Adenosine tetraphosphate (BioDeep_00001869032)

Main id: BioDeep_00000005221

 


代谢物信息卡片


Adenosine tetraphosphate

化学式: C10H17N5O16P4 (586.9621)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C([C@@H]1[C@H]([C@H]([C@H](n2cnc3c(N)ncnc23)O1)O)O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)O
InChI: InChI=1S/C10H17N5O16P4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(28-10)1-27-33(21,22)30-35(25,26)31-34(23,24)29-32(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H,25,26)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

描述信息

同义名列表

1 个代谢物同义名

Adenosine tetraphosphate



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 APRT, CAT, EMP2, GUCY1A1, MYLK, PKM, RELA, WARS1, YARS1
Peripheral membrane protein 1 COQ10A
Nucleus 7 EMP2, PKM, RELA, REPIN1, TRIM33, WARS1, YARS1
cytosol 9 APRT, CAT, GUCY1A1, MYLK, PKM, RELA, REPIN1, WARS1, YARS1
dendrite 1 P2RY1
nuclear body 1 YARS1
nucleoplasm 6 APRT, ATP2B1, CD2, RELA, REPIN1, TRIM33
Cell membrane 5 ATP2B1, CD2, EMP2, P2RX1, P2RY1
Cleavage furrow 1 MYLK
lamellipodium 1 MYLK
Multi-pass membrane protein 4 ATP2B1, EMP2, P2RX1, P2RY1
Golgi apparatus membrane 1 EMP2
Synapse 2 ATP2B1, MYLK
cell surface 3 CD2, EMP2, P2RY1
glutamatergic synapse 5 ATP2B1, GUCY1A1, P2RX1, P2RY1, RELA
Golgi apparatus 2 CD2, EMP2
Golgi membrane 1 EMP2
mitochondrial inner membrane 1 COQ10A
postsynapse 1 P2RX1
presynaptic membrane 1 ATP2B1
Cytoplasm, cytosol 1 REPIN1
plasma membrane 8 ATP2B1, CD2, EMP2, F2, KNG1, MYLK, P2RX1, P2RY1
synaptic vesicle membrane 1 ATP2B1
Membrane 4 ATP2B1, CAT, EMP2, P2RX1
apical plasma membrane 2 EMP2, P2RY1
basolateral plasma membrane 2 ATP2B1, P2RY1
extracellular exosome 7 APRT, ATP2B1, CAT, F2, KNG1, PKM, WARS1
extracellular space 4 CRP, F2, KNG1, YARS1
perinuclear region of cytoplasm 1 EMP2
mitochondrion 3 CAT, COQ10A, PKM
protein-containing complex 4 CAT, CD2, P2RX1, WARS1
intracellular membrane-bounded organelle 2 ATP2B1, CAT
postsynaptic density 1 P2RY1
Single-pass type I membrane protein 1 CD2
Secreted 2 CRP, F2
extracellular region 7 APRT, CAT, CD2, CRP, F2, KNG1, PKM
cytoplasmic side of plasma membrane 1 CD2
mitochondrial matrix 2 CAT, NUDT2
transcription regulator complex 1 RELA
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
nuclear membrane 1 REPIN1
external side of plasma membrane 2 CD2, P2RX1
Extracellular vesicle 1 PKM
actin cytoskeleton 1 MYLK
cytoplasmic vesicle 1 EMP2
apical part of cell 1 EMP2
cell-cell junction 1 CD2
vesicle 1 PKM
postsynaptic membrane 2 P2RX1, P2RY1
presynaptic active zone membrane 2 P2RX1, P2RY1
Apical cell membrane 1 EMP2
Cell projection, lamellipodium 1 MYLK
Cytoplasm, perinuclear region 1 EMP2
Mitochondrion inner membrane 1 COQ10A
Matrix side 1 COQ10A
Membrane raft 2 EMP2, P2RX1
focal adhesion 1 CAT
GABA-ergic synapse 1 GUCY1A1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 3 F2, KNG1, PKM
lateral plasma membrane 1 ATP2B1
cilium 2 P2RY1, PKM
chromatin 2 RELA, TRIM33
cell projection 1 ATP2B1
Chromosome 1 REPIN1
Secreted, extracellular space 1 KNG1
blood microparticle 2 F2, KNG1
Basolateral cell membrane 1 ATP2B1
specific granule membrane 1 P2RX1
Presynaptic cell membrane 1 ATP2B1
cell body 1 P2RY1
stress fiber 1 MYLK
ficolin-1-rich granule lumen 2 CAT, PKM
secretory granule lumen 3 APRT, CAT, PKM
secretory granule membrane 1 P2RX1
Golgi lumen 1 F2
endoplasmic reticulum lumen 2 F2, KNG1
platelet alpha granule lumen 1 KNG1
immunological synapse 1 ATP2B1
Cytoplasm, cytoskeleton, stress fiber 1 MYLK
Rough endoplasmic reticulum 1 PKM
guanylate cyclase complex, soluble 1 GUCY1A1
catalase complex 1 CAT
photoreceptor ribbon synapse 1 ATP2B1
[Isoform M2]: Cytoplasm 1 PKM
[Isoform M1]: Cytoplasm 1 PKM
NF-kappaB p50/p65 complex 1 RELA
NF-kappaB complex 1 RELA


