dantrolene (BioDeep_00000413098)

   


代谢物信息卡片


Dantrolenum; Dantrium; Dantrolenum

化学式: C14H10N4O5 (314.065117)
中文名称: 旦著能
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(=O)NC(=O)N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-]
InChI: InChI=1S/C14H10N4O5/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22/h1-7H,8H2,(H,16,19,20)

描述信息

M - Musculo-skeletal system > M03 - Muscle relaxants > M03C - Muscle relaxants, directly acting agents > M03CA - Dantrolene and derivatives
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents
D002491 - Central Nervous System Agents
CONFIDENCE standard compound; INTERNAL_ID 992; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3945; ORIGINAL_PRECURSOR_SCAN_NO 3940
CONFIDENCE standard compound; INTERNAL_ID 992; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3956; ORIGINAL_PRECURSOR_SCAN_NO 3954
CONFIDENCE standard compound; INTERNAL_ID 992; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3932; ORIGINAL_PRECURSOR_SCAN_NO 3929
CONFIDENCE standard compound; INTERNAL_ID 992; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3942; ORIGINAL_PRECURSOR_SCAN_NO 3939
CONFIDENCE standard compound; INTERNAL_ID 992; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3694; ORIGINAL_PRECURSOR_SCAN_NO 3692
CONFIDENCE standard compound; INTERNAL_ID 992; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3687; ORIGINAL_PRECURSOR_SCAN_NO 3685

同义名列表

2 个代谢物同义名

Dantrolenum; Dantrium; Dantrolenum; dantrolene



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kafa Walweel, Nicole Beard, Dirk F van Helden, Derek R Laver. Dantrolene inhibition of ryanodine channels (RyR2) in artificial lipid bilayers depends on FKBP12.6. The Journal of general physiology. 2023 08; 155(8):. doi: 10.1085/jgp.202213277. [PMID: 37279522]
  • Tomohito Mizuno, Riku Takahashi, Takahiro Kamiyama, Atsushi Suzuki, Masashi Suzuki. Neuroleptic Malignant Syndrome with Adrenal Insufficiency After BNT162b2 COVID-19 Vaccination in a Man Taking Valproate: A Case Report. The American journal of case reports. 2022 May; 23(?):e936217. doi: 10.12659/ajcr.936217. [PMID: 35514081]
  • Damien Abreu, Stephen I Stone, Toni S Pearson, Robert C Bucelli, Ashley N Simpson, Stacy Hurst, Cris M Brown, Kelly Kries, Chinyere Onwumere, Hongjie Gu, James Hoekel, Lawrence Tychsen, Gregory P Van Stavern, Neil H White, Bess A Marshall, Tamara Hershey, Fumihiko Urano. A phase Ib/IIa clinical trial of dantrolene sodium in patients with Wolfram syndrome. JCI insight. 2021 08; 6(15):. doi: 10.1172/jci.insight.145188. [PMID: 34185708]
  • Mohammed Salem Rizk, Maha Sultan, Dalia Mohamed, Rehab MoussaTony. Simultaneous determination of dantrolene and paracetamol in human plasma by liquid chromatography tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 Aug; 1179(?):122816. doi: 10.1016/j.jchromb.2021.122816. [PMID: 34329892]
  • Beatriz Prieto-Moure, Dolores Cejalvo-Lapeña, Mariola Belda-Antolí, Carolina Padrón-Sanz, José Miguel Lloris-Cejalvo, José Miguel Lloris-Carsí. Combination Therapy of Allopurinol and Dantrolene and Its Role In The Prevention of Experimental Ischemia Reperfusion Injury Of The Small Intestine. Journal of investigative surgery : the official journal of the Academy of Surgical Research. 2021 Jul; 34(7):800-807. doi: 10.1080/08941939.2019.1696904. [PMID: 31906750]
