Coformycin (BioDeep_00000004735)

   

Chemicals and Drugs Antibiotics


代谢物信息卡片


Coformycin

化学式: C11H16N4O5 (284.1120646)
中文名称:
谱图信息: 最多检出来源 Macaca mulatta(otcml) 0.28%

分子结构信息

SMILES: C1C(C2=C(NC=N1)N(C=N2)C3C(C(C(O3)CO)O)O)O
InChI: InChI=1S/C11H16N4O5/c16-2-6-8(18)9(19)11(20-6)15-4-14-7-5(17)1-12-3-13-10(7)15/h3-6,8-9,11,16-19H,1-2H2,(H,12,13)/t5-,6-,8-,9-,11-/m1/s1

描述信息

An N-glycosyl in which (8R)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol is attached to ribofuranose via a beta-N(3)-glycosidic bond. compound The parent of the class of coformycins.
D000970 - Antineoplastic Agents > D000903 - Antibiotics, Antineoplastic > D005573 - Formycins
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D004791 - Enzyme Inhibitors

同义名列表

2 个代谢物同义名

Coformycin; NSC 277817



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • S D Lindell, B A Moloney, B D Hewitt, C G Earnshaw, P J Dudfield, J E Dancer. The design and synthesis of inhibitors of adenosine 5'-monophosphate deaminase. Bioorganic & medicinal chemistry letters. 1999 Jul; 9(14):1985-90. doi: 10.1016/s0960-894x(99)00298-x. [PMID: 10450967]
  • S V Komarova, E V Mosharov, V M Vitvitsky, F I Ataullakhanov. Adenine nucleotide synthesis in human erythrocytes depends on the mode of supplementation of cell suspension with adenosine. Blood cells, molecules & diseases. 1999 Jun; 25(3-4):170-9. doi: 10.1006/bcmd.1999.0243. [PMID: 10575543]
  • S M Johnson, S Patel, F E Bruckner, D A Collins. 5'-Nucleotidase as a marker of both general and local inflammation in rheumatoid arthritis patients. Rheumatology (Oxford, England). 1999 May; 38(5):391-6. doi: 10.1093/rheumatology/38.5.391. [PMID: 10371274]
  • J E Dancer, R G Hughes, S D Lindell. Adenosine-5'-phosphate deaminase. A novel herbicide target. Plant physiology. 1997 May; 114(1):119-29. doi: 10.1104/pp.114.1.119. [PMID: 9159944]
  • J Stepinski, T Pawelczyk, D Bizon, S Angielski. Purine nucleotide cycle in rat renal cortex and medulla under conditions that mimic normal and low oxygen supply. Kidney international. 1996 Oct; 50(4):1195-201. doi: 10.1038/ki.1996.428. [PMID: 8887278]
  • J G Niedzwicki, D R Abernethy. Structure-activity relationship of ligands of human plasma adenosine deaminase2. Biochemical pharmacology. 1991 Jun; 41(11):1615-24. doi: 10.1016/0006-2952(91)90162-x. [PMID: 2043151]
  • A D Ho, M Grossmann, W Knauf, H Martin, L Trümper, T Zwingers, R Sonnen, H Pralle, W Hunstein. Plasma levels of soluble CD8 antigen and interleukin-2 receptor antigen in patients with hairy cell leukemia, relationship with splenectomy and with clinical response to therapy. Leukemia. 1989 Oct; 3(10):718-23. doi: NULL. [PMID: 2506398]
  • P G Plagemann, C Woffendin. Permeation and salvage of dideoxyadenosine in mammalian cells. Molecular pharmacology. 1989 Jul; 36(1):185-92. doi: . [PMID: 2787472]
  • M E Stromski, A van Waarde, M J Avison, G Thulin, K M Gaudio, M Kashgarian, R G Shulman, N J Siegel. Metabolic and functional consequences of inhibiting adenosine deaminase during renal ischemia in rats. The Journal of clinical investigation. 1988 Nov; 82(5):1694-9. doi: 10.1172/jci113782. [PMID: 3263396]
  • K M Skubitz, N W Wickham, D E Hammerschmidt. Endogenous and exogenous adenosine inhibit granulocyte aggregation without altering the associated rise in intracellular calcium concentration. Blood. 1988 Jul; 72(1):29-33. doi: . [PMID: 3260524]
