Methylamine (BioDeep_00000004397)

 

Secondary id: BioDeep_00000268066, BioDeep_00000860588

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Toxin


代谢物信息卡片


Methylamine hydrochloride, 14C-labeled

化学式: CH5N (31.0422)
中文名称: 氨基甲烷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN
InChI: InChI=1S/CH5N/c1-2/h2H2,1H3

描述信息

Methylamine occurs endogenously from amine catabolism and its tissue levels increase in some pathological conditions, including diabetes. Interestingly, methylamine and ammonia levels are reciprocally controlled by a semicarbazide-sensitive amine oxidase activity that deaminates methylamine to formaldehyde with the production of ammonia and hydrogen peroxide. Methylamine also targets the voltage-operated neuronal potassium channels, probably inducing release of neurotransmitter(s). Semicarbazide-sensitive amine oxidase (SSAO) catalyzes the deamination of primary amines. Such deamination has been shown capable of regulating glucose transport in adipose cells. It has been independently discovered that the primary structure of vascular adhesion protein-1 (VAP-1) is identical to SSAO. Increased serum SSAO activities have been found in patients with diabetic mellitus, vascular disorders, and Alzheimers disease. The SSAO-catalyzed deamination of endogenous substrates like methylamine led to production of toxic formaldehyde. Chronic elevated methylamine increases the excretion of malondialdehyde and microalbuminuria. Amine oxidase substrates such as methylamine have been shown to stimulate glucose uptake by increasing the recruitment of the glucose transporter GLUT4 from vesicles within the cell to the cell surface. Inhibition of this effect by the presence of semicarbazide and catalase led to the suggestion that the process is mediated by the hydrogen peroxide produced in the oxidation of these amines (PMID: 16049393 , 12686132 , 17406961). Methylamine has been identified as a uremic toxin according to the European Uremic Toxin Working Group (PMID: 22626821).
Methylamine is a colourless gas derivative of ammonia, but with one H atom replaced by a methyl group. It is the simplest primary amine. It has a strong odor similar to fish. Methylamine is used as a building block for the synthesis of many other commercially available compounds. Hundreds of millions of kilograms are produced annually. Methylamine is found in many foods, some of which are french plantain, tea, barley, and wild celery.

同义名列表

46 个代谢物同义名

Methylamine hydrochloride, 14C-labeled; Methyl OF gamma-N-methylasparagine; Methylamine, monopotassium salt; Methylamine, monosodium salt; Methylamine hydrogen cyanide; Methylamine aqueous solution; Methylamine hydrofluoride; Methylamine hydrochloride; Methylamine sulfate (1:1); Methylamine sulfate (2:1); Methylamine, 13C-labeled; Methylamine, 14C-labeled; Methylamine, 15N-labeled; Methylamine hydrobromide; Methylamine, cesium salt; Methylamine hydroiodide; Methylamine perchlorate; Monomethylammonium ion; Methylamine bisulfite; Methylamine solutions; Methylamine anhydrous; Anhydrous methylamine; Methylamine ion (1-); Methylamine solution; Methylamine nitrate; Methylamine hydride; Methylammonium ion; Monomethylamine; Methylammonium; N-Methylamine; Methylaminen; Methyl group; Aminomethane; Mercurialin; METHYLAMINE; Metyloamina; Methanamine; Carbinamine; Metilamine; CH3-NH2; Imizin; MeNH2; NME; MMA; NMA; Methylamine



