Arsenate (BioDeep_00000004697)

 

Secondary id: BioDeep_00001867766

human metabolite Endogenous


代谢物信息卡片


Orthoarsenic acid, dihydrate

化学式: AsH3O4 (141.9247)
中文名称: 砷酸、原砷酸
谱图信息: 最多检出来源 Viridiplantae(plant) 73.52%

分子结构信息

SMILES: O=[As](O)(O)O
InChI: InChI=1S/AsH3O4/c2-1(3,4)5/h(H3,2,3,4,5)

描述信息

Arsenate is an ion consisting of arsenic. An arsenate is any compound containing the arsenate ion AsO43−. Arsenates are also referred to as pentavalent arsenic [As(V)] as the arsenic atom in arsenate has a valence of five. Arsenates can be both salts and esters of arsenic acid. Arsenate can be used as an indicator of mineral deposits, as a result of transition metals reacting with it to form bright colours. These mineral blooms can be used to find nickel (annabergite), copper (chalcophyllite), and cobalt (erythrite) arsenide ores. Arsenate is a chemical analogue of phosphate due to arsenic and phosphorous being part of the same group (pnictogens). Because of the similarities, arsenate can be taken by phosphate transporters due to imperfect selectivity (PMID: 328484, 8598055). Arsenate is much less toxic than the trivalent form arsenite, which is more mobile in groundwater and soils, and forms strong metal-like interactions with thiol groups in protein cysteine residues and small molecule thiols (PMID: 30852446).
The arsenate ion is AsO43−. An arsenate (compound) is any compound that contains this ion.The arsenic atom in arsenate has a valency of 5 and is also known as pentavalent arsenic or As[V].Arsenate resembles phosphate in many respects, since arsenic and phosphorus occur in the same group (column) of the periodic table.
D010575 - Pesticides > D006540 - Herbicides
D009676 - Noxae > D013723 - Teratogens
D016573 - Agrochemicals

同义名列表

21 个代谢物同义名

Orthoarsenic acid, dihydrate; Tetraoxidoarsenate(3-); Tetraoxoarsenate(3-); Tetraoxoarsenate(V); Orthoarsenic acid; Metaarsenic acid; Pyroarsenic acid; Arsenate ions; Orthoarsenate; arsenate(3-); arsoric acid; Arsenate ion; Arsenic acid; Arsic acid; [AsO(OH)3]; Arsorate; Arsenate; H3AsO4; Arsate; ART; Arsenic acid



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(1)

代谢反应

158 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(156)

INOH(0)

