Pentostatin (BioDeep_00000004888)

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

(8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H,6H,7H,8H-imidazo[4,5-d][1,3]diazepin-8-ol

化学式: C11H16N4O4 (268.1171496)
中文名称: 喷司他丁
谱图信息: 最多检出来源 Homo sapiens(blood) 6.25%

分子结构信息

SMILES: C1C(C(OC1N2C=NC3=C2NC=NCC3O)CO)O
InChI: InChI=1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)

描述信息

Pentostatin is only found in individuals that have used or taken this drug. It is a potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. [PubChem]Pentostatin is a potent transition state inhibitor of adenosine deaminase (ADA), the greatest activity of which is found in cells of the lymphoid system. T-cells have higher ADA activity than B-cells, and T-cell malignancies have higher activity than B-cell malignancies. The cytotoxicity that results from prevention of catabolism of adenosine or deoxyadenosine is thought to be due to elevated intracellular levels of dATP, which can block DNA synthesis through inhibition of ribonucleotide reductase. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).
D000970 - Antineoplastic Agents > D000903 - Antibiotics, Antineoplastic > D005573 - Formycins
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents
D004791 - Enzyme Inhibitors > D058892 - Adenosine Deaminase Inhibitors
C471 - Enzyme Inhibitor > C2157 - Adenosine Deaminase Inhibitor

同义名列表

16 个代谢物同义名

(8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H,6H,7H,8H-imidazo[4,5-d][1,3]diazepin-8-ol; Warner-lambert brand OF pentostatin; Prasfarma brand OF pentostatin; Supergen brand OF pentostatin; Lederle brand OF pentostatin; Wyeth brand OF pentostatin; CI-825;Deoxycoformycin; 2-Dexoycoformycin; 2-Deoxycoformycin; 2 Deoxycoformycin; Deoxycoformycin; CO-Vidarabine; Co vidarabine; PENTOSTATIN; Nipent; 2-DCF

数据库引用编号

18 个数据库交叉引用编号

ChEBI: CHEBI:27834
KEGG: C02267
KEGGdrug: D00155
PubChem: 439693
PubChem: 4739
HMDB: HMDB0014692
Metlin: METLIN65742
DrugBank: DB00552
ChEMBL: CHEMBL1580
Wikipedia: Pentostatin
MeSH: Pentostatin
chemspider: 388759
CAS: 53910-25-1
PMhub: MS000017517
PubChem: 5328
PDB-CCD: DCF
NIKKAJI: J10.843J
RefMet: Pentostatin

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Minmin Zhao, Hongyu Zhang, Tingting Lou, Kongxiang Zhao, Suying Wang. [Simultaneous determination of pentostatin and 2'-amino-2'-deoxyadenosine in fermentation broth by high performance liquid chromatography-tandem mass spectrometry]. Se pu = Chinese journal of chromatography. 2021 Jul; 39(7):744-749. doi: 10.3724/sp.j.1123.2020.09018. [PMID: 34227372]
Dimana Dimitrova, Juan Gea-Banacloche, Seth M Steinberg, Jennifer L Sadler, Stephanie N Hicks, Ellen Carroll, Jennifer S Wilder, Mark Parta, Lauren Skeffington, Thomas E Hughes, Jenny E Blau, Miranda M Broadney, Jeremy J Rose, Amy P Hsu, Rochelle Fletcher, Natalia S Nunes, Xiao-Yi Yan, William G Telford, Veena Kapoor, Jeffrey I Cohen, Alexandra F Freeman, Elizabeth Garabedian, Steven M Holland, Andrea Lisco, Harry L Malech, Luigi D Notarangelo, Irini Sereti, Nirali N Shah, Gulbu Uzel, Christa S Zerbe, Daniel H Fowler, Ronald E Gress, Christopher G Kanakry, Jennifer A Kanakry. Prospective Study of a Novel, Radiation-Free, Reduced-Intensity Bone Marrow Transplantation Platform for Primary Immunodeficiency Diseases. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2020 01; 26(1):94-106. doi: 10.1016/j.bbmt.2019.08.018. [PMID: 31493539]
Barbara Kutryb-Zajac, Paulina Mierzejewska, Elzbieta Sucajtys-Szulc, Alicja Bulinska, Magdalena A Zabielska, Patrycja Jablonska, Marcin Serocki, Patrycja Koszalka, Ryszard Milczarek, Agnieszka Jasztal, Rafal Bartoszewski, Stefan Chlopicki, Ewa M Slominska, Ryszard T Smolenski. Inhibition of LPS-stimulated ecto-adenosine deaminase attenuates endothelial cell activation. Journal of molecular and cellular cardiology. 2019 03; 128(?):62-76. doi: 10.1016/j.yjmcc.2019.01.004. [PMID: 30641086]
