Pteryxin (BioDeep_00000000523)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


2-Butenoic acid, 2-methyl-, 9-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo(1,2-b:3- ,4-b)dipyran-10-yl ester, (9R-(9alpha,10alpha(Z)))-

化学式: C21H22O7 (386.1365462)
中文名称: 北美芹素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 8.33%

分子结构信息

SMILES: C/C=C(/C)C(=O)OC1c2c(ccc3ccc(=O)oc23)OC(C)(C)C1OC(C)=O
InChI: InChI=1S/C21H22O7/c1-6-11(2)20(24)27-18-16-14(28-21(4,5)19(18)25-12(3)22)9-7-13-8-10-15(23)26-17(13)16/h6-10,18-19H,1-5H3/b11-6-

描述信息

Pteryxin is a member of coumarins.
Pteryxin is a natural product found in Musineon divaricatum, Pteryxia terebinthina, and other organisms with data available.
Origin: Plant, Coumarins
Pteryxin, a coumarin in Peucedanum japonicum Thunb leaves, exerts antiobesity activity[1]. Pteryxin is a potent butyrylcholinesterase (BChE) inhibitor, with an IC50 of 12.96 μg/ml[2].
Pteryxin, a coumarin in Peucedanum japonicum Thunb leaves, exerts antiobesity activity[1]. Pteryxin is a potent butyrylcholinesterase (BChE) inhibitor, with an IC50 of 12.96 μg/ml[2].

同义名列表

26 个代谢物同义名

2-Butenoic acid, 2-methyl-, 9-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo(1,2-b:3- ,4-b)dipyran-10-yl ester, (9R-(9alpha,10alpha(Z)))-; 2-Butenoic acid, 2-methyl-, 9-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo(1,2-b:3,4-b)dipyran-10-yl ester, (9R-(9alpha,10alpha(Z)))-; 2-Butenoic acid, 2-methyl-, (9R,10R)-9-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b]dipyran-10-yl ester, (2Z)-; 2-BUTENOIC ACID, 2-METHYL-, (9R,10R)-9-(ACETYLOXY)-9,10-DIHYDRO-8,8-DIMETHYL-2-OXO-2H,8H-BENZO(1,2-B:3,4-B)DIPYRAN-10-YL ESTER, (2Z)-; CROTONIC ACID, 2-METHYL-, 10-ESTER WITH 9,10-DIHYDRO-9,10-DIHYDROXY-8,8-DIMETHYL-2H,8H-BENZO(1,2-B:3,4-B)DIPYRAN-2-ONE ACETATE, (Z)-; [(9R,10R)-9-acetyloxy-8,8-dimethyl-2-oxo-9,10-dihydropyrano[2,3-f]chromen-10-yl] (Z)-2-methylbut-2-enoate; [(9R,10R)-9-acetoxy-8,8-dimethyl-2-oxo-9,10-dihydropyrano[2,3-f]chromen-10-yl] (Z)-2-methylbut-2-enoate; (+)-(3R,4R)-3-ACETYL-4-ANGELOYLKHELLACTONE; UNII-C1G8A9744Z; (+)-Pteryxin; C1G8A9744Z; PTERYXINE; Pteryxin; Pterixin; AC1NQYG8; (Z)-2-methylbut-2-enoic acid [(9R,10R)-9-acetoxy-2-keto-8,8-dimethyl-9,10-dihydropyrano[6,5-h]chromen-10-yl] ester; (Z)-2-methylbut-2-enoic acid [(9R,10R)-9-acetoxy-8,8-dimethyl-2-oxo-9,10-dihydropyrano[6,5-h]chromen-10-yl] ester; [(9R,10R)-9-acetyloxy-8,8-dimethyl-2-oxo-9,10-dihydropyrano[6,5-h]chromen-10-yl] (Z)-2-methylbut-2-enoate; [(9R,10R)-9-acetoxy-8,8-dimethyl-2-oxo-9,10-dihydropyrano[6,5-h]chromen-10-yl] (Z)-2-methylbut-2-enoate; STOCK1N-52523; ZINC04081606; AIDS-006515; AIDS006515; 17944-23-9; 13161-75-6; C09307



