PROCAINAMIDE (BioDeep_00000415925)
Main id: BioDeep_00000001511
代谢物信息卡片
PROCAINAMIDE
化学式: C13H21N3O (235.1685)
中文名称: 4-氨基-N-(2-二乙氨基乙基)苯甲酰胺
谱图信息:
最多检出来源 Mus musculus(urine) 29.67%
分子结构信息
SMILES: CCN(CC)CCNC(=O)C1=CC=C(C=C1)N
InChI: InChI=1S/C13H21N3O/c1-3-16(4-2)10-9-15-13(17)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3,(H,15,17)
描述信息
C - Cardiovascular system > C01 - Cardiac therapy > C01B - Antiarrhythmics, class i and iii > C01BA - Antiarrhythmics, class ia
D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers > D061567 - Voltage-Gated Sodium Channel Blockers
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
同义名列表
2 个代谢物同义名
数据库引用编号
21 个数据库交叉引用编号
- ChEBI: CHEBI:8428
- KEGG: C75392
- KEGG: C07401
- KEGGdrug: D08421
- PubChem: 4913
- DrugBank: DB01035
- ChEMBL: CHEMBL640
- MeSH: Procainamide
- CAS: 51-06-9
- MoNA: MoNA038224
- MoNA: MoNA037473
- MoNA: MoNA035195
- MoNA: MoNA035193
- MoNA: MoNA035190
- MoNA: MoNA033004
- MoNA: MoNA033002
- MoNA: MoNA033001
- PubChem: 9605
- NIKKAJI: J4.110F
- RefMet: Procainamide
- KNApSAcK: 8428
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Wenbin Fu, Hongmei Ren, Jialing Shou, Qiao Liao, Liangpeng Li, Yu Shi, Pedro A Jose, Chunyu Zeng, Wei Eric Wang. Loss of NPPA-AS1 promotes heart regeneration by stabilizing SFPQ-NONO heteromer-induced DNA repair.
Basic research in cardiology.
2022 03; 117(1):10. doi:
10.1007/s00395-022-00921-y. [PMID: 35247074] - Markus Hahn, Ulrike M Stamer, Markus M Luedi, Malte Book, Heinz U Rieder, Frank Stüber. ASA Status, NPPA/NPPB Haplotype and Coronary Artery Disease Have an Impact on BNP/NT-proBNP Plasma Levels.
Cells.
2022 02; 11(5):. doi:
10.3390/cells11050766. [PMID: 35269388] - Linan Chen, Jing Li, Min Zhang, Qiu Zhang, Lei Wu, Ying Lu, Yan He, Jun Jiang, Xiaolong Zhang, Jianwei Hu, Yi Ding, Mingzhi Zhang, Hao Peng. Serum Atrial Natriuretic Peptide, NPPA Promoter Methylation, and Cardiovascular Disease: A 10-year Follow-Up Study in Chinese Adults.
Global heart.
2022; 17(1):27. doi:
10.5334/gh.1116. [PMID: 35586748] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Qingjun Pan, Yun Guo, Linjie Guo, Shuzhen Liao, Chunfei Zhao, Sijie Wang, Hua-Feng Liu. Mechanistic Insights of Chemicals and Drugs as Risk Factors for Systemic Lupus Erythematosus.
Current medicinal chemistry.
2020; 27(31):5175-5188. doi:
10.2174/0929867326666190404140658. [PMID: 30947650] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - J D Thomason, D Boothe, B KuKanich, G Rapoport. Pharmacokinetic evaluation of a sustained-release compounded procainamide preparation after 24-h (acute) administration in normal dogs.
Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology.
2019 Aug; 24(?):58-63. doi:
10.1016/j.jvc.2019.06.002. [PMID: 31405555] - Jorge A Irizarry-Caro, Carmelo Carmona-Rivera, Daniella M Schwartz, Sami S Khaznadar, Mariana J Kaplan, Peter C Grayson. Brief Report: Drugs Implicated in Systemic Autoimmunity Modulate Neutrophil Extracellular Trap Formation.
Arthritis & rheumatology (Hoboken, N.J.).