Xuan Zhao, Guoying Zhang, Caiyi Li, Jianya Ling. Cordycepin and pentostatin biosynthesis gene identified through transcriptome and proteomics analysis of Cordyceps kyushuensis Kob. Microbiological research. 2019 Jan; 218(?):12-21. doi: 10.1016/j.micres.2018.09.005. [PMID: 30454654]
Yongliang Xia, Feifei Luo, Yanfang Shang, Peilin Chen, Yuzhen Lu, Chengshu Wang. Fungal Cordycepin Biosynthesis Is Coupled with the Production of the Safeguard Molecule Pentostatin. Cell chemical biology. 2017 12; 24(12):1479-1489.e4. doi: 10.1016/j.chembiol.2017.09.001. [PMID: 29056419]
Guilherme M do Carmo, Pedro H Doleski, Mariângela F de Sá, Thirssa H Grando, Maria I Azevedo, Alessandra G Manzoni, Daniela B R Leal, Lucas T Gressler, Luan C Henker, Ricardo E Mendes, Matheus D Baldissera, Silvia G Monteiro, Lenita M Stefani, Aleksandro S Da Silva. Treatment with 3'-deoxyadenosine and deoxycoformycin in mice infected by Trypanosoma cruzi and its side effect on purinergic enzymes. Microbial pathogenesis. 2017 Dec; 113(?):51-56. doi: 10.1016/j.micpath.2017.10.030. [PMID: 29051060]
Jonathan J Hogan, Brendan M Weiss. Bridging the Divide: An Onco-Nephrologic Approach to the Monoclonal Gammopathies of Renal Significance. Clinical journal of the American Society of Nephrology : CJASN. 2016 09; 11(9):1681-91. doi: 10.2215/cjn.03160316. [PMID: 27416775]
Paolo Strati, Samih H Nasr, Nelson Leung, Curtis A Hanson, Kari G Chaffee, Susan M Schwager, Sara J Achenbach, Timothy G Call, Sameer A Parikh, Wei Ding, Neil E Kay, Tait D Shanafelt. Renal complications in chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis: the Mayo Clinic experience. Haematologica. 2015 Sep; 100(9):1180-8. doi: 10.3324/haematol.2015.128793. [PMID: 26088927]
Luciana Dalla Rosa, Aleksandro S Da Silva, Camila B Oliveira, Lucas T Gressler, Caroline B Arnold, Matheus D Baldissera, Michele Sagrillo, Manuela Sangoi, Rafael Moresco, Ricardo E Mendes, Paulo E Weiss, Luiz C Miletti, Silvia G Monteiro. Dose finding of 3'deoxyadenosine and deoxycoformycin for the treatment of Trypanosoma evansi infection: An effective and nontoxic dose. Microbial pathogenesis. 2015 Aug; 85(?):21-8. doi: 10.1016/j.micpath.2015.05.005. [PMID: 26025154]
Kazuki Nakamura, Kazumasa Shinozuka, Noriko Yoshikawa. Anticancer and antimetastatic effects of cordycepin, an active component of Cordyceps sinensis. Journal of pharmacological sciences. 2015 Jan; 127(1):53-6. doi: 10.1016/j.jphs.2014.09.001. [PMID: 25704018]
Nisar A Baig, Ronald P Taylor, Margaret A Lindorfer, Amy K Church, Betsy R LaPlant, Adam M Pettinger, Tait D Shanafelt, Grzegorz S Nowakowski, Clive S Zent. Induced resistance to ofatumumab-mediated cell clearance mechanisms, including complement-dependent cytotoxicity, in chronic lymphocytic leukemia. Journal of immunology (Baltimore, Md. : 1950). 2014 Feb; 192(4):1620-9. doi: 10.4049/jimmunol.1302954. [PMID: 24431228]
Luciana Dalla Rosa, Aleksandro S Da Silva, Jader B Ruchel, Lucas T Gressler, Camila B Oliveira, Raqueli T França, Sonia T A Lopes, Daniela B R Leal, Silvia G Monteiro. Influence of treatment with 3'-deoxyadenosine associated deoxycoformycin on hematological parameters and activity of adenosine deaminase in infected mice with Trypanosoma evansi. Experimental parasitology. 2013 Oct; 135(2):357-62. doi: 10.1016/j.exppara.2013.07.019. [PMID: 23933282]
Ming J Poi, Craig C Hofmeister, Jeffrey S Johnston, Ryan B Edwards, Buffy S Jansak, David M Lucas, Sherif S Farag, James T Dalton, Steven M Devine, Michael R Grever, Mitch A Phelps. Standard pentostatin dose reductions in renal insufficiency are not adequate: selected patients with steroid-refractory acute graft-versus-host disease. Clinical pharmacokinetics. 2013 Aug; 52(8):705-12. doi: 10.1007/s40262-013-0064-7. [PMID: 23588536]