  • BaRun Kim, Renato Molina, Gabrielle Jensen, Damon Poburko. A differentiated Ca2+ signalling phenotype has minimal impact on myocardin expression in an automated differentiation assay using A7r5 cells. Cell calcium. 2021 06; 96(?):102369. doi: 10.1016/j.ceca.2021.102369. [PMID: 33677175]
  • Natsumi Miyazaki, Takayuki Kobayashi, Takako Komiya, Toshio Okada, Yusuke Ishida, Hidekimi Fukui, Yukihiko Ogihara, Hiroyuki Uchino. Postoperative malignant hyperthermia confirmed by calcium-induced calcium release rate after breast cancer surgery, in which prompt recognition and immediate dantrolene administration were life-saving: a case report. Journal of medical case reports. 2021 Apr; 15(1):201. doi: 10.1186/s13256-021-02681-0. [PMID: 33863374]
  • H Wei, G Liang, R M Vera. Dantrolene repurposed to treat sepsis or septic shock and COVID-19 patients. European review for medical and pharmacological sciences. 2021 04; 25(7):3136-3144. doi: 10.26355/eurrev_202104_25569. [PMID: 33877683]
  • Nobutaka Chiba, Masakazu Matsuzaki, Takayuki Mawatari, Minori Mizuochi, Atsushi Sakurai, Kosaku Kinoshita. Beneficial effects of dantrolene in the treatment of rhabdomyolysis as a potential late complication associated with COVID-19: a case report. European journal of medical research. 2021 Feb; 26(1):18. doi: 10.1186/s40001-021-00489-8. [PMID: 33557936]
  • Kennedy Aldrich, Deborah Velez-Irizarry, Clara Fenger, Melissa Schott, Stephanie J Valberg. Pathways of calcium regulation, electron transport, and mitochondrial protein translation are molecular signatures of susceptibility to recurrent exertional rhabdomyolysis in Thoroughbred racehorses. PloS one. 2021; 16(2):e0244556. doi: 10.1371/journal.pone.0244556. [PMID: 33566847]
  • Sherin Zakaria, Abeer Ansary, Nabil M Abdel-Hamid, Mamdouh M El-Shishtawy. Dantrolene Potentiates the Antineoplastic Effect of Sorafenib in Hepatocellular Carcinoma via Targeting Ca+2/PI3K Signaling Pathway. Current molecular pharmacology. 2021; 14(5):900-913. doi: 10.2174/1874467214666210126110627. [PMID: 33573585]
  • Monica Aleman, Rui Zhang, Wei Feng, Lihong Qi, Jose R Lopez, Chelsea Crowe, Yao Dong, Genady Cherednichenko, Isaac N Pessah. Dietary Caffeine Synergizes Adverse Peripheral and Central Responses to Anesthesia in Malignant Hyperthermia Susceptible Mice. Molecular pharmacology. 2020 10; 98(4):351-363. doi: 10.1124/mol.120.119412. [PMID: 32764093]
  • B Jiang, S Liang, G Liang, H Wei. Could dantrolene be explored as a repurposed drug to treat COVID-19 patients by restoring intracellular calcium homeostasis?. European review for medical and pharmacological sciences. 2020 10; 24(19):10228-10238. doi: 10.26355/eurrev_202010_23247. [PMID: 33090434]
  • Raahil Kajani, Austin Apramian, Arturo Vega, Nitin Ubhayakar, Prissilla Xu, Antonio Liu. Neuroleptic malignant syndrome in a COVID-19 patient. Brain, behavior, and immunity. 2020 08; 88(?):28-29. doi: 10.1016/j.bbi.2020.05.042. [PMID: 32425332]
  • A Ashna, D F van Helden, C Dos Remedios, P Molenaar, D R Laver. Phenytoin Reduces Activity of Cardiac Ryanodine Receptor 2; A Potential Mechanism for Its Cardioprotective Action. Molecular pharmacology. 2020 04; 97(4):250-258. doi: 10.1124/mol.119.117721. [PMID: 32015008]
