o-Xylene (BioDeep_00000004352)

 

Secondary id: BioDeep_00000860246, BioDeep_00001867646

human metabolite blood metabolite


代谢物信息卡片


1,2-Dimethylbenzene

化学式: C8H10 (106.07824600000001)
中文名称: 邻二甲苯
谱图信息: 最多检出来源 Homo sapiens(blood) 0.83%

分子结构信息

SMILES: CC1=CC=CC=C1C
InChI: InChI=1S/C8H10/c1-7-5-3-4-6-8(7)2/h3-6H,1-2H3

描述信息

1,2-dimethylbenzene, also known as 2-xylene or ortho-xylene, is a member of the class of compounds known as O-xylenes. O-xylenes are aromatic compounds that contain a o-xylene moiety, which is a monocyclic benzene carrying exactly two methyl groups at the 1- and 2-positions. 1,2-dimethylbenzene is a geranium tasting compound found in black walnut and papaya, which makes 1,2-dimethylbenzene a potential biomarker for the consumption of these food products. 1,2-dimethylbenzene can be found primarily in blood, feces, and saliva. 1,2-dimethylbenzene exists in all eukaryotes, ranging from yeast to humans. 1,2-dimethylbenzene is formally rated as an unfounded non-carcinogenic (IARC 3) potentially toxic compound. o-Xylene (ortho-xylene) is an aromatic hydrocarbon with the formula C6H4(CH3)2. with two methyl substituents bonded to adjacent carbon atoms of a benzene ring (the ortho configuration). It is a constitutional isomer of m-xylene and p-xylene, the mixture being called xylene or xylenes. o-Xylene is a colorless slightly oily flammable liquid . If the compound has been ingested, rapid gastric lavage should be performed using 5\\% sodium bicarbonate. For skin contact, the skin should be washed with soap and water. If the compound has entered the eyes, they should be washed with large quantities of isotonic saline or water. In serious cases, atropine and/or pralidoxime should be administered. Anti-cholinergic drugs work to counteract the effects of excess acetylcholine and reactivate AChE. Atropine can be used as an antidote in conjunction with pralidoxime or other pyridinium oximes (such as trimedoxime or obidoxime), though the use of -oximes has been found to be of no benefit, or possibly harmful, in at least two meta-analyses. Atropine is a muscarinic antagonist, and thus blocks the action of acetylcholine peripherally (T3DB).
o-Xylene belongs to the family of Toluenes. These are compounds containing a benzene ring which bears a methane group.

同义名列表

10 个代谢物同义名

1,2-Dimethylbenzene; 1,2-Dimethylbenzol; O-Dimethylbenzene; O-Methyltoluene; ORTHO-xylene; 3,4-Xylene; 1,2-Xylene; O-XYLENE; 2-Xylene; O-Xylol



