Angiotensin II (BioDeep_00000004853)

 

Secondary id: BioDeep_00001868088

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


(3S)-3-amino-3-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S,2S)-1-{[(2S)-1-[(2S)-2-{[(1S)-1-carboxy-2-phenylethyl]carbamoyl}pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]carbamoyl}-2-methylbutyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(diaminomethylidene)amino]butyl]carbamoyl}propanoic acid

化学式: C50H71N13O12 (1045.5345)
中文名称: 血管紧张素II
谱图信息: 最多检出来源 not specific(not specific) 0%

分子结构信息

SMILES: CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N
InChI: InChI=1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)

描述信息

Angiotensin II is a hormone that may act on the central nervous system to regulate renal sympathetic nerve activity, renal function, and, therefore, blood pressure. Angiotensin II is produced locally within the kidney and mediates tissue injury through a series of nonhemodynamic effects. angiotensin II is not only involved in the regulation of blood pressure, water and sodium homeostasis, and control of other neurohumoral systems, but also leads to excessive production of reactive oxygen species and to hypertrophy, proliferation, migration, and apoptosis of vascular cells. Angiotensin II is one of the main factors involved in hypertension-induced tissue damage. This peptide regulates the inflammatory process. Angiotensin II activates circulating cells, and participates in their adhesion to the activated endothelium and subsequent transmigration through the synthesis of adhesion molecules, chemokines and cytokines. Among the intracellular signals involved in angiotensin II-induced inflammation, the production of reactive oxygen species and the activation of nuclear factor-kappaB are the best known. Classical, well-defined actions of Angiotensin II in the brain include the regulation of hormone formation and release, the control of the central and peripheral sympathoadrenal systems, and the regulation of water and sodium intake. As a consequence of changes in the hormone, sympathetic and electrolyte systems, feedback mechanisms in turn modulate the activity of the brain Angiotensin II systems. There are two Angiotensin II systems in the brain. The discovery of brain Angiotensin II receptors located in neurons inside the blood brain barrier confirmed the existence of an endogenous brain Angiotensin II system, responding to Angiotensin II generated in and/or transported into the brain. In addition, Angiotensin II receptors in circumventricular organs and in cerebrovascular endothelial cells respond to circulating Angiotensin II of peripheral origin. Thus, the brain responds to both circulating and tissue Angiotensin II, and the two systems are integrated. (PMID: 17147923, 16672146, 16601568, 16481883, 16075377).
Angiotensin II is a hormone that may act on the central nervous system to regulate renal sympathetic nerve activity, renal function, and, therefore, blood pressure. Angiotensin II is produced locally within the kidney and mediates tissue injury through a series of nonhemodynamic effects. angiotensin II is not only involved in the regulation of blood pressure, water and sodium homeostasis, and control of other neurohumoral systems, but also leads to excessive production of reactive oxygen species and to hypertrophy, proliferation, migration, and apoptosis of vascular cells. Angiotensin II is one of the main factors involved in hypertension-induced tissue damage. This peptide regulates the inflammatory process. Angiotensin II activates circulating cells, and participates in their adhesion to the activated endothelium and subsequent transmigration through the synthesis of adhesion molecules, chemokines and cytokines. Among the intracellular signals involved in angiotensin II-induced inflammation, the production of reactive oxygen species and the activation of nuclear factor-kappaB are the best known.
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Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway[1][2][3][4].
Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway[1][2][3][4].
Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway[1][2][3][4].
Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway[1][2][3][4].