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

24 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Dong Zhen, Tian-Qi Xuan, Boqin Hu, Xue Bai, Dan-Ni Fu, Yu Wang, Yun Wu, Jingfeng Yang, Qianqian Ma. Pteryxin attenuates LPS-induced inflammatory responses and inhibits NLRP3 inflammasome activation in RAW264.7 cells. Journal of ethnopharmacology. 2022 Feb; 284(?):114753. doi: 10.1016/j.jep.2021.114753. [PMID: 34662667]
  • Mutaib M Mashraqi, Navaneet Chaturvedi, Qamre Alam, Saleh Alshamrani, Mosa M Bahnass, Khurshid Ahmad, Amany I Alqosaibi, Mashael M Alnamshan, Syed Sayeed Ahmad, Mirza Masroor Ali Beg, Abha Mishra, Sibhghatulla Shaikh, Syed Mohd Danish Rizvi. Biocomputational Prediction Approach Targeting FimH by Natural SGLT2 Inhibitors: A Possible Way to Overcome the Uropathogenic Effect of SGLT2 Inhibitor Drugs. Molecules (Basel, Switzerland). 2021 Jan; 26(3):. doi: 10.3390/molecules26030582. [PMID: 33499241]
  • Ilkay Erdogan Orhan, Fatma Sezer Senol, Suhaib Shekfeh, Krystyna Skalicka-Wozniak, Erden Banoglu. Pteryxin - A promising butyrylcholinesterase-inhibiting coumarin derivative from Mutellina purpurea. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2017 Nov; 109(Pt 2):970-974. doi: 10.1016/j.fct.2017.03.016. [PMID: 28286309]
  • Ruwani N Nugara, Masashi Inafuku, Kensaku Takara, Hironori Iwasaki, Hirosuke Oku. Pteryxin: a coumarin in Peucedanum japonicum Thunb leaves exerts antiobesity activity through modulation of adipogenic gene network. Nutrition (Burbank, Los Angeles County, Calif.). 2014 Oct; 30(10):1177-84. doi: 10.1016/j.nut.2014.01.015. [PMID: 24993752]
  • Juan Wang, Yufeng Ma, Wen Li, Fangdi Hu, Tongqiang Chen, Xiaoli Shen, Shilan Feng. Study on pharmacokinetics and tissue distribution of pteryxin in mice by ultra-pressure liquid chromatography with tandem mass spectrometry. Biomedical chromatography : BMC. 2012 Jul; 26(7):802-7. doi: 10.1002/bmc.1733. [PMID: 22102402]
  • Toshihiro Akihisa, Harukuni Tokuda, Motohiko Ukiya, Masao Iizuka, Stefan Schneider, Kazuya Ogasawara, Teruo Mukainaka, Kenji Iwatsuki, Takashi Suzuki, Hoyoku Nishino. Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects. Cancer letters. 2003 Nov; 201(2):133-7. doi: 10.1016/s0304-3835(03)00466-x. [PMID: 14607326]
  • N C Zhao, W B Jin, X H Zhang, F L Guan, Y B Sun, H Adachi, T Okuyama. Relaxant effects of pyranocoumarin compounds isolated from a Chinese medical plant, Bai-Hua Qian-Hu, on isolated rabbit tracheas and pulmonary arteries. Biological & pharmaceutical bulletin. 1999 Sep; 22(9):984-7. doi: 10.1248/bpb.22.984. [PMID: 10513627]
  • E B Thompson, G H Aynilian, R H Dobberstein, G A Cordell, H H Fong, N R Farnsworth. Biological and phytochemical investigation of plants XV. Pteryxia terebinthina var. terebinthina (Umbelliferae). Journal of natural products. 1979 Jan; 42(1):120-5. doi: 10.1021/np50001a008. [PMID: 469553]