Kynurenate (BioDeep_00000412666)

Main id: BioDeep_00000001106

 

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


1,4-Dihydro-4-oxoquinoline-2-carboxylic acid

化学式: C10H7NO3 (189.0426)
中文名称: 犬尿喹啉酸, 1,4-二氢-4-氧喹啉-2-羧酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C2C(=C1)C(=O)C=C(N2)C(=O)O
InChI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)

描述信息

D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists
Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.
Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.
Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.
Transtorine is a quinoline alkaloid, found from Ephedra transitoria, with antibacterial activity[1].
Transtorine is a quinoline alkaloid, found from Ephedra transitoria, with antibacterial activity[1].

同义名列表

63 个代谢物同义名

1,4-Dihydro-4-oxoquinoline-2-carboxylic acid; 2-Quinolinecarboxylic acid, 4-hydroxy-; 4-keto-1H-quinoline-2-carboxylic acid; 4-oxo-1H-quinoline-2-carboxylic acid; 4-Hydroxy-2-quinolinecarboxylic acid; 4-Hydroxyquinoline-2-carboxylic acid; Quinaldic acid, 4-hydroxy- (8CI); Quinaldic acid, 4-hydroxy-; 4-Hydroxyquinaldinic acid; 4-Hydroxyquinaldic acid; Spectrum5_001318; Spectrum3_001390; EINECS 207-751-5; Biomol-NT_000229; Spectrum4_000814; Spectrum2_001342; NCGC00024505-07; Spectrum_001116; NCGC00015581-01; SPECTRUM1500688; NCGC00024505-01; Quinurenic acid; NCGC00024505-04; NCGC00024505-03; Kynurenic acid; Kynuronic acid; Kinurenic acid; Lopac0_000716; KBioGR_001327; BPBio1_001350; DivK1c_000309; Oprea1_032085; BSPBio_002980; KBioSS_001596; Lopac-K-3375; PDSP2_000131; KBio2_004164; KBio3_002200; KBio2_006732; PDSP1_000132; KBio1_000309; NINDS_000309; SPBio_001523; KBio2_001596; SMP1_000172; K3375_SIGMA; Transtorine; CHEBI:18344; IDI1_000309; Tocris-0223; EU-0100716; UX00002048; Kynurenate; CCRIS 4428; 13593-94-7; NSC-58973; NSC 58973; SBB003671; 492-27-3; NSC58973; C01717; KYNA; 4-Hydroxy-2-quinolinecarboxylic acid



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(8)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

