Methane (BioDeep_00000004689)

 

Secondary id: BioDeep_00001867664

human metabolite Endogenous blood metabolite


代谢物信息卡片


Methane in gaseus STate

化学式: CH4 (16.0312984)
中文名称: 甲烷-13C, 甲烷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C
InChI: InChI=1S/CH4/h1H4

描述信息

Methane (CH4), is a gas produced by a group of colonic anaerobes, absorbed from the colon and excreted in expired air. As a result, breath CH4 excretion can be used as an indicator of the in situ activity of the methanogenic flora. All CH4 produced in human beings is a metabolic product of intestinal bacteria, and about 50\\% of CH4 produced in the gut is absorbed and excreted in expired air. Because there appears to be no catabolism of this gas by other colonic organisms or host cells, breath CH4 measurements provide a rapid, simple means of semi quantitatively assessing the ongoing in situ metabolism of the methanogenic flora. It could seem likely that the intracolonic activity of a variety of bacteria similarly might be assessed quantitatively via analysis of expired air. However, the application of this methodology has been confounded by the rapid catabolism of many volatile bacterial products by other bacteria or human tissue. A striking aspect of the studies of breath CH4 measurements is the enormous individual variations in the excretion of this gas. Virtually all children under 5 years of age and 66\\% of the adult population do not exhale appreciable quantities of CH4. The remaining 34\\% of the adult population has appreciable breath methane concentrations of up to 80 ppm (mean, 15.2 ppm; median, 11.8 ppm). On this basis the population can be divided into CH4 producers or nonproducers, although a more accurate term would be to define subjects as being low or high CH4 producers. The primary methanogen present in the human colon, Methanobrevibacter smithii, produces methane via a reaction that relies entirely on H2 produced by other organisms to reduce CO2 to CH4. Thus, breath CH4 concentrations might be expected to mirror breath H2 concentrations; however, the high levels of CH4 observed in the fasting state may result from H2 derived from endogenous rather than dietary substrates. A diverse assortment of conditions has been associated with a high prevalence of methane producers including diverticulosis, cystic fibrosis, high fasting serum cholesterol levels, encopresis in children, and aorto-iliac vascular disease, whereas obesity (measured as skin-fold thickness) was related inversely to methane production. The challenge that remains is to determine to what extent methanogens actively influence body physiology vs. simply serve as passive indicators of colonic function. (PMID: 16469670, Clinical Gastroenterology and Hepatology Volume 4, Issue 2, February 2006, Pages 123-129). Methane can be found in Desulfovibrio, Methanobacterium, Methanobrevibacter, Methanococcus, Methanocorpusculum, Methanoculleus, Methanoflorens, Methanofollis, Methanogenium, Methanomicrobium, Methanopyrus, Methanoregula, Methanosaeta, Methanosarcina, Methanosphaera, Methanospirillium, Methanothermobacter (Wikipedia).
Methane (CH4), is a gas produced by a group of colonic anaerobes, absorbed from the colon and excreted in expired air. As a result, breath CH4 excretion can be used as an indicator of the in situ activity of the methanogenic flora. All CH4 produced in human beings is a metabolic product of intestinal bacteria, and about 50\\% of CH4 produced in the gut is absorbed and excreted in expired air. Because there appears to be no catabolism of this gas by other colonic organisms or host cells, breath CH4 measurements provide a rapid, simple means of semi quantitatively assessing the ongoing in situ metabolism of the methanogenic flora. It could seem likely that the intracolonic activity of a variety of bacteria similarly might be assessed quantitatively via analysis of expired air. However, the application of this methodology has been confounded by the rapid catabolism of many volatile bacterial products by other bacteria or human tissue. A striking aspect of the studies of breath CH4 measurements is the enormous individual variations in the excretion of this gas. Virtually all children under 5 years of age and 66\\% of the adult population do not exhale appreciable quantities of CH4. The remaining 34\\% of the adult population has appreciable breath methane concentrations of up to 80 ppm (mean, 15.2 ppm; median, 11.8 ppm). On this basis the population can be divided into CH4 producers or nonproducers, although a more accurate term would be to define subjects as being low or high CH4 producers. The primary methanogen present in the human colon, Methanobrevibacter smithii, produces methane via a reaction that relies entirely on H2 produced by other organisms to reduce CO2 to CH4. Thus, breath CH4 concentrations might be expected to mirror breath H2 concentrations; however, the high levels of CH4 observed in the fasting state may result from H2 derived from endogenous rather than dietary substrates. A diverse assortment of conditions has been associated with a high prevalence of methane producers including diverticulosis, cystic fibrosis, high fasting serum cholesterol levels, encopresis in children, and aorto-iliac vascular disease, whereas obesity (measured as skin-fold thickness) was related inversely to methane production. The challenge that remains is to determine to what extent methanogens actively influence body physiology vs. simply serve as passive indicators of colonic function. (PMID: 16469670, Clinical Gastroenterology and Hepatology Volume 4, Issue 2, February 2006, Pages 123-129) [HMDB]

