4-Aminobutyraldehyde (BioDeep_00000004446)
Secondary id: BioDeep_00001868921
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
gamma-Aminobutyraldehyde
化学式: C4H9NO (87.0684104)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 0.31%
分子结构信息
SMILES: C(CC=O)CN
InChI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2
描述信息
4-Aminobutyraldehyde is a metabolite of putrescine. It is a substrate of human liver aldehyde dehydrogenase (EC 1.2.1.3) cytoplasmic (E1) and mitochondrial (E2) isozymes (PMID 3324802). [HMDB]. 4-Aminobutyraldehyde is found in many foods, some of which are naranjilla, rambutan, oval-leaf huckleberry, and pepper (capsicum).
4-Aminobutyraldehyde is a metabolite of putrescine. It is a substrate of human liver aldehyde dehydrogenase (EC 1.2.1.3) cytoplasmic (E1) and mitochondrial (E2) isozymes (PMID 3324802).
同义名列表
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:17769
- KEGG: C00555
- PubChem: 118
- HMDB: HMDB0001080
- Metlin: METLIN3225
- ChEMBL: CHEMBL2261442
- MetaCyc: 4-AMINO-BUTYRALDEHYDE
- KNApSAcK: C00019656
- foodb: FDB022412
- chemspider: 115
- CAS: 4390-05-0
- PMhub: MS000016903
- PubChem: 3835
- 3DMET: B00129
- NIKKAJI: J38.531J
- RefMet: 4-Aminobutyraldehyde
分类词条
相关代谢途径
Reactome(0)
BioCyc(2)
PlantCyc(0)
代谢反应
21 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(4)
- superpathway of ornithine degradation:
γ-glutamyl-L-putrescine + H2O + O2 ⟶ γ-glutamyl-γ-aminobutyraldehyde + ammonium + hydrogen peroxide - putrescine degradation I:
2-oxoglutarate + putrescine ⟶ 4-aminobutanal + glt - superpathway of arginine and ornithine degradation:
γ-glutamyl-L-putrescine + H2O + O2 ⟶ γ-glutamyl-γ-aminobutyraldehyde + ammonium + hydrogen peroxide - superpathway of arginine, putrescine, and 4-aminobutyrate degradation:
γ-glutamyl-L-putrescine + H2O + O2 ⟶ γ-glutamyl-γ-aminobutyraldehyde + ammonium + hydrogen peroxide
WikiPathways(0)
Plant Reactome(12)
- Metabolism and regulation:
ATP + CoA + propionate ⟶ AMP + PPi + PROP-CoA - Amino acid metabolism:
ATP + CoA + propionate ⟶ AMP + PPi + PROP-CoA - Amino acid biosynthesis:
ATP + CoA + propionate ⟶ AMP + PPi + PROP-CoA - Beta-alanine biosynthesis I:
H2O + SPM + hydrogen acceptor ⟶ 1,3-diaminopropane + 4-aminobutanal + hydrogen donor - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Beta-alanine biosynthesis I:
H2O + SPM + hydrogen acceptor ⟶ 1,3-diaminopropane + 4-aminobutanal + hydrogen donor - Metabolism and regulation:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Amino acid metabolism:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Amino acid biosynthesis:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Beta-alanine biosynthesis I:
H2O + SPM + hydrogen acceptor ⟶ 1,3-diaminopropane + 4-aminobutanal + hydrogen donor
INOH(1)
- Arginine and Proline metabolism ( Arginine and Proline metabolism ):
ATP + Creatine ⟶ ADP + N-Phospho-creatine
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(4)
- Arginine Metabolism:
N-Acetylornithine + Water ⟶ Acetic acid + Ornithine - Ornithine Metabolism:
N-Acetylornithine + Water ⟶ Acetic acid + Ornithine - Arginine Metabolism:
N-Acetylornithine + Water ⟶ Acetic acid + Ornithine - Ornithine Metabolism:
N-Acetylornithine + Water ⟶ Acetic acid + Ornithine
PharmGKB(0)
2 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Vacha Bhatt, Vitthal T Barvkar, Agnelo Furtado, Robert J Henry, Altafhusain Nadaf. Fragrance in Pandanus amaryllifoliusRoxb. Despite the Presence of a Betaine Aldehyde Dehydrogenase 2.
International journal of molecular sciences.
2021 Jun; 22(13):. doi:
10.3390/ijms22136968. [PMID: 34203477] - Barry J Shelp, Gale G Bozzo, Christopher P Trobacher, Adel Zarei, Kristen L Deyman, Carolyne J Brikis. Hypothesis/review: contribution of putrescine to 4-aminobutyrate (GABA) production in response to abiotic stress.
Plant science : an international journal of experimental plant biology.
2012 Sep; 193-194(?):130-135. doi:
10.1016/j.plantsci.2012.06.001. [PMID: 22794926] - Kultida Jiamsomboon, Witcha Treesuwan, Nonlawat Boonyalai. Dissecting substrate specificity of two rice BADH isoforms: Enzyme kinetics, docking and molecular dynamics simulation studies.
Biochimie.
2012 Aug; 94(8):1773-83. doi:
10.1016/j.biochi.2012.04.009. [PMID: 22534193] - Shiyong Zhang, Yan Zhao. Flexible oligocholate foldamers as membrane transporters and their guest-dependent transport mechanism.