22 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 AHR, BDNF, CA3, DAO, HTT, IDO1, KYAT1, KYNU
Peripheral membrane protein 1 DAO
Endosome membrane 1 HTT
Nucleus 2 AHR, HTT
autophagosome 1 HTT
cytosol 8 AHR, CA3, DAO, HTT, IDO1, KMO, KYAT1, KYNU
dendrite 2 BDNF, HTT
nucleoplasm 3 AHR, HTT, KYNU
Cell membrane 6 DAO, GPR35, GPRC5A, GRID1, HTT, TNF
Multi-pass membrane protein 6 GPR35, GPRC5A, GRID1, HTT, KMO, SLC22A6
Synapse 1 HTT
cell surface 1 TNF
glutamatergic synapse 1 GRID1
Golgi apparatus 1 HTT
Golgi membrane 1 INS
neuronal cell body 1 TNF
presynaptic membrane 1 HTT
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 4 DAO, IDO1, KYAT1, KYNU
plasma membrane 8 DAO, GPR35, GPRC5A, GRID1, HTT, IFNLR1, SLC22A6, TNF
presynaptic active zone 1 DAO
Membrane 4 BDNF, IFNLR1, KMO, SLC22A6
axon 2 BDNF, HTT
basolateral plasma membrane 1 SLC22A6
caveola 1 SLC22A6
extracellular exosome 4 DAO, GPRC5A, GRID1, SLC22A6
endoplasmic reticulum 1 HTT
extracellular space 8 BDNF, CRP, DAO, IL10, IL6, INS, KMO, TNF
perinuclear region of cytoplasm 2 BDNF, HTT
bicellular tight junction 1 DAO
mitochondrion 4 AADAT, KMO, KYAT1, KYNU
protein-containing complex 3 AHR, HTT, SLC22A6
intracellular membrane-bounded organelle 1 GPRC5A
Single-pass type I membrane protein 1 IFNLR1
Secreted 6 BDNF, CRP, DAO, IL10, IL6, INS
extracellular region 7 BDNF, CRP, DAO, IL10, IL6, INS, TNF
Mitochondrion outer membrane 1 KMO
mitochondrial outer membrane 1 KMO
mitochondrial matrix 1 AADAT
Extracellular side 1 DAO
transcription regulator complex 1 AHR
external side of plasma membrane 1 TNF
nucleolus 1 GPRC5A
Early endosome 1 HTT
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 GPRC5A
postsynaptic membrane 2 GRID1, HTT
Membrane raft 2 HTT, TNF
Cell junction, focal adhesion 1 HTT
focal adhesion 1 HTT
GABA-ergic synapse 1 GRID1
Peroxisome 1 DAO
Peroxisome matrix 1 DAO
peroxisomal matrix 1 DAO
Postsynaptic cell membrane 1 GRID1
Late endosome 1 HTT
receptor complex 1 GPRC5A
Cell projection, neuron projection 1 HTT
neuron projection 1 HTT
chromatin 1 AHR
stereocilium bundle 1 IDO1
cell projection 1 DAO
phagocytic cup 1 TNF
centriole 1 HTT
Secreted, extracellular space 1 DAO
Basolateral cell membrane 1 SLC22A6
Endomembrane system 1 HTT
endosome lumen 1 INS
aryl hydrocarbon receptor complex 1 AHR
Cytoplasmic vesicle membrane 2 GPRC5A, HTT
basal plasma membrane 1 SLC22A6
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 BDNF, IL6, INS
specific granule lumen 1 DAO
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 GRID1
Basal cell membrane 1 SLC22A6
postsynaptic cytosol 1 HTT
presynaptic cytosol 1 HTT
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
inclusion body 1 HTT
interleukin-6 receptor complex 1 IL6
smooth muscle contractile fiber 1 IDO1
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
nuclear aryl hydrocarbon receptor complex 1 AHR
serotonergic synapse 1 HTT
cytosolic aryl hydrocarbon receptor complex 1 AHR
[Huntingtin]: Cytoplasm 1 HTT
[Huntingtin, myristoylated N-terminal fragment]: Cytoplasmic vesicle, autophagosome 1 HTT
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Magdalena Wróbel-Kwiatkowska, Waldemar Turski, Grażyna Silska, Magdalena Rakicka-Pustułka, Lucyna Dymińska, Waldemar Rymowicz. Determination of Bioactive Compound Kynurenic Acid in Linum usitatissimum L. Molecules (Basel, Switzerland). 2024 Apr; 29(8):. doi: 10.3390/molecules29081702. [PMID: 38675522]