PlantCyc(2)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 AKT1, ALB, ANPEP, BCL2, CASP3, CASP7, FOXO1, HPGDS, MARK2, MVD, PML
Peripheral membrane protein 2 GORASP1, PML
Endoplasmic reticulum membrane 3 BCL2, HSP90B1, PML
Nucleus 10 ACR, AKT1, ALB, BCL2, CASP3, CASP7, FOXO1, HSP90B1, MPO, PML
cytosol 10 AKT1, ALB, BCL2, CASP3, CASP7, FOXO1, HPGDS, HSP90B1, MVD, PML
dendrite 1 MARK2
centrosome 1 ALB
nucleoplasm 9 AKT1, CASP3, CASP7, CD33, FOXO1, HPGDS, MARK2, MPO, PML
Cell membrane 3 AKT1, ANPEP, CD9
Cytoplasmic side 2 GORASP1, PML
lamellipodium 1 AKT1
Early endosome membrane 2 GPNMB, PML
Multi-pass membrane protein 1 CD9
Golgi apparatus membrane 1 GORASP1
cell cortex 1 AKT1
cell surface 3 ARSB, CD33, CD38
glutamatergic synapse 2 AKT1, CASP3
Golgi apparatus 3 ALB, CD33, GORASP1
Golgi membrane 1 GORASP1
lysosomal membrane 1 ANPEP
neuronal cell body 1 CASP3
postsynapse 1 AKT1
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 1 CASP7
Lysosome 2 ARSB, MPO
plasma membrane 7 AKT1, ANPEP, CD33, CD38, CD9, GPNMB, MARK2
Membrane 8 AKT1, BCL2, CD33, CD38, CD9, GPNMB, HSP90B1, MARK2
basolateral plasma membrane 1 CD38
extracellular exosome 7 ALB, ANPEP, ARSB, CD38, CD9, HSP90B1, MPO
endoplasmic reticulum 3 ALB, BCL2, HSP90B1
extracellular space 5 ALB, ANPEP, CASP7, CD9, MPO
lysosomal lumen 1 ARSB
perinuclear region of cytoplasm 1 HSP90B1
mitochondrion 3 BCL2, FOXO1, MARK2
protein-containing complex 6 ACR, AKT1, ALB, BCL2, CD9, HSP90B1
intracellular membrane-bounded organelle 2 HPGDS, MPO
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 GPNMB
Secreted 1 ALB
extracellular region 6 ACR, ALB, ARSB, CD9, HSP90B1, MPO
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, CD33
mitochondrial outer membrane 1 BCL2
anchoring junction 1 ALB
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 3 BCL2, CD38, PML
external side of plasma membrane 3 ANPEP, CD33, CD9
Extracellular vesicle 1 CD9
microtubule cytoskeleton 1 AKT1
nucleolus 1 PML
Melanosome membrane 1 GPNMB
midbody 1 HSP90B1
cell-cell junction 1 AKT1
Golgi-associated vesicle 1 ACR
Single-pass type II membrane protein 2 ANPEP, CD38
vesicle 1 AKT1
pore complex 1 BCL2
focal adhesion 2 CD9, HSP90B1
spindle 1 AKT1
cis-Golgi network 1 GORASP1
Peroxisome 1 CD33
Nucleus, PML body 1 PML
PML body 1 PML
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 HSP90B1
secretory granule 1 MPO
lateral plasma membrane 1 MARK2
ciliary basal body 2 AKT1, ALB
chromatin 1 FOXO1
centriole 1 ALB
Secreted, extracellular space 1 CASP7
spindle pole 1 ALB
chromosome, telomeric region 1 PML
actin filament 1 MARK2
blood microparticle 1 ALB
Cell projection, dendrite 1 MARK2
specific granule membrane 1 CD33
tertiary granule membrane 1 CD33
Melanosome 1 HSP90B1
myelin sheath 1 BCL2
sperm plasma membrane 1 HSP90B1
azurophil granule 1 MPO
ficolin-1-rich granule lumen 1 ARSB
secretory granule membrane 1 ANPEP
endoplasmic reticulum lumen 3 ALB, ARSB, HSP90B1
nuclear matrix 1 PML
platelet alpha granule lumen 1 ALB
endocytic vesicle membrane 1 CD9
Secreted, extracellular exosome 1 CD9
azurophil granule lumen 2 ARSB, MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
clathrin-coated endocytic vesicle membrane 1 CD9
Sarcoplasmic reticulum lumen 1 HSP90B1
phagocytic vesicle lumen 1 MPO
endoplasmic reticulum-Golgi intermediate compartment 1 ANPEP
death-inducing signaling complex 1 CASP3
platelet alpha granule membrane 1 CD9
endocytic vesicle lumen 1 HSP90B1
endoplasmic reticulum chaperone complex 1 HSP90B1
acrosomal matrix 1 ACR
BAD-BCL-2 complex 1 BCL2
[Isoform CD33M]: Cell membrane 1 CD33
[Isoform CD33m]: Peroxisome 1 CD33
ciliary transition fiber 1 ALB
microtubule bundle 1 MARK2


