Adenosine tetraphosphate (BioDeep_00000005221)

 

Secondary id: BioDeep_00001869032

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


{[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}phosphonic acid

化学式: C10H17N5O16P4 (586.9620802)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 2.5%

分子结构信息

SMILES: C([C@@H]1[C@H]([C@H]([C@H](n2cnc3c(N)ncnc23)O1)O)O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)O
InChI: InChI=1S/C10H17N5O16P4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(28-10)1-27-33(21,22)30-35(25,26)31-34(23,24)29-32(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H,25,26)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

描述信息

Adenosine 5 tetraphosphate, Ap4, is a natural nucleotide present in many biological systems. This nucleotide has been found as a constituent of the nucleotide pool present in the aqueous humor of a number of mammals and appears to act as a regulator of intraocular pressure (PMID: 14600249). AP4 may also play a significant role in the physiological regulation of vascular tone (PMID: 8599250). The plasma concentration of AP4 is in the nanomolar range. Technically adenosine tetraphosphate is condensation product of adenosine with tetraphosphoric acid at the 5 position. Acetyl coenzyme A (CoA) synthetase (EC 6.2.1.1) catalyzes the synthesis of adenosine 5-tetraphosphate (P4A) and adenosine 5-pentaphosphate (p5A) from ATP and tri- or tetrapolyphosphate (P3 or P4). [HMDB]
Adenosine 5 tetraphosphate, Ap4, is a natural nucleotide present in many biological systems. This nucleotide has been found as a constituent of the nucleotide pool present in the aqueous humor of a number of mammals and appears to act as a regulator of intraocular pressure (PMID: 14600249). AP4 may also play a significant role in the physiological regulation of vascular tone (PMID: 8599250). The plasma concentration of AP4 is in the nanomolar range. Technically adenosine tetraphosphate is condensation product of adenosine with tetraphosphoric acid at the 5 position. Acetyl coenzyme A (CoA) synthetase (EC 6.2.1.1) catalyzes the synthesis of adenosine 5-tetraphosphate (P4A) and adenosine 5-pentaphosphate (p5A) from ATP and tri- or tetrapolyphosphate (P3 or P4).

同义名列表

9 个代谢物同义名

{[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}phosphonic acid; Adenosine 5-tetraphosphoric acid; Adenosine tetraphosphoric acid; adenosine tetraphosphic acid; Adenosine 5-tetraphosphate; Adenosine tetraphosphate; ATPP; P4A; Ap4



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Adolfo Amici, Ambra A Grolla, Erika Del Grosso, Roberta Bellini, Michele Bianchi, Cristina Travelli, Silvia Garavaglia, Leonardo Sorci, Nadia Raffaelli, Silverio Ruggieri, Armando A Genazzani, Giuseppe Orsomando. Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases. Cell chemical biology. 2017 May; 24(5):553-564.e4. doi: 10.1016/j.chembiol.2017.03.010. [PMID: 28416276]
  • Markus Tölle, Vera Jankowski, Mirjam Schuchardt, Annette Wiedon, Tao Huang, Franziska Hub, Joanna Kowalska, Jacek Jemielity, Andrzej Guranowski, Christoph Loddenkemper, Walter Zidek, Joachim Jankowski, Markus van der Giet. Adenosine 5'-tetraphosphate is a highly potent purinergic endothelium-derived vasoconstrictor. Circulation research. 2008 Nov; 103(10):1100-8. doi: 10.1161/circresaha.108.177865. [PMID: 18832747]
  • Geoffrey Burnstock. Endothelium-derived vasoconstriction by purines and pyrimidines. Circulation research. 2008 Nov; 103(10):1056-7. doi: 10.1161/circresaha.108.187963. [PMID: 18988902]
  • Andrzej Guranowski, Elzbieta Starzyńska, Małgorzata Pietrowska-Borek, Jacek Jemielity, Joanna Kowalska, Edward Darzynkiewicz, Mark J Thompson, G Michael Blackburn. Methylene analogues of adenosine 5'-tetraphosphate. Their chemical synthesis and recognition by human and plant mononucleoside tetraphosphatases and dinucleoside tetraphosphatases. The FEBS journal. 2006 Feb; 273(4):829-38. doi: 10.1111/j.1742-4658.2006.05115.x. [PMID: 16441668]
  • Andrzej Guranowski. Metabolism of diadenosine tetraphosphate (Ap4A) and related nucleotides in plants; review with historical and general perspective. Frontiers in bioscience : a journal and virtual library. 2004 May; 9(?):1398-411. doi: 10.2741/1338. [PMID: 14977555]
  • Małgorzata Pietrowska-Borek, Hans-Peter Stuible, Erich Kombrink, Andrzej Guranowski. 4-Coumarate:coenzyme A ligase has the catalytic capacity to synthesize and reuse various (di)adenosine polyphosphates. Plant physiology. 2003 Mar; 131(3):1401-10. doi: 10.1104/pp.011684. [PMID: 12644689]
  • A Guranowski, E Starzyńska, P Brown, G M Blackburn. Adenosine 5'-tetraphosphate phosphohydrolase from yellow lupin seeds: purification to homogeneity and some properties. The Biochemical journal. 1997 Nov; 328 ( Pt 1)(?):257-62. doi: 10.1042/bj3280257. [PMID: 9359862]
  • J E De Larco, D A Pigott. Ectopic peptides released by a human melanoma cell line that modulate the transformed phenotype. Ciba Foundation symposium. 1985; 116(?):224-40. doi: 10.1002/9780470720974.ch14. [PMID: 3000706]
  • S Husted, T Hjort. Sperm antibodies in serum and seminal plasma. International journal of fertility. 1975; 20(2):97-105. doi: NULL. [PMID: 3485]