Araloside A (BioDeep_00000000436)

 

Secondary id: BioDeep_00000398513, BioDeep_00001867503

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


(2S,3S,4R,5R,6R)-6-[[(3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-4,4,6a,6b,11,11,14b-heptamethyl-8a-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycarbonyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3-[(2S,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxyoxane-2-carboxylic acid

化学式: C47H74O18 (926.4875)
中文名称: 竹节参皂苷 IV, 楤木皂苷A, 木皂苷A
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 68.75%

分子结构信息

SMILES: CC1(C)CCC2(C(=O)OC3OC(CO)C(O)C(O)C3O)CCC3(C)C(=CCC4C5(C)CCC(OC6OC(C(=O)O)C(OC7OC(CO)C(O)C7O)C(O)C6O)C(C)(C)C5CCC43C)C2C1
InChI: InChI=1S/C47H74O18/c1-42(2)14-16-47(41(59)65-39-33(55)30(52)28(50)23(19-48)61-39)17-15-45(6)21(22(47)18-42)8-9-26-44(5)12-11-27(43(3,4)25(44)10-13-46(26,45)7)62-40-34(56)31(53)35(36(64-40)37(57)58)63-38-32(54)29(51)24(20-49)60-38/h8,22-36,38-40,48-56H,9-20H2,1-7H3,(H,57,58)

描述信息

Chikusetsusaponin-IV is a triterpenoid saponin. It has a role as a metabolite.
Araloside A is a natural product found in Kalopanax septemlobus, Bassia muricata, and other organisms with data available.
Araloside A is found in green vegetables. Araloside A is from Aralia elata (Japanese angelica tree
From Aralia elata (Japanese angelica tree). Araloside A is found in green vegetables.
Araloside A (Chikusetsusaponin IV) is a component of Panax japonicus, with low-renin-inhibitory activity, with an IC50 of 77.4 μM[1].
Araloside A (Chikusetsusaponin IV) is a component of Panax japonicus, with low-renin-inhibitory activity, with an IC50 of 77.4 μM[1].

同义名列表

16 个代谢物同义名

(2S,3S,4R,5R,6R)-6-[[(3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-4,4,6a,6b,11,11,14b-heptamethyl-8a-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycarbonyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3-[(2S,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxyoxane-2-carboxylic acid; 6-{[4,4,6a,6b,11,11,14b-heptamethyl-8a-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}carbonyl)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl]oxy}-3-{[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-4,5-dihydroxyoxane-2-carboxylic acid; 6-{[4,4,6a,6b,11,11,14b-heptamethyl-8a-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}carbonyl)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl]oxy}-3-{[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-4,5-dihydroxyoxane-2-carboxylate; 6-{[4,4,6a,6b,11,11,14b-heptamethyl-8a-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}carbonyl)-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy}-3-{[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-4,5-dihydroxyoxane-2-carboxylic acid; beta-D-Glucopyranosiduronic acid, (3beta)-28-(beta-D-glucopyranosyloxy)-28-oxoolean-12-en-3-yl 4-O-alpha-L-arabinofuranosyl-; (3beta)-28-(beta-D-Glucopyranosyloxy)-28-oxoolean-12-en-3-yl 4-O-alpha-L-arabinofuranosyl-beta-D-glucopyranosiduronic acid; b-D-Glucopyranosiduronic acid, (3b)-28-(b-D-glucopyranosyloxy)-28-oxoolean-12-en-3-yl 4-O-a-L-arabinofuranosyl-; Chikusetsusaponin-IV; Chikusetsusaponin IV; Chikusetsusaponin 4; Araloside (8ci); Oleanoside e; Araloside A; 32BF7Y358G; Araloside; Chikusetsusaponin IV