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

31 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Lin Li, Fengguang Chai, Cunzhen Liang, Ying Wang, Xiao Zhang, Kaixiong Yang, Benyi Xiao. Comparison and application of biofilter and suspended bioreactor in removing gaseous o-xylene. Environmental research. 2020 09; 188(?):109853. doi: 10.1016/j.envres.2020.109853. [PMID: 32846642]
  • Yuxiu Zhang, Tingting Zang, Bo Yan, Chaohai Wei. Distribution Characteristics of Volatile Organic Compounds and Contribution to Ozone Formation in a Coking Wastewater Treatment Plant. International journal of environmental research and public health. 2020 01; 17(2):. doi: 10.3390/ijerph17020553. [PMID: 31952237]
  • Liying Jiang, Runye Zhu, Yubo Mao, Jianmeng Chen, Liang Zhang. Conversion characteristics and production evaluation of styrene/o-xylene mixtures removed by DBD pretreatment. International journal of environmental research and public health. 2015 Jan; 12(2):1334-50. doi: 10.3390/ijerph120201334. [PMID: 25629961]
  • K Udeni Alwis, Benjamin C Blount, April S Britt, Dhrusti Patel, David L Ashley. Simultaneous analysis of 28 urinary VOC metabolites using ultra high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (UPLC-ESI/MSMS). Analytica chimica acta. 2012 Oct; 750(?):152-60. doi: 10.1016/j.aca.2012.04.009. [PMID: 23062436]
  • Xia Li, Junying Zhang, Wenyuan Gao, Haiyang Wang. Study on chemical composition, anti-inflammatory and anti-microbial activities of extracts from Chinese pear fruit (Pyrus bretschneideri Rehd.). Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012 Oct; 50(10):3673-9. doi: 10.1016/j.fct.2012.07.019. [PMID: 22824088]
  • Fatmah Md Salleh, Tengku Shahrul Anuar, Azlin Mohd Yasin, Norhayati Moktar. Wintergreen oil: a novel method in Wheatley's trichrome staining technique. Journal of microbiological methods. 2012 Oct; 91(1):174-8. doi: 10.1016/j.mimet.2012.08.004. [PMID: 22986100]
  • Miriam Cohen, Nissi M Varki, Mark D Jankowski, Pascal Gagneux. Using unfixed, frozen tissues to study natural mucin distribution. Journal of visualized experiments : JoVE. 2012 Sep; ?(67):e3928. doi: 10.3791/3928. [PMID: 23023050]
  • Laura Vallecillos, Eva Pocurull, Francesc Borrull. Fully automated ionic liquid-based headspace single drop microextraction coupled to GC-MS/MS to determine musk fragrances in environmental water samples. Talanta. 2012 Sep; 99(?):824-32. doi: 10.1016/j.talanta.2012.07.036. [PMID: 22967629]
  • Pinaki R Desai, Punit P Shah, Ram R Patlolla, Mandip Singh. Dermal microdialysis technique to evaluate the trafficking of surface-modified lipid nanoparticles upon topical application. Pharmaceutical research. 2012 Sep; 29(9):2587-600. doi: 10.1007/s11095-012-0789-2. [PMID: 22644591]
  • Tatsunori Takayasu, Yuko Ishida, Mizuho Nosaka, Mariko Kawaguchi, Yumi Kuninaka, Akihiko Kimura, Toshikazu Kondo. High concentration of methidathion detected in a fatal case of organophosphate-poisoning. Legal medicine (Tokyo, Japan). 2012 Sep; 14(5):263-6. doi: 10.1016/j.legalmed.2012.04.007. [PMID: 22704879]
  • Grażyna Bieniek, Agnieszka Łusiak. Occupational exposure to aromatic hydrocarbons and polycyclic aromatic hydrocarbons at a coke plant. The Annals of occupational hygiene. 2012 Aug; 56(7):796-807. doi: 10.1093/annhyg/mes016. [PMID: 22539560]
  • Adrián Flores Orozco, Andreas Kemna, Christoph Oberdörster, Ludwig Zschornack, Carsten Leven, Peter Dietrich, Holger Weiss. Delineation of subsurface hydrocarbon contamination at a former hydrogenation plant using spectral induced polarization imaging. Journal of contaminant hydrology. 2012 Aug; 136-137(?):131-44. doi: 10.1016/j.jconhyd.2012.06.001. [PMID: 22784635]
  • Aneta Salińska, Tadeusz Włostowski, Sebastian Maciak, Barbara Łaszkiewicz-Tiszczenko, Paweł Kozłowski. Combined effect of dietary cadmium and benzo(a)pyrene on metallothionein induction and apoptosis in the liver and kidneys of bank voles. Biological trace element research. 2012 Jun; 147(1-3):189-94. doi: 10.1007/s12011-011-9279-3. [PMID: 22124863]
  • Nils van der Lubbe, Christina H Lim, Marcel E Meima, Richard van Veghel, Lena Lindtoft Rosenbaek, Kerim Mutig, Alexander H J Danser, Robert A Fenton, Robert Zietse, Ewout J Hoorn. Aldosterone does not require angiotensin II to activate NCC through a WNK4-SPAK-dependent pathway. Pflugers Archiv : European journal of physiology. 2012 Jun; 463(6):853-63. doi: 10.1007/s00424-012-1104-0. [PMID: 22549242]