  • Jintao Wang, Yun Shi, Shuchun Yu, Yan Wang, Qingcheng Meng, Ge Liang, Maryellen F Eckenhoff, Huafeng Wei. Intranasal administration of dantrolene increased brain concentration and duration. PloS one. 2020; 15(3):e0229156. doi: 10.1371/journal.pone.0229156. [PMID: 32160210]
  • Yun Shi, Lei Zhang, Xue Gao, Jing Zhang, Matan Ben Abou, Ge Liang, Qingcheng Meng, Adrian Hepner, Maryellen F Eckenhoff, Huafeng Wei. Intranasal Dantrolene as a Disease-Modifying Drug in Alzheimer 5XFAD Mice. Journal of Alzheimer's disease : JAD. 2020; 76(4):1375-1389. doi: 10.3233/jad-200227. [PMID: 32623395]
  • Ibrahim Keles, Mehmet Fatih Bozkurt, Erdogan Aglamis, Abdurrahman Fatih Fidan, Cavit Ceylan, Mustafa Karalar, Soner Coban, Baris Denk, Mehmet Emin Buyukokuroglu. Protective effects of dantrolene and methylprednisolone against spinal cord injury-induced early oxidative damage in rabbit bladder: A comparative experimental study. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2019 Dec; 28(12):1697-1704. doi: 10.17219/acem/110326. [PMID: 31851793]
  • Peng Zhao, Xiu-Min Liu, Qian-Chuang Sun, Yun-Feng Cui. Overactivation of the sodium-calcium exchanger and transient receptor potential in anesthesia-induced malignant hyperthermia. IUBMB life. 2019 12; 71(12):2048-2054. doi: 10.1002/iub.2138. [PMID: 31381266]
  • Ruixue Liu, Yu Chen, Shen Zhao, Min Zhao, Chunjie Zhao, Miao Wang. Determination and tissue distribution studies of dantrolene sodium with hydroxypropyl-β-cyclodextrin in rat tissue by HPLC/MS/MS. Biomedical chromatography : BMC. 2019 Oct; 33(10):e4616. doi: 10.1002/bmc.4616. [PMID: 31166607]
  • Yan Zhang, Ronghua Zhou. Almost-certain malignant hyperthermia during cardiopulmonary bypass: a case report and literature review. Perfusion. 2019 09; 34(6):490-494. doi: 10.1177/0267659119833230. [PMID: 30843472]
  • Michael T Kuntz, Amanda D Saab. Presumed Malignant Hyperthermia Treated During Cardiopulmonary Bypass in a Pediatric Patient Undergoing Aortic Valve Replacement: A Case Report. A&A practice. 2019 Apr; 12(7):246-248. doi: 10.1213/xaa.0000000000000902. [PMID: 30299295]
  • Saki Manabe, Hidetaka Yanagi, Hideki Ozawa, Atsushi Takagi. Neuroleptic malignant syndrome as part of an akinetic crisis associated with sepsis in a patient with Lewy body disease. BMJ case reports. 2019 Feb; 12(2):. doi: 10.1136/bcr-2018-227216. [PMID: 30824461]
  • Marwa Aa Ragab, Mohamed A Korany, Shereen M Galal, Aya R Ahmed. Voltammetric analysis of dantrolene and its active metabolite with indomethacin in rat plasma. Bioanalysis. 2019 Jan; 11(2):73-84. doi: 10.4155/bio-2018-0165. [PMID: 30539646]
  • Kathleen A Trychta, Susanne Bäck, Mark J Henderson, Brandon K Harvey. KDEL Receptors Are Differentially Regulated to Maintain the ER Proteome under Calcium Deficiency. Cell reports. 2018 11; 25(7):1829-1840.e6. doi: 10.1016/j.celrep.2018.10.055. [PMID: 30428351]
  • Anthony L Ashley. TREATMENT OF SUSPECTED EXERTIONAL MYOPATHY USING DANTROLENE IN A COYOTE ( CANIS LATRANS). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2018 Jun; 49(2):508-510. doi: 10.1638/2017-0225.1. [PMID: 29900791]
  • D Helf, D Schneiderbanger, C K Markus, S Johannsen, F Schuster. [Abortive course of malignant hyperthermia following preclinical induction of general anesthesia using succinylcholine]. Der Anaesthesist. 2018 04; 67(4):275-279. doi: 10.1007/s00101-018-0419-4. [PMID: 29480319]