  • R G Steis, L Marcon, J Clark, W Urba, D L Longo, D L Nelson, A E Maluish. Serum soluble IL-2 receptor as a tumor marker in patients with hairy cell leukemia. Blood. 1988 May; 71(5):1304-9. doi: . [PMID: 3129046]
  • N Winick, G R Buchanan, S B Murphy, A Yu, J Boyett. Deoxycoformycin treatment for childhood T-cell acute lymphoblastic leukemia early in second remission: a Pediatric Oncology Group Study. Medical and pediatric oncology. 1988; 16(5):327-32. doi: 10.1002/mpo.2950160507. [PMID: 3263563]
  • D L Marquardt, L L Walker. Inhibition of mast cell adenosine responsiveness by chronic exposure to adenosine receptor agonists. Biochemical pharmacology. 1987 Dec; 36(24):4297-302. doi: 10.1016/0006-2952(87)90674-5. [PMID: 2825721]
  • D A Galton, F Brito-Babapulle. The management of myelomatosis. European journal of haematology. 1987 Nov; 39(5):385-98. doi: 10.1111/j.1600-0609.1987.tb01445.x. [PMID: 2446915]
  • D de Korte, W A Haverkort, E F van Leeuwen, D Roos, A H van Gennip. Biochemical consequences of 2'-deoxycoformycin treatment in a patient with T-cell lymphoma. Some unusual findings. Cancer. 1987 Aug; 60(4):750-5. doi: 10.1002/1097-0142(19870815)60:4<750::aid-cncr2820600407>3.0.co;2-1. [PMID: 3496148]
  • V P Kontinen, J P Pispa. Enhancement of biotinidase activity in mouse serum by inhibitors of methylation. Molecular and cellular biochemistry. 1987 Jul; 76(1):85-91. doi: 10.1007/bf00219401. [PMID: 3498118]
  • A Begleiter, R I Glazer, L G Israels, L Pugh, J B Johnston. Induction of DNA strand breaks in chronic lymphocytic leukemia following treatment with 2'-deoxycoformycin in vivo and in vitro. Cancer research. 1987 May; 47(9):2498-503. doi: . [PMID: 3494509]
  • B A Bouroncle, M R Grever, E H Kraut. Treatment of hairy cell leukemia: the Ohio State University experience with deoxycoformycin. Leukemia. 1987 Apr; 1(4):350-4. doi: NULL. [PMID: 3499542]
  • E Giulotto, C Knights, G R Stark. Hamster cells with increased rates of DNA amplification, a new phenotype. Cell. 1987 Mar; 48(5):837-45. doi: 10.1016/0092-8674(87)90080-8. [PMID: 3815526]
  • J Schwartz, M Ostrander, N J Butkiewicz, M Lieberman, C Lin, J Lim, G H Miller. Activity of (+)-cyclaradine (Sch 31172) against herpes simplex virus in vitro and in vivo. Antimicrobial agents and chemotherapy. 1987 Jan; 31(1):21-6. doi: 10.1128/aac.31.1.21. [PMID: 3032089]
  • J B Johnston, R I Glazer, L Pugh, L G Israels. The treatment of hairy-cell leukaemia with 2'-deoxycoformycin. British journal of haematology. 1986 Jul; 63(3):525-34. doi: 10.1111/j.1365-2141.1986.tb07530.x. [PMID: 3488071]
  • J B Johnston, A Begleiter, L Pugh, M K Leith, J A Wilkins, D J Cavers, L G Israels. Biochemical changes induced in hairy-cell leukemia following treatment with the adenosine deaminase inhibitor 2'-deoxycoformycin. Cancer research. 1986 Apr; 46(4 Pt 2):2179-84. doi: . [PMID: 2418965]
  • D E Ingolia, C Y Yeung, C Shoemaker, R J Kaufman, R E Kellems. Expression of murine ADA cDNA in bacterial and mammalian cells. Advances in experimental medicine and biology. 1986; 195 Pt A(?):223-9. doi: 10.1007/978-1-4684-5104-7_35. [PMID: 3524134]
  • J Renshaw, K R Harrap. In vivo inhibition of mouse liver methyltransferase enzymes following treatment with 2'-deoxycoformycin and 2'-deoxyadenosine. Advances in experimental medicine and biology. 1986; 195 Pt B(?):673-5. doi: 10.1007/978-1-4684-1248-2_105. [PMID: 3490129]
