3,5-Cyclic IMP (BioDeep_00000004524)

   


代谢物信息卡片


3,5-Cyclic Inosine monophosphate (cIMP)

化学式: C10H11N4O7P (330.0365)
中文名称:
谱图信息: 最多检出来源 Macaca mulatta(otcml) 17.22%

分子结构信息

SMILES: C1C2C(C(C(O2)N3C=NC4=C3N=CNC4=O)O)OP(=O)(O1)O
InChI: InChI=1S/C10H11N4O7P/c15-6-7-4(1-19-22(17,18)21-7)20-10(6)14-3-13-5-8(14)11-2-12-9(5)16/h2-4,6-7,10,15H,1H2,(H,17,18)(H,11,12,16)/t4-,6-,7-,10-/m1/s1

描述信息

A 3,5-cyclic purine nucleotide having hypoxanthine as the nucleobase.

同义名列表

3 个代谢物同义名

3,5-Cyclic IMP; 3,5-Cyclic Inosine monophosphate (cIMP); INOSINE-3,5-cyclic-MONOPHOSPHATE



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 BRAF, CACNA1G, CDKN2A, CRABP1, CTNNB1, DAPK1, EGFR, IDH1, PIK3CA, RUNX3, SOCS1, TP53
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 1 EGFR
Nucleus 15 BRAF, CDKN2A, CDX2, CRABP1, CTNNB1, DAPK1, DNMT1, EGFR, HIC1, MGMT, MLH1, NEUROG1, RUNX3, SOCS1, TP53
cytosol 10 BRAF, CDKN2A, CRABP1, CTNNB1, IDH1, IDH2, PIK3CA, RUNX3, SOCS1, TP53
centrosome 2 CTNNB1, TP53
nucleoplasm 10 CDKN2A, CDX2, CTNNB1, DNMT1, HIC1, MGMT, MLH1, RUNX3, SOCS1, TP53
Cell membrane 4 BRAF, CACNA1G, CTNNB1, EGFR
lamellipodium 2 CTNNB1, PIK3CA
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 1 CACNA1G
Synapse 2 CACNA1G, CTNNB1
cell cortex 1 CTNNB1
cell junction 2 CTNNB1, EGFR
cell surface 1 EGFR
glutamatergic synapse 4 BRAF, CTNNB1, DAPK1, EGFR
Golgi membrane 1 EGFR
postsynapse 1 BRAF
presynaptic membrane 1 CTNNB1
Cytoplasm, cytosol 1 IDH1
Presynapse 1 BRAF
endosome 1 EGFR
plasma membrane 6 BRAF, CACNA1G, CTNNB1, DAPK1, EGFR, PIK3CA
Membrane 6 CACNA1G, CTNNB1, EGFR, MGMT, MLH1, TP53
apical plasma membrane 1 EGFR
basolateral plasma membrane 2 CTNNB1, EGFR
extracellular exosome 3 CTNNB1, IDH1, IDH2
endoplasmic reticulum 1 TP53
extracellular space 2 EGFR, IGF2
perinuclear region of cytoplasm 3 CTNNB1, EGFR, PIK3CA
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
intercalated disc 1 PIK3CA
mitochondrion 6 BRAF, CDKN2A, DNMT1, IDH1, IDH2, TP53
protein-containing complex 4 CDKN2A, CTNNB1, EGFR, TP53
intracellular membrane-bounded organelle 2 BRAF, RUNX3
postsynaptic density 1 DAPK1
pericentric heterochromatin 1 DNMT1
Single-pass type I membrane protein 1 EGFR
Secreted 1 IGF2
extracellular region 2 IDH1, IGF2
Mitochondrion matrix 1 TP53
mitochondrial matrix 3 CDKN2A, IDH2, TP53
transcription regulator complex 2 CTNNB1, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
nuclear membrane 1 EGFR
actin cytoskeleton 1 DAPK1
perikaryon 1 NEUROG1
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
cytoplasmic vesicle 1 SOCS1
nucleolus 3 CDKN2A, RUNX3, TP53
Wnt signalosome 1 CTNNB1
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
postsynaptic membrane 1 CTNNB1
Membrane raft 1 EGFR
Cytoplasm, cytoskeleton 2 CTNNB1, TP53
focal adhesion 2 CTNNB1, EGFR
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
Peroxisome 2 IDH1, IDH2
intracellular vesicle 1 EGFR
peroxisomal matrix 1 IDH1
Nucleus, PML body 1 TP53
PML body 1 TP53
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
receptor complex 1 EGFR
neuron projection 1 BRAF
chromatin 5 CDX2, HIC1, NEUROG1, RUNX3, TP53
cell periphery 1 CTNNB1
Chromosome 1 MLH1
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
cytoplasmic ribonucleoprotein granule 1 SOCS1
Nucleus, nucleolus 1 CDKN2A
spindle pole 1 CTNNB1
mismatch repair complex 1 MLH1
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
site of double-strand break 1 TP53
Endomembrane system 1 CTNNB1
female germ cell nucleus 1 DNMT1
Nucleus, nucleoplasm 1 CDKN2A
euchromatin 1 CTNNB1
cell body 1 BRAF
germ cell nucleus 1 TP53
replication fork 2 DNMT1, TP53
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 1 IDH1
secretory granule lumen 1 IDH1
nuclear matrix 1 TP53
transcription repressor complex 2 CDX2, TP53
male germ cell nucleus 1 MLH1
platelet alpha granule lumen 1 IGF2
voltage-gated calcium channel complex 1 CACNA1G
phosphatidylinositol 3-kinase complex 2 PIK3CA, SOCS1
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
tertiary granule lumen 1 IDH1
beta-catenin-TCF complex 1 CTNNB1
condensed nuclear chromosome 1 CDX2
presynaptic active zone cytoplasmic component 1 CTNNB1
clathrin-coated endocytic vesicle membrane 1 EGFR
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 1 CTNNB1
synaptonemal complex 1 MLH1
catenin complex 1 CTNNB1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
beta-catenin-TCF7L2 complex 1 CTNNB1
senescence-associated heterochromatin focus 1 CDKN2A
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
chiasma 1 MLH1
late recombination nodule 1 MLH1
MutLalpha complex 1 MLH1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
DAPK1-calmodulin complex 1 DAPK1
core-binding factor complex 1 RUNX3
[Isoform smARF]: Mitochondrion 1 CDKN2A