  • Ádám Juhász, Ditta Ungor, Norbert Varga, Gábor Katona, György T Balogh, Edit Csapó. Lipid-Based Nanocarriers for Delivery of Neuroprotective Kynurenic Acid: Preparation, Characterization, and BBB Transport. International journal of molecular sciences. 2023 Sep; 24(18):. doi: 10.3390/ijms241814251. [PMID: 37762551]
  • Xiaoli Qi, Keyi Fu, Mingyuan Yue, Na Shou, Xuefeng Yuan, Xi Chen, Chunyu He, Yunfeng Yang, Zunji Shi. Kynurenic acid mediates bacteria-algae consortium in resisting environmental cadmium toxicity. Journal of hazardous materials. 2023 02; 444(Pt A):130397. doi: 10.1016/j.jhazmat.2022.130397. [PMID: 36403444]
  • Magdalena Matusiewicz, Magdalena Wróbel-Kwiatkowska, Tomasz Niemiec, Wiesław Świderek, Iwona Kosieradzka, Aleksandra Rosińska, Anna Niwińska, Magdalena Rakicka-Pustułka, Tomasz Kocki, Waldemar Rymowicz, Waldemar A Turski. Effect of Yarrowia lipolytica yeast biomass with increased kynurenic acid content on selected metabolic indicators in mice. PeerJ. 2023; 11(?):e15833. doi: 10.7717/peerj.15833. [PMID: 37780388]
  • Yanmei Chen, Jiahui Zhang, Yueying Yang, Ke Xiang, Hua Li, Dejuan Sun, Lixia Chen. Kynurenine-3-monooxygenase (KMO): From its biological functions to therapeutic effect in diseases progression. Journal of cellular physiology. 2022 12; 237(12):4339-4355. doi: 10.1002/jcp.30876. [PMID: 36088660]
  • Yanpo Si, Wenjun Wei, Xiaohui Chen, Xiaolong Xie, Tao Guo, Yohei Sasaki, Youbo Zhang, Lili Wang, Fei Zhang, Shuying Feng. A comprehensive study on the relieving effect of Lilium brownii on the intestinal flora and metabolic disorder in p-chlorphenylalanine induced insomnia rats. Pharmaceutical biology. 2022 Dec; 60(1):131-143. doi: 10.1080/13880209.2021.2019283. [PMID: 34978949]
  • Liying Cheng, Liming Wang, Biying Chen, Chenxi Wang, Mengxi Wang, Jie Li, Xiumei Gao, Zhu Zhang, Lifeng Han. A multiple-metabolites model to predict preliminary renal injury induced by iodixanol based on UHPLC/Q-Orbitrap-MS and 1H-NMR. Metabolomics : Official journal of the Metabolomic Society. 2022 10; 18(11):85. doi: 10.1007/s11306-022-01942-3. [PMID: 36307737]
  • Melike Kucukkarapinar, Aysegul Yay-Pence, Yesim Yildiz, Merve Buyukkoruk, Gizem Yaz-Aydin, Tuba S Deveci-Bulut, Ozlem Gulbahar, Esin Senol, Selcuk Candansayar. Psychological outcomes of COVID-19 survivors at sixth months after diagnose: the role of kynurenine pathway metabolites in depression, anxiety, and stress. Journal of neural transmission (Vienna, Austria : 1996). 2022 08; 129(8):1077-1089. doi: 10.1007/s00702-022-02525-1. [PMID: 35796878]
  • Petra Majerova, Dominika Olesova, Greta Golisova, Martina Buralova, Alena Michalicova, Jozef Vegh, Juraj Piestansky, Mangesh Bhide, Jozef Hanes, Andrej Kovac. Analog of kynurenic acid decreases tau pathology by modulating astrogliosis in rat model for tauopathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Aug; 152(?):113257. doi: 10.1016/j.biopha.2022.113257. [PMID: 35714514]
  • Wenhua Ding, Fengchun Wu, Sumiao Zhou, Hehua Li, Runhua Wang, Yuping Ning. Increased plasma level of kynurenic acid in drug-free patients with first-episode schizophrenia compared to patients with chronic schizophrenia and healthy controls: preliminary data. Nordic journal of psychiatry. 2022 Aug; 76(6):451-456. doi: 10.1080/08039488.2021.1992647. [PMID: 34928781]
  • Duygu Eryavuz Onmaz, Dilek Tezcan, Sedat Abusoglu, Abdullah Sivrikaya, Menekse Kuzu, Fatma Humeyra Yerlikaya, Sema Yilmaz, Ali Unlu. Elevated serum levels of kynurenine pathway metabolites in patients with Behçet disease. Amino acids. 2022 Jun; 54(6):877-887. doi: 10.1007/s00726-022-03170-4. [PMID: 35604497]