  • Hui-Kyoung Sun, Yun Mi Lee, Kum Hyun Han, Han-Seong Kim, Seon-Ho Ahn, Sang-Youb Han. Phosphodiesterase inhibitor improves renal tubulointerstitial hypoxia of the diabetic rat kidney. The Korean journal of internal medicine. 2012 Jun; 27(2):163-70. doi: 10.3904/kjim.2012.27.2.163. [PMID: 22707888]
  • Romy Ouziel, Thierry Gustot, Christophe Moreno, Marianna Arvanitakis, Delphine Degré, Eric Trépo, Eric Quertinmont, Vincent Vercruysse, Pieter Demetter, Olivier Le Moine, Andrew N J McKenzie, Myriam Delhaye, Jacques Devière, Arnaud Lemmers. The ST2 pathway is involved in acute pancreatitis: a translational study in humans and mice. The American journal of pathology. 2012 Jun; 180(6):2330-9. doi: 10.1016/j.ajpath.2012.03.009. [PMID: 22542450]
  • Giuseppe De Palma, Diana Poli, Paola Manini, Roberta Andreoli, Paola Mozzoni, Pietro Apostoli, Antonio Mutti. Biomarkers of exposure to aromatic hydrocarbons and methyl tert-butyl ether in petrol station workers. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2012 Jun; 17(4):343-51. doi: 10.3109/1354750x.2012.672459. [PMID: 22458326]
  • Urmila M Aswar, V Mohan, Subhash L Bodhankar. Antiosteoporotic activity of phytoestrogen-rich fraction separated from ethanol extract of aerial parts of Cissus quadrangularis in ovariectomized rats. Indian journal of pharmacology. 2012 May; 44(3):345-50. doi: 10.4103/0253-7613.96310. [PMID: 22701244]
  • Urszula Kotowska, Maciej Żalikowski, Valery A Isidorov. HS-SPME/GC-MS analysis of volatile and semi-volatile organic compounds emitted from municipal sewage sludge. Environmental monitoring and assessment. 2012 May; 184(5):2893-907. doi: 10.1007/s10661-011-2158-8. [PMID: 21688031]
  • Emanuela Esposito, Barbara Rinaldi, Emanuela Mazzon, Maria Donniacuo, Daniela Impellizzeri, Irene Paterniti, Annalisa Capuano, Placido Bramanti, Salvatore Cuzzocrea. Anti-inflammatory effect of simvastatin in an experimental model of spinal cord trauma: involvement of PPAR-α. Journal of neuroinflammation. 2012 Apr; 9(?):81. doi: 10.1186/1742-2094-9-81. [PMID: 22537532]
  • Sigrid Em Heinsbroek, Anneke Oei, Joris J T H Roelofs, Shobhit Dhawan, Anje te Velde, Siamon Gordon, Wouter J de Jonge. Genetic deletion of dectin-1 does not affect the course of murine experimental colitis. BMC gastroenterology. 2012 Apr; 12(?):33. doi: 10.1186/1471-230x-12-33. [PMID: 22507600]
  • Gordana Dorđević, Koviljka Matušan Ilijaš, Ita Hadžisejdić, Anton Maričić, Blaženka Grahovac, Nives Jonjić. EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma. Journal of biomedical science. 2012 Apr; 19(?):40. doi: 10.1186/1423-0127-19-40. [PMID: 22475688]
  • Jeong Dong Park, Sang-Il Lee, A Ram Kim, Jong Moon Park, Sang-Yeop Shin, Jun Hwa Shin, Seung Won Moon, Hyun Park, Min-Kyun Oh, Hee Suk Shin. The effect of human placental extract on rheumatoid arthritis in an animal model. Annals of rehabilitation medicine. 2012 Apr; 36(2):197-206. doi: 10.5535/arm.2012.36.2.197. [PMID: 22639743]
  • Rahul V Takawale, Vishal R Mali, Chinmay U Kapase, Subhash L Bodhankar. Effect of Lagenaria siceraria fruit powder on sodium oxalate induced urolithiasis in Wistar rats. Journal of Ayurveda and integrative medicine. 2012 Apr; 3(2):75-9. doi: 10.4103/0975-9476.96522. [PMID: 22707863]
  • Agata Kowalska, Zdzisław Zakęś, Andrzej Krzysztof Siwicki, Barbara Jankowska, Sylwia Jarmołowicz, Krystyna Demska-Zakęś. Impact of diets with different proportions of linseed and sunflower oils on the growth, liver histology, immunological and chemical blood parameters, and proximate composition of pikeperch Sander lucioperca (L.). Fish physiology and biochemistry. 2012 Apr; 38(2):375-88. doi: 10.1007/s10695-011-9514-z. [PMID: 21656178]
  • Boris Rewald, Eran Raveh, Tanya Gendler, Jhonathan E Ephrath, Shimon Rachmilevitch. Phenotypic plasticity and water flux rates of Citrus root orders under salinity. Journal of experimental botany. 2012 Apr; 63(7):2717-27. doi: 10.1093/jxb/err457. [PMID: 22268156]
  • Nancy B Hopf, Jorunn Kirkeleit, Magne Bråtveit, Paul Succop, Glenn Talaska, Bente E Moen. Evaluation of exposure biomarkers in offshore workers exposed to low benzene and toluene concentrations. International archives of occupational and environmental health. 2012 Apr; 85(3):261-71. doi: 10.1007/s00420-011-0664-1. [PMID: 21671104]
  • Teijiro Hirashita, Yukio Iwashita, Masayuki Ohta, Yoko Komori, Hidetoshi Eguchi, Kazuhiro Yada, Seigo Kitano. Expression of matrix metalloproteinase-7 is an unfavorable prognostic factor in intrahepatic cholangiocarcinoma. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 2012 Apr; 16(4):842-8. doi: 10.1007/s11605-011-1813-2. [PMID: 22246855]