2018 03; 70(3):468-474. doi:
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Plant physiology.
2017 Aug; 174(4):2146-2165. doi:
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Talanta.
2017 May; 167(?):709-713. doi:
10.1016/j.talanta.2017.02.051. [PMID: 28340783] - Chang-Cai Liu, Gui-Lan Huang, Hai-Ling Xi, Shi-Lei Liu, Jing-Quan Liu, Hui-Lan Yu, Shi-Kun Zhou, Long-Hui Liang, Ling Yuan. Simultaneous quantification of soman and VX adducts to butyrylcholinesterase, their aged methylphosphonic acid adduct and butyrylcholinesterase in plasma using an off-column procainamide-gel separation method combined with UHPLC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Nov; 1036-1037(?):57-65. doi:
10.1016/j.jchromb.2016.09.044. [PMID: 27718463] - Hong-Bing Duan, Jun-Tao Cao, Jiu-Jun Yang, Hui Wang, Yan-Ming Liu. Simultaneous determination of four local anesthetics by CE with ECL and study on interaction between procainamide and human serum albumin.
Talanta.
2016 07; 154(?):341-5. doi:
10.1016/j.talanta.2016.03.093. [PMID: 27154684] - Chih-Chin Shih, Hiong-Ping Hii, Cheng-Ming Tsao, Shiu-Jen Chen, Shuk-Man Ka, Mei-Hui Liao, Chin-Chen Wu. Therapeutic Effects of Procainamide on Endotoxin-Induced Rhabdomyolysis in Rats.
PloS one.
2016; 11(2):e0150319. doi:
10.1371/journal.pone.0150319. [PMID: 26918767] - Ahmed N Mohamed, Ahmed M Abdelhady, Dustin Spencer, Kevin M Sowinski, James E Tisdale, Brian R Overholser. Pharmacokinetic modeling and simulation of procainamide and N-acetylprocainamide in a patient receiving continuous renal replacement therapy: a novel approach to guide renal dose adjustments.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2013 Jun; 61(6):1046-8. doi:
10.1053/j.ajkd.2013.02.358. [PMID: 23562328] - Marios Spanakis, Ioannis Niopas. Determination of atenolol in human plasma by HPLC with fluorescence detection: validation and application in a pharmacokinetic study.
Journal of chromatographic science.
2013 Feb; 51(2):128-32. doi:
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Drug metabolism and pharmacokinetics.
2013; 28(6):491-6. doi:
10.2133/dmpk.dmpk-13-rg-017. [PMID: 23719964] - Fei Li, Andrew D Patterson, Kristopher W Krausz, Bernhard Dick, Felix J Frey, Frank J Gonzalez, Jeffrey R Idle. Metabolomics reveals the metabolic map of procainamide in humans and mice.
Biochemical pharmacology.
2012 May; 83(10):1435-44. doi:
10.1016/j.bcp.2012.02.013. [PMID: 22387617] - Sachiko Arase, Megumi Kasai, Akira Kanazawa. In planta assays involving epigenetically silenced genes reveal inhibition of cytosine methylation by genistein.
Plant methods.
2012 Mar; 8(?):10. doi:
10.1186/1746-4811-8-10. [PMID: 22424588] - Carlos Wong-Baeza, Rogelio Hernández-Pando, Albany Reséndiz, Alonso Tescucano, Israel Bustos, Miguel Ibáñez, Carlos Wong, Isabel Baeza. Molecular organization of the non-bilayer phospholipid arrangements that induce an autoimmune disease resembling human lupus in mice.
Molecular membrane biology.
2012 Mar; 29(2):52-67. doi:
10.3109/09687688.2012.667577. [PMID: 22416965] - Rami A Jambeih, Wassim H Shaheen, Vuy Y Li, Mazen H Shaheen. ST-segment elevation and ventricular tachycardia after ingestion of a common ornamental plant-a case report.
Indian heart journal.