  • Gregory D Bowden, Kirkwood M Land, Roberta M O'Connor, Heather M Fritz. High-throughput screen of drug repurposing library identifies inhibitors of Sarcocystis neurona growth. International journal for parasitology. Drugs and drug resistance. 2018 04; 8(1):137-144. doi: 10.1016/j.ijpddr.2018.02.002. [PMID: 29547840]
  • Atsushi Kambayashi, Jennifer B Dressman. Forecasting gastrointestinal precipitation and oral pharmacokinetics of dantrolene in dogs using an in vitro precipitation testing coupled with in silico modeling and simulation. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2017 Oct; 119(?):107-113. doi: 10.1016/j.ejpb.2017.06.012. [PMID: 28619610]
  • Birgitta C Burckhardt, Maja Henjakovic, Yohannes Hagos, Gerhard Burckhardt. Differential Interaction of Dantrolene, Glafenine, Nalidixic Acid, and Prazosin with Human Organic Anion Transporters 1 and 3. The Journal of pharmacology and experimental therapeutics. 2017 09; 362(3):450-458. doi: 10.1124/jpet.117.241406. [PMID: 28630284]
  • NULL. JSA guideline for the management of malignant hyperthermia crisis 2016. Journal of anesthesia. 2017 Apr; 31(2):307-317. doi: 10.1007/s00540-016-2305-z. [PMID: 28246924]
  • A Kollmann-Camaiora, E Alsina, A Domínguez, B Del Blanco, M J Yepes, J L Guerrero, A García. Clinical protocol for the management of malignant hyperthermia. Revista espanola de anestesiologia y reanimacion. 2017 Jan; 64(1):32-40. doi: 10.1016/j.redar.2016.06.004. [PMID: 27633384]
  • Lygia M Malvestio, Mara Rúbia N Celes, Linda A Jelicks, Herbert B Tanowitz, Cibele M Prado. Dantrolene improves in vitro structural changes induced by serum from Trypanosoma cruzi-infected mice. Parasitology research. 2017 Jan; 116(1):429-433. doi: 10.1007/s00436-016-5281-1. [PMID: 27730362]
  • Birgitta C Burckhardt, Maja Henjakovic, Yohannes Hagos, Gerhard Burckhardt. Counter-flow suggests transport of dantrolene and 5-OH dantrolene by the organic anion transporters 2 (OAT2) and 3 (OAT3). Pflugers Archiv : European journal of physiology. 2016 11; 468(11-12):1909-1918. doi: 10.1007/s00424-016-1894-6. [PMID: 27812757]
  • Ye Win Oo, Nieves Gomez-Hurtado, Kafa Walweel, Dirk F van Helden, Mohammad S Imtiaz, Bjorn C Knollmann, Derek R Laver. Essential Role of Calmodulin in RyR Inhibition by Dantrolene. Molecular pharmacology. 2015 Jul; 88(1):57-63. doi: 10.1124/mol.115.097691. [PMID: 25920678]
  • Noriko Kaifuchi, Yuji Omiya, Hirotaka Kushida, Miwako Fukutake, Hiroaki Nishimura, Yoshio Kase. Effects of shakuyakukanzoto and its absorbed components on twitch contractions induced by physiological Ca2+ release in rat skeletal muscle. Journal of natural medicines. 2015 Jul; 69(3):287-95. doi: 10.1007/s11418-015-0890-z. [PMID: 25783410]
  • Erica C McKenzie, Stefano Di Concetto, Mark E Payton, Ronald E Mandsager, Matevz Arko. Effect of dantrolene premedication on various cardiovascular and biochemical variables and the recovery in healthy isoflurane-anesthetized horses. American journal of veterinary research. 2015 Apr; 76(4):293-301. doi: 10.2460/ajvr.76.4.293. [PMID: 25815570]
  • C I N'Da, A Petzer, J P Petzer. The inhibition of acetylcholinesterase by dantrolene and ondansetron. Drug research. 2015 Jan; 65(1):46-51. doi: 10.1055/s-0034-1372612. [PMID: 24764253]