同义名列表

92 个代谢物同义名

Methane in gaseus STate; Electrographite; Methyl hydride; (11c)methane; Thermatomic; Acticarbone; Kohlenstoff; Methylidyne; Hydrodarco; carbane-13; Filtrasorb; Anthrasorb; Kosmotherm; Thermblack; Carbosieve; Watercarb; Excelsior; Marsh gas; Humenegro; Methylene; Fire dAMP; Schungite; Carbonium; Collocarb; Conductex; Lampblack; Philblack; Sevacarb; Adsorbit; Canesorb; Kosmobil; Shungite; Tinolite; Flamruss; Atlantic; Carbomet; Kosmolak; Farbruss; Continex; Pelletex; Carbolac; Cecarbon; Plumbago; Kosmovar; Micronex; Carbodis; Arotone; Magecol; Grafoil; Korobon; Thermax; Molacco; Modulex; Printex; Aquadag; Rebonex; Grosafe; Spheron; Superba; Croflex; Carbone; Carbono; Aroflow; Cancarb; Kosmink; methane; Degussa; Carbene; Metanex; Nuchar; Papyex; Kosmos; Furnex; Arovel; Neotex; Crolac; Arogen; Furnal; Canlub; Metano; Biogas; Elftex; Methan; Statex; Gastex; Fecto; Huber; Arrow; Essex; Darco; R 50; CH4



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(7)

PlantCyc(0)

代谢反应

17 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(15)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(1)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