2012 Mar; 64(2):211-3. doi:
10.1016/s0019-4832(12)60066-2. [PMID: 22572505] - Eduardo Puertas-Abreu, Elaudi Rodríguez Polanco, Miriam Azocar, Luis Antonio Mundarain, Concepción Morelia Nuñez-Sotelo, Rafael Montaño, Freddy Herrera Vivas, Zair Tovar Noguera, Francisco Marín, Omar Bellorin, José Gregorio Rivas, Eduardo Toro, Eugenia Benzaquen, Mayra Rauseo, Luis Arturo Gutiérrez González. Onset of lupus like syndrome in patients with spondyloarthritis treated with anti-TNF-α.
International archives of medicine.
2012 Feb; 5(1):7. doi:
10.1186/1755-7682-5-7. [PMID: 22336076] - Meenakshi Sharma, Rakesh Sehgal, Sukhbir Kaur. Evaluation of nephroprotective and immunomodulatory activities of antioxidants in combination with cisplatin against murine visceral leishmaniasis.
PLoS neglected tropical diseases.
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Journal of mass spectrometry : JMS.
2011 Nov; 46(11):1125-30. doi:
10.1002/jms.1998. [PMID: 22124983] - Sunipa Majumdar, Eric Buckles, John Estrada, Shahriar Koochekpour. Aberrant DNA methylation and prostate cancer.
Current genomics.
2011 Nov; 12(7):486-505. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2011 Sep; 39(9):1674-9. doi:
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Drugs & aging.
2011 Aug; 28(8):617-33. doi:
10.2165/11591680-000000000-00000. [PMID: 21812498] - Hyun Seok Hwang, Can Hasdemir, Derek Laver, Divya Mehra, Kutsal Turhan, Michela Faggioni, Huiyong Yin, Björn C Knollmann. Inhibition of cardiac Ca2+ release channels (RyR2) determines efficacy of class I antiarrhythmic drugs in catecholaminergic polymorphic ventricular tachycardia.
Circulation. Arrhythmia and electrophysiology.
2011 Apr; 4(2):128-35. doi:
10.1161/circep.110.959916. [PMID: 21270101] - Ja Olaniyi, Sa Olomu, Oa Finomo. Lupus anticoagulant (LA) in pregnant women with history of recurrent fetal loss.
Journal of blood medicine.
2011; 2(?):87-90. doi:
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2010 Aug; 30(6):559-65. doi:
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North American journal of medical sciences.
2010 Jun; 2(6):276-80. doi:
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British journal of cancer.
2010 May; 102(11):1627-35. doi:
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Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2010 Jan; 93 Suppl 1(?):S139-46. doi:
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Biological & pharmaceutical bulletin.
2010; 33(8):1407-12. doi:
10.1248/bpb.33.1407. [PMID: 20686239] - Laurence Colin, Carine Van Lint. Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies.
Retrovirology.
2009 Dec; 6(?):111. doi:
10.1186/1742-4690-6-111. [PMID: 19961595] - A V Marzano, P Vezzoli, C Crosti. Drug-induced lupus: an update on its dermatologic aspects.
Lupus.
2009 Oct; 18(11):935-40. doi:
10.1177/0961203309106176. [PMID: 19762393] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
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Arhiv za higijenu rada i toksikologiju.
2009 Jun; 60(2):147-56. doi:
10.2478/10004-1254-60-2009-1915. [PMID: 19581207] - Ju Seop Kang, Min Ho Lee. Overview of therapeutic drug monitoring.
The Korean journal of internal medicine.
2009 Mar; 24(1):1-10. doi:
10.3904/kjim.2009.24.1.1. [PMID: 19270474] - Camilla Dalle Vedove, Micol Del Giglio, Donatella Schena, Giampiero Girolomoni. Drug-induced lupus erythematosus.
Archives of dermatological research.
2009 Jan; 301(1):99-105. doi:
10.1007/s00403-008-0895-5. [PMID: 18797892] - Ryan R Woods, Brian C Geyer, Tsafrir S Mor. Hairy-root organ cultures for the production of human acetylcholinesterase.
BMC biotechnology.
2008 Dec; 8(?):95. doi:
10.1186/1472-6750-8-95. [PMID: 19105816] - Ashima Saxena, Chunyuan Luo, Bhupendra P Doctor. Developing procedures for the large-scale purification of human serum butyrylcholinesterase.