  • Shi-Qi Ji, Lin Yao, Xiao-Yu Zhang, Xue-Song Li, Li-Qun Zhou. Knockdown of the nucleosome binding protein 1 inhibits the growth and invasion of clear cell renal cell carcinoma cells in vitro and in vivo. Journal of experimental & clinical cancer research : CR. 2012 Mar; 31(?):22. doi: 10.1186/1756-9966-31-22. [PMID: 22420896]
  • Jeffrey B Eells, Josiah Wilcots, Scott Sisk, Shirley X Guo-Ross. NR4A gene expression is dynamically regulated in the ventral tegmental area dopamine neurons and is related to expression of dopamine neurotransmission genes. Journal of molecular neuroscience : MN. 2012 Mar; 46(3):545-53. doi: 10.1007/s12031-011-9642-z. [PMID: 21932041]
  • Emmeline Tan, Dorothee Bienzle, Patricia Shewen, Stephen Kruth, Darren Wood. Potentially antigenic RBC membrane proteins in dogs with primary immune-mediated hemolytic anemia. Veterinary clinical pathology. 2012 Mar; 41(1):45-55. doi: 10.1111/j.1939-165x.2011.00391.x. [PMID: 22315967]
  • Mathias Uhlén, Per Oksvold, Cajsa Älgenäs, Carl Hamsten, Linn Fagerberg, Daniel Klevebring, Emma Lundberg, Jacob Odeberg, Fredrik Pontén, Tadashi Kondo, Åsa Sivertsson. Antibody-based protein profiling of the human chromosome 21. Molecular & cellular proteomics : MCP. 2012 Mar; 11(3):M111.013458. doi: 10.1074/mcp.m111.013458. [PMID: 22042635]
  • Akram Eidi, Sara Moghadam-kia, Jalal Zarringhalam Moghadam, Maryam Eidi, Shamsali Rezazadeh. Antinociceptive and anti-inflammatory effects of olive oil (Olea europeae L.) in mice. Pharmaceutical biology. 2012 Mar; 50(3):332-7. doi: 10.3109/13880209.2011.600318. [PMID: 22085252]
  • Ju Han, Bicheng Yong, Canqiao Luo, Pingxian Tan, Tingsheng Peng, Jingnan Shen. High serum alkaline phosphatase cooperating with MMP-9 predicts metastasis and poor prognosis in patients with primary osteosarcoma in Southern China. World journal of surgical oncology. 2012 Feb; 10(?):37. doi: 10.1186/1477-7819-10-37. [PMID: 22333159]
  • Nesrine Ben Azouna, Faouzi Jenhani, Zohra Regaya, Lamia Berraeis, Tarek Ben Othman, Elfi Ducrocq, Jorge Domenech. Phenotypical and functional characteristics of mesenchymal stem cells from bone marrow: comparison of culture using different media supplemented with human platelet lysate or fetal bovine serum. Stem cell research & therapy. 2012 Feb; 3(1):6. doi: 10.1186/scrt97. [PMID: 22333342]
  • Darcy A Chase, Adcharee Karnjanapiboonwong, Yu Fang, George P Cobb, Audra N Morse, Todd A Anderson. Occurrence of synthetic musk fragrances in effluent and non-effluent impacted environments. The Science of the total environment. 2012 Feb; 416(?):253-60. doi: 10.1016/j.scitotenv.2011.11.067. [PMID: 22197110]
  • Junqi Wang, Yu Chung Tse, Giselbert Hinz, David G Robinson, Liwen Jiang. Storage globulins pass through the Golgi apparatus and multivesicular bodies in the absence of dense vesicle formation during early stages of cotyledon development in mung bean. Journal of experimental botany. 2012 Feb; 63(3):1367-80. doi: 10.1093/jxb/err366. [PMID: 22143915]
  • Hyemin Kim, Seyeon Bae, Yeonsil Yu, Yejin Kim, Hang-Rae Kim, Young-Il Hwang, Jae Seung Kang, Wang Jae Lee. The analysis of vitamin C concentration in organs of gulo(-/-) mice upon vitamin C withdrawal. Immune network. 2012 Feb; 12(1):18-26. doi: 10.4110/in.2012.12.1.18. [PMID: 22536166]
  • Habib Abbasi, Mir Manochehr Hamedi, Tayebe Bagheri Lotfabad, Hossein Shahbani Zahiri, Hakimeh Sharafi, Fatemeh Masoomi, Ali Akbar Moosavi-Movahedi, Antonio Ortiz, Massoud Amanlou, Kambiz Akbari Noghabi. Biosurfactant-producing bacterium, Pseudomonas aeruginosa MA01 isolated from spoiled apples: physicochemical and structural characteristics of isolated biosurfactant. Journal of bioscience and bioengineering. 2012 Feb; 113(2):211-9. doi: 10.1016/j.jbiosc.2011.10.002. [PMID: 22036074]
  • Hua-Ling Zhai, Hui Wu, Hui Xu, Pan Weng, Fang-Zhen Xia, Yi Chen, Ying-Li Lu. Trace glucose and lipid metabolism in high androgen and high-fat diet induced polycystic ovary syndrome rats. Reproductive biology and endocrinology : RB&E. 2012 Jan; 10(?):5. doi: 10.1186/1477-7827-10-5. [PMID: 22276997]
  • Jameel G Jargar, Shaheenkousar H Hattiwale, Swastika Das, Salim A Dhundasi, Kusal K Das. A modified simple method for determination of serum α-tocopherol (vitamin E). Journal of basic and clinical physiology and pharmacology. 2012 Jan; 23(1):45-8. doi: 10.1515/jbcpp-2011-0033. [PMID: 22865449]
  • Shuyu Zhang, Chuanjun Song, Jundong Zhou, Ling Xie, Xingjun Meng, Pengfei Liu, Jianping Cao, Xueguang Zhang, Wei-Qun Ding, Jinchang Wu. Amelioration of radiation-induced skin injury by adenovirus-mediated heme oxygenase-1 (HO-1) overexpression in rats. Radiation oncology (London, England). 2012 Jan; 7(?):4. doi: 10.1186/1748-717x-7-4. [PMID: 22247972]