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

46 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ABCB1, BCL2, CASP3, CASP7, CASP9, HIF1A, NOS3, PTGS2, RB1, RP1
Peripheral membrane protein 1 PTGS2
Endoplasmic reticulum membrane 2 BCL2, PTGS2
Mitochondrion membrane 1 ABCG2
Nucleus 9 BCL2, CASP3, CASP7, CASP9, HIF1A, NOS3, PARP1, RB1, RP1
cytosol 9 ATP12A, BCL2, CASP3, CASP7, CASP9, HIF1A, NOS3, PARP1, RB1
mitochondrial membrane 1 ABCG2
nuclear body 2 HIF1A, PARP1
nucleoplasm 7 ABCG2, CASP3, CASP7, HIF1A, NOS3, PARP1, RB1
RNA polymerase II transcription regulator complex 1 HIF1A
Cell membrane 2 ABCB1, ABCG2
Multi-pass membrane protein 3 ABCB1, ABCG2, ATP12A
cell surface 1 ABCB1
glutamatergic synapse 1 CASP3
Golgi apparatus 1 NOS3
Golgi membrane 1 NOS3
lysosomal membrane 1 GAA
neuronal cell body 1 CASP3
Cytoplasm, cytosol 2 CASP7, PARP1
Lysosome 1 GAA
plasma membrane 7 ABCB1, ABCG2, ATP12A, F2, GAA, NOS3, REN
Membrane 6 ABCB1, ABCG2, BCL2, GAA, PARP1, REN
apical plasma membrane 3 ABCB1, ABCG2, ATP12A
axon 1 CCK
basolateral plasma membrane 1 ATP12A
caveola 2 NOS3, PTGS2
extracellular exosome 3 ABCB1, F2, GAA
Lysosome membrane 1 GAA
endoplasmic reticulum 2 BCL2, PTGS2
extracellular space 6 CASP7, CCK, CXCL8, F2, IL6, REN
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 1 NOS3
mitochondrion 3 BCL2, CASP9, PARP1
protein-containing complex 5 BCL2, CASP9, HIF1A, PARP1, PTGS2
intracellular membrane-bounded organelle 1 GAA
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Secreted 6 CCK, CXCL8, F2, GAA, IL6, REN
extracellular region 6 CCK, CXCL8, F2, GAA, IL6, REN
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
transcription regulator complex 1 PARP1
motile cilium 1 HIF1A
photoreceptor connecting cilium 1 RP1
photoreceptor inner segment 1 RP1
photoreceptor outer segment 1 RP1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
actin cytoskeleton 1 ATP12A
microtubule cytoskeleton 1 RP1
nucleolus 1 PARP1
axon cytoplasm 1 HIF1A
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
apical part of cell 1 REN
spindle midzone 1 RP1
Apical cell membrane 3 ABCB1, ABCG2, ATP12A
Membrane raft 1 ABCG2
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 RP1
focal adhesion 1 RP1
microtubule 1 RP1
spindle 1 RB1
PML body 1 RB1
collagen-containing extracellular matrix 1 F2
axoneme 1 RP1
ciliary tip 1 RP1
nuclear speck 2 HIF1A, RP1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
chromatin 3 HIF1A, PARP1, RB1
microtubule associated complex 1 RP1
Chromosome 1 PARP1
cytoskeleton 1 NOS3
[Isoform 3]: Nucleus 1 RP1
Cell projection, cilium, photoreceptor outer segment 1 RP1
Secreted, extracellular space 1 CASP7
brush border membrane 1 ABCG2
Nucleus, nucleolus 1 PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
blood microparticle 1 F2
Cytoplasm, cytoskeleton, cilium axoneme 1 RP1
site of double-strand break 1 PARP1
nuclear envelope 1 PARP1
microtubule organizing center 1 RP1
tertiary granule membrane 1 GAA
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
Nucleus speckle 1 HIF1A
euchromatin 1 HIF1A
myelin sheath 1 BCL2
Golgi lumen 1 F2
endoplasmic reticulum lumen 3 F2, IL6, PTGS2
endocytic vesicle membrane 1 NOS3
azurophil granule membrane 1 GAA
SWI/SNF complex 1 RB1
microtubule plus-end 1 RP1
apoptosome 1 CASP9
[Isoform 1]: Nucleus 1 RP1
cytoplasmic microtubule 1 RP1
protein-DNA complex 1 PARP1
ficolin-1-rich granule membrane 1 GAA
external side of apical plasma membrane 2 ABCB1, ABCG2
death-inducing signaling complex 1 CASP3
site of DNA damage 1 PARP1
interleukin-6 receptor complex 1 IL6
chromatin lock complex 1 RB1
Rb-E2F complex 1 RB1
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
potassium:proton exchanging ATPase complex 1 ATP12A
caspase complex 1 CASP9