Organic & biomolecular chemistry.
2012 Jan; 10(2):260-6. doi:
10.1039/c1ob06364b. [PMID: 22068436] - Ratree Wongpanya, Nonlawat Boonyalai, Napaporn Thammachuchourat, Natharinee Horata, Siwaret Arikit, Khin Myo Myint, Apichart Vanavichit, Kiattawee Choowongkomon. Biochemical and enzymatic study of rice BADH wild-type and mutants: an insight into fragrance in rice.
The protein journal.
2011 Dec; 30(8):529-38. doi:
10.1007/s10930-011-9358-5. [PMID: 21959793] - David Kopečný, Martina Tylichová, Jacques Snegaroff, Hana Popelková, Marek Šebela. Carboxylate and aromatic active-site residues are determinants of high-affinity binding of ω-aminoaldehydes to plant aminoaldehyde dehydrogenases.
The FEBS journal.
2011 Sep; 278(17):3130-9. doi:
10.1111/j.1742-4658.2011.08239.x. [PMID: 21740525] - Naim Stiti, Tagnon D Missihoun, Simeon O Kotchoni, Hans-Hubert Kirch, Dorothea Bartels. Aldehyde Dehydrogenases in Arabidopsis thaliana: Biochemical Requirements, Metabolic Pathways, and Functional Analysis.
Frontiers in plant science.
2011; 2(?):65. doi:
10.3389/fpls.2011.00065. [PMID: 22639603] - Martina Tylichová, David Kopecný, Solange Moréra, Pierre Briozzo, René Lenobel, Jacques Snégaroff, Marek Sebela. Structural and functional characterization of plant aminoaldehyde dehydrogenase from Pisum sativum with a broad specificity for natural and synthetic aminoaldehydes.
Journal of molecular biology.
2010 Mar; 396(4):870-82. doi:
10.1016/j.jmb.2009.12.015. [PMID: 20026072] - Louis M T Bradbury, Susan A Gillies, Donald J Brushett, Daniel L E Waters, Robert J Henry. Inactivation of an aminoaldehyde dehydrogenase is responsible for fragrance in rice.
Plant molecular biology.
2008 Nov; 68(4-5):439-49. doi:
10.1007/s11103-008-9381-x. [PMID: 18704694] - Takashi Fujiwara, Kazuya Hori, Keiko Ozaki, Yuka Yokota, Shiro Mitsuya, Tsuyoshi Ichiyanagi, Tasuku Hattori, Tetsuko Takabe. Enzymatic characterization of peroxisomal and cytosolic betaine aldehyde dehydrogenases in barley.
Physiologia plantarum.
2008 Sep; 134(1):22-30. doi:
10.1111/j.1399-3054.2008.01122.x. [PMID: 18429940] - Zhuo Wang, Xin-Guang Zhu, Yazhu Chen, Yuanyuan Li, Jing Hou, Yixue Li, Lei Liu. Exploring photosynthesis evolution by comparative analysis of metabolic networks between chloroplasts and photosynthetic bacteria.
BMC genomics.
2006 Apr; 7(?):100. doi:
10.1186/1471-2164-7-100. [PMID: 16646993] - Christopher P Leamon, Scott R Cooper, Gregory E Hardee. Folate-liposome-mediated antisense oligodeoxynucleotide targeting to cancer cells: evaluation in vitro and in vivo.
Bioconjugate chemistry.
2003 Jul; 14(4):738-47. doi:
10.1021/bc020089t. [PMID: 12862426] - Jeyanthi Rebecca Livingstone, Toshiya Maruo, Izumi Yoshida, Yutaka Tarui, Kiyoo Hirooka, Yoshihiro Yamamoto, Nobuo Tsutui, Eiji Hirasawa. Purification and properties of betaine aldehyde dehydrogenase from Avena sativa.
Journal of plant research.
2003 Apr; 116(2):133-40. doi:
10.1007/s10265-003-0077-7. [PMID: 12736784] - S Yamamoto, S Nagata, K Kusaba. Purification and characterization of homospermidine synthase in Acinetobacter tartarogenes ATCC 31105.
Journal of biochemistry.
1993 Jul; 114(1):45-9. doi:
10.1093/oxfordjournals.jbchem.a124137. [PMID: 8407874] - H Tamura, K Horiike, H Fukuda, T Watanabe. Kinetic studies on the inhibition mechanism of diamine oxidase from porcine kidney by aminoguanidine.
Journal of biochemistry.
1989 Feb; 105(2):299-306. doi:
10.1093/oxfordjournals.jbchem.a122657. [PMID: 2498301] - W Ambroziak, C Maśliński. Participation of aldehyde dehydrogenase in the oxidative deamination pathway of histamine and putrescine.
Agents and actions.
1988 Apr; 23(3-4):311-3. doi:
10.1007/bf02142573. [PMID: 3394581] - J M Gaugas, D L Dewey. Hog kidney diamine oxidase conversion of biogenic diamines to inhibitors of cell proliferation.
The Journal of pathology.
1981 Jul; 134(3):243-52. doi:
10.1002/path.1711340308. [PMID: 6790686]