43 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Suli He, Chao Yan, Min Wu, Haiyan Peng, Ren Li, Jian Wan, Xin Ye, Hongmao Zhang, Shumao Ding. Dibutyl phthalate adsorbed on multi-walled carbon nanotubes can aggravate liver injury in mice via the Jak2/STAT3 pathway. Toxicology and industrial health. 2024 Jan; ?(?):7482337241230701. doi: 10.1177/07482337241230701. [PMID: 38285958]
  • Eman Soliman, Ahmed E M Elhassanny, Anagha Malur, Matthew McPeek, Aaron Bell, Nancy Leffler, Rukiyah Van Dross, Jacob L Jones, Achut G Malur, Mary Jane Thomassen. Impaired mitochondrial function of alveolar macrophages in carbon nanotube-induced chronic pulmonary granulomatous disease. Toxicology. 2020 12; 445(?):152598. doi: 10.1016/j.tox.2020.152598. [PMID: 32976959]
  • Ting Yang, Jiamao Chen, Lingqiang Gao, Yuanyu Huang, Guochao Liao, Yi Cao. Induction of lipid droplets in THP-1 macrophages by multi-walled carbon nanotubes in a diameter-dependent manner: A transcriptomic study. Toxicology letters. 2020 Oct; 332(?):65-73. doi: 10.1016/j.toxlet.2020.07.007. [PMID: 32649966]
  • Haiyin Yang, Jing Li, Chunguang Yang, Hongwen Liu, Yi Cao. Multi-walled carbon nanotubes promoted lipid accumulation in human aortic smooth muscle cells. Toxicology and applied pharmacology. 2019 07; 374(?):11-19. doi: 10.1016/j.taap.2019.04.022. [PMID: 31047983]
  • Chunxue Zhao, Yiwei Zhou, Liangliang Liu, Jimin Long, Hongwen Liu, Juan Li, Yi Cao. Lipid accumulation in multi-walled carbon nanotube-exposed HepG2 cells: Possible role of lipophagy pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2018 Nov; 121(?):65-71. doi: 10.1016/j.fct.2018.08.033. [PMID: 30138652]
  • Shukry Zawahir, Indika Gawarammana, Paul I Dargan, Mahfoudh Abdulghni, Andrew H Dawson. Activated charcoal significantly reduces the amount of colchicine released from Gloriosa superba in simulated gastric and intestinal media. Clinical toxicology (Philadelphia, Pa.). 2017 Sep; 55(8):914-918. doi: 10.1080/15563650.2017.1325897. [PMID: 28535126]
  • Gholamhossein Yousefi, Mohammad Bizhani, Akram Jamshidzadeh, Saeid Gholamzadeh. Comparison of activated charcoal and sodium polystyrene sulfonate resin efficiency on reduction of amitriptyline oral absorption in rat as treatments for overdose and toxicities. Iranian journal of basic medical sciences. 2017 Jan; 20(1):46-52. doi: 10.22038/ijbms.2017.8092. [PMID: 28133524]
  • Daniel V Christophersen, Nicklas R Jacobsen, Maria H G Andersen, Shea P Connell, Kenneth K Barfod, Morten B Thomsen, Mark R Miller, Rodger Duffin, Jens Lykkesfeldt, Ulla Vogel, Håkan Wallin, Steffen Loft, Martin Roursgaard, Peter Møller. Cardiovascular health effects of oral and pulmonary exposure to multi-walled carbon nanotubes in ApoE-deficient mice. Toxicology. 2016 Sep; 371(?):29-40. doi: 10.1016/j.tox.2016.10.003. [PMID: 27725195]
  • T I Vitkina, V I Yankova, T A Gvozdenko, V L Kuznetsov, D V Krasnikov, A V Nazarenko, V V Chaika, S V Smagin, A Μ Tsatsakis, A B Engin, S P Karakitsios, D A Sarigiannis, K S Golokhvast. The impact of multi-walled carbon nanotubes with different amount of metallic impurities on immunometabolic parameters in healthy volunteers. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2016 Jan; 87(?):138-47. doi: 10.1016/j.fct.2015.11.023. [PMID: 26683310]
  • Zaigham Abbas Rizvi, Niti Puri, Rajiv K Saxena. Lipid antigen presentation through CD1d pathway in mouse lung epithelial cells, macrophages and dendritic cells and its suppression by poly-dispersed single-walled carbon nanotubes. Toxicology in vitro : an international journal published in association with BIBRA. 2015 Sep; 29(6):1275-82. doi: 10.1016/j.tiv.2014.10.022. [PMID: 25448806]