  • Huan Wang, Jian Li, Zheng Wang, Yanfeng Tian, Chunlei Li, Feng Jin, Jia Li, Lanfeng Wang. Perivascular brown adipocytes-derived kynurenic acid relaxes blood vessel via endothelium PI3K-Akt-eNOS pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):113040. doi: 10.1016/j.biopha.2022.113040. [PMID: 35658210]
  • Ebru Nur Ay, Şeyda Demirkol, Mehmet Tolgahan Hakan, Cem Horozoğlu, Soykan Arıkan, Mehmet Baki Doğan, Filiz Akyüz, Ceylan Özsoy Hepokur, İlhan Yaylım. Investigation of possible associations between tryptophan/kynurenine status and FOXP3 expression in colorectal cancer. Scandinavian journal of clinical and laboratory investigation. 2022 05; 82(3):185-191. doi: 10.1080/00365513.2022.2040050. [PMID: 35452343]
  • Johann Steiner, Henrik Dobrowolny, Paul C Guest, Hans-Gert Bernstein, Dietmar Fuchs, Julien Roeser, Paul Summergrad, Gregory Oxenkrug. Gender-specific elevation of plasma anthranilic acid in schizophrenia: Protection against glutamatergic hypofunction?. Schizophrenia research. 2022 05; 243(?):483-485. doi: 10.1016/j.schres.2022.01.048. [PMID: 35151533]
  • Qiufen Li, Hua Zhou, Jingxin Ouyang, Shuaipeng Guo, Jun Zheng, Guanhong Li. Effects of dietary tryptophan supplementation on body temperature, hormone, and cytokine levels in broilers exposed to acute heat stress. Tropical animal health and production. 2022 Apr; 54(3):164. doi: 10.1007/s11250-022-03161-3. [PMID: 35435494]
  • Fabiana Russo, Francesco Tolomeo, Maria Angela Vandelli, Giuseppe Biagini, Roberta Paris, Flavia Fulvio, Aldo Laganà, Anna Laura Capriotti, Luigi Carbone, Giuseppe Gigli, Giuseppe Cannazza, Cinzia Citti. Kynurenine and kynurenic acid: Two human neuromodulators found in Cannabis sativa L. Journal of pharmaceutical and biomedical analysis. 2022 Mar; 211(?):114636. doi: 10.1016/j.jpba.2022.114636. [PMID: 35124451]
  • Murat Cihan, Özlem Doğan, Ceyhan Ceran Serdar, Arzu Altunçekiç Yıldırım, Celali Kurt, Muhittin A Serdar. Kynurenine pathway in Coronavirus disease (COVID-19): Potential role in prognosis. Journal of clinical laboratory analysis. 2022 Mar; 36(3):e24257. doi: 10.1002/jcla.24257. [PMID: 35092710]
  • Elisabeth R Paul, Lilly Schwieler, Sophie Erhardt, Sandra Boda, Ada Trepci, Robin Kämpe, Anna Asratian, Lovisa Holm, Adam Yngve, Robert Dantzer, Markus Heilig, J Paul Hamilton, Martin Samuelsson. Peripheral and central kynurenine pathway abnormalities in major depression. Brain, behavior, and immunity. 2022 03; 101(?):136-145. doi: 10.1016/j.bbi.2022.01.002. [PMID: 34999196]
  • Mary Kimmel, Wanting Jin, Kai Xia, Kun Lun, Andrea Azcarate-Peril, Anna Plantinga, Michael Wu, Shirin Ataei, Hannah Rackers, Ian Carroll, Samantha Meltzer-Brody, Emma Fransson, Rebecca Knickmeyer. Metabolite trajectories across the perinatal period and mental health: A preliminary study of tryptophan-related metabolites, bile acids and microbial composition. Behavioural brain research. 2022 02; 418(?):113635. doi: 10.1016/j.bbr.2021.113635. [PMID: 34755640]
  • Zhuowei Shen, Haihong Hu, Jie Pan, Mingcheng Xu, Fengting Ou, Kaifeng He, Kui Zeng, Jianbiao Yao, Ruwei Wang, Yan Lou, Su Zeng. Pharmacokinetics and brain distribution studies of 6-hydroxykynurenic acid and its structural modified compounds. The Journal of pharmacy and pharmacology. 2022 Jan; 74(1):22-31. doi: 10.1093/jpp/rgab132. [PMID: 34586411]
  • Kaat Hebbrecht, Manuel Morrens, Erik J Giltay, Alexander L N van Nuijs, Bernard Sabbe, Seline van den Ameele. The Role of Kynurenines in Cognitive Dysfunction in Bipolar Disorder. Neuropsychobiology. 2022; 81(3):184-191. doi: 10.1159/000520152. [PMID: 34883494]