Protein expression and purification.
2008 Oct; 61(2):191-6. doi:
10.1016/j.pep.2008.05.021. [PMID: 18602477] - Tomoko Sato, Satohiro Masuda, Atsushi Yonezawa, Yuko Tanihara, Toshiya Katsura, Ken-Ichi Inui. Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1.
Biochemical pharmacology.
2008 Oct; 76(7):894-903. doi:
10.1016/j.bcp.2008.07.005. [PMID: 18674516] - He Li, Larry Tong, Lawrence M Schopfer, Patrick Masson, Oksana Lockridge. Fast affinity purification coupled with mass spectrometry for identifying organophosphate labeled plasma butyrylcholinesterase.
Chemico-biological interactions.
2008 Sep; 175(1-3):68-72. doi:
10.1016/j.cbi.2008.04.027. [PMID: 18586231] - Shi-Jian Ding, John Carr, James E Carlson, Larry Tong, Weihua Xue, Yifeng Li, Lawrence M Schopfer, Bin Li, Florian Nachon, Oluwatoyin Asojo, Charles M Thompson, Steven H Hinrichs, Patrick Masson, Oksana Lockridge. Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin.
Chemical research in toxicology.
2008 Sep; 21(9):1787-94. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
2008 Sep; 38(9):1203-18. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
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BMC biotechnology.
2008 May; 8(?):50. doi:
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Indian pacing and electrophysiology journal.
2008 Apr; 8(2):102-13. doi:
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Therapeutic drug monitoring.
2008 Apr; 30(2):212-7. doi:
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Neuropsychiatric disease and treatment.
2007 Dec; 3(6):869-97. doi:
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Biochemical pharmacology.
2007 Jul; 74(2):359-71. doi:
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International journal of cardiology.
2007 Jul; 119(2):235-6. doi:
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Archives of pathology & laboratory medicine.
2007 Jul; 131(7):1094-8. doi:
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Dialogues in clinical neuroscience.
2007; 9(1):29-45. doi:
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Analytical chemistry.
2006 Sep; 78(18):6640-4. doi:
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Journal of the American Society of Nephrology : JASN.
2006 Aug; 17(8):2127-35. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Jun; 838(1):21-30. doi:
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Annals of clinical biochemistry.
2006 May; 43(Pt 3):223-5. doi:
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The American journal of managed care.
2006 May; 12(5):268-74. doi:
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Arthritis research & therapy.
2006; 8(1):203. doi:
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Journal of clinical laboratory analysis.
2006; 20(2):62-7. doi:
10.1002/jcla.20098. [PMID: 16538644] - Brian C Geyer, Mrinalini Muralidharan, Irene Cherni, Jeffrey Doran, Samuel P Fletcher, Tama Evron, Hermona Soreq, Tsafrir S Mor. Purification of transgenic plant-derived recombinant human acetylcholinesterase-R.
Chemico-biological interactions.
2005 Dec; 157-158(?):331-4. doi:
10.1016/j.cbi.2005.10.097. [PMID: 16269140] - Carla Fenoglio, Eleonora Boncompagni, Barbara Chiavarina, Sergio Cafaggi, Michele Cilli, Maurizio Viale. Morphological and histochemical evidence of the protective effect of procainamide hydrochloride on tissue damage induced by repeated administration of low doses of cisplatin.
Anticancer research.
2005 Nov; 25(6B):4123-8. doi:
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Molecular cancer.
2005 Oct; 4(?):38. doi:
10.1186/1476-4598-4-38. [PMID: 16248899] - J Ablin, I Verbovetski, U Trahtemberg, S Metzger, D Mevorach. Quinidine and procainamide inhibit murine macrophage uptake of apoptotic and necrotic cells: a novel contributing mechanism of drug-induced-lupus.
Apoptosis : an international journal on programmed cell death.