  • Neil S Greenspan, Myro A Lu, Jacob W Shipley, Xuedong Ding, Qing Li, Dilara Sultana, Maria Kollaros, John R Schreiber, Pingfu Fu, Chaim Putterman, Steven N Emancipator. IgG3 deficiency extends lifespan and attenuates progression of glomerulonephritis in MRL/lpr mice. Biology direct. 2012 Jan; 7(?):3. doi: 10.1186/1745-6150-7-3. [PMID: 22248284]
  • Mark Feldman, Shinichi Tanabe, Amy Howell, Daniel Grenier. Cranberry proanthocyanidins inhibit the adherence properties of Candida albicans and cytokine secretion by oral epithelial cells. BMC complementary and alternative medicine. 2012 Jan; 12(?):6. doi: 10.1186/1472-6882-12-6. [PMID: 22248145]
  • Qiang Yan, Baoyao Wang, Weiguo Sui, Guimian Zou, Huaizhou Chen, Shenping Xie, Hequn Zou. Expression of GSK-3β in renal allograft tissue and its significance in pathogenesis of chronic allograft dysfunction. Diagnostic pathology. 2012 Jan; 7(?):5. doi: 10.1186/1746-1596-7-5. [PMID: 22243669]
  • Dongdong Wang, Shu Wang, Xiong Chen, Xiaolong Xu, Jingyi Zhu, Lihuan Nie, Xia Long. Antitussive, expectorant and anti-inflammatory activities of four alkaloids isolated from Bulbus of Fritillaria wabuensis. Journal of ethnopharmacology. 2012 Jan; 139(1):189-93. doi: 10.1016/j.jep.2011.10.036. [PMID: 22101082]
  • Jijing Tian, Kangkang Xia, Ruiping She, Wengui Li, Ye Ding, Jiande Wang, Mingyong Chen, Jun Yin. Detection of Hepatitis B virus in serum and liver of chickens. Virology journal. 2012 Jan; 9(?):2. doi: 10.1186/1743-422x-9-2. [PMID: 22217003]
  • Amad M Al-Azzawi, Ekbal Al-Khateeb, Kulood Al-Sameraei, Alyaa G Al-Juboori. Antibacterial activity and the histopathological study of crude extracts and isolated tecomine from Tecoma stans Bignoniaceae in Iraq. Pharmacognosy research. 2012 Jan; 4(1):37-43. doi: 10.4103/0974-8490.91033. [PMID: 22224060]
  • Julie M Clarke, Graeme P Young, David L Topping, Anthony R Bird, Lynne Cobiac, Benjamin L Scherer, Jessica G Winkler, Trevor J Lockett. Butyrate delivered by butyrylated starch increases distal colonic epithelial apoptosis in carcinogen-treated rats. Carcinogenesis. 2012 Jan; 33(1):197-202. doi: 10.1093/carcin/bgr254. [PMID: 22080572]
  • Xiao-Feng Song, Hao Ren, Arne Andreasen, Jesper Skovhus Thomsen, Xiao-Yue Zhai. Expression of Bcl-2 and Bax in mouse renal tubules during kidney development. PloS one. 2012; 7(2):e32771. doi: 10.1371/journal.pone.0032771. [PMID: 22389723]
  • Qing Miao, Jing-Ge Li, Shan Miao, Nan Hu, Jin Zhang, Song Zhang, Yan-Hua Xie, Jian-Bo Wang, Si-Wang Wang. The bone-protective effect of genistein in the animal model of bilateral ovariectomy: roles of phytoestrogens and PTH/PTHR1 against post-menopausal osteoporosis. International journal of molecular sciences. 2012; 13(1):56-70. doi: 10.3390/ijms13010056. [PMID: 22312238]
  • Fatemeh Talaei, Martina Schmidt, Robert H Henning. Induction of VMAT-1 and TPH-1 expression induces vesicular accumulation of serotonin and protects cells and tissue from cooling/rewarming injury. PloS one. 2012; 7(1):e30400. doi: 10.1371/journal.pone.0030400. [PMID: 22253933]
  • Tomoaki Nagao, Takafumi Okura, Jun Irita, Masanori Jotoku, Daijiro Enomoto, Veena Rasika Desilva, Ken-Ichi Miyoshi, Mie Kurata, Yutaka Matsui, Toshimitsu Uede, Jitsuo Higaki. Osteopontin plays a critical role in interstitial fibrosis but not glomerular sclerosis in diabetic nephropathy. Nephron extra. 2012 Jan; 2(1):87-103. doi: 10.1159/000337330. [PMID: 22619671]
  • Fátima Martín, Cristina Núñez, M Teresa Marín, M Luisa Laorden, Krisztina J Kovács, M Victoria Milanés. Involvement of noradrenergic transmission in the PVN on CREB activation, TORC1 levels, and pituitary-adrenal axis activity during morphine withdrawal. PloS one. 2012; 7(2):e31119. doi: 10.1371/journal.pone.0031119. [PMID: 22355339]
  • Bronwyn M Gunn, Thomas E Morrison, Alan C Whitmore, Lance K Blevins, Linda Hueston, Robert J Fraser, Lara J Herrero, Ruben Ramirez, Paul N Smith, Suresh Mahalingam, Mark T Heise. Mannose binding lectin is required for alphavirus-induced arthritis/myositis. PLoS pathogens. 2012; 8(3):e1002586. doi: 10.1371/journal.ppat.1002586. [PMID: 22457620]
  • Shane A Liddelow, Sally Temple, Kjeld Møllgård, Renate Gehwolf, Andrea Wagner, Hannelore Bauer, Hans-Christian Bauer, Timothy N Phoenix, Katarzyna M Dziegielewska, Norman R Saunders. Molecular characterisation of transport mechanisms at the developing mouse blood-CSF interface: a transcriptome approach. PloS one. 2012; 7(3):e33554. doi: 10.1371/journal.pone.0033554. [PMID: 22457777]