  • Siyu Wang, Liangshan Mu, Chunmei Zhang, Xiaoyu Long, Yurong Zhang, Rong Li, Yue Zhao, Jie Qiao. Abnormal Activation of Tryptophan-Kynurenine Pathway in Women With Polycystic Ovary Syndrome. Frontiers in endocrinology. 2022; 13(?):877807. doi: 10.3389/fendo.2022.877807. [PMID: 35721725]
  • Mary I Butler, Caitriona Long-Smith, Gerard M Moloney, Sabrina Morkl, Siobhain M O'Mahony, John F Cryan, Gerard Clarke, Timothy G Dinan. The immune-kynurenine pathway in social anxiety disorder. Brain, behavior, and immunity. 2022 01; 99(?):317-326. doi: 10.1016/j.bbi.2021.10.020. [PMID: 34758380]
  • Katinka Nordheim Alme, Arve Ulvik, Torunn Askim, Jörg Assmus, Tom Eirik Mollnes, Mala Naik, Halvor Næss, Ingvild Saltvedt, Per-Magne Ueland, Anne-Brita Knapskog. Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke. BMC neurology. 2021 Dec; 21(1):476. doi: 10.1186/s12883-021-02498-w. [PMID: 34879833]
  • Jennifer Tang, Hong Shen, Xiaofeng Zhao, Vinay K Holenarsipur, T Thanga Mariappan, Yueping Zhang, Erika Panfen, Jim Zheng, W Griffith Humphreys, Yurong Lai. Endogenous Plasma Kynurenic Acid in Human: A Newly Discovered Biomarker for Drug-Drug Interactions Involving Organic Anion Transporter 1 and 3 Inhibition. Drug metabolism and disposition: the biological fate of chemicals. 2021 12; 49(12):1063-1069. doi: 10.1124/dmd.121.000486. [PMID: 34599018]
  • Deborah Benevenuto, Kirti Saxena, Gabriel R Fries, Samira S Valvassori, Ramandeep Kahlon, Johanna Saxena, Sherin Kurian, Cristian P Zeni, Iram F Kazimi, Giselli Scaini, Jair C Soares, João Quevedo. Alterations in plasma kynurenine pathway metabolites in children and adolescents with bipolar disorder and unaffected offspring of bipolar parents: A preliminary study. Bipolar disorders. 2021 11; 23(7):689-696. doi: 10.1111/bdi.13027. [PMID: 33098737]
  • W Kędzierski, I Sadok, S Kowalik, I Janczarek, M Staniszewska. Does the type of exercise affect tryptophan catabolism in horses?. Animal : an international journal of animal bioscience. 2021 Nov; 15(11):100377. doi: 10.1016/j.animal.2021.100377. [PMID: 34624767]
  • Jiankai Fang, Chao Feng, Wangwang Chen, Pengbo Hou, Zhanhong Liu, Muqiu Zuo, Yuyi Han, Chenchang Xu, Gerry Melino, Alexei Verkhratsky, Ying Wang, Changshun Shao, Yufang Shi. Redressing the interactions between stem cells and immune system in tissue regeneration. Biology direct. 2021 10; 16(1):18. doi: 10.1186/s13062-021-00306-6. [PMID: 34670590]
  • Yuri Milaneschi, Kelly A Allers, Aartjan T F Beekman, Erik J Giltay, Sascha Keller, Robert A Schoevers, Sigurd D Süssmuth, Heiko G Niessen, Brenda W J H Penninx. The association between plasma tryptophan catabolites and depression: The role of symptom profiles and inflammation. Brain, behavior, and immunity. 2021 10; 97(?):167-175. doi: 10.1016/j.bbi.2021.07.007. [PMID: 34252568]
  • Halina Baran, Markus Draxler, Carina Kronsteiner, Berthold Kepplinger. Increase of Kynurenic Acid after Encephalomyocarditis Virus Infection and Its Significances. Neuro-Signals. 2021 09; 29(1):24-34. doi: 10.33594/000000434. [PMID: 34590795]
  • Antonio Molina-Carballo, Isabel Cubero-Millán, Luisa Fernández-López, Ana Checa-Ros, Irene Machado-Casas, Antonio Jerez-Calero, Enrique Blanca-Jover, Antonio-Manuel Cantarero-Malagón, José Uberos, Antonio Muñoz-Hoyos. Methylphenidate ameliorates the homeostatic balance between levels of kynurenines in ADHD children. Psychiatry research. 2021 09; 303(?):114060. doi: 10.1016/j.psychres.2021.114060. [PMID: 34175711]