文献列表

  • Muhammad Saeed, Umar Masood Quraishi, Ghazala Mustafa, Abida Farooqi, Maria Greger, Riffat Naseem Malik. Metabolomics profiling reveals the detoxification and tolerance behavior of two bread wheat (Triticum aestivum L.) varieties under arsenate stress. Food chemistry. 2024 Jun; 443(?):138612. doi: 10.1016/j.foodchem.2024.138612. [PMID: 38306910]
  • Ze-Wen Wang, Guang Yang, Jian Chen, Yaoyu Zhou, Avelino Núñez Delgado, Hui-Ling Cui, Gui-Lan Duan, Barry P Rosen, Yong-Guan Zhu. Fundamentals and application in phytoremediation of an efficient arsenate reducing bacterium Pseudomonas putida ARS1. Journal of environmental sciences (China). 2024 Mar; 137(?):237-244. doi: 10.1016/j.jes.2023.02.020. [PMID: 37980011]
  • Pooja Singh, Saumya Jaiswal, Durgesh Kumar Tripathi, Vijay Pratap Singh. Nitric oxide acts upstream of indole-3-acetic acid in ameliorating arsenate stress in tomato seedlings. Plant physiology and biochemistry : PPB. 2024 Mar; 208(?):108461. doi: 10.1016/j.plaphy.2024.108461. [PMID: 38461754]
  • Jingyu Wen, Xin Tang, Mengyuan Wang, Li Mu, Weidan Hao, Jingxian Weng, Ziwei Gao, Xiangang Hu. Regulation and mechanism of pyrite and humic acid on the toxicity of arsenate in lettuce. The Science of the total environment. 2024 Feb; 912(?):168980. doi: 10.1016/j.scitotenv.2023.168980. [PMID: 38040366]
  • Juthathip Janejobkhet, Wasinee Pongprayoon, Kullanart Obsuwan, Supakit Jaiyindee, Sarunyaporn Maksup. Multifaceted response mechanisms of Oryza sativa L. 'KDML105' to high arsenite and arsenate stress levels. Environmental science and pollution research international. 2024 Feb; 31(9):13816-13832. doi: 10.1007/s11356-024-32122-6. [PMID: 38265595]
  • Muhammad Saeed, Umar Masood Quraishi, Tommy Landberg, Maria Greger, Riffat Naseem Malik. Phenomic profiling to reveal tolerance mechanisms and regulation of ascorbate-glutathione cycle in wheat varieties (Triticum aestivum L.) under arsenic stress. Environmental geochemistry and health. 2023 Dec; 46(1):2. doi: 10.1007/s10653-023-01784-5. [PMID: 38071652]
  • Adrián Domene, Helena Orozco, Pilar Rodríguez-Viso, Vicente Monedero, Manuel Zúñiga, Dinoraz Vélez, Vicenta Devesa. Impact of Chronic Exposure to Arsenate through Drinking Water on the Intestinal Barrier. Chemical research in toxicology. 2023 Oct; ?(?):. doi: 10.1021/acs.chemrestox.3c00201. [PMID: 37819996]
  • Yi Hao, Zeyu Cai, Chuanxin Ma, Jason C White, Yini Cao, Zhaofeng Chang, Xinxin Xu, Lanfang Han, Weili Jia, Jian Zhao, Baoshan Xing. Root Exposure of Graphitic Carbon Nitride (g-C3N4) Modulates Metabolite Profile and Endophytic Bacterial Community to Alleviate Cadmium- and Arsenate-Induced Phytotoxicity to Rice (Oryza sativa L.). ACS nano. 2023 Oct; ?(?):. doi: 10.1021/acsnano.3c03066. [PMID: 37812587]
  • Muhammad Qadir, Anwar Hussain, Mohib Shah, Muhammad Hamayun, Amjad Iqbal, Muhammad Irshad, Zafar Hayat Khan, Badshah Islam, Hosam O Elansary, Eman A Mahmoud, In-Jung Lee. Pantoea conspicua promoted sunflower growth and engulfed rhizospheric arsenate by secreting exopolysaccharide. Plant physiology and biochemistry : PPB. 2023 Aug; 201(?):107826. doi: 10.1016/j.plaphy.2023.107826. [PMID: 37331076]