  • L Fiume, B Bassi, C Busi, A Mattioli, T Wieland. A study on the pharmacokinetics in mouse of adenine-9-beta-D-arabinofuranoside 5-monophosphate conjugated with lactosaminated albumin. Experientia. 1985 Oct; 41(10):1326-8. doi: 10.1007/bf01952078. [PMID: 2412878]
  • A Goday, H A Simmonds, G S Morris, L D Fairbanks. Human B lymphocytes and thymocytes but not peripheral blood mononuclear cells accumulate high dATP levels in conditions simulating ADA deficiency. Biochemical pharmacology. 1985 Oct; 34(19):3561-9. doi: 10.1016/0006-2952(85)90734-8. [PMID: 3876835]
  • J F Henderson, C M Smith, G Zombor. Regulation of purine metabolism in lymphocytes. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1985 Sep; 179(4):419-26. doi: 10.3181/00379727-179-42117. [PMID: 3875099]
  • S Archer, P F Juranka, J H Ho, V L Chan. An analysis of multiple mechanisms of adenosine toxicity in baby hamster kidney cells. Journal of cellular physiology. 1985 Aug; 124(2):226-32. doi: 10.1002/jcp.1041240209. [PMID: 3900094]
  • D C Doll, R B Weiss. Hemolytic anemia associated with antineoplastic agents. Cancer treatment reports. 1985 Jul; 69(7-8):777-82. doi: NULL. [PMID: 3160460]
  • H Ratech, R Hirschhorn, G J Thorbecke. Effects of deoxycoformycin in mice. III. A murine model reproducing multi-system pathology of human adenosine deaminase deficiency. The American journal of pathology. 1985 Apr; 119(1):65-72. doi: . [PMID: 3872599]
  • R B Gilbertsen. Effects of pentostatin (2'deoxycoformycin), an inhibitor of adenosine deaminase, on type II collagen-induced arthritis in rats. Journal of immunopharmacology. 1985; 7(3):325-41. doi: 10.3109/08923978509026480. [PMID: 3877119]
  • A R Belch, J F Henderson, L W Brox. Treatment of multiple myeloma with deoxycoformycin. Cancer chemotherapy and pharmacology. 1985; 14(1):49-52. doi: 10.1007/bf00552725. [PMID: 3871175]
  • J F Smyth, H G Prentice, S Proctor, A V Hoffbrand. Deoxycoformycin in the treatment of leukemias and lymphomas. Annals of the New York Academy of Sciences. 1985; 451(?):123-8. doi: 10.1111/j.1749-6632.1985.tb27102.x. [PMID: 3878113]
  • C T Lum, D E Sutherland, N Hsiao, J S Najarian. Relevance of adenosine deaminase to organ transplantation. Annals of the New York Academy of Sciences. 1985; 451(?):113-22. doi: 10.1111/j.1749-6632.1985.tb27101.x. [PMID: 3907451]
  • J H Southhard, M Kuniyoshi, M F Lutz, M Ametani, F O Belzer. Comparison of the effect of 3- and 5-day hypothermic perfusion of dog kidneys on metabolism of tissue slices. Cryobiology. 1984 Jun; 21(3):285-95. doi: 10.1016/0011-2240(84)90324-9. [PMID: 6610535]
  • A E Staubus, A B Weinrib, L Malspeis. An enzymatic kinetic method for the determination of 2'-deoxycoformycin in biological fluids. Biochemical pharmacology. 1984 May; 33(10):1633-7. doi: 10.1016/0006-2952(84)90285-5. [PMID: 6610419]
  • D C Harris, S Lawrence, K F Bradstock, J J Carter, W G Jones. Intraglomerular thrombosis with deoxycoformycin--reversible acute renal failure. Clinical nephrology. 1984 Mar; 21(3):194-6. doi: NULL. [PMID: 6608428]
  • H Azuma, Y Takashima, M Ishikawa, T Yamakado. Potentiation of antiaggregating activity of adenosine by a phosphodiesterase inhibitor, EG626 (oxagrelate), in human platelets in vitro. Japanese journal of pharmacology. 1984 Feb; 34(2):159-70. doi: 10.1254/jjp.34.159. [PMID: 6205194]