文献列表

  • Yaqin Tian, Xiuling Zhang, Meiling Du, Fengfeng Li, Manyu Xiao, Wentao Zhang. Synergistic Antioxidant Effects of Araloside A and L-Ascorbic Acid on H2O2-Induced HEK293 Cells: Regulation of Cellular Antioxidant Status. Oxidative medicine and cellular longevity. 2021; 2021(?):9996040. doi: 10.1155/2021/9996040. [PMID: 34336129]
  • Yi Tao, Surun Huang, Jizhong Yan, Baochang Cai. Determination of major components from Radix Achyranthes bidentate using ultra high performance liquid chromatography with triple quadrupole tandem mass spectrometry and an evaluation of their anti-osteoporosis effect in vitro. Journal of separation science. 2019 Jul; 42(13):2214-2221. doi: 10.1002/jssc.201900146. [PMID: 31037819]
  • Haibo He, Xiaomei Li, Haili Yu, Shu Zhu, Yumin He, Katsuko Komatsu, Dongyan Guo, Xiaoqin Li, Junzhi Wang, Huajun Luo, Daoxiang Xu, Kun Zou. Gastroprotective effect of araloside A on ethanol- and aspirin-induced gastric ulcer in mice: involvement of H+/K+-ATPase and mitochondrial-mediated signaling pathway. Journal of natural medicines. 2019 Mar; 73(2):339-352. doi: 10.1007/s11418-018-1256-0. [PMID: 30523551]
  • Dong-Yan Guo, Bing-Tao Zhai, Yang Lv, Ya-Jun Shi, Yu Fan, Lu Wang, Mei Wang. [Tissue distribution of araloside A in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2017 Oct; 42(20):4002-4006. doi: 10.19540/j.cnki.cjcmm.20170901.011. [PMID: 29243440]
  • Keisuke Tomohara, Tomohiro Ito, Saika Onikata, Atsushi Kato, Isao Adachi. Discovery of hyaluronidase inhibitors from natural products and their mechanistic characterization under DMSO-perturbed assay conditions. Bioorganic & medicinal chemistry letters. 2017 04; 27(7):1620-1623. doi: 10.1016/j.bmcl.2017.01.083. [PMID: 28202328]
  • Sainan Li, Ying Tang, Chunming Liu, Yuchi Zhang. Development of a method to screen and isolate potential α-glucosidase inhibitors from Panax japonicus C.A. Meyer by ultrafiltration, liquid chromatography, and counter-current chromatography. Journal of separation science. 2015 Jun; 38(12):2014-23. doi: 10.1002/jssc.201500064. [PMID: 25847676]
  • Hsiu-Hui Chan, Tsong-Long Hwang, Mopur Vijaya Bhaskar Reddy, Ding-Tzai Li, Keduo Qian, Kenneth F Bastow, Kuo-Hsiung Lee, Tian-Shung Wu. Bioactive constituents from the roots of Panax japonicus var. major and development of a LC-MS/MS method for distinguishing between natural and artifactual compounds. Journal of natural products. 2011 Apr; 74(4):796-802. doi: 10.1021/np100851s. [PMID: 21417387]
  • Eun Bang Lee, Oon Ja Kim, Sam Sik Kang, Choonsik Jeong. Araloside A, an antiulcer constituent from the root bark of Aralia elata. Biological & pharmaceutical bulletin. 2005 Mar; 28(3):523-6. doi: 10.1248/bpb.28.523. [PMID: 15744082]