers as natural nanosorbents for the extraction of polycyclic aromatic hydrocarbons and phenoxyacetic acid herbicides by microextraction in packed syringe method prior to GC-FID detection. Mikrochimica acta. 2020 06; 187(7):401. doi: 10.1007/s00604-020-04374-9. [PMID: 32572604]
  • Chao Niu, Weijian Ye, Xiao Cui, Jia Sun, Shuyi Xiao, Gen Chen, Shihui Bao, Ruijie Chen. UHPLC-MS/MS method for the quantification of aloin-A in rat plasma and its application to a pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2020 Jan; 178(?):112928. doi: 10.1016/j.jpba.2019.112928. [PMID: 31708267]
  • Ulrich Girreser, Tommaso Ugolini, Serhat Sezai Çiçek. Quality control of Aloe vera (Aloe barbadensis) and Aloe ferox using band-selective quantitative heteronuclear single quantum correlation spectroscopy (bs-qHSQC). Talanta. 2019 Dec; 205(?):120109. doi: 10.1016/j.talanta.2019.07.004. [PMID: 31450436]
  • Ching-Tai Huang, Chen-Yiu Hung, Yu-Chia Hseih, Chia-Shiang Chang, Arul Balaji Velu, Yueh-Chia He, Yu-Lin Huang, Ting-An Chen, Tse-Ching Chen, Chun-Yen Lin, Yung-Chang Lin, Shin-Ru Shih, Avijit Dutta. Effect of aloin on viral neuraminidase and hemagglutinin-specific T cell immunity in acute influenza. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Nov; 64(?):152904. doi: 10.1016/j.phymed.2019.152904. [PMID: 31454654]
  • Mohammad K Parvez, Mohammed S Al-Dosari, Perwez Alam, MdTabish Rehman, Mohammed F Alajmi, Ali S Alqahtani. The anti-hepatitis B virus therapeutic potential of anthraquinones derived from Aloe vera. Phytotherapy research : PTR. 2019 Nov; 33(11):2960-2970. doi: 10.1002/ptr.6471. [PMID: 31410907]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Chang Peng, WeiJia Zhang, Cong Dai, Wa Li, Xue Shen, YueMei Yuan, Li Yan, Wei Zhang, MeiCun Yao. Study of the aqueous extract of Aloe vera and its two active components on the Wnt/β-catenin and Notch signaling pathways in colorectal cancer cells. Journal of ethnopharmacology. 2019 Oct; 243(?):112092. doi: 10.1016/j.jep.2019.112092. [PMID: 31319122]
  • Wonhwa Lee, Gil-Saeng Jeong, Moon-Chang Baek, Sae-Kwang Ku, Jong-Sup Bae. Renal protective effects of aloin in a mouse model of sepsis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2019 Oct; 132(?):110651. doi: 10.1016/j.fct.2019.110651. [PMID: 31254592]
  • Guglielmina Froldi, Federica Baronchelli, Elisa Marin, Margherita Grison. Antiglycation Activity and HT-29 Cellular Uptake of Aloe-Emodin, Aloin, and Aloe arborescens Leaf Extracts. Molecules (Basel, Switzerland). 2019 Jun; 24(11):. doi: 10.3390/molecules24112128. [PMID: 31195732]
  • Wonhwa Lee, Sumin Yang, Changhun Lee, Eui Kyun Park, Kyung-Min Kim, Sae-Kwang Ku, Jong-Sup Bae. Aloin reduces inflammatory gene iNOS via inhibition activity and p-STAT-1 and NF-κB. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2019 Apr; 126(?):67-71. doi: 10.1016/j.fct.2019.02.025. [PMID: 30769049]
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  • Tibebu Hailesillassie, Daniel Bisrat, Kaleab Asres. Larvicidal effect of the leaf latex of Aloe yavellana Reynolds and its major compounds against Amblyomma variegatum (Ixodidae). Veterinary parasitology. 2018 Nov; 263(?):23-26. doi: 10.1016/j.vetpar.2018.09.015. [PMID: 30389020]
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