Luciana Dalla Rosa, Aleksandro S da Silva, Lucas T Gressler, Camila B Oliveira, Maria G C Dambrós, Luiz C Miletti, Raqueli T França, Sonia T A Lopes, Yasmin N Samara, Marcelo L da Veiga, Silvia G Monteiro. Cordycepin (3'-deoxyadenosine) pentostatin (deoxycoformycin) combination treatment of mice experimentally infected with Trypanosoma evansi. Parasitology. 2013 Apr; 140(5):663-71. doi: 10.1017/s0031182012001990. [PMID: 23361035]
James B Johnston. Mechanism of action of pentostatin and cladribine in hairy cell leukemia. Leukemia & lymphoma. 2011 Jun; 52 Suppl 2(?):43-5. doi: 10.3109/10428194.2011.570394. [PMID: 21463108]
Jeffrey B Brown, Goo Lee, Gery R Grimm, Terrence A Barrett. Therapeutic benefit of pentostatin in severe IL-10-/- colitis. Inflammatory bowel diseases. 2008 Jul; 14(7):880-7. doi: 10.1002/ibd.20410. [PMID: 18340641]
Sara S Kim. Treatment options in steroid-refractory acute graft-versus-host disease following hematopoietic stem cell transplantation. The Annals of pharmacotherapy. 2007 Sep; 41(9):1436-44. doi: 10.1345/aph.1k179. [PMID: 17684033]
Tait D Shanafelt, Thomas Lin, Susan M Geyer, Clive S Zent, Nelson Leung, Brian Kabat, Deborah Bowen, Michael R Grever, John C Byrd, Neil E Kay. Pentostatin, cyclophosphamide, and rituximab regimen in older patients with chronic lymphocytic leukemia. Cancer. 2007 Jun; 109(11):2291-8. doi: 10.1002/cncr.22662. [PMID: 17514743]
Noriko Yoshikawa, Kazuki Nakamura, Yu Yamaguchi, Satomi Kagota, Kazumasa Shinozuka, Masaru Kunitomo. Reinforcement of antitumor effect of Cordyceps sinensis by 2'-deoxycoformycin, an adenosine deaminase inhibitor. In vivo (Athens, Greece). 2007 Mar; 21(2):291-5. doi: . [PMID: 17436579]
Jim Zhen Wu, Li-Tain Yeh, Chin-Chung Lin, Zhi Hong. Conversion of viramidine to ribavirin in vivo by adenosine deaminase and its inhibition by 2'-deoxycoformycin. Antiviral chemistry & chemotherapy. 2006; 17(1):33-9. doi: 10.1177/095632020601700105. [PMID: 16542004]
Nobuyoshi Arima, Tadahiro Sugiyama. [Pentostatin treatment for a patient with chronic type adult T-cell leukemia undergoing hemodialysis]. [Rinsho ketsueki] The Japanese journal of clinical hematology. 2005 Nov; 46(11):1191-5. doi: . [PMID: 16440802]
Manfred Hensel, Matthias Villalobos, Martin Kornacker, Fatime Krasniqi, Anthony D Ho. Pentostatin/cyclophosphamide with or without rituximab: an effective regimen for patients with Waldenstrom's macroglobulinemia/lymphoplasmacytic lymphoma. Clinical lymphoma & myeloma. 2005 Sep; 6(2):131-5. doi: 10.3816/clm.2005.n.039. [PMID: 16231851]
William R Law, Victor E Valli, Beth A Conlon. Therapeutic potential for transient inhibition of adenosine deaminase in systemic inflammatory response syndrome. Critical care medicine. 2003 May; 31(5):1475-81. doi: 10.1097/01.ccm.0000063259.09580.d8. [PMID: 12771621]
Varsha Gandhi, Wei Chen, Mary Ayres, Julie K Rhie, Timothy L Madden, Robert A Newman. Plasma and cellular pharmacology of 8-chloro-adenosine in mice and rats. Cancer chemotherapy and pharmacology. 2002 Aug; 50(2):85-94. doi: 10.1007/s00280-002-0456-0. [PMID: 12172971]
Chetan Lathia, Gini F Fleming, Mark Meyer, Mark J Ratain, Lloyd Whitfield. Pentostatin pharmacokinetics and dosing recommendations in patients with mild renal impairment. Cancer chemotherapy and pharmacology. 2002 Aug; 50(2):121-6. doi: 10.1007/s00280-002-0468-9. [PMID: 12172976]
Simon Adanin, Igor V Yalovetskiy, Beth A Nardulli, Albert D Sam, Zivojin S Jonjev, William R Law. Inhibiting adenosine deaminase modulates the systemic inflammatory response syndrome in endotoxemia and sepsis. American journal of physiology. Regulatory, integrative and comparative physiology. 2002 May; 282(5):R1324-32. doi: 10.1152/ajpregu.00373.2001. [PMID: 11959672]