同义名列表

37 个代谢物同义名

(3S)-3-amino-3-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S,2S)-1-{[(2S)-1-[(2S)-2-{[(1S)-1-carboxy-2-phenylethyl]carbamoyl}pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]carbamoyl}-2-methylbutyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(diaminomethylidene)amino]butyl]carbamoyl}propanoic acid; (3S)-3-amino-3-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S,2S)-1-{[(2S)-1-[(2S)-2-{[(1S)-1-carboxy-2-phenylethyl]carbamoyl}pyrrolidin-1-yl]-3-(3H-imidazol-4-yl)-1-oxopropan-2-yl]carbamoyl}-2-methylbutyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(diaminomethylidene)amino]butyl]carbamoyl}propanoic acid; 3-amino-4-[[1-[[1-[[1-[[1-[[1-[2-[(1-carboxy-2-phenylethyl)carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid; N-(1-(N-(N-(N-(N-(N(2)-L-alpha-Aspartyl-L-arginyl)-L-valyl)-L-tyrosyl)-L-isoleucyl)-L-histidyl)-L-prolyl)-L-phenylalanine; N-(1-(N-(N-(N-(N-(N(2)-L-a-Aspartyl-L-arginyl)-L-valyl)-L-tyrosyl)-L-isoleucyl)-L-histidyl)-L-prolyl)-L-phenylalanine; N-(1-(N-(N-(N-(N-(N(2)-L-Α-aspartyl-L-arginyl)-L-valyl)-L-tyrosyl)-L-isoleucyl)-L-histidyl)-L-prolyl)-L-phenylalanine; 1-L-Aspasaginyl-5-L-valyl angiotensin octapeptide; Asp-arg-val-tyr-ile-his-pro-phe; II, 5-L-isoleucine angiotensin; Angiotensin II, 5-L-isoleucine; 5-L-Isoleucine angiotensin II; 5 L Isoleucine angiotensin II; Angiotensin-(1-8) octapeptide; Isoleucine(5)-angiotensin II; 5-L-Isoleucineangiotensin II; Angiotensin II acetate salt; Isoleucyl(5)-angiotensin II; 5-Isoleucine-angiotensin II; Isoleucine(5)-angiotensin; Valyl(5)-angiotensin II; Angiotensin II (human); Angiotensin II (mouse); Ile(5)-angiotensin II; Human angiotensin II; ANG-(1-8)octapeptide; 1-8-Angiotensin I; Angiotensina II; Angiotensin II; Angiotensin 2; Hypertensin; Angiotensin; Angiotonin; Delivert; Ang II; DRVYIHPF; Angiotensin II human; Angiotensin II



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

40 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(13)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

