Pentostatin (BioDeep_00000004888)
Secondary id: BioDeep_00000409390
human metabolite blood metabolite Chemicals and Drugs Antibiotics Cytotoxicity natural product
代谢物信息卡片
(8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H,6H,7H,8H-imidazo[4,5-d][1,3]diazepin-8-ol
化学式: C11H16N4O4 (268.1171)
中文名称: 喷司他丁
谱图信息:
最多检出来源 Homo sapiens(natural_products) 37.5%
分子结构信息
SMILES: C1C(C(OC1N2C=NC3=C2NC=NCC3O)CO)O
InChI: InChI=1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)
描述信息
Pentostatin is only found in individuals that have used or taken this drug. It is a potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. [PubChem]Pentostatin is a potent transition state inhibitor of adenosine deaminase (ADA), the greatest activity of which is found in cells of the lymphoid system. T-cells have higher ADA activity than B-cells, and T-cell malignancies have higher activity than B-cell malignancies. The cytotoxicity that results from prevention of catabolism of adenosine or deoxyadenosine is thought to be due to elevated intracellular levels of dATP, which can block DNA synthesis through inhibition of ribonucleotide reductase. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).
D000970 - Antineoplastic Agents > D000903 - Antibiotics, Antineoplastic > D005573 - Formycins
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents
D004791 - Enzyme Inhibitors > D058892 - Adenosine Deaminase Inhibitors
C471 - Enzyme Inhibitor > C2157 - Adenosine Deaminase Inhibitor
同义名列表
17 个代谢物同义名
(8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H,6H,7H,8H-imidazo[4,5-d][1,3]diazepin-8-ol; Warner-lambert brand OF pentostatin; Prasfarma brand OF pentostatin; Supergen brand OF pentostatin; Lederle brand OF pentostatin; Wyeth brand OF pentostatin; CI-825;Deoxycoformycin; 2-Dexoycoformycin; 2-Deoxycoformycin; 2 Deoxycoformycin; Deoxycoformycin; CO-Vidarabine; Co vidarabine; PENTOSTATIN; Nipent; 2-DCF; Deoxycoformycin
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:27834
- KEGG: C02267
- KEGGdrug: D00155
- PubChem: 439693
- PubChem: 4739
- HMDB: HMDB0014692
- Metlin: METLIN65742
- DrugBank: DB00552
- ChEMBL: CHEMBL1580
- Wikipedia: Pentostatin
- MeSH: Pentostatin
- chemspider: 388759
- CAS: 53910-25-1
- PMhub: MS000017517
- PubChem: 5328
- PDB-CCD: DCF
- NIKKAJI: J10.843J
- RefMet: Pentostatin
- LOTUS: LTS0069464
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
6 个相关的物种来源信息
- 2 - Bacteria: LTS0069464
- 9606 - Homo sapiens: -
- 1883 - Streptomyces: LTS0069464
- 1890 - Streptomyces antibioticus:
- 1890 - Streptomyces antibioticus: LTS0069464
- 2062 - Streptomycetaceae: LTS0069464
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Minmin Zhao, Hongyu Zhang, Tingting Lou, Kongxiang Zhao, Suying Wang. [Simultaneous determination of pentostatin and 2'-amino-2'-deoxyadenosine in fermentation broth by high performance liquid chromatography-tandem mass spectrometry].
Se pu = Chinese journal of chromatography.
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Journal of molecular and cellular cardiology.
2019 03; 128(?):62-76. doi:
10.1016/j.yjmcc.2019.01.004. [PMID: 30641086] - Xuan Zhao, Guoying Zhang, Caiyi Li, Jianya Ling. Cordycepin and pentostatin biosynthesis gene identified through transcriptome and proteomics analysis of Cordyceps kyushuensis Kob.
Microbiological research.
2019 Jan; 218(?):12-21. doi:
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1987 Dec; 36(24):4297-302. doi:
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