Cibele N Peroni, Carlos R J Soares, Elizabeth Gimbo, Ligia Morganti, Maria Teresa C P Ribela, Paolo Bartolini. High-level expression of human thyroid-stimulating hormone in Chinese hamster ovary cells by co-transfection of dicistronic expression vectors followed by a dual-marker amplification strategy. Biotechnology and applied biochemistry. 2002 02; 35(1):19-26. doi: 10.1042/ba20010061. [PMID: 11834126]
Asad Bashey. Immunosuppression with limited toxicity: the characteristics of nucleoside analogs and anti-lymphocyte antibodies used in non-myeloablative hematopoietic cell transplantation. Cancer treatment and research. 2002; 110(?):39-49. doi: 10.1007/978-1-4615-0919-6_2. [PMID: 11908199]
NULL. Pentostatin effective as preparative regimen for kidney transplants. Expert review of anticancer therapy. 2001 Dec; 1(4):508. doi: NULL. [PMID: 12113079]
T Suzuki, H Takemura, E Noiri, K Nosaka, A Toda, S Taniguchi, K Uchida, T Fujita, S Kimura, A Nakao. Puromycin aminonucleoside induces apoptosis and increases HNE in cultured glomerular epithelial cells(1). Free radical biology & medicine. 2001 Sep; 31(5):615-23. doi: 10.1016/s0891-5849(01)00641-4. [PMID: 11522446]
P E Kintzel. Anticancer drug-induced kidney disorders. Drug safety. 2001 Jan; 24(1):19-38. doi: 10.2165/00002018-200124010-00003. [PMID: 11219485]
J Margolis, M R Grever. Pentostatin (Nipent): a review of potential toxicity and its management. Seminars in oncology. 2000 Apr; 27(2 Suppl 5):9-14. doi: . [PMID: 10877045]
B Arun, B D Curti, D L Longo, D Stevens, W G Alvord, B L Gause, T Watson, W C Kopp, J E Janik. Elevations in serum soluble interleukin-2 receptor levels predict relapse in patients with hairy cell leukemia. The cancer journal from Scientific American. 2000 Jan; 6(1):21-4. doi: NULL. [PMID: 10696734]
O Le Moine, E Quertinmont, B Gulbis, J Devière. Blunted anti-inflammatory response to adenosine in alcoholic cirrhosis. Journal of hepatology. 1999 Sep; 31(3):457-63. doi: 10.1016/s0168-8278(99)80037-3. [PMID: 10488704]
J W Leach, T Pham, D Diamandidis, J N George. Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS) following treatment with deoxycoformycin in a patient with cutaneous T-cell lymphoma (Sezary syndrome): A case report. American journal of hematology. 1999 Aug; 61(4):268-70. doi: 10.1002/(sici)1096-8652(199908)61:4<268::aid-ajh9>3.0.co;2-o. [PMID: 10440915]
M V Bor, O Durmuş, A Bilgihan, C Cevik, N Türközkan. The beneficial effect of 2'-deoxycoformycin in renal ischemia-reperfusion is mediated both by preservation of tissue ATP and inhibition of lipid peroxidation. International journal of clinical & laboratory research. 1999; 29(2):75-9. doi: 10.1007/s005990050067. [PMID: 10436265]
A Miyagawa, H Sakabe, Y Amakata, T Inoue, A Andoh, K Hodohara, Y Fujiyama, T Bamba. [Effective pentostatin-based treatment of adult T cell leukemia in a patient with severe arthritis]. [Rinsho ketsueki] The Japanese journal of clinical hematology. 1998 Jul; 39(7):487-92. doi: . [PMID: 9750455]
S A Johnson, D Catovsky, J A Child, A C Newland, D W Milligan, R Janmohamed. Phase I/II evaluation of pentostatin (2'-deoxycoformycin) in a five day schedule for the treatment of relapsed/refractory B-cell chronic lymphocytic leukaemia. Investigational new drugs. 1998; 16(2):155-60. doi: 10.1023/a:1006100900082. [PMID: 9848579]
L E Rodman, D R Farnell, J M Coyne, P W Allan, D L Hill, K L Duncan, J E Tomaszewski, A C Smith, J G Page. Toxicity of cordycepin in combination with the adenosine deaminase inhibitor 2'-deoxycoformycin in beagle dogs. Toxicology and applied pharmacology. 1997 Nov; 147(1):39-45. doi: 10.1006/taap.1997.8264. [PMID: 9356305]