  • J H Southard, M F Lutz, M S Ametani, F O Belzer. Stimulation of ATP synthesis in hypothermically perfused dog kidneys by adenosine and PO4. Cryobiology. 1984 Feb; 21(1):13-9. doi: 10.1016/0011-2240(84)90017-8. [PMID: 6609048]
  • B E Checkik, A Perets, S SenGupta, B Fernandes. Morphologic changes and immunohistochemical localization of adenosine deaminase in tissues of rats given injections of 2'-deoxycoformycin. Journal of the National Cancer Institute. 1983 Nov; 71(5):999-1010. doi: . [PMID: 6358608]
  • B N Cronstein, S B Kramer, G Weissmann, R Hirschhorn. Adenosine: a physiological modulator of superoxide anion generation by human neutrophils. The Journal of experimental medicine. 1983 Oct; 158(4):1160-77. doi: 10.1084/jem.158.4.1160. [PMID: 6311934]
  • S Helland, P M Ueland. Effect of 2'-deoxycoformycin infusion on S-adenosylhomocysteine hydrolase and the amount of S-adenosylhomocysteine and related compounds in tissues of mice. Cancer research. 1983 Sep; 43(9):4142-7. doi: . [PMID: 6603264]
  • B S Mitchell, N L Edwards, C A Koller. Deoxyribonucleoside triphosphate accumulation by leukemic cells. Blood. 1983 Aug; 62(2):419-24. doi: . [PMID: 6603241]
  • M S Hershfield, N M Kredich, C A Koller, B S Mitchell, J Kurtzberg, T R Kinney, J M Falletta. S-adenosylhomocysteine catabolism and basis for acquired resistance during treatment of T-cell acute lymphoblastic leukemia with 2'-deoxycoformycin alone and in combination with 9-beta-D-arabinofuranosyladenine. Cancer research. 1983 Jul; 43(7):3451-8. doi: . [PMID: 6601986]
  • M Bergeron, T Hoang. Adenosine and compensatory renal growth. Kidney international. 1983 Apr; 23(4):588-93. doi: 10.1038/ki.1983.62. [PMID: 6571412]
  • M R Grever, E Bisaccia, D A Scarborough, E N Metz, J A Neidhart. An investigation of 2'-deoxycoformycin in the treatment of cutaneous T-cell lymphoma. Blood. 1983 Feb; 61(2):279-82. doi: . [PMID: 6600401]
  • B Ashby, E Wernick, H Holmsen. Coformycin inhibition of platelet AMP deaminase has no effect on thrombin-induced platelet secretion nor on glycolysis or glycogenolysis. The Journal of biological chemistry. 1983 Jan; 258(1):321-5. doi: . [PMID: 6848504]
  • A D Webster, H Ip, S Pereira. Effects of deoxyadenosine on the activation of ADA inhibited T & B cells. Clinical and experimental immunology. 1982 Dec; 50(3):587-95. doi: . [PMID: 6299634]
  • R P Agarwal, J Blatt, J Miser, S Sallan, J M Lipton, G H Reaman, J Holcenberg, D G Poplack. Clinical pharmacology of 9-beta-D-arabinofuranosyladenine in combination with 2'-deoxycoformycin. Cancer research. 1982 Sep; 42(9):3884-6. doi: NULL. [PMID: 6980706]
  • J Blatt, P M Venner, R Riccardi, L F Cohen, D Gangji, R I Glazer, D G Poplack. Cerebrospinal fluid levels of 2'-deoxycoformycin after systemic administration in monkeys. Journal of the National Cancer Institute. 1982 Mar; 68(3):391-3. doi: NULL. [PMID: 6977672]
  • J F Kuttesch, J A Nelson. Renal handling of 2'-deoxyadenosine and adenosine in humans and mice. Cancer chemotherapy and pharmacology. 1982; 8(2):221-9. doi: 10.1007/bf00255488. [PMID: 6980741]
  • H G Prentice, N H Russell, N Lee, K Ganeshaguru, H Blacklock, A Piga, J F Smyth, A V Hoffbrand. Therapeutic selectivity of and predication of response to 2'-deoxycoformycin in acute leukaemia. Lancet (London, England). 1981 Dec; 2(8258):1250-4. doi: 10.1016/s0140-6736(81)91491-4. [PMID: 6118669]