2005 Oct; 10(5):1009-18. doi:
10.1007/s10495-005-1189-4. [PMID: 16151636] - P Nazare, P Massaroti, L F Duarte, D R Campos, M A M Marchioretto, G Bernasconi, S Calafatti, F A P Barros, E C Meurer, J Pedrazzoli, L A B Moraes. Validated method for determination of bromopride in human plasma by liquid chromatography--electrospray tandem mass spectrometry: application to the bioequivalence study.
Journal of mass spectrometry : JMS.
2005 Sep; 40(9):1197-202. doi:
10.1002/jms.898. [PMID: 16127659] - David N Bailey, John R Briggs. Studies of the inhibition of serum pseudocholinesterase activity in vitro by commonly used drugs.
American journal of clinical pathology.
2005 Aug; 124(2):226-8. doi:
10.1309/9x17-7kvu-1tmm-ax28. [PMID: 16040293] - Alma Chavez-Blanco, Blanca Segura-Pacheco, Enrique Perez-Cardenas, Lucia Taja-Chayeb, Lucely Cetina, Myrna Candelaria, David Cantu, Aurora Gonzalez-Fierro, Patricia Garcia-Lopez, Pilar Zambrano, Carlos Perez-Plasencia, Gustavo Cabrera, Catalina Trejo-Becerril, Enrique Angeles, Alfonso Duenas-Gonzalez. Histone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral blood of patients with cervical cancer. A phase I study.
Molecular cancer.
2005 Jul; 4(1):22. doi:
10.1186/1476-4598-4-22. [PMID: 16001982] - Tristan Ruysschaert, Audrey Marque, Jean-Luc Duteyrat, Sylviane Lesieur, Mathias Winterhalter, Didier Fournier. Liposome retention in size exclusion chromatography.
BMC biotechnology.
2005 May; 5(?):11. doi:
10.1186/1472-6750-5-11. [PMID: 15885140] - Naoki Ishiguro, Asami Saito, Kazutoshi Yokoyama, Makoto Morikawa, Takashi Igarashi, Ikumi Tamai. Transport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney.
Drug metabolism and disposition: the biological fate of chemicals.
2005 Apr; 33(4):495-9. doi:
10.1124/dmd.104.002519. [PMID: 15640376] - Takashi Kato, Yoshifumi Ubara, Tetsuo Tagami, Naoki Sawa, Junichi Hoshino, Tatsuya Suwabe, Takaaki Yamagata, Hideyuki Katori, Fumi Takemoto, Shigeko Hara, Shuichirou Matoba, Kenmei Takaichi. Autosomal dominant polycystic kidney disease showing rupture of a lateral ventral hernia following paralytic ileus.
Internal medicine (Tokyo, Japan).
2005 Apr; 44(4):311-4. doi:
10.2169/internalmedicine.44.311. [PMID: 15897642] - Larry A Bauer, Douglas J Black, Jennifer S Lill, Julie Garrison, Vidmantas A Raisys, Thomas M Hooton. Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances.
Antimicrobial agents and chemotherapy.
2005 Apr; 49(4):1649-51. doi:
10.1128/aac.49.4.1649-1651.2005. [PMID: 15793163] - Theofilos M Kolettis, Nikolaos Kazakos, Christos S Katsouras, Dimitra Niokou, Lamprini Pappa, Vassilios Koulouras, Panagiotis Stefanou, Constantinos Seferiadis, Vassiliki Malamou-Mitsi, Lampros K Michalis, Marios Marselos, Dimitrios A Sideris. Intrapericardial drug delivery: pharmacologic properties and long-term safety in swine.
International journal of cardiology.
2005 Mar; 99(3):415-21. doi:
10.1016/j.ijcard.2004.03.004. [PMID: 15771922] - Hiroshi Sawada, Kenji Takami, Satoru Asahi. A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system.
Toxicological sciences : an official journal of the Society of Toxicology.
2005 Feb; 83(2):282-92. doi:
10.1093/toxsci/kfh264. [PMID: 15342952] - Naoko Kimura, Masahiro Okuda, Ken-ichi Inui. Metformin transport by renal basolateral organic cation transporter hOCT2.
Pharmaceutical research.