F Morabito, I Callea, G Console, C Stelitano, G Sculli, M Filangeri, B Oliva, C Musolino, P Iacopino, M Brugiatelli. The in vitro cytotoxic effect of mitoxantrone in combination with fludarabine or pentostatin in B-cell chronic lymphocytic leukemia. Haematologica. 1997 Sep; 82(5):560-5. doi: NULL. [PMID: 9407721]
D Singhal, M E Morgan, B D Anderson. Role of brain tissue localized purine metabolizing enzymes in the central nervous system delivery of anti-HIV agents 2'-beta-fluoro-2',3'-dideoxyinosine and 2'-beta-fluoro-2',3'-dideoxyadenosine in rats. Pharmaceutical research. 1997 Jun; 14(6):786-92. doi: 10.1023/a:1012110724604. [PMID: 9210198]
K Nosaka, T Takahashi, T Nishi, H Imaki, T Suzuki, K Suzuki, K Kurokawa, H Endou. An adenosine deaminase inhibitor prevents puromycin aminonucleoside nephrotoxicity. Free radical biology & medicine. 1997; 22(4):597-605. doi: 10.1016/s0891-5849(96)00349-8. [PMID: 9013123]
D D Jeanfavre, J R Woska, C A Pargellis, C A Kennedy, J Prendergast, C Stearns, P L Reilly, R W Barton, B J Bormann. Effect of deoxycoformycin and Val-boroPro on the associated catalytic activities of lymphocyte CD26 and ecto-adenosine deaminase. Biochemical pharmacology. 1996 Dec; 52(11):1757-65. doi: 10.1016/s0006-2952(96)00597-7. [PMID: 8986139]
W Plunkett, V Gandhi. Pharmacology of purine nucleoside analogues. Hematology and cell therapy. 1996 Dec; 38 Suppl 2(?):S67-74. doi: NULL. [PMID: 9137959]
D Singhal, M E Morgan, B D Anderson. Role of altered metabolism in dideoxynucleoside pharmacokinetics. Studies of 2'-beta-fluoro-2',3'-dideoxyinosine and 2'-beta-fluoro-2',3'-dideoxyadenosine in rats. Drug metabolism and disposition: the biological fate of chemicals. 1996 Oct; 24(10):1155-61. doi: . [PMID: 8894519]
A S Spiers. Deoxycoformycin (pentostatin): clinical pharmacology, role in the chemotherapy of cancer, and use in other diseases. Haematologia. 1996; 27(2):55-84. doi: . [PMID: 14651224]
K Kodama, T Yamada, K Kawakami, K Yasui, T Nomura, M Yamaoka, T Matsuo. [Successful combination chemotherapy including deoxycoformycin in a case of cutaneous T cell lymphoma]. [Rinsho ketsueki] The Japanese journal of clinical hematology. 1996 Jan; 37(1):65-71. doi: . [PMID: 8683870]
M Camici, M Turriani, M G Tozzi, G Turchi, J Cos, C Alemany, A Miralles, V Noe, C J Ciudad. Purine enzyme profile in human colon-carcinoma cell lines and differential sensitivity to deoxycoformycin and 2'-deoxyadenosine in combination. International journal of cancer. 1995 Jul; 62(2):176-83. doi: 10.1002/ijc.2910620212. [PMID: 7622293]
C Sakai, T Takagi, S Wakatsuki, O Matsuzaki. Hemolytic-uremic syndrome due to deoxycoformycin: a report of the second case. Internal medicine (Tokyo, Japan). 1995 Jun; 34(6):593-6. doi: 10.2169/internalmedicine.34.593. [PMID: 7549151]
A Ar'Rajab, R B Harris, T A Khair-el-Din, J T Sentementes, C Lu, I J Dawidson. Immunosuppressive effect of 2'-deoxycoformycin (Pentostatin) for rat islet allotransplantation. Cell transplantation. 1995 May; 4(3):315-21. doi: 10.1177/096368979500400310. [PMID: 7640871]
P H Silva, D Dillon, D G Van Wylen. Adenosine deaminase inhibition augments interstitial adenosine but does not attenuate myocardial infarction. Cardiovascular research. 1995 May; 29(5):616-23. doi: NULL. [PMID: 7606748]
C W Lee, R E Handschumacher. Concentrative transport of adenosine in murine splenocytes: limitation by an ecto-adenosine deaminase. In vivo (Athens, Greece). 1995 Jan; 9(1):1-6. doi: NULL. [PMID: 7669942]
L Chrobák, K Podzimek, P Zak, L Plísková, J Voglová. Hairy cell leukaemia, its therapy and prognosis (historical review with own experiences). Acta haematologica Polonica. 1995; 26(2 Suppl 1):56-62. doi: NULL. [PMID: 7653236]