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PathBank(27)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ADM, EDN1, ITPR3, MME, NFKB1, POMC, PRL, RHOA, SRC, TGFB1
Endosome membrane 1 ATP6AP2
Endoplasmic reticulum membrane 3 ATP6AP2, ITPR3, RHOA
Nucleus 7 NFKB1, PLCZ1, PRL, RAPGEF5, RHOA, SRC, TGFB1
cytosol 5 DUOX2, NFKB1, PLCZ1, RHOA, SRC
dendrite 1 MME
nuclear body 1 RAPGEF5
trans-Golgi network 1 MME
nucleoplasm 6 ITPR3, NFKB1, PLCZ1, PRL, RAPGEF5, SRC
RNA polymerase II transcription regulator complex 1 PRL
Cell membrane 4 GPRC5A, MME, RHOA, SRC
Lipid-anchor 2 RHOA, SRC
Cytoplasmic side 1 RHOA
Cleavage furrow 1 RHOA
lamellipodium 1 RHOA
ruffle membrane 2 RHOA, SRC
Cell projection, axon 1 ATP6AP2
Multi-pass membrane protein 3 DUOX2, GPRC5A, ITPR3
Synapse 3 CRH, MME, TAC1
cell cortex 1 RHOA
cell junction 3 DUOX2, RHOA, SRC
cell surface 3 DUOX2, MME, TGFB1
glutamatergic synapse 2 RHOA, SRC
Golgi membrane 1 ATP6AP2
lysosomal membrane 2 ATP6AP2, EGF
mitochondrial inner membrane 1 SRC
neuronal cell body 5 ITPR3, MME, SRC, TAC1, TGFB1
postsynapse 1 RHOA
synaptic vesicle 1 MME
Cytoplasmic vesicle, secretory vesicle 1 NTS
Lysosome 2 ATP6AP2, SRC
Presynapse 1 MME
endosome 1 RHOA
plasma membrane 10 ATP6AP2, DUOX2, EGF, GPRC5A, ITPR3, MME, RAPGEF5, RHOA, SRC, TGFB1
synaptic vesicle membrane 1 ATP6AP2
Membrane 5 ATP6AP2, DUOX2, EGF, ITPR3, MME
apical plasma membrane 1 DUOX2
axon 4 ATP6AP2, MME, TAC1, TGFB1
brush border 2 ITPR3, MME
caveola 1 SRC
extracellular exosome 7 ATP6AP2, DUOX2, EGF, GPRC5A, MME, RHOA, SRC
Lysosome membrane 1 ATP6AP2
endoplasmic reticulum 2 DUOX2, ITPR3
extracellular space 9 ADM, CRH, CRP, EDN1, EGF, POMC, PRL, TAC1, TGFB1
perinuclear region of cytoplasm 2 PLCZ1, SRC
mitochondrion 2 NFKB1, SRC
intracellular membrane-bounded organelle 2 GPRC5A, NTS
pronucleus 1 PLCZ1
Single-pass type I membrane protein 1 ATP6AP2
Secreted 8 ADM, CRH, CRP, EDN1, NTS, POMC, PRL, TGFB1
extracellular region 11 ADM, CRH, CRP, EDN1, EGF, NFKB1, NTS, POMC, PRL, TAC1, TGFB1
cytoplasmic side of plasma membrane 1 RHOA
basal part of cell 1 EDN1
anchoring junction 1 DUOX2
transcription regulator complex 1 NFKB1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP6AP2
external side of plasma membrane 1 ATP6AP2
varicosity 1 CRH
Secreted, extracellular space, extracellular matrix 1 TGFB1
dendritic spine 1 RHOA
neuronal dense core vesicle lumen 1 CRH
perikaryon 1 CRH
cytoplasmic vesicle 1 MME
nucleolus 3 GPRC5A, ITPR3, PLCZ1
Cytoplasmic vesicle, clathrin-coated vesicle membrane 1 ATP6AP2
clathrin-coated vesicle membrane 1 ATP6AP2
midbody 1 RHOA
Early endosome 1 MME
apical part of cell 2 DUOX2, ITPR3
Single-pass type II membrane protein 1 MME
vesicle 2 GPRC5A, RHOA
postsynaptic membrane 1 ATP6AP2
Apical cell membrane 1 DUOX2
Cell projection, lamellipodium 1 RHOA
Cytoplasm, perinuclear region 2 PLCZ1, SRC
Mitochondrion inner membrane 1 SRC
Membrane raft 2 MME, SRC
Cell junction, focal adhesion 1 SRC
Cytoplasm, cytoskeleton 1 SRC
focal adhesion 3 MME, RHOA, SRC
extracellular matrix 1 TGFB1
sarcoplasmic reticulum 1 ITPR3
collagen-containing extracellular matrix 1 TGFB1
secretory granule 2 POMC, TGFB1
nuclear outer membrane 1 ITPR3
Late endosome 1 SRC
receptor complex 2 GPRC5A, ITPR3
chromatin 2 NFKB1, PRL
cell leading edge 1 DUOX2
Cytoplasmic vesicle, autophagosome membrane 1 ATP6AP2
autophagosome membrane 1 ATP6AP2
cell periphery 1 RHOA
cytoskeleton 1 RHOA
podosome 1 SRC
Cytoplasm, cell cortex 1 RHOA
actin filament 1 SRC
blood microparticle 1 TGFB1
endosome lumen 1 PRL
Cytoplasmic vesicle membrane 1 GPRC5A
Cell projection, dendrite 1 RHOA
tertiary granule membrane 1 ATP6AP2
dendritic growth cone 1 SRC
synaptic membrane 1 SRC
secretory granule lumen 2 NFKB1, POMC
secretory granule membrane 3 ITPR3, MME, RHOA
Golgi lumen 1 TGFB1
platelet alpha granule lumen 2 EGF, TGFB1
axon terminus 1 NTS
specific granule lumen 1 NFKB1
transport vesicle 2 EDN1, NTS
clathrin-coated endocytic vesicle membrane 1 EGF
platelet dense tubular network membrane 1 ITPR3
ficolin-1-rich granule membrane 2 ATP6AP2, RHOA
apical junction complex 1 RHOA
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
postsynaptic specialization, intracellular component 1 SRC
Cell projection, dendritic spine membrane 1 ATP6AP2
dendritic spine membrane 1 ATP6AP2
proton-transporting V-type ATPase complex 1 ATP6AP2
vacuolar proton-transporting V-type ATPase complex 1 ATP6AP2
vacuolar proton-transporting V-type ATPase, V0 domain 1 ATP6AP2
[Latency-associated peptide]: Secreted, extracellular space, extracellular matrix 1 TGFB1
[Transforming growth factor beta-1]: Secreted 1 TGFB1
transport vesicle membrane 1 ITPR3
rough endoplasmic reticulum lumen 1 EDN1
sperm head 1 PLCZ1
Weibel-Palade body 1 EDN1
NADPH oxidase complex 1 DUOX2
neuron projection terminus 1 MME
dendritic filopodium 1 SRC
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1


