Acetoin (BioDeep_00000004235)

 

Secondary id: BioDeep_00000405550

human metabolite blood metabolite BioNovoGene_Lab2019 natural product


代谢物信息卡片


1-Hydroxyethyl methyl ketone

化学式: C4H8O2 (88.0524)
中文名称: 乙偶姻, 乙酰甲基甲醇
谱图信息: 最多检出来源 Homo sapiens(blood) 51.54%

分子结构信息

SMILES: CC(=O)C(C)O
InChI: InChI=1S/C4H8O2/c1-3(5)4(2)6/h3,5H,1-2H3

描述信息

Acetoin, also known as dimethylketol or 2,3-butanolone, belongs to the class of organic compounds known as acyloins. These are organic compounds containing an alpha hydroxy ketone. Acyloins are formally derived from reductive coupling of carboxylic acyl groups. Thus, acetoin is considered to be an oxygenated hydrocarbon lipid molecule. Acetoin is used as an external energy store by a number of fermentive bacteria. Acetoin, along with diacetyl, is one of the compounds giving butter its characteristic flavor. Acetoin is a very hydrophobic molecule, practically insoluble in water, and relatively neutral. Acetoin is used as a food flavoring (in baked goods) and a fragrance. Acetoin is a sweet, buttery, and creamy tasting compound. Outside of the human body, Acetoin has been detected, but not quantified in several different foods, such as cocoa and cocoa products, evergreen blackberries, orange bell peppers, tortilla chips, and pomes. This could make acetoin a potential biomarker for the consumption of these foods. Constituent of beer, wine, fresh or cooked apple, fresh or cooked leak, corn, honey, cocoa, butter, cheeses, roasted coffee and other foodstuffs. Acetoin, with regard to humans, has been found to be associated with several diseases such as eosinophilic esophagitis and ulcerative colitis; acetoin has also been linked to the inborn metabolic disorder celiac disease. Acetoin is a colorless or pale yellow to green yellow liquid with a pleasant, buttery odor. It can be found in apples, butter, yogurt, asparagus, black currants, blackberry, wheat, broccoli, brussels sprouts, cantaloupe.
Constituent of beer, wine, fresh or cooked apple, fresh or cooked leak, corn, honey, cocoa, butter, cheeses, roasted coffee and other foodstuffs. Flavouring ingredient. [DFC]

同义名列表

29 个代谢物同义名

1-Hydroxyethyl methyl ketone; gamma-Hydroxy-beta-oxobutane; (R)-3-Hydroxybutan-2-one; (R)-3-Hydroxy-2-butanone; Acetyl methyl carbinol; Γ-hydroxy-β-oxobutane; g-Hydroxy-b-oxobutane; 3-Hydroxyl-2-butanone; 2-Hydroxy-3-oxobutane; 3-hydroxy-2-Butanone; 3-Hydroxybutan-2-one; 2-Hydroxy-3-butanone; Acetylmethylcarbinol; (R)-Dimethylketol; 2-Butanol-3-one; beta-Oxobutane; 3H-2b Butanone; 2,3-Butanolone; Dimethylketol; (R)-2-Acetoin; (S)-2-Acetoin; b-Oxobutane; (R)-Acetoin; 2-Acetoin; Acetoine; acetoin; Acetoin; Acetoin; Acetoin