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

38 个相关的代谢反应过程信息。

Reactome(12)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(26)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ADH5, ALB, AOC3, CAT, GLUL, PMP2
Peripheral membrane protein 2 HSD17B6, MBP
Endosome membrane 2 BACE1, TF
Nucleus 5 ALB, GLUL, LRP1, MBP, PMP2
cytosol 7 ADH5, ALB, CAT, GLUL, LIPE, MBP, PMP2
dendrite 1 BACE1
trans-Golgi network 1 BACE1
centrosome 1 ALB
nucleoplasm 2 ATP2B1, GLDC
Cell membrane 7 AOC3, ATP2B1, BACE1, GLUL, ITGAM, LIPE, RHBG
Lipid-anchor 1 GLUL
Cytoplasmic side 1 MBP
Cell projection, axon 1 BACE1
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 2 ATP2B1, RHBG
Synapse 2 ATP2B1, MBP
cell surface 6 AOC3, BACE1, C3, ITGAM, MBP, TF
glutamatergic synapse 1 ATP2B1
Golgi apparatus 4 ALB, AOC3, BACE1, LRP1
Golgi membrane 1 INS
lysosomal membrane 1 LRP1
neuronal cell body 2 BACE1, MBP
presynaptic membrane 1 ATP2B1
synaptic vesicle 1 BACE1
Cytoplasm, cytosol 2 GLUL, LIPE
Lysosome 1 BACE1
endosome 1 BACE1
plasma membrane 12 AOC3, ATP2B1, BACE1, C3, F2, GLDC, GLUL, ITGAM, LRP1, MBP, RHBG, TF
synaptic vesicle membrane 1 ATP2B1
Membrane 8 AOC3, ATP2B1, BACE1, CAT, ITGAM, LIPE, LRP1, RHBG
apical plasma membrane 1 TF
axon 1 BACE1
basolateral plasma membrane 3 ATP2B1, LRP1, RHBG
caveola 1 LIPE
extracellular exosome 12 A2M, ADH5, ALB, ATP2B1, C3, CAT, F2, GLUL, ITGAM, MBP, PMP2, TF
Lumenal side 1 HSD17B6
endoplasmic reticulum 5 ALB, AOC3, BACE1, GLUL, HSD17B6
extracellular space 7 A2M, ALB, C3, F2, INS, ITGAM, TF
perinuclear region of cytoplasm 1 TF
mitochondrion 4 ADH5, CAT, GLDC, GLUL
protein-containing complex 4 ALB, C3, CAT, MBP
intracellular membrane-bounded organelle 3 ATP2B1, CAT, HSD17B6
Microsome membrane 1 HSD17B6
Single-pass type I membrane protein 2 BACE1, ITGAM
Secreted 6 A2M, ALB, C3, F2, INS, TF
extracellular region 8 A2M, ALB, C3, CAT, F2, INS, MBP, TF
Single-pass membrane protein 1 LRP1
basal part of cell 1 TF
hippocampal mossy fiber to CA3 synapse 1 BACE1
mitochondrial matrix 2 CAT, GLDC
anchoring junction 1 ALB
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 1 ITGAM
multivesicular body 1 BACE1
cytoplasmic vesicle 1 TF
Early endosome 4 AOC3, BACE1, LRP1, TF
clathrin-coated pit 2 LRP1, TF
recycling endosome 2 BACE1, TF
Single-pass type II membrane protein 1 AOC3
vesicle 1 TF
Membrane raft 2 BACE1, ITGAM
focal adhesion 2 CAT, LRP1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 3 A2M, F2, MBP
lateral plasma membrane 1 ATP2B1
Cytoplasm, cytoskeleton, microtubule organizing center 1 LRP1
Late endosome 2 BACE1, TF
receptor complex 1 LRP1
ciliary basal body 1 ALB
cell projection 1 ATP2B1
cell periphery 1 MBP
[Isoform 3]: Nucleus 1 MBP
centriole 1 ALB
plasma membrane protein complex 1 LRP1
Golgi apparatus, trans-Golgi network 1 BACE1
spindle pole 1 ALB
blood microparticle 5 A2M, ALB, C3, F2, TF
Basolateral cell membrane 2 ATP2B1, RHBG
Endomembrane system 1 BACE1
endosome lumen 1 INS
microvillus 1 AOC3
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
microtubule organizing center 1 LRP1
Cytoplasmic vesicle membrane 1 BACE1
Cell projection, dendrite 1 BACE1
specific granule membrane 1 ITGAM
tertiary granule membrane 1 ITGAM
Presynaptic cell membrane 1 ATP2B1
cell body 1 GLUL
myelin sheath 2 MBP, PMP2
basal plasma membrane 1 TF
Microsome 1 GLUL
plasma membrane raft 1 ITGAM
ficolin-1-rich granule lumen 2 CAT, MBP
secretory granule lumen 4 C3, CAT, INS, TF
HFE-transferrin receptor complex 1 TF
Golgi lumen 2 F2, INS
endoplasmic reticulum lumen 6 ALB, BACE1, C3, F2, INS, TF
platelet alpha granule lumen 2 A2M, ALB
endocytic vesicle membrane 1 LRP1
endocytic vesicle 1 TF
transport vesicle 2 INS, MBP
azurophil granule lumen 1 C3
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 ATP2B1
clathrin-coated endocytic vesicle membrane 1 TF
integrin complex 1 ITGAM
Golgi outpost 1 LRP1
vesicle coat 1 TF
glial cell projection 1 GLUL
spectrin-associated cytoskeleton 1 RHBG
compact myelin 1 MBP
internode region of axon 1 MBP
catalase complex 1 CAT
integrin alphaM-beta2 complex 1 ITGAM
photoreceptor ribbon synapse 1 ATP2B1
[Bone marrow proteoglycan]: Secreted 1 MBP
glycine cleavage complex 1 GLDC
ciliary transition fiber 1 ALB
Golgi-associated vesicle lumen 1 BACE1
Myelin membrane 1 MBP
dense body 1 TF
[Low-density lipoprotein receptor-related protein 1 intracellular domain]: Cytoplasm 1 LRP1


文献列表

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