  • R Hirschhorn, V Roegner-Maniscalco, L Kuritsky, F S Rosen. Bone marrow transplantation only partially restores purine metabolites to normal in adenosine deaminase-deficient patients. The Journal of clinical investigation. 1981 Dec; 68(6):1387-93. doi: 10.1172/jci110389. [PMID: 7033281]
  • M T Aye, J V Dunne. Effect of 2'-deoxycoformycin on erythroid, granulocytic, and T-lymphocyte colony growth. Blood. 1981 Nov; 58(5):1043-6. doi: NULL. [PMID: 6975136]
  • P M Venner, R I Glazer, J Blatt, S Sallan, G Rivera, J S Holcenberg, J Lipton, S B Murphy, D G Poplack. Levels of 2'-deoxycoformycin, adenosine, and deoxyadenosine in patients with acute lymphoblastic leukemia. Cancer research. 1981 Nov; 41(11 Pt 1):4508-11. doi: . [PMID: 6975654]
  • F G King, R L Dedrick. Physiologic model for the pharmacokinetics of 2'deoxycoformycin in normal and leukemic mice. Journal of pharmacokinetics and biopharmaceutics. 1981 Oct; 9(5):519-34. doi: 10.1007/bf01061024. [PMID: 6977636]
  • H Ratech, G J Thorbecke, R Hirschhorn. Metabolic abnormalities of human adenosine deaminase deficiency reproduced in the mouse by 2'-deoxycoformycin, and adenosine deaminase inhibitor. Clinical immunology and immunopathology. 1981 Oct; 21(1):119-27. doi: 10.1016/0090-1229(81)90200-2. [PMID: 6268339]
  • P P Major, R P Agarwal, D W Kufe. Clinical pharmacology of deoxycoformycin. Blood. 1981 Jul; 58(1):91-6. doi: . [PMID: 6263381]
  • R M Paine, B J Weston, H M Clink, J Kohn, A M Neville, K G McGhee, K R Harrap. Toxicity and immunosuppressive activity of binary combinations of 2'-deoxycoformycin and 2'-deoxyadenosine. Cancer treatment reports. 1981 Mar; 65(3-4):259-66. doi: . [PMID: 6972254]
  • M R Grever, M F Siaw, W F Jacob, J A Neidhart, J S Miser, M S Coleman, J J Hutton, S P Balcerzak. The biochemical and clinical consequences of 2'-deoxycoformycin in refractory lymphoproliferative malignancy. Blood. 1981 Mar; 57(3):406-17. doi: . [PMID: 6970050]
  • P P Major, R P Agarwal, D W Kufe. Deoxycoformycin: neurological toxicity. Cancer chemotherapy and pharmacology. 1981; 5(3):193-6. doi: 10.1007/bf00258479. [PMID: 6975188]
  • M F Siaw, B S Mitchell, C A Koller, M S Coleman, J J Hutton. ATP depletion as a consequence of adenosine deaminase inhibition in man. Proceedings of the National Academy of Sciences of the United States of America. 1980 Oct; 77(10):6157-61. doi: 10.1073/pnas.77.10.6157. [PMID: 6969403]
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  • A Tedde, M E Balis, S Ikehara, R Pahwa, R A Good, P P Trotta. Animal model for immune dysfunction associated with adenosine deaminase deficiency. Proceedings of the National Academy of Sciences of the United States of America. 1980 Aug; 77(8):4899-903. doi: 10.1073/pnas.77.8.4899. [PMID: 6968908]
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  • T Hidaka, K Katayama, K Yamashita, T Yamashita, K Watanabe, M Shimazaki, M Ohno, T Takeuchi, H Umezawa. Effects of a new adenosine deaminase inhibitor, isocoformycin, on toxicity, antitumor activity and tissue distribution of formycin A and 9-beta-D-arabinofuranosyladenine. The Journal of antibiotics. 1980 Mar; 33(3):303-9. doi: 10.7164/antibiotics.33.303. [PMID: 7380742]
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