  • Ambika Pandey, Lin-Bo Wu, Varunseelan Murugaiyan, Gabriel Schaaf, Jauhar Ali, Michael Frei. Differential effects of arsenite and arsenate on rice (Oryza sativa) plants differing in glutathione S-transferase gene expression. Environmental science and pollution research international. 2023 Jul; ?(?):. doi: 10.1007/s11356-023-28833-x. [PMID: 37486470]
  • Pengfei Wang, Zedong Chen, Yanjun Meng, Huanting Shi, Chuang Lou, Xu Zheng, Gezi Li, Xiangnan Li, Wanxi Peng, Guozhang Kang. Wheat PHT1;9 acts as one candidate arsenate absorption transporter for phytoremediation. Journal of hazardous materials. 2023 06; 452(?):131219. doi: 10.1016/j.jhazmat.2023.131219. [PMID: 36940527]
  • Yisong Liu, Yanting Zhang, Zhangqing Wang, Shiyuan Guo, Yanjun Fang, Zhenqian Zhang, Huiling Gao, Huimin Ren, Cun Wang. Plasma membrane-associated calcium signaling regulates arsenate tolerance in Arabidopsis. Plant physiology. 2023 05; 192(2):910-926. doi: 10.1093/plphys/kiad171. [PMID: 36943277]
  • Matheus Sampaio C Barreto, Evert J Elzinga, Donald L Sparks. The adsorption of arsenate and p-arsanilic acid onto ferrihydrite and subsequent desorption by sulfate and artificial seawater: Future implications of sea level rise. Environmental pollution (Barking, Essex : 1987). 2023 Apr; 323(?):121302. doi: 10.1016/j.envpol.2023.121302. [PMID: 36804144]
  • You-Jing Peng, Chun-Yan Hu, Wei Li, Zhi-Hua Dai, Chen-Jing Liu, Lena Q Ma. Arsenic induced plant growth by increasing its nutrient uptake in As-hyperaccumulator Pteris vittata: Comparison of arsenate and arsenite. Environmental pollution (Barking, Essex : 1987). 2023 Apr; 322(?):121168. doi: 10.1016/j.envpol.2023.121168. [PMID: 36740166]
  • Jasvinder Kaur, Vandana Anand, Sonal Srivastava, Vidisha Bist, Mariya Naseem, Pallavi Singh, Vartika Gupta, Poonam C Singh, Sangeeta Saxena, Saraswati Bisht, Pankaj Kumar Srivastava, Suchi Srivastava. Mitigation of arsenic toxicity in rice by the co-inoculation of arsenate reducer yeast with multifunctional arsenite oxidizing bacteria. Environmental pollution (Barking, Essex : 1987). 2023 Mar; 320(?):120975. doi: 10.1016/j.envpol.2022.120975. [PMID: 36584855]
  • Ghanshyam Kumar Satyapal, Raghawendra Kumar, Sanjeev Kumar, Ravi Shankar Singh, Prashant, Rajesh Kumar Ranjan, Kundan Kumar, Amrit Kumar Jha, Nater Pal Singh, Rizwanul Haque, Asheesh Shanker, Nitish Kumar. Cloning and functional characterization of arsenite oxidase (aoxB) gene associated with arsenic transformation in Pseudomonas sp. strain AK9. Gene. 2023 Jan; 850(?):146926. doi: 10.1016/j.gene.2022.146926. [PMID: 36191825]
  • Husna, Anwar Hussain, Mohib Shah, Muhammad Hamayun, Amjad Iqbal, Muhammad Qadir, Abed Alataway, Ahmed Z Dewidar, Hosam O Elansary, In-Jung Lee. Phytohormones producing rhizobacteria alleviate heavy metals stress in soybean through multilayered response. Microbiological research. 2023 Jan; 266(?):127237. doi: 10.1016/j.micres.2022.127237. [PMID: 36270107]