  • Ting Wu, Heng-Tao Zhang, Yi Wang, Wen-Suo Jia, Xue-Feng Xu, Xin-Zhong Zhang, Zhen Hai Han. Induction of root Fe(lll) reductase activity and proton extrusion by iron deficiency is mediated by auxin-based systemic signalling in Malus xiaojinensis. Journal of experimental botany. 2012 Jan; 63(2):859-70. doi: 10.1093/jxb/err314. [PMID: 22058407]
  • Nesma A Z Sarhan, Ezzeldein S El-Denshary, Nabila S Hassan, Ferial M Abu-Salem, Mosaad A Abdel-Wahhab. Isoflavones-Enriched Soy Protein Prevents CCL(4)-Induced Hepatotoxicity in Rats. ISRN pharmacology. 2012; 2012(?):347930. doi: 10.5402/2012/347930. [PMID: 22530140]
  • Behnam Rahimi, Abolfazl Semnani, Alireza Nezamzadeh-Ejhieh, Hamid Shakoori Langeroodi, Massoud Hakim Davood. Monitoring of the Physical and Chemical Properties of a Gasoline Engine Oil during Its Usage. Journal of analytical methods in chemistry. 2012; 2012(?):819524. doi: 10.1155/2012/819524. [PMID: 22567569]
  • Neil Auricchio, Izabela Malinowska, Reuben Shaw, Brendan D Manning, David J Kwiatkowski. Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC). PloS one. 2012; 7(2):e31900. doi: 10.1371/journal.pone.0031900. [PMID: 22363765]
  • Chung-Hsiang Liu, Yi-Wen Lin, Nou-Ying Tang, Hsu-Jan Liu, Ching-Liang Hsieh. Neuroprotective Effect of Uncaria rhynchophylla in Kainic Acid-Induced Epileptic Seizures by Modulating Hippocampal Mossy Fiber Sprouting, Neuron Survival, Astrocyte Proliferation, and S100B Expression. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):194790. doi: 10.1155/2012/194790. [PMID: 21837247]
  • Hua Sun, Linghong Yu, Huailing Wei, Gengtao Liu. A novel antihepatitis drug, bicyclol, prevents liver carcinogenesis in diethylnitrosamine-initiated and phenobarbital-promoted mice tumor model. Journal of biomedicine & biotechnology. 2012; 2012(?):584728. doi: 10.1155/2012/584728. [PMID: 22500097]
  • Kenji Hashimoto, Yuko Sasajima, Masashi Ando, Kan Yonemori, Akihiro Hirakawa, Koh Furuta, Hitoshi Tsuda, Yasuhiro Fujiwara. Immunohistochemical profile for unknown primary adenocarcinoma. PloS one. 2012; 7(1):e31181. doi: 10.1371/journal.pone.0031181. [PMID: 22299055]
  • Gustavo Rodrigues Pedrino, André Henrique Freiria-Oliveira, Débora Simões Almeida Colombari, Daniel Alves Rosa, Sergio Luiz Cravo. A2 noradrenergic lesions prevent renal sympathoinhibition induced by hypernatremia in rats. PloS one. 2012; 7(5):e37587. doi: 10.1371/journal.pone.0037587. [PMID: 22629424]
  • Pinki Nandi, Swatilekha Ghosh, Kuladip Jana, Parimal C Sen. Elucidation of the involvement of p14, a sperm protein during maturation, capacitation and acrosome reaction of caprine spermatozoa. PloS one. 2012; 7(1):e30552. doi: 10.1371/journal.pone.0030552. [PMID: 22291985]
  • Erin E Niland, Audrey McGuire, Mary H Cox, George E Sandusky. High quality DNA obtained with an automated DNA extraction method with 70+ year old formalin-fixed celloidin-embedded (FFCE) blocks from the indiana medical history museum. American journal of translational research. 2012; 4(2):198-205. doi: . [PMID: 22611472]
  • Dennys E Cintra, Eduardo R Ropelle, Juliana C Moraes, José R Pauli, Joseane Morari, Claudio T de Souza, Renato Grimaldi, Marcela Stahl, José B Carvalheira, Mario J Saad, Licio A Velloso. Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity. PloS one. 2012; 7(1):e30571. doi: 10.1371/journal.pone.0030571. [PMID: 22279596]
  • Jennifer S Carew, Juan A Esquivel, Claudia M Espitia, Christoph M Schultes, Marcel Mülbaier, Joe D Lewis, Bernd Janssen, Francis J Giles, Steffan T Nawrocki. ELR510444 inhibits tumor growth and angiogenesis by abrogating HIF activity and disrupting microtubules in renal cell carcinoma. PloS one. 2012; 7(1):e31120. doi: 10.1371/journal.pone.0031120. [PMID: 22295124]
  • Zhi-Gao He, Jian Huang, Shun-Gang Zhou, Jing He, Fang-Xiang Chen, Xian-Kai Huang. Peripheral leukocytapheresis attenuates acute lung injury induced by lipopolysaccharide in vivo. Mediators of inflammation. 2012; 2012(?):694635. doi: 10.1155/2012/694635. [PMID: 22529529]
  • Wei-Chih Kan, Hsien-Yi Wang, Chih-Chiang Chien, Shun-Lai Li, Yu-Chun Chen, Liang-Hao Chang, Chia-Hui Cheng, Wan-Chen Tsai, Jyh-Chang Hwang, Shih-Bin Su, Li-Hsueh Huang, Jiunn-Jye Chuu. Effects of Extract from Solid-State Fermented Cordyceps sinensis on Type 2 Diabetes Mellitus. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):743107. doi: 10.1155/2012/743107. [PMID: 22474523]