文献列表

  • Lin Liao, Pengyu Tao, Qiming Xu, Jie Chen, Weiwei Liu, Jing Hu, Jianrao Lu. Bushen Huoxue formula protects against renal fibrosis and pyroptosis in chronic kidney disease by inhibiting ROS/NLRP3-mediated inflammasome activation. Renal failure. 2024 Dec; 46(1):2354444. doi: 10.1080/0886022x.2024.2354444. [PMID: 38785272]
  • Xue-Min Yin, Yi-Yi Song, Wen-Yi Jiang, Hao-Tian Zhang, Jing-Wei Chen, Koji Murao, Meng-Xiao Han, Wan-Ping Sun, Guo-Xing Zhang. Mitochondrial KATP channel-mediated autophagy contributes to angiotensin II-induced vascular dysfunction in mice. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2024 Jun; 34(6):1571-1580. doi: 10.1016/j.numecd.2024.01.019. [PMID: 38418351]
  • Pingping Tuo, Risheng Zhao, Ning Li, Shuang Yan, Gege Yang, Chunmei Wang, Jinghui Sun, Haiming Sun, Mengyang Wang. Lycorine inhibits Ang II-induced heart remodeling and inflammation by suppressing the PI3K-AKT/NF-κB pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155464. doi: 10.1016/j.phymed.2024.155464. [PMID: 38484625]
  • Ren Ozawa, Hisataka Iwata, Takehito Kuwayama, Koumei Shirasuna. Maternal hypertensive condition alters adipose tissue function and blood pressure sensitivity in offspring. Biochemical and biophysical research communications. 2024 May; 707(?):149617. doi: 10.1016/j.bbrc.2024.149617. [PMID: 38520942]
  • Jinxiang Xie, Shupeng Chen, Pengtao Huan, Shuguang Wang, Yongliang Zhuang. A novel angiotensin I-converting enzyme inhibitory peptide from walnut (Juglans sigillata) protein hydrolysates and its evaluation in Ang II-induced HUVECs and hypertensive rats. International journal of biological macromolecules. 2024 May; 266(Pt 2):131152. doi: 10.1016/j.ijbiomac.2024.131152. [PMID: 38556230]
  • Ying Cheng, Mengchao Yan, Shuyu He, Yi Xie, Lihui Wei, Bihan Xuan, Zucheng Shang, Meizhu Wu, Huifang Zheng, Youqin Chen, Meng Yuan, Jun Peng, Aling Shen. Baicalin alleviates angiotensin II-induced cardiomyocyte apoptosis and autophagy and modulates the AMPK/mTOR pathway. Journal of cellular and molecular medicine. 2024 May; 28(9):e18321. doi: 10.1111/jcmm.18321. [PMID: 38712979]
  • Qiuxiang Chen, Juan Wang, Lihua Sun, Bayinsilema Ba, Difei Shen. Mechanism of Astragalus membranaceus (Huangqi, HQ) for treatment of heart failure based on network pharmacology and molecular docking. Journal of cellular and molecular medicine. 2024 May; 28(10):e18331. doi: 10.1111/jcmm.18331. [PMID: 38780500]
  • Xiaohu Yang, Wenchao Yang, Shuang He, He Ye, Shanshan Lei. Danhong formula alleviates endothelial dysfunction and reduces blood pressure in hypertension by regulating MicroRNA 24 - Phosphatidylinositol 3-Kinase-Serine/Threonine Kinase- Endothelial Nitric Oxide Synthase axis. Journal of ethnopharmacology. 2024 Apr; 323(?):117615. doi: 10.1016/j.jep.2023.117615. [PMID: 38163560]
  • Zimri Aziel Alvarado-Ojeda, Celeste Trejo-Moreno, Eduardo Ferat-Osorio, Marisol Méndez-Martínez, Gladis Fragoso, Gabriela Rosas-Salgado. Role of Angiotensin II in Non-Alcoholic Steatosis Development. Archives of medical research. 2024 Apr; 55(3):102986. doi: 10.1016/j.arcmed.2024.102986. [PMID: 38492325]