2005 Feb; 22(2):255-9. doi:
10.1007/s11095-004-1193-3. [PMID: 15783073] - Shufeng Zhou, Eli Chan, Wei Duan, Min Huang, Yu-Zong Chen. Drug bioactivation, covalent binding to target proteins and toxicity relevance.
Drug metabolism reviews.
2005; 37(1):41-213. doi:
10.1081/dmr-200028812. [PMID: 15747500] - P H Jones, K Christodoulos, N Dobbs, P Thavasu, F Balkwill, A D Blann, G J Caine, S Kumar, A J Kakkar, N Gompertz, D C Talbot, T S Ganesan, A L Harris. Combination antiangiogenesis therapy with marimastat, captopril and fragmin in patients with advanced cancer.
British journal of cancer.
2004 Jul; 91(1):30-6. doi:
10.1038/sj.bjc.6601897. [PMID: 15162145] - Guillaume Morissette, Emmanuel Moreau, René C-Gaudreault, François Marceau. Massive cell vacuolization induced by organic amines such as procainamide.
The Journal of pharmacology and experimental therapeutics.
2004 Jul; 310(1):395-406. doi:
10.1124/jpet.104.066084. [PMID: 15007104] - Inge D Wijnberg, F F T Ververs. Phenytoin sodium as a treatment for ventricular dysrhythmia in horses.
Journal of veterinary internal medicine.
2004 May; 18(3):350-3. doi:
10.1892/0891-6640(2004)18<350:psaatf>2.0.co;2. [PMID: 15188823] - Franco Lombardo, R Scott Obach, Marina Y Shalaeva, Feng Gao. Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Journal of medicinal chemistry.
2004 Feb; 47(5):1242-50. doi:
10.1021/jm030408h. [PMID: 14971904] - David N Bailey, John R Briggs. The effect of parenteral nutrition fluids on the binding of therapeutic drugs to human serum in vitro.
Therapeutic drug monitoring.
2004 Feb; 26(1):31-4. doi:
10.1097/00007691-200402000-00007. [PMID: 14749546] - René Severijnen, Nazila Bayat, Hans Bakker, Jules Tolboom, Ger Bongaerts. Enteral drug absorption in patients with short small bowel : a review.
Clinical pharmacokinetics.
2004; 43(14):951-62. doi:
10.2165/00003088-200443140-00001. [PMID: 15530127] - Maria Koufaki, Theodora Calogeropoulou, Eleni Rekka, Michael Chryselis, Panagiota Papazafiri, Catherine Gaitanaki, Alexandros Makriyannis. Bifunctional agents for reperfusion arrhythmias: novel hybrid vitamin E/class I antiarrhythmics.
Bioorganic & medicinal chemistry.
2003 Nov; 11(23):5209-19. doi:
10.1016/j.bmc.2003.08.010. [PMID: 14604685] - John M Ridley, James T Milnes, Andrew V Benest, Joe D Masters, Harry J Witchel, Jules C Hancox. Characterisation of recombinant HERG K+ channel blockade by the Class Ia antiarrhythmic drug procainamide.
Biochemical and biophysical research communications.
2003 Jun; 306(2):388-93. doi:
10.1016/s0006-291x(03)00980-x. [PMID: 12804575] - Shinji Fukui, Hiroshi Katoh, Nobusuke Tsuzuki, Shoichiro Ishihara, Naoki Otani, Hidetoshi Ooigawa, Terushige Toyooka, Akira Ohnuki, Takahito Miyazawa, Hiroshi Nawashiro, Katsuji Shima. Multivariate analysis of risk factors for QT prolongation following subarachnoid hemorrhage.
Critical care (London, England).
2003 Jun; 7(3):R7-R12. doi:
10.1186/cc2160. [PMID: 12793884] - Sandra R Knowles, Lori E Shapiro, Neil H Shear. Reactive metabolites and adverse drug reactions: clinical considerations.
Clinical reviews in allergy & immunology.
2003 Jun; 24(3):229-38. doi:
10.1385/criai:24:3:229. [PMID: 12721394] - Ludmiła Weglarz, Aneta Koceva-Chyła, Krzysztof Gwoździński, Zofia Dzierzewicz, Zofia Jóźwiak. Evaluation of hydralazine and procainamide effects on fibroblast membrane fluidity.