  • Sarah S Poulsen, Anne T Saber, Alicja Mortensen, Józef Szarek, Dongmei Wu, Andrew Williams, Ole Andersen, Nicklas R Jacobsen, Carole L Yauk, Håkan Wallin, Sabina Halappanavar, Ulla Vogel. Changes in cholesterol homeostasis and acute phase response link pulmonary exposure to multi-walled carbon nanotubes to risk of cardiovascular disease. Toxicology and applied pharmacology. 2015 Mar; 283(3):210-22. doi: 10.1016/j.taap.2015.01.011. [PMID: 25620056]
  • Jin Wuk Lee, Young Chul Choi, Rosa Kim, Sung Kyu Lee. Multiwall Carbon Nanotube-Induced Apoptosis and Antioxidant Gene Expression in the Gills, Liver, and Intestine of Oryzias latipes. BioMed research international. 2015; 2015(?):485343. doi: 10.1155/2015/485343. [PMID: 26146619]
  • Silvia Pichardo, Daniel Gutiérrez-Praena, María Puerto, Elena Sánchez, Antonio Grilo, Ana M Cameán, Angeles Jos. Oxidative stress responses to carboxylic acid functionalized single wall carbon nanotubes on the human intestinal cell line Caco-2. Toxicology in vitro : an international journal published in association with BIBRA. 2012 Aug; 26(5):672-7. doi: 10.1016/j.tiv.2012.03.007. [PMID: 22449549]
  • Jingyun Wang, Pingping Sun, Yongming Bao, Bairui Dou, Dandan Song, Yachen Li. Vitamin E renders protection to PC12 cells against oxidative damage and apoptosis induced by single-walled carbon nanotubes. Toxicology in vitro : an international journal published in association with BIBRA. 2012 Feb; 26(1):32-41. doi: 10.1016/j.tiv.2011.10.004. [PMID: 22020378]
  • Jingyun Wang, Pingping Sun, Yongming Bao, Jiwen Liu, Lijia An. Cytotoxicity of single-walled carbon nanotubes on PC12 cells. Toxicology in vitro : an international journal published in association with BIBRA. 2011 Feb; 25(1):242-50. doi: 10.1016/j.tiv.2010.11.010. [PMID: 21094249]
  • Anita Patlolla, Brittney McGinnis, Paul Tchounwou. Biochemical and histopathological evaluation of functionalized single-walled carbon nanotubes in Swiss-Webster mice. Journal of applied toxicology : JAT. 2011 Jan; 31(1):75-83. doi: 10.1002/jat.1579. [PMID: 20737426]
  • Anreddy Rama Narsimha Reddy, Yellu Narsimha Reddy, Devarakonda Rama Krishna, Vurimindi Himabindu. Multi wall carbon nanotubes induce oxidative stress and cytotoxicity in human embryonic kidney (HEK293) cells. Toxicology. 2010 Jun; 272(1-3):11-6. doi: 10.1016/j.tox.2010.03.017. [PMID: 20371264]
  • Prabakaran Ravichandran, Adaikkappan Periyakaruppan, Bindu Sadanandan, Vani Ramesh, Joseph C Hall, Olufisayo Jejelowo, Govindarajan T Ramesh. Induction of apoptosis in rat lung epithelial cells by multiwalled carbon nanotubes. Journal of biochemical and molecular toxicology. 2009 Sep; 23(5):333-44. doi: 10.1002/jbt.20296. [PMID: 19827037]
  • Kazuki Shimoishi, Makoto Anraku, Kenichiro Kitamura, Yuka Tasaki, Kazuaki Taguchi, Mitsuru Hashimoto, Eiko Fukunaga, Toru Maruyama, Masaki Otagiri. An oral adsorbent, AST-120 protects against the progression of oxidative stress by reducing the accumulation of indoxyl sulfate in the systemic circulation in renal failure. Pharmaceutical research. 2007 Jul; 24(7):1283-9. doi: 10.1007/s11095-007-9248-x. [PMID: 17387602]
  • J W Hubbard, K K Midha, J K Cooper. The metabolism of p-methoxyamphetamine in dog and monkey. O-demethylation as a major route. Drug metabolism and disposition: the biological fate of chemicals. 1977 Jul; 5(4):329-34. doi: NULL. [PMID: 19212]
  • F R DeRubertis, P A Craven. Calcium-independent modulation of cyclic GMP and activation of guanylate cyclase by nitrosamines. Science (New York, N.Y.). 1976 Sep; 193(4256):897-9. doi: 10.1126/science.7837. [PMID: 7837]