文献列表

  • Rong-fa Guan, Fei Lyu, Xiao-qiang Chen, Jie-qing Ma, Han Jiang, Chao-geng Xiao. Meat quality traits of four Chinese indigenous chicken breeds and one commercial broiler stock. Journal of Zhejiang University. Science. B. 2013 Oct; 14(10):896-902. doi: 10.1631/jzus.b1300163. [PMID: 24101206]
  • R P Newton, E E Kingston, N A Hakeem, S G Salih, J H Beynon, C D Moyse. Extraction, purification, identification and metabolism of 3',5'-cyclic UMP, 3',5'-cyclic IMP and 3',5'-cyclic dTMP from rat tissues. The Biochemical journal. 1986 Jun; 236(2):431-9. doi: 10.1042/bj2360431. [PMID: 3019316]
  • R S Sawhney, R K Sharma. Different plasma membrane effects of adrenocorticotropic hormone and cyclic nucleotides in normal and malignant adrenal cells. FEBS letters. 1976 Nov; 70(1):163-6. doi: 10.1016/0014-5793(76)80749-1. [PMID: 186318]
  • J P Miller, K H Boswell, A M Mian, R B Meyer, R K Robins, T A Khwaja. 2' Derivatives of guanosine and inosine cyclic 3',5'-phosphates. Synthesis, enzymic activity, and the effect of 8-substituents. Biochemistry. 1976 Jan; 15(1):217-23. doi: 10.1021/bi00646a033. [PMID: 174713]
  • R B Meyer, H Uno, R K Robins, L N Simon, J P Miller. 2-substituted derivatives of adenosine and inosine cyclic 3',5'-phosphate. Synthesis, enzymic activity, and analysis of the structural requirements of the binding locale of the 2-substituent on bovine brain protein kinase. Biochemistry. 1975 Jul; 14(15):3315-21. doi: 10.1021/bi00686a005. [PMID: 167824]
  • P Insel, R Balakir, B Sacktor. The binding of cyclic AMP to renal brush border membranes. Journal of cyclic nucleotide research. 1975; 1(2):107-22. doi: . [PMID: 177456]