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

122 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 BDH2, CAT, G6PD, GPD1, ITPR3, LDHA, ODC1, WT1
Peripheral membrane protein 3 G6PD, HSD17B6, MBP
Endoplasmic reticulum membrane 1 ITPR3
Nucleus 6 ACR, DLD, LDHA, MBP, PNKD, WT1
cytosol 9 BDH2, CAT, G6PD, GPD1, LDHA, LIPE, MBP, ODC1, WT1
dendrite 1 ACVRL1
nucleoplasm 2 ITPR3, WT1
Cell membrane 2 ACVRL1, LIPE
Cytoplasmic side 1 MBP
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 1 ITPR3
Synapse 1 MBP
cell surface 3 ACVRL1, MBP, TNFRSF10B
Golgi apparatus 1 ATRN
mitochondrial inner membrane 2 BDH1, GPD2
neuronal cell body 3 ACVRL1, ITPR3, MBP
Cytoplasm, cytosol 2 G6PD, LIPE
acrosomal vesicle 1 DLD
plasma membrane 5 ACVRL1, ATRN, ITPR3, MBP, TNFRSF10B
Membrane 10 ACVRL1, BDH1, CAT, G6PD, GPD2, ITPR3, LDHA, LIPE, PNKD, TNFRSF10B
brush border 1 ITPR3
caveola 1 LIPE
extracellular exosome 8 ATRN, BDH2, CAT, G6PD, GPD1, LDHA, LYZ, MBP
Lumenal side 1 HSD17B6
endoplasmic reticulum 2 HSD17B6, ITPR3
extracellular space 2 ATRN, LYZ
mitochondrion 6 BDH1, CAT, DLD, GPD2, LDHA, PNKD
protein-containing complex 3 ACR, CAT, MBP
intracellular membrane-bounded organelle 4 BDH1, CAT, G6PD, HSD17B6
Microsome membrane 1 HSD17B6
Single-pass type I membrane protein 2 ACVRL1, ATRN
extracellular region 4 ACR, CAT, LYZ, MBP
cytoplasmic side of plasma membrane 1 G6PD
[Isoform 2]: Secreted 1 ATRN
Mitochondrion matrix 2 BDH1, DLD
mitochondrial matrix 3 BDH1, CAT, DLD
centriolar satellite 1 G6PD
motile cilium 1 DLD
nucleolus 2 ITPR3, WT1
apical part of cell 1 ITPR3
Golgi-associated vesicle 1 ACR
Mitochondrion inner membrane 1 BDH1
focal adhesion 1 CAT
Peroxisome 1 CAT
sarcoplasmic reticulum 1 ITPR3
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 MBP
nuclear speck 1 WT1
nuclear outer membrane 1 ITPR3
receptor complex 1 ITPR3
cell periphery 1 MBP
[Isoform 3]: Nucleus 1 MBP
Cytoplasmic vesicle, secretory vesicle, acrosome 1 DLD
Cell projection, cilium, flagellum 1 DLD
[Isoform 3]: Secreted 1 ATRN
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
Nucleus speckle 1 WT1
myelin sheath 1 MBP
ficolin-1-rich granule lumen 2 CAT, MBP
secretory granule lumen 1 CAT
secretory granule membrane 1 ITPR3
pyruvate dehydrogenase complex 1 DLD
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
transport vesicle 1 MBP
azurophil granule lumen 1 LYZ
oxoglutarate dehydrogenase complex 1 DLD
platelet dense tubular network membrane 1 ITPR3
[Isoform 1]: Cell membrane 1 ATRN
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
presynaptic cytosol 1 PNKD
oxidoreductase complex 1 LDHA
transport vesicle membrane 1 ITPR3
compact myelin 1 MBP
internode region of axon 1 MBP
catalase complex 1 CAT
acetyltransferase complex 1 DLD
acrosomal matrix 2 ACR, DLD
branched-chain alpha-ketoacid dehydrogenase complex 1 DLD
oxoadipate dehydrogenase complex 1 DLD
BMP receptor complex 1 ACVRL1
[Bone marrow proteoglycan]: Secreted 1 MBP
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
[Isoform 1]: Nucleus speckle 1 WT1
[Isoform 4]: Nucleus, nucleoplasm 1 WT1
Myelin membrane 1 MBP
matrix side of mitochondrial inner membrane 1 BDH1
glycerol-3-phosphate dehydrogenase (FAD) complex 1 GPD2


文献列表

  • Tania N N Tanwee, Gina L Lipscomb, Jason L Vailionis, Ke Zhang, Ryan G Bing, Hailey C O'Quinn, Farris L Poole, Ying Zhang, Robert M Kelly, Michael W W Adams. Metabolic engineering of Caldicellulosiruptor bescii for 2,3-butanediol production from unpretreated lignocellulosic biomass and metabolic strategies for improving yields and titers. Applied and environmental microbiology. 2024 Jan; 90(1):e0195123. doi: 10.1128/aem.01951-23. [PMID: 38131671]
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  • Bénédicte Cesselin, Céline Henry, Alexandra Gruss, Karine Gloux, Philippe Gaudu. Mechanisms of Acetoin Toxicity and Adaptive Responses in an Acetoin-Producing Species, Lactococcus lactis. Applied and environmental microbiology. 2021 11; 87(24):e0107921. doi: 10.1128/aem.01079-21. [PMID: 34613757]
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