  • Fernanda Oliveira Reis, Eduarda de Moura Garcia, Lisiane Martins Volcão, Ronan Adler Tavella, Rodrigo de Lima Brum, Larissa Müller, Erico Kunde Correa, Juliane Ventura-Lima, Flavio Manoel Rodrigues da Silva Júnior. Arsenite and arsenate toxicity in the earthworm Eisenia andrei (Bouché 1972) in natural soil and tropical artificial soil. Environmental science and pollution research international. 2023 Jan; 30(5):12872-12882. doi: 10.1007/s11356-022-23025-5. [PMID: 36114968]
  • Yaqi Wang, Lingxuan Kong, Kang Wang, Yanjin Tao, Hao Qi, Yanan Wan, Qi Wang, Huafen Li. The combined impacts of selenium and phosphorus on the fate of arsenic in rice seedlings (Oryza sativa L.). Chemosphere. 2022 Dec; 308(Pt 3):136590. doi: 10.1016/j.chemosphere.2022.136590. [PMID: 36167200]
  • Kang Wang, Yaqi Wang, Chen Zhang, Lijie Zhao, Lingxuan Kong, Qi Wang, Huafen Li, Yanan Wan. Selenite and selenate showed contrasting impacts on the fate of arsenic in rice (Oryza sativa L.) regardless of the formation of iron plaque. Environmental pollution (Barking, Essex : 1987). 2022 Nov; 312(?):120039. doi: 10.1016/j.envpol.2022.120039. [PMID: 36041566]
  • Jiexuan Yu, Kegang Zhang, Xuelei Duan, Changxian Zhao, Xiaoyang Wei, Qi Guo, Chun-Gang Yuan. Simultaneous removal of arsenate and arsenite in water using a novel functional halloysite nanotube composite. Environmental science and pollution research international. 2022 Nov; 29(51):77131-77144. doi: 10.1007/s11356-022-20261-7. [PMID: 35676577]
  • Zhi-Hua Dai, You-Jing Peng, Song Ding, Jia-Yi Chen, Si-Xue He, Chun-Yan Hu, Yue Cao, Dong-Xing Guan, Lena Q Ma. Selenium Increased Arsenic Accumulation by Upregulating the Expression of Genes Responsible for Arsenic Reduction, Translocation, and Sequestration in Arsenic Hyperaccumulator Pteris vittata. Environmental science & technology. 2022 10; 56(19):14146-14153. doi: 10.1021/acs.est.2c03147. [PMID: 36121644]
  • Sheetal Bhadwal, Sucheta Sharma. Selenium alleviates physiological traits, nutrient uptake and nitrogen metabolism in rice under arsenate stress. Environmental science and pollution research international. 2022 Oct; 29(47):70862-70881. doi: 10.1007/s11356-022-20762-5. [PMID: 35589895]
  • Daniel Rodríguez-Martín, Antonio Murciano, Marta Herráiz, Patricia de Francisco, Francisco Amaro, Juan Carlos Gutiérrez, Ana Martín-González, Silvia Díaz. Arsenate and arsenite differential toxicity in Tetrahymena thermophila. Journal of hazardous materials. 2022 06; 431(?):128532. doi: 10.1016/j.jhazmat.2022.128532. [PMID: 35248958]
  • Nidhi Kandhol, Vijay Pratap Singh, Luis Herrera-Estrella, Lam-Son Phan Tran, Durgesh Kumar Tripathi. Arsenite: the umpire of arsenate perception and responses in plants. Trends in plant science. 2022 05; 27(5):420-422. doi: 10.1016/j.tplants.2022.02.005. [PMID: 35249810]
  • Mi-Mi Sun, Yan Tian, Mei Chun, Yi-Fang Chen. The Ubiquitin E3 Ligase PRU2 Modulates Phosphate Uptake in Arabidopsis. International journal of molecular sciences. 2022 Feb; 23(4):. doi: 10.3390/ijms23042273. [PMID: 35216388]