  • Francesca M Notarangelo, Robert Schwarcz. A single prenatal lipopolysaccharide injection has acute, but not long-lasting, effects on cerebral kynurenine pathway metabolism in mice. The European journal of neuroscience. 2021 09; 54(6):5968-5981. doi: 10.1111/ejn.15416. [PMID: 34363411]
  • Yenan Mo, Xina Jie, Lixin Wang, Chunlan Ji, Yueyu Gu, Zhaoyu Lu, Xusheng Liu. Bupi Yishen formula attenuates kidney injury in 5/6 nephrectomized rats via the tryptophan-kynurenic acid-aryl hydrocarbon receptor pathway. BMC complementary medicine and therapies. 2021 Aug; 21(1):207. doi: 10.1186/s12906-021-03376-1. [PMID: 34376166]
  • Bashkim Kadriu, Cristan A Farmer, Peixiong Yuan, Lawrence T Park, Zhi-De Deng, Ruin Moaddel, Ioline D Henter, Bridget Shovestul, Elizabeth D Ballard, Cristoph Kraus, Philip W Gold, Rodrigo Machado-Vieira, Carlos A Zarate. The kynurenine pathway and bipolar disorder: intersection of the monoaminergic and glutamatergic systems and immune response. Molecular psychiatry. 2021 08; 26(8):4085-4095. doi: 10.1038/s41380-019-0589-8. [PMID: 31732715]
  • Juncai Pu, Yiyun Liu, Hanping Zhang, Lu Tian, Siwen Gui, Yue Yu, Xiang Chen, Yue Chen, Lining Yang, Yanqin Ran, Xiaogang Zhong, Shaohua Xu, Xuemian Song, Lanxiang Liu, Peng Zheng, Haiyang Wang, Peng Xie. An integrated meta-analysis of peripheral blood metabolites and biological functions in major depressive disorder. Molecular psychiatry. 2021 08; 26(8):4265-4276. doi: 10.1038/s41380-020-0645-4. [PMID: 31959849]
  • Yan Chen, Leila R Zelnick, Matthew P Huber, Ke Wang, Nisha Bansal, Andrew N Hoofnagle, Rajan K Paranji, Susan R Heckbert, Noel S Weiss, Alan S Go, Chi-Yuan Hsu, Harold I Feldman, Sushrut S Waikar, Rupal C Mehta, Anand Srivastava, Stephen L Seliger, James P Lash, Anna C Porter, Dominic S Raj, Bryan R Kestenbaum. Association Between Kidney Clearance of Secretory Solutes and Cardiovascular Events: The Chronic Renal Insufficiency Cohort (CRIC) Study. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2021 08; 78(2):226-235.e1. doi: 10.1053/j.ajkd.2020.12.005. [PMID: 33421453]
  • Yuping Cai, Daniel J Kim, Takehiro Takahashi, David I Broadhurst, Hong Yan, Shuangge Ma, Nicholas J W Rattray, Arnau Casanovas-Massana, Benjamin Israelow, Jon Klein, Carolina Lucas, Tianyang Mao, Adam J Moore, M Catherine Muenker, Ji Eun Oh, Julio Silva, Patrick Wong, Albert I Ko, Sajid A Khan, Akiko Iwasaki, Caroline H Johnson. Kynurenic acid may underlie sex-specific immune responses to COVID-19. Science signaling. 2021 07; 14(690):. doi: 10.1126/scisignal.abf8483. [PMID: 34230210]
  • Do Hyeon Pyun, Tae Jin Kim, Myeong Jun Kim, Soon Auck Hong, A M Abd El-Aty, Ji Hoon Jeong, Tae Woo Jung. Endogenous metabolite, kynurenic acid, attenuates nonalcoholic fatty liver disease via AMPK/autophagy- and AMPK/ORP150-mediated signaling. Journal of cellular physiology. 2021 07; 236(7):4902-4912. doi: 10.1002/jcp.30199. [PMID: 33283879]
  • Bernadett Tuka, Aliz Nyári, Edina Katalin Cseh, Tamás Körtési, Dániel Veréb, Ferenc Tömösi, Gábor Kecskeméti, Tamás Janáky, János Tajti, László Vécsei. Clinical relevance of depressed kynurenine pathway in episodic migraine patients: potential prognostic markers in the peripheral plasma during the interictal period. The journal of headache and pain. 2021 Jun; 22(1):60. doi: 10.1186/s10194-021-01239-1. [PMID: 34171996]
  • Chen-Chen Li, Long Gan, Yue Tan, Ming-Zhu Yan, Xin-Min Liu, Qi Chang, Rui-Le Pan. Chronic restraint stress induced changes in colonic homeostasis-related indexes and tryptophan-kynurenine metabolism in rats. Journal of proteomics. 2021 05; 240(?):104190. doi: 10.1016/j.jprot.2021.104190. [PMID: 33766670]
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