  • Liyue Huang, Xingwen Li, Jonathan Roberts, Brett Janosky, Min-Hwa Jasmine Lin. Differential role of P-glycoprotein and breast cancer resistance protein in drug distribution into brain, CSF and peripheral nerve tissues in rats. Xenobiotica; the fate of foreign compounds in biological systems. 2015; 45(6):547-55. doi: 10.3109/00498254.2014.997324. [PMID: 25539457]
  • Simin Lu, Kohsuke Kanekura, Takashi Hara, Jana Mahadevan, Larry D Spears, Christine M Oslowski, Rita Martinez, Mayu Yamazaki-Inoue, Masashi Toyoda, Amber Neilson, Patrick Blanner, Cris M Brown, Clay F Semenkovich, Bess A Marshall, Tamara Hershey, Akihiro Umezawa, Peter A Greer, Fumihiko Urano. A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome. Proceedings of the National Academy of Sciences of the United States of America. 2014 Dec; 111(49):E5292-301. doi: 10.1073/pnas.1421055111. [PMID: 25422446]
  • Meng-Liang Lin, Shih-Shun Chen, Ren-Yu Huang, Yao-Cheng Lu, Yu-Ren Liao, Mopuru Vijaya Bhaskar Reddy, Chuan-Chun Lee, Tian-Shung Wu. Suppression of PI3K/Akt signaling by synthetic bichalcone analog TSWU-CD4 induces ER stress- and Bax/Bak-mediated apoptosis of cancer cells. Apoptosis : an international journal on programmed cell death. 2014 Nov; 19(11):1637-53. doi: 10.1007/s10495-014-1031-y. [PMID: 25183449]
  • Holger Fuchs, Wataru Kishimoto, Dietmar Gansser, Paul Tanswell, Naoki Ishiguro. Brain penetration of WEB 2086 (Apafant) and dantrolene in Mdr1a (P-glycoprotein) and Bcrp knockout rats. Drug metabolism and disposition: the biological fate of chemicals. 2014 Oct; 42(10):1761-5. doi: 10.1124/dmd.114.058545. [PMID: 25053619]
  • J L Haraschak, V C Langston, R Wang, C Riggs, C Fellman, M K Ross, C Bulla, K Lunsford, A Mackin, T Archer. Pharmacokinetic evaluation of oral dantrolene in the dog. Journal of veterinary pharmacology and therapeutics. 2014 Jun; 37(3):286-94. doi: 10.1111/jvp.12089. [PMID: 24219828]
  • Mayuko Uehara, Masami Inaoka, Yasuko Miyaki, Shinji Nakashima, Akira Fuzii, Tetsuya Higami. [Neuroleptic malignant syndrome after cardiac surgery]. Kyobu geka. The Japanese journal of thoracic surgery. 2013 Nov; 66(12):1052-5. doi: NULL. [PMID: 24322311]
  • Keiko K Lee, Yuji Omiya, Mitsutoshi Yuzurihara, Yoshio Kase, Hiroyuki Kobayashi. Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: role of the active constituents of Glycyrrhizae radix. Journal of ethnopharmacology. 2013 Jan; 145(1):286-93. doi: 10.1016/j.jep.2012.11.005. [PMID: 23164761]
  • R A Bannister. Dantrolene-induced inhibition of skeletal L-type Ca2+ current requires RyR1 expression. BioMed research international. 2013; 2013(?):390493. doi: 10.1155/2013/390493. [PMID: 23509717]
  • Mara R N Celes, Lygia M Malvestio, Sylvia O Suadicani, Cibele M Prado, Maria J Figueiredo, Erica C Campos, Ana C S Freitas, David C Spray, Herbert B Tanowitz, João S da Silva, Marcos A Rossi. Disruption of calcium homeostasis in cardiomyocytes underlies cardiac structural and functional changes in severe sepsis. PloS one. 2013; 8(7):e68809. doi: 10.1371/journal.pone.0068809. [PMID: 23935889]
  • Paul J Perry, Courtney A Wilborn. Serotonin syndrome vs neuroleptic malignant syndrome: a contrast of causes, diagnoses, and management. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists. 2012 May; 24(2):155-62. doi: . [PMID: 22563571]