文献列表

  • Adolfo Amici, Ambra A Grolla, Erika Del Grosso, Roberta Bellini, Michele Bianchi, Cristina Travelli, Silvia Garavaglia, Leonardo Sorci, Nadia Raffaelli, Silverio Ruggieri, Armando A Genazzani, Giuseppe Orsomando. Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases. Cell chemical biology. 2017 May; 24(5):553-564.e4. doi: 10.1016/j.chembiol.2017.03.010. [PMID: 28416276]
  • Markus Tölle, Vera Jankowski, Mirjam Schuchardt, Annette Wiedon, Tao Huang, Franziska Hub, Joanna Kowalska, Jacek Jemielity, Andrzej Guranowski, Christoph Loddenkemper, Walter Zidek, Joachim Jankowski, Markus van der Giet. Adenosine 5'-tetraphosphate is a highly potent purinergic endothelium-derived vasoconstrictor. Circulation research. 2008 Nov; 103(10):1100-8. doi: 10.1161/circresaha.108.177865. [PMID: 18832747]
  • Geoffrey Burnstock. Endothelium-derived vasoconstriction by purines and pyrimidines. Circulation research. 2008 Nov; 103(10):1056-7. doi: 10.1161/circresaha.108.187963. [PMID: 18988902]
  • Andrzej Guranowski, Elzbieta Starzyńska, Małgorzata Pietrowska-Borek, Jacek Jemielity, Joanna Kowalska, Edward Darzynkiewicz, Mark J Thompson, G Michael Blackburn. Methylene analogues of adenosine 5'-tetraphosphate. Their chemical synthesis and recognition by human and plant mononucleoside tetraphosphatases and dinucleoside tetraphosphatases. The FEBS journal. 2006 Feb; 273(4):829-38. doi: 10.1111/j.1742-4658.2006.05115.x. [PMID: 16441668]
  • Andrzej Guranowski. Metabolism of diadenosine tetraphosphate (Ap4A) and related nucleotides in plants; review with historical and general perspective. Frontiers in bioscience : a journal and virtual library. 2004 May; 9(?):1398-411. doi: 10.2741/1338. [PMID: 14977555]
  • Małgorzata Pietrowska-Borek, Hans-Peter Stuible, Erich Kombrink, Andrzej Guranowski. 4-Coumarate:coenzyme A ligase has the catalytic capacity to synthesize and reuse various (di)adenosine polyphosphates. Plant physiology. 2003 Mar; 131(3):1401-10. doi: 10.1104/pp.011684. [PMID: 12644689]
  • A Guranowski, E Starzyńska, P Brown, G M Blackburn. Adenosine 5'-tetraphosphate phosphohydrolase from yellow lupin seeds: purification to homogeneity and some properties. The Biochemical journal. 1997 Nov; 328 ( Pt 1)(?):257-62. doi: 10.1042/bj3280257. [PMID: 9359862]
  • J E De Larco, D A Pigott. Ectopic peptides released by a human melanoma cell line that modulate the transformed phenotype. Ciba Foundation symposium. 1985; 116(?):224-40. doi: 10.1002/9780470720974.ch14. [PMID: 3000706]