  • M E M Dolman, Stefan Harmsen, Ebel H E Pieters, Rolf W Sparidans, Marie Lacombe, Bálint Szokol, László Orfi, György Kéri, Gert Storm, Wim E Hennink, Robbert J Kok. Targeting of a platinum-bound sunitinib analog to renal proximal tubular cells. International journal of nanomedicine. 2012; 7(?):417-33. doi: 10.2147/ijn.s26485. [PMID: 22334775]
  • I-Min Liu, Thing-Fong Tzeng, Shorong-Shii Liou, Chia Ju Chang. Beneficial effect of traditional chinese medicinal formula danggui-shaoyao-san on advanced glycation end-product-mediated renal injury in streptozotocin-diabetic rats. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):140103. doi: 10.1155/2012/140103. [PMID: 21837246]
  • Zong Rui-Kai, Liu Jian. Effects of xinfeng capsules on expression of platelet granule membrane protein 140 and platelet cluster of differentiation 40 ligand in peripheral blood of adjuvant arthritis rats. International journal of rheumatology. 2012; 2012(?):139696. doi: 10.1155/2012/139696. [PMID: 22611405]
  • Thing-Fong Tzeng, Hung-Jen Lu, Shorong-Shii Liou, Chia Ju Chang, I-Min Liu. Vinegar-Baked Radix Bupleuri Regulates Lipid Disorders via a Pathway Dependent on Peroxisome-Proliferator-Activated Receptor-α in High-Fat-Diet-Induced Obese Rats. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):827278. doi: 10.1155/2012/827278. [PMID: 22253647]
  • Eric S McCoy, Bonnie Taylor-Blake, Mark J Zylka. CGRPα-expressing sensory neurons respond to stimuli that evoke sensations of pain and itch. PloS one. 2012; 7(5):e36355. doi: 10.1371/journal.pone.0036355. [PMID: 22563493]
  • Pratima Srivastava. Pharmacokinetics and Excretion Studies on CDRI-85/92, an Antiulcer Proton Pump Inhibitor. Scientia pharmaceutica. 2012 Jan; 80(1):167-77. doi: 10.3797/scipharm.1111-05. [PMID: 22396912]
  • Lena A Basile, Dolph Ellefson, Zoya Gluzman-Poltorak, Katiana Junes-Gill, Vernon Mar, Sarita Mendonca, Joseph D Miller, Jamie Tom, Alice Trinh, Timothy K Gallaher. HemaMax™, a recombinant human interleukin-12, is a potent mitigator of acute radiation injury in mice and non-human primates. PloS one. 2012; 7(2):e30434. doi: 10.1371/journal.pone.0030434. [PMID: 22383962]
  • Mingli Liu, Audu S Amodu, Sidney Pitts, John Patrickson, Jacqueline M Hibbert, Monica Battle, Solomon F Ofori-Acquah, Jonathan K Stiles. Heme mediated STAT3 activation in severe malaria. PloS one. 2012; 7(3):e34280. doi: 10.1371/journal.pone.0034280. [PMID: 22479586]
  • Yunchao Chang, Zhi-Gang She, Kenji Sakimura, Amanda Roberts, Karolina Kucharova, David H Rowitch, William B Stallcup. Ablation of NG2 proteoglycan leads to deficits in brown fat function and to adult onset obesity. PloS one. 2012; 7(1):e30637. doi: 10.1371/journal.pone.0030637. [PMID: 22295099]
  • Juan Gui, Fan Xiong, Jing Li, Guangying Huang. Effects of acupuncture on Th1, th2 cytokines in rats of implantation failure. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):893023. doi: 10.1155/2012/893023. [PMID: 22315633]
  • Ruth E Schietke, Thomas Hackenbeck, Maxine Tran, Regina Günther, Bernd Klanke, Christina L Warnecke, Karl X Knaup, Deepa Shukla, Christian Rosenberger, Robert Koesters, Sebastian Bachmann, Peter Betz, Gunnar Schley, Johannes Schödel, Carsten Willam, Thomas Winkler, Kerstin Amann, Kai-Uwe Eckardt, Patrick Maxwell, Michael S Wiesener. Renal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cysts. PloS one. 2012; 7(1):e31034. doi: 10.1371/journal.pone.0031034. [PMID: 22299048]
  • Venkat R Katkoori, Chandrakumar Shanmugam, Xu Jia, Swaroop P Vitta, Meenakshi Sthanam, Tom Callens, Ludwine Messiaen, Dongquan Chen, Bin Zhang, Harvey L Bumpers, Temesgen Samuel, Upender Manne. Prognostic significance and gene expression profiles of p53 mutations in microsatellite-stable stage III colorectal adenocarcinomas. PloS one. 2012; 7(1):e30020. doi: 10.1371/journal.pone.0030020. [PMID: 22276141]
  • Claudia Sticozzi, Giuseppe Belmonte, Alessandra Pecorelli, Beatrice Arezzini, Concetta Gardi, Emanuela Maioli, Clelia Miracco, Marzia Toscano, Henry Jay Forman, Giuseppe Valacchi. Cigarette smoke affects keratinocytes SRB1 expression and localization via H2O2 production and HNE protein adducts formation. PloS one. 2012; 7(3):e33592. doi: 10.1371/journal.pone.0033592. [PMID: 22442701]
  • Wentao Xu, Zhifang Zhai, Kunlun Huang, Nan Zhang, Yanfang Yuan, Ying Shang, Yunbo Luo. A novel universal primer-multiplex-PCR method with sequencing gel electrophoresis analysis. PloS one. 2012; 7(1):e22900. doi: 10.1371/journal.pone.0022900. [PMID: 22272223]