  • Ya-ting Tina Yang, Matthew Whiteman, Steven P Gieseg. HOCl causes necrotic cell death in human monocyte derived macrophages through calcium dependent calpain activation. Biochimica et biophysica acta. 2012 Feb; 1823(2):420-9. doi: 10.1016/j.bbamcr.2011.09.019. [PMID: 22008466]
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  • Kazuna Sugiyama, Akina Toya, Kouta Shimomatsu, Yoko Saitoh, Yozo Manabe, Atsushi Kohjitani. [Case of fulminant-malignant hyperthermia occurring on sixth sevoflurane anesthesia]. Masui. The Japanese journal of anesthesiology. 2011 Jun; 60(6):703-5. doi: . [PMID: 21710767]
  • H K DiMaio Knych, R M Arthur, A Taylor, B C Moeller, S D Stanley. Pharmacokinetics and metabolism of dantrolene in horses. Journal of veterinary pharmacology and therapeutics. 2011 Jun; 34(3):238-46. doi: 10.1111/j.1365-2885.2010.01214.x. [PMID: 21492188]
  • Jan K Schütte, Sandra Becker, Sascha Burmester, Alexander Starosse, Daniel Lenz, Lars Kröner, Frank Wappler, Mark U Gerbershagen. Comparison of the therapeutic effectiveness of a dantrolene sodium solution and a novel nanocrystalline suspension of dantrolene sodium in malignant hyperthermia normal and susceptible pigs. European journal of anaesthesiology. 2011 Apr; 28(4):256-64. doi: . [PMID: 21513076]
  • E C McKenzie, R L Garrett, M E Payton, J H Riehl, A M Firshman, S J Valberg. Effect of feed restriction on plasma dantrolene concentrations in horses. Equine veterinary journal. Supplement. 2010 Nov; ?(38):613-7. doi: 10.1111/j.2042-3306.2010.00262.x. [PMID: 21059069]
  • Joshua A Boys, Alexander H Toledo, Roberto Anaya-Prado, Fernando Lopez-Neblina, Luis H Toledo-Pereyra. Effects of dantrolene on ischemia-reperfusion injury in animal models: a review of outcomes in heart, brain, liver, and kidney. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 2010 Oct; 58(7):875-82. doi: 10.231/jim.0b013e3181e5d719. [PMID: 20517166]
  • P Jason Toppin, Tony T Chandy, Anand Ghanekar, Natalia Kraeva, W Scott Beattie, Sheila Riazi. A report of fulminant malignant hyperthermia in a patient with a novel mutation of the CACNA1S gene. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 2010 Jul; 57(7):689-93. doi: 10.1007/s12630-010-9314-4. [PMID: 20431982]
  • Abrahim I Orabi, Ahsan U Shah, Mahwish U Ahmad, Rayman Choo-Wing, Jerome Parness, Dhanpat Jain, Vineet Bhandari, Sohail Z Husain. Dantrolene mitigates caerulein-induced pancreatitis in vivo in mice. American journal of physiology. Gastrointestinal and liver physiology. 2010 Jul; 299(1):G196-204. doi: 10.1152/ajpgi.00498.2009. [PMID: 20448143]
  • Hiroshi Kodaira, Hiroyuki Kusuhara, Junko Ushiki, Eiichi Fuse, Yuichi Sugiyama. Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone. The Journal of pharmacology and experimental therapeutics. 2010 Jun; 333(3):788-96. doi: 10.1124/jpet.109.162321. [PMID: 20304939]
  • Adem Aslan, Mustafa Cemek, Mehmet Emin Buyukokuroglu, Korhan Altunbas, Orhan Bas, Yusuf Yurumez, Murat Cosar. Dantrolene can reduce secondary damage after spinal cord injury. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. 2009 Oct; 18(10):1442-51. doi: 10.1007/s00586-009-1033-6. [PMID: 19468761]
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