  • Guan-Hua Cao, Xi-Fu Wang, Ze-Dong Li, Xue Zhang, Xiao-Gang Li, Wen Gu, Fan Zhang, Jie Yu, Sen He. A Panax notoginseng phosphate transporter, PnPht1;3, greatly contributes to phosphate and arsenate uptake. Functional plant biology : FPB. 2022 02; 49(3):259-271. doi: 10.1071/fp21218. [PMID: 35115080]
  • Cristina Navarro, Cristian Mateo-Elizalde, Thotegowdanapalya C Mohan, Eduardo Sánchez-Bermejo, Oscar Urrutia, María Nieves Fernández-Muñiz, José M García-Mina, Riansares Muñoz, Javier Paz-Ares, Gabriel Castrillo, Antonio Leyva. Arsenite provides a selective signal that coordinates arsenate uptake and detoxification through the regulation of PHR1 stability in Arabidopsis. Molecular plant. 2021 09; 14(9):1489-1507. doi: 10.1016/j.molp.2021.05.020. [PMID: 34048950]
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  • Juan Francisco Martín, Paloma Liras. Molecular Mechanisms of Phosphate Sensing, Transport and Signalling in Streptomyces and Related Actinobacteria. International journal of molecular sciences. 2021 Jan; 22(3):. doi: 10.3390/ijms22031129. [PMID: 33498785]
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  • Qi Wang, Jingyu Wen, Jinxin Zheng, Jiaqi Zhao, Chunsheng Qiu, Di Xiao, Li Mu, Xiaowei Liu. Arsenate phytotoxicity regulation by humic acid and related metabolic mechanisms. Ecotoxicology and environmental safety. 2021 Jan; 207(?):111379. doi: 10.1016/j.ecoenv.2020.111379. [PMID: 33017691]
  • Rong Zhao, Chao-Tian Xie, Yan Xu, De-Hua Ji, Chang-Sheng Chen, Jun Ye, Xi-Mei Xue, Wen-Lei Wang. The response of Pyropia haitanensis to inorganic arsenic under laboratory culture. Chemosphere. 2020 Dec; 261(?):128160. doi: 10.1016/j.chemosphere.2020.128160. [PMID: 33113648]
  • Thi Thuc Quyen Nguyen, Paripurnanda Loganathan, Tien Vinh Nguyen, Saravanamuthu Vigneswaran, Huu Hao Ngo. Iron and zirconium modified luffa fibre as an effective bioadsorbent to remove arsenic from drinking water. Chemosphere. 2020 Nov; 258(?):127370. doi: 10.1016/j.chemosphere.2020.127370. [PMID: 32554019]
  • Juan Manuel Peralta, Claudia N Travaglia, María C Romero-Puertas, Ana Furlan, Stella Castro, Eliana Bianucci. Unraveling the impact of arsenic on the redox response of peanut plants inoculated with two different Bradyrhizobium sp. strains. Chemosphere. 2020 Nov; 259(?):127410. doi: 10.1016/j.chemosphere.2020.127410. [PMID: 32615455]
  • Yuan Zhao, Changzhou Yan, Zhuo Zhen. Influence of environmental factors on arsenite transformation and fate in the Hydrilla verticillata (L.f.) royle - Medium system. Chemosphere. 2020 Nov; 259(?):127442. doi: 10.1016/j.chemosphere.2020.127442. [PMID: 32593827]
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  • Barsha Majumder, Susmita Das, Soumyajit Biswas, Asis Mazumdar, Asok K Biswas. Differential responses of photosynthetic parameters and its influence on carbohydrate metabolism in some contrasting rice (Oryza sativa L.) genotypes under arsenate stress. Ecotoxicology (London, England). 2020 Sep; 29(7):912-931. doi: 10.1007/s10646-020-02241-0. [PMID: 32594380]
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