  • Zhe Lu, Kyung-Jin Lee, Yingxue Shao, Jeong-Hwan Lee, Yangkang So, Young-Kug Choo, Doo-Byoung Oh, Kyung-A Hwang, Seung Han Oh, Yeon Soo Han, Kisung Ko. Expression of GA733-Fc fusion protein as a vaccine candidate for colorectal cancer in transgenic plants. Journal of biomedicine & biotechnology. 2012; 2012(?):364240. doi: 10.1155/2012/364240. [PMID: 22675251]
  • Elena Bravo, Simonetta Palleschi, Barbara Rossi, Mariarosaria Napolitano, Luca Tiano, Emanuela D'Amore, Kathleen M Botham. Coenzyme Q metabolism is disturbed in high fat diet-induced non-alcoholic fatty liver disease in rats. International journal of molecular sciences. 2012; 13(2):1644-57. doi: 10.3390/ijms13021644. [PMID: 22408414]
  • Ju Wang, Ying Pan, Ye Hong, Qing-Yu Zhang, Xiao-Ning Wang, Ling-Dong Kong. Quercetin Protects against Cadmium-Induced Renal Uric Acid Transport System Alteration and Lipid Metabolism Disorder in Rats. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):548430. doi: 10.1155/2012/548430. [PMID: 22690247]
  • Matthew L Broadhead, Peter F M Choong, Crispin R Dass. Efficacy of continuously administered PEDF-derived synthetic peptides against osteosarcoma growth and metastasis. Journal of biomedicine & biotechnology. 2012; 2012(?):230298. doi: 10.1155/2012/230298. [PMID: 22701300]
  • Jung Pyo Lee, Seung Hee Yang, Hee-Yoon Lee, Bora Kim, Joo-Youn Cho, Jin Ho Paik, Yun Jung Oh, Dong Ki Kim, Chun Soo Lim, Yon Su Kim. Soluble epoxide hydrolase activity determines the severity of ischemia-reperfusion injury in kidney. PloS one. 2012; 7(5):e37075. doi: 10.1371/journal.pone.0037075. [PMID: 22590647]
  • Adaweyah El-Merhibi, Kerry Lymn, Irene Kanter, Irmeli A Penttila. Early oral ovalbumin exposure during maternal milk feeding prevents spontaneous allergic sensitization in allergy-prone rat pups. Clinical & developmental immunology. 2012; 2012(?):396232. doi: 10.1155/2012/396232. [PMID: 22203855]
  • Tao Liu, Jun Zhao, Long Ma, Yusong Ding, Deqi Su. Hepatoprotective Effects of Total Triterpenoids and Total Flavonoids from Vitis vinifera L against Immunological Liver Injury in Mice. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):969386. doi: 10.1155/2012/969386. [PMID: 22262981]
  • Carine Munaut, Sophie Lorquet, Christel Pequeux, Capucine Coulon, Jeanne Le Goarant, Frédéric Chantraine, Agnès Noël, Frédéric Goffin, Vassilis Tsatsaris, Damien Subtil, Jean-Michel Foidart. Differential expression of Vegfr-2 and its soluble form in preeclampsia. PloS one. 2012; 7(3):e33475. doi: 10.1371/journal.pone.0033475. [PMID: 22428059]
  • Sreenivasan Sasidharan, Selvarasoo Logeswaran, Lachimanan Yoga Latha. Wound healing activity of Elaeis guineensis leaf extract ointment. International journal of molecular sciences. 2012; 13(1):336-47. doi: 10.3390/ijms13010336. [PMID: 22312255]
  • Chuang Wang, Ying Pan, Qing-Yu Zhang, Fu-Meng Wang, Ling-Dong Kong. Quercetin and allopurinol ameliorate kidney injury in STZ-treated rats with regulation of renal NLRP3 inflammasome activation and lipid accumulation. PloS one. 2012; 7(6):e38285. doi: 10.1371/journal.pone.0038285. [PMID: 22701621]
  • Yi-Ching Lo, Yu-Tzu Shih, Yu-Ting Tseng, Hung-Te Hsu. Neuroprotective Effects of San-Huang-Xie-Xin-Tang in the MPP(+)/MPTP Models of Parkinson's Disease In Vitro and In Vivo. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):501032. doi: 10.1155/2012/501032. [PMID: 22474505]
  • Anil U Tatiya, Sanjay J Surana, Manisha P Sutar, Nehal H Gamit. Hepatoprotective effect of poly herbal formulation against various hepatotoxic agents in rats. Pharmacognosy research. 2012 Jan; 4(1):50-6. doi: 10.4103/0974-8490.91040. [PMID: 22224062]
  • Victoria Tyndall, Marie Broyde, Richard Sharpe, Michelle Welsh, Amanda J Drake, Alan S McNeilly. Effect of androgen treatment during foetal and/or neonatal life on ovarian function in prepubertal and adult rats. Reproduction (Cambridge, England). 2012 Jan; 143(1):21-33. doi: 10.1530/rep-11-0239. [PMID: 22016380]
  • Hanna Lee, Meiying Song, Nara Shin, Chang Hoon Shin, Byung Soh Min, Hyon-Suk Kim, Jong Shin Yoo, Hoguen Kim. Diagnostic significance of serum HMGB1 in colorectal carcinomas. PloS one. 2012; 7(4):e34318. doi: 10.1371/journal.pone.0034318. [PMID: 22496788]
  • Md Jelas Haron, Hossein Jahangirian, Sidik Silong, Nor Azah Yusof, Anuar Kassim, Roshanak Rafiee-Moghaddam, Behnam Mahdavi, Mazyar Peyda, Yadollah Abdollahi, Jamileh Amin. Benzyl and methyl fatty hydroxamic acids based on palm kernel oil as chelating agent for liquid-liquid iron(III) extraction. International journal of molecular sciences. 2012; 13(2):2148-2159. doi: 10.3390/ijms13022148. [PMID: 22408444]