Biochimie.
2003 May; 85(5):549-56. doi:
10.1016/s0300-9084(03)00033-6. [PMID: 12763314] - K Bachmann, J Byers, R Ghosh. Prediction of in vivo hepatic clearance from in vitro data using cryopreserved human hepatocytes.
Xenobiotica; the fate of foreign compounds in biological systems.
2003 May; 33(5):475-83. doi:
10.1080/0049825031000076177. [PMID: 12746104] - François Hélie, Alain Vinet, René Cardinal. Spatiotemporal dynamics of reentrant ventricular tachycardias in canine myocardial infarction: pharmacological modulation.
Canadian journal of physiology and pharmacology.
2003 May; 81(5):413-22. doi:
10.1139/y03-040. [PMID: 12774847] - Dallas Bednarczyk, Sean Ekins, James H Wikel, Stephen H Wright. Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1.
Molecular pharmacology.
2003 Mar; 63(3):489-98. doi:
10.1124/mol.63.3.489. [PMID: 12606755] - Norbert Iost, László Virág, András Varró, Julius Gy Papp. Comparison of the effect of class IA antiarrhythmic drugs on transmembrane potassium currents in rabbit ventricular myocytes.
Journal of cardiovascular pharmacology and therapeutics.
2003 Mar; 8(1):31-41. doi:
10.1177/107424840300800i106. [PMID: 12652328] - Maria O Vannozzi, Massimo Ottone, Maria A Mariggiò, Sergio Cafaggi, Brunella Parodi, Michele Cilli, Edward Lindup, Maurizio Viale. Pharmacokinetic and pharmacodynamic analysis of platinum after combined treatment of cisplatin and procainamide hydrochloride in mice bearing P388 leukemia.
Anticancer research.
2003 Mar; 23(2B):1509-16. doi:
NULL. [PMID: 12820417] - Ralf Stahlmann, Hartmut Lode. Fluoroquinolones in the elderly: safety considerations.
Drugs & aging.
2003; 20(4):289-302. doi:
10.2165/00002512-200320040-00005. [PMID: 12641485] - Kerry B Goralski, Ganlu Lou, Matthew T Prowse, Valentin Gorboulev, Christopher Volk, Hermann Koepsell, Daniel S Sitar. The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules.
The Journal of pharmacology and experimental therapeutics.
2002 Dec; 303(3):959-68. doi:
10.1124/jpet.102.038885. [PMID: 12438515] - Fei Li, Zhaojun Han. Purification and characterization of acetylcholinesterase from cotton aphid (Aphis gossypii Glover).
Archives of insect biochemistry and physiology.
2002 Sep; 51(1):37-45. doi:
10.1002/arch.10048. [PMID: 12210959] - Toshihiro Kitahashi, Itaru Furuta. Quantification of pilsicainide in serum by capillary electrophoresis.
Journal of pharmaceutical and biomedical analysis.
2002 Jul; 29(4):625-9. doi:
10.1016/s0731-7085(02)00077-8. [PMID: 12093491] - Yumiko Urakami, Maiko Akazawa, Hideyuki Saito, Masahiro Okuda, Ken-Ichi Inui. cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney.
Journal of the American Society of Nephrology : JASN.
2002 Jul; 13(7):1703-10. doi:
10.1097/01.asn.0000019413.78751.46. [PMID: 12089365] - Franco Lombardo, R Scott Obach, Marina Y Shalaeva, Feng Gao. Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Journal of medicinal chemistry.
2002 Jun; 45(13):2867-76. doi:
10.1021/jm0200409. [PMID: 12061889] - Michael R Ujhelyi, Kelly Z Hadsall, David E Euler, Rahul Mehra. Intrapericardial therapeutics: a pharmacodynamic and pharmacokinetic comparison between pericardial and intravenous procainamide delivery.
Journal of cardiovascular electrophysiology.
2002 Jun; 13(6):605-11. doi:
10.1046/j.1540-8167.2002.00605.x. [PMID: 12108506]