G S Ahluwalia, D A Cooney, T Shirasaka, H Mitsuya, J S Driscoll, D G Johns. Enhancement by 2'-deoxycoformycin of the 5'-phosphorylation and anti-human immunodeficiency virus activity of 2',3'-dideoxyadenosine and 2'-beta-fluoro-2',3'-dideoxyadenosine. Molecular pharmacology. 1994 Nov; 46(5):1002-8. doi: . [PMID: 7969062]
C L Courtney, K L Hawkins, C E Rothwell. Subchronic toxicity of pentostatin in Wistar rats. Toxicologic pathology. 1994 Sep; 22(5):519-23. doi: 10.1177/019262339402200506. [PMID: 7899780]
L Annino, A Ferrari, F Giona, G Cimino, S Crescenzi, M C Cava, A Pacchiarotti, F Mandelli. Deoxycoformycin induces long-lasting remissions in hairy cell leukemia: clinical and biological results of two different regimens. Leukemia & lymphoma. 1994; 14 Suppl 1(?):115-9. doi: . [PMID: 7820042]
J N Lorenz, H Weihprecht, X R He, O Skøtt, J P Briggs, J Schnermann. Effects of adenosine and angiotensin on macula densa-stimulated renin secretion. The American journal of physiology. 1993 Aug; 265(2 Pt 2):F187-94. doi: 10.1152/ajprenal.1993.265.2.f187. [PMID: 8368332]
R S Witte, C Walsh, H Fisher, M M Okem, D J Reding, D L Trump. Evaluation of deoxycoformycin in patients with advanced renal cell carcinoma. An ECOG pilot study. Investigational new drugs. 1992 Apr; 10(1):49-50. doi: 10.1007/bf01275482. [PMID: 1607253]
A D Ho, A Klotzbücher, A Gross, G Dietz, J Mestan, H Jakobsen, W Hunstein. Induction of intracellular and plasma 2',5'-oligoadenylate synthetase by pentostatin. Leukemia. 1992 Mar; 6(3):209-14. doi: NULL. [PMID: 1564958]
T B Knudsen, R S Winters, S K Otey, M R Blackburn, M J Airhart, J K Church, R G Skalko. Effects of (R)-deoxycoformycin (pentostatin) on intrauterine nucleoside catabolism and embryo viability in the pregnant mouse. Teratology. 1992 Jan; 45(1):91-103. doi: 10.1002/tera.1420450109. [PMID: 1731400]
J Sayos, J J Centelles, J Mallol, E I Canela, C Lluis, R Franco. Adenosine (Ado) uptake in brush-border membrane vesicles from rat kidney (BBM). Biochemical Society transactions. 1991 Aug; 19(3):323S. doi: 10.1042/bst019323s. [PMID: 1783158]
P Venner, E A Eisenhauer, R Wierzbicki, J Johnston. Phase II study of 2'-deoxycoformycin in patients with renal cell carcinoma. A National Cancer Institute of Canada Clinical Trials Group study. Investigational new drugs. 1991 Aug; 9(3):273-5. doi: 10.1007/bf00176983. [PMID: 1783528]
J G Niedzwicki, D R Abernethy. Structure-activity relationship of ligands of human plasma adenosine deaminase2. Biochemical pharmacology. 1991 Jun; 41(11):1615-24. doi: 10.1016/0006-2952(91)90162-x. [PMID: 2043151]
R Yamane, T Nakamura, E Matsuura, H Ishige, M Fujimoto. A simple and sensitive radioimmunoassay for adenosine. Journal of immunoassay. 1991; 12(4):501-19. doi: 10.1080/01971529108053277. [PMID: 1806586]
L Escoda, A López-Guillermo, M Formigón, T Estrach, F Cervantes, E Montserrat, C Rozman. [Treatment of various lymphoproliferative syndromes with deoxycoformycin: results in 6 patients]. Sangre. 1990 Dec; 35(6):421-4. doi: NULL. [PMID: 2087659]
J M Richards, R Mick, J M Latta, K Daly, M J Ratain, J W Vardiman, H M Golomb. Serum soluble interleukin-2 receptor is associated with clinical and pathologic disease status in hairy cell leukemia. Blood. 1990 Nov; 76(10):1941-5. doi: NULL. [PMID: 1700727]
R Fanin, S Minutillo, P D'Agaro, D Raspadori, A Tassinari, P Tazzari, N Testoni, D Damiani, C Gallizia, M Michieli. HTLV-I positive adult T-cell leukaemia-lymphoma: report of a typical case from Italy. Haematologica. 1990 Jul; 75(4):375-80. doi: NULL. [PMID: 1980480]
R B Montgomery, J Kurtzberg, A Rhinehardt-Clark, A Haleen, S Ramakrishnan, G A Olsen, W P Peters, C A Smith, B F Haynes, L L Houston. Elimination of malignant clonogenic T cells from human bone marrow using chemoimmunoseparation with 2'-deoxycoformycin, deoxyadenosine and an immunotoxin. Bone marrow transplantation. 1990 Jun; 5(6):395-402. doi: . [PMID: 2369680]