  • Yue He, Xinsheng Gu, Zhou Yang, Hao Wang, Ping Liu. Study on the mechanism underlying Trichosanthis peel injection-induced improvements in myocardial fibrosis markers in patients with chronic heart failure. Clinical and experimental pharmacology & physiology. 2024 04; 51(4):e13848. doi: 10.1111/1440-1681.13848. [PMID: 38423007]
  • Tianyuan Song, Yin-Yi Ding, Tiantian Zhang, Qiaolin Cai, Yonghong Hu, Qing Gu, Zhenyu Gu. Soybean-derived antihypertensive hydrolysates attenuate Ang II-induced renal damage by modulating MAPK and NF-κB signaling pathways. Food & function. 2024 Mar; 15(5):2485-2496. doi: 10.1039/d3fo05247h. [PMID: 38334682]
  • Martina Mihalj, Mario Štefanić, Zrinka Mihaljević, Nikolina Kolobarić, Ivana Jukić, Ana Stupin, Anita Matić, Ruža Frkanec, Branka Tavčar, Anita Horvatić, Ines Drenjančević. Early Low-Grade Inflammation Induced by High-Salt Diet in Sprague Dawley Rats Involves Th17/Treg Axis Dysregulation, Vascular Wall Remodeling, and a Shift in the Fatty Acid Profile. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2024 Feb; 58(1):83-103. doi: 10.33594/000000684. [PMID: 38459804]
  • Longyue Zhou, Shankang Chen, Yuanyi Wei, Yihui Sun, Yifan Yang, Bingqi Lin, Yuhao Li, Chunxia Wang. Glycyrrhizic acid restores the downregulated hepatic ACE2 signaling in the attenuation of mouse steatohepatitis. European journal of pharmacology. 2024 Feb; ?(?):176365. doi: 10.1016/j.ejphar.2024.176365. [PMID: 38316247]
  • Mingchuan Yang, Ximing Wu, Yufeng He, Xiuli Li, Lumin Yang, Tingting Song, Fuming Wang, Chung S Yang, Jinsong Zhang. EGCG oxidation-derived polymers induce apoptosis in digestive tract cancer cells via regulating the renin-angiotensin system. Food & function. 2024 Jan; ?(?):. doi: 10.1039/d3fo03795a. [PMID: 38293823]
  • Hui-Hsuan Lin, Chia-Lin Tsai, Chiao-Yun Tseng, Pei-Rong Yu, Pei-Yu Chiu, Cheng-Chin Hsu, Jing-Hsien Chen. Anti-Hypertensive Effect of Solanum muricatum Aiton Leaf Extract In Vivo and In Vitro. Plant foods for human nutrition (Dordrecht, Netherlands). 2024 Jan; ?(?):. doi: 10.1007/s11130-024-01146-1. [PMID: 38270742]
  • Hao Yu, Daojing Gan, Zhen Luo, Qilin Yang, Dongqi An, Hao Zhang, Yingchun Hu, Zhuang Ma, Qingchun Zeng, Dingli Xu, Hao Ren. α-Ketoglutarate improves cardiac insufficiency through NAD+-SIRT1 signaling-mediated mitophagy and ferroptosis in pressure overload-induced mice. Molecular medicine (Cambridge, Mass.). 2024 Jan; 30(1):15. doi: 10.1186/s10020-024-00783-1. [PMID: 38254035]
  • Qian Xu, Kunping Zhuo, Xiaotian Zhang, Yanru Zhen, Limin Liu, Lu Zhang, Yufan Gu, Hui Jia, Qing Chen, Meixi Liu, Jiawei Dong, Ming-Sheng Zhou. The role of angiotensin II activation of yes-associated protein/PDZ-binding motif signaling in hypertensive cardiac and vascular remodeling. European journal of pharmacology. 2024 Jan; 962(?):176252. doi: 10.1016/j.ejphar.2023.176252. [PMID: 38061470]
  • Ru-Li Li, Cai-Li Zhuo, Xin Yan, He Li, Lan Lin, Ling-Yu Li, Qiying Jiang, Die Zhang, Xue-Mei Wang, Lin-Ling Liu, Wen-Jing Huang, Ying-Ling Wang, Xin-Yue Li, Yan Mao, Yixin Chen, Xiao Liu, Quan-Chen Xu, Yu-Yan Cai, Xi-Jing Yang, Hong-Ying Chen, Si-Si Wu, Wei Jiang. Irisin attenuates vascular remodeling in hypertensive mice induced by Ang II by suppressing Ca2+-dependent endoplasmic reticulum stress in VSMCs. International journal of biological sciences. 2024; 20(2):680-700. doi: 10.7150/ijbs.84153. [PMID: 38169582]
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