J Blanco, J Mallol, C Lluis, E I Canela, R Franco. Adenosine metabolism in kidney slices under normoxic conditions. Journal of cellular physiology. 1990 May; 143(2):344-51. doi: 10.1002/jcp.1041430219. [PMID: 2332456]
A Martin, S Nerenstone, W J Urba, D L Longo, J B Lawrence, J W Clark, M J Hawkins, S P Creekmore, J W Smith, R G Steis. Treatment of hairy cell leukemia with alternating cycles of pentostatin and recombinant leukocyte A interferon: results of a phase II study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1990 Apr; 8(4):721-30. doi: 10.1200/jco.1990.8.4.721. [PMID: 2313337]
A D Ho, M Grossmann, W Knauf, H Martin, L Trümper, T Zwingers, R Sonnen, H Pralle, W Hunstein. Plasma levels of soluble CD8 antigen and interleukin-2 receptor antigen in patients with hairy cell leukemia, relationship with splenectomy and with clinical response to therapy. Leukemia. 1989 Oct; 3(10):718-23. doi: NULL. [PMID: 2506398]
P G Plagemann, C Woffendin. Permeation and salvage of dideoxyadenosine in mammalian cells. Molecular pharmacology. 1989 Jul; 36(1):185-92. doi: . [PMID: 2787472]
M E Stromski, A van Waarde, M J Avison, G Thulin, K M Gaudio, M Kashgarian, R G Shulman, N J Siegel. Metabolic and functional consequences of inhibiting adenosine deaminase during renal ischemia in rats. The Journal of clinical investigation. 1988 Nov; 82(5):1694-9. doi: 10.1172/jci113782. [PMID: 3263396]
K M Skubitz, N W Wickham, D E Hammerschmidt. Endogenous and exogenous adenosine inhibit granulocyte aggregation without altering the associated rise in intracellular calcium concentration. Blood. 1988 Jul; 72(1):29-33. doi: . [PMID: 3260524]
R G Steis, L Marcon, J Clark, W Urba, D L Longo, D L Nelson, A E Maluish. Serum soluble IL-2 receptor as a tumor marker in patients with hairy cell leukemia. Blood. 1988 May; 71(5):1304-9. doi: . [PMID: 3129046]
N Winick, G R Buchanan, S B Murphy, A Yu, J Boyett. Deoxycoformycin treatment for childhood T-cell acute lymphoblastic leukemia early in second remission: a Pediatric Oncology Group Study. Medical and pediatric oncology. 1988; 16(5):327-32. doi: 10.1002/mpo.2950160507. [PMID: 3263563]
D L Marquardt, L L Walker. Inhibition of mast cell adenosine responsiveness by chronic exposure to adenosine receptor agonists. Biochemical pharmacology. 1987 Dec; 36(24):4297-302. doi: 10.1016/0006-2952(87)90674-5. [PMID: 2825721]
D A Galton, F Brito-Babapulle. The management of myelomatosis. European journal of haematology. 1987 Nov; 39(5):385-98. doi: 10.1111/j.1600-0609.1987.tb01445.x. [PMID: 2446915]
D de Korte, W A Haverkort, E F van Leeuwen, D Roos, A H van Gennip. Biochemical consequences of 2'-deoxycoformycin treatment in a patient with T-cell lymphoma. Some unusual findings. Cancer. 1987 Aug; 60(4):750-5. doi: 10.1002/1097-0142(19870815)60:4<750::aid-cncr2820600407>3.0.co;2-1. [PMID: 3496148]
V P Kontinen, J P Pispa. Enhancement of biotinidase activity in mouse serum by inhibitors of methylation. Molecular and cellular biochemistry. 1987 Jul; 76(1):85-91. doi: 10.1007/bf00219401. [PMID: 3498118]
A Begleiter, R I Glazer, L G Israels, L Pugh, J B Johnston. Induction of DNA strand breaks in chronic lymphocytic leukemia following treatment with 2'-deoxycoformycin in vivo and in vitro. Cancer research. 1987 May; 47(9):2498-503. doi: . [PMID: 3494509]
B A Bouroncle, M R Grever, E H Kraut. Treatment of hairy cell leukemia: the Ohio State University experience with deoxycoformycin. Leukemia. 1987 Apr; 1(4):350-4. doi: NULL. [PMID: 3499542]
J Schwartz, M Ostrander, N J Butkiewicz, M Lieberman, C Lin, J Lim, G H Miller. Activity of (+)-cyclaradine (Sch 31172) against herpes simplex virus in vitro and in vivo. Antimicrobial agents and chemotherapy. 1987 Jan; 31(1):21-6. doi: 10.1128/aac.31.1.21. [PMID: 3032089]
J B Johnston, R I Glazer, L Pugh, L G Israels. The treatment of hairy-cell leukaemia with 2'-deoxycoformycin. British journal of haematology. 1986 Jul; 63(3):525-34. doi: 10.1111/j.1365-2141.1986.tb07530.x. [PMID: 3488071]
J B Johnston, A Begleiter, L Pugh, M K Leith, J A Wilkins, D J Cavers, L G Israels. Biochemical changes induced in hairy-cell leukemia following treatment with the adenosine deaminase inhibitor 2'-deoxycoformycin. Cancer research. 1986 Apr; 46(4 Pt 2):2179-84. doi: . [PMID: 2418965]
D E Ingolia, C Y Yeung, C Shoemaker, R J Kaufman, R E Kellems. Expression of murine ADA cDNA in bacterial and mammalian cells. Advances in experimental medicine and biology. 1986; 195 Pt A(?):223-9. doi: 10.1007/978-1-4684-5104-7_35. [PMID: 3524134]
J Renshaw, K R Harrap. In vivo inhibition of mouse liver methyltransferase enzymes following treatment with 2'-deoxycoformycin and 2'-deoxyadenosine. Advances in experimental medicine and biology. 1986; 195 Pt B(?):673-5. doi: 10.1007/978-1-4684-1248-2_105. [PMID: 3490129]
L Fiume, B Bassi, C Busi, A Mattioli, T Wieland. A study on the pharmacokinetics in mouse of adenine-9-beta-D-arabinofuranoside 5-monophosphate conjugated with lactosaminated albumin. Experientia. 1985 Oct; 41(10):1326-8. doi: 10.1007/bf01952078. [PMID: 2412878]
A Goday, H A Simmonds, G S Morris, L D Fairbanks. Human B lymphocytes and thymocytes but not peripheral blood mononuclear cells accumulate high dATP levels in conditions simulating ADA deficiency. Biochemical pharmacology. 1985 Oct; 34(19):3561-9. doi: 10.1016/0006-2952(85)90734-8. [PMID: 3876835]
J F Henderson, C M Smith, G Zombor. Regulation of purine metabolism in lymphocytes. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1985 Sep; 179(4):419-26. doi: 10.3181/00379727-179-42117. [PMID: 3875099]
S Archer, P F Juranka, J H Ho, V L Chan. An analysis of multiple mechanisms of adenosine toxicity in baby hamster kidney cells. Journal of cellular physiology. 1985 Aug; 124(2):226-32. doi: 10.1002/jcp.1041240209. [PMID: 3900094]
D C Doll, R B Weiss. Hemolytic anemia associated with antineoplastic agents. Cancer treatment reports. 1985 Jul; 69(7-8):777-82. doi: NULL. [PMID: 3160460]
H Ratech, R Hirschhorn, G J Thorbecke. Effects of deoxycoformycin in mice. III. A murine model reproducing multi-system pathology of human adenosine deaminase deficiency. The American journal of pathology. 1985 Apr; 119(1):65-72. doi: . [PMID: 3872599]
A R Belch, J F Henderson, L W Brox. Treatment of multiple myeloma with deoxycoformycin. Cancer chemotherapy and pharmacology. 1985; 14(1):49-52. doi: 10.1007/bf00552725. [PMID: 3871175]
R B Gilbertsen. Effects of pentostatin (2'deoxycoformycin), an inhibitor of adenosine deaminase, on type II collagen-induced arthritis in rats. Journal of immunopharmacology. 1985; 7(3):325-41. doi: 10.3109/08923978509026480. [PMID: 3877119]
J F Smyth, H G Prentice, S Proctor, A V Hoffbrand. Deoxycoformycin in the treatment of leukemias and lymphomas. Annals of the New York Academy of Sciences. 1985; 451(?):123-8. doi: 10.1111/j.1749-6632.1985.tb27102.x. [PMID: 3878113]
C T Lum, D E Sutherland, N Hsiao, J S Najarian. Relevance of adenosine deaminase to organ transplantation. Annals of the New York Academy of Sciences. 1985; 451(?):113-22. doi: 10.1111/j.1749-6632.1985.tb27101.x. [PMID: 3907451]
J H Southhard, M Kuniyoshi, M F Lutz, M Ametani, F O Belzer. Comparison of the effect of 3- and 5-day hypothermic perfusion of dog kidneys on metabolism of tissue slices. Cryobiology. 1984 Jun; 21(3):285-95. doi: 10.1016/0011-2240(84)90324-9. [PMID: 6610535]
A E Staubus, A B Weinrib, L Malspeis. An enzymatic kinetic method for the determination of 2'-deoxycoformycin in biological fluids. Biochemical pharmacology. 1984 May; 33(10):1633-7. doi: 10.1016/0006-2952(84)90285-5. [PMID: 6610419]