thioguanine (BioDeep_00000408975)
Main id: BioDeep_00000001876
natural product
代谢物信息卡片
6-Thioguanine
化学式: C5H5N5S (167.0266)
中文名称: 硫鸟嘌呤
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=NC2=C(N1)C(=S)N=C(N2)N
InChI: InChI=1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)
描述信息
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01B - Antimetabolites > L01BB - Purine analogues
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
C471 - Enzyme Inhibitor > C2254 - Amidophosphoribosyltransferase Inhibitor
D009676 - Noxae > D000963 - Antimetabolites
D000970 - Antineoplastic Agents
6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC50s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.
同义名列表
5 个代谢物同义名
6-Thioguanine; thioguanine; 2-Amino-6-purinethiol; Thioguanine; Thioguanine
数据库引用编号
29 个数据库交叉引用编号
- ChEBI: CHEBI:9555
- KEGG: C07648
- KEGGdrug: D08603
- PubChem: 2723601
- DrugBank: DB00352
- ChEMBL: CHEMBL727
- MeSH: Thioguanine
- CAS: 1330266-29-9
- CAS: 157646-93-0
- CAS: 611-67-6
- CAS: 154-42-7
- MoNA: CCMSLIB00000005168
- MoNA: CCMSLIB00000005164
- MoNA: CCMSLIB00000005165
- MoNA: CCMSLIB00000005163
- MoNA: CCMSLIB00000005166
- MoNA: CCMSLIB00000005167
- MoNA: WA002776
- MoNA: WA002775
- MoNA: WA002774
- MoNA: WA002773
- MoNA: WA002772
- PubChem: 9850
- KNApSAcK: C00018807
- PDB-CCD: DX4
- NIKKAJI: J21.274A
- RefMet: Thioguanine
- medchemexpress: HY-13765
- KNApSAcK: 9555
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 221254 - Paris polyphylla var. chinensis: 10.1016/J.JPBA.2011.12.027
- 286 - Pseudomonas: 10.7164/ANTIBIOTICS.24.328
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qiang Zhang, Qiwei Liu, Ping He. Fully optimized new sensitive electrochemical device for the selective determination of 6-thioguanine anticancer drug in wastewater and biological samples.
Chemosphere.
2023 Jul; 330(?):138634. doi:
10.1016/j.chemosphere.2023.138634. [PMID: 37030348] - Jinping Zhang, Meimei Gao, Ying Niu, Jiangang Sun. From DNMT1 degrader to ferroptosis promoter: Drug repositioning of 6-Thioguanine as a ferroptosis inducer in gastric cancer.
Biochemical and biophysical research communications.
2022 05; 603(?):75-81. doi:
10.1016/j.bbrc.2022.03.026. [PMID: 35278883] - Wen Liu, Shana Zhou, Jing Liu, Xin Zhao, Zhe Feng, Dongmei Wang, Zhengjun Gong, Meikun Fan. Quantitative detection of 6-thioguanine in body fluids based on a free-standing liquid membrane SERS substrate.
Analytical and bioanalytical chemistry.
2022 Feb; 414(4):1663-1670. doi:
10.1007/s00216-021-03790-x. [PMID: 34812902] - Pedro R Chocair, Precil Diego Miranda de Menezes Neves, Sara Mohrbacher, Maurilio Pacheco Neto, Victor A H Sato, Érico S Oliveira, Leonardo V Barbosa, Alessandra M Bales, Fagner Pereira da Silva, Américo L Cuvello-Neto, John A Duley. Case Report: Azathioprine: An Old and Wronged Immunosuppressant.
Frontiers in immunology.
2022; 13(?):903012. doi:
10.3389/fimmu.2022.903012. [PMID: 35757730] - Martin Stanulla, Elke Schaeffeler, Anja Möricke, Swantje Buchmann, Martin Zimmermann, Svitlana Igel, Kjeld Schmiegelow, Christian Flotho, Hans Hartmann, Sabine Illsinger, Axel Sauerbrey, Stefanie V Junk, Peter Schütte, Laura Hinze, Melchior Lauten, Simon Modlich, Reinhard Kolb, Claudia Rossig, Georg Schwabe, Astrid K Gnekow, Gudrun Fleischhack, Paul Gerhard Schlegel, Holger J Schünemann, Christian P Kratz, Gunnar Cario, Martin Schrappe, Matthias Schwab. Hepatic sinusoidal obstruction syndrome and short-term application of 6-thioguanine in pediatric acute lymphoblastic leukemia.
Leukemia.
2021 09; 35(9):2650-2657. doi:
10.1038/s41375-021-01203-7. [PMID: 33714975] - I T Gatchell, R B Huntley, N P Schultes, G S Mourad. The guanine-hypoxanthine permease GhxP of Erwinia amylovora facilitates the influx of the toxic guanine derivative 6-thioguanine.
Journal of applied microbiology.
2021 Jun; 130(6):2018-2028. doi:
10.1111/jam.14925. [PMID: 33152175] - Leandro Rocha Silva, Paulo Fernando da Silva Santos-Júnior, Júlia de Andrade Brandão, Letícia Anderson, Ênio José Bassi, João Xavier de Araújo-Júnior, Sílvia Helena Cardoso, Edeildo Ferreira da Silva-Júnior. Druggable targets from coronaviruses for designing new antiviral drugs.
Bioorganic & medicinal chemistry.
2020 11; 28(22):115745. doi:
10.1016/j.bmc.2020.115745. [PMID: 33007557] - Rafael Martín-Masot, María Pilar Ortiz Pérez, Natalia Ramos Rueda, Juliana Serrano Nieto, Javier Blasco-Alonso, Víctor Manuel Navas-López. [Laboratory determination of thiopurine levels in paediatric patients with inflammatory bowel disease].
Anales de pediatria.
2020 Jul; 93(1):34-40. doi:
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United European gastroenterology journal.
2020 02; 8(1):68-76. doi:
10.1177/2050640619868387. [PMID: 32213059] - Jiaqi Han, Shenghui Mei, Jiamin Xu, Dongjie Zhang, Siyao Jin, Zhigang Zhao, Libo Zhao. Simultaneous UPLC-MS/MS Determination of 6-mercaptopurine, 6-methylmercaptopurine and 6-thioguanine in Plasma: Application to the Pharmacokinetic Evaluation of Novel Dosage forms in Beagle Dogs.
Current pharmaceutical design.
2020; 26(46):6013-6020. doi:
10.2174/1381612826999200820161343. [PMID: 32867649] - Shabi Abbas Zaidi. Effective imprinting of an anticancer drug, 6-thioguanine, via mussel-inspired self-polymerization of dopamine over reduced graphene oxide.
The Analyst.
2019 Mar; 144(7):2345-2352. doi:
10.1039/c8an02348d. [PMID: 30785148] - Mohammad Amjadi, Tooba Hallaj, Rana Salari. A sensitive colorimetric probe for detection of 6-thioguanine based on its protective effect on the silver nanoprisms.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2019 Mar; 210(?):30-35. doi:
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2019 Jan; 80(1):56. doi:
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Luminescence : the journal of biological and chemical luminescence.
2017 May; 32(3):292-297. doi:
10.1002/bio.3177. [PMID: 27406471] - Hassan Karimi-Maleh, Abdollah Fallah Shojaei, Khalil Tabatabaeian, Fatemeh Karimi, Shahryar Shakeri, Reza Moradi. Simultaneous determination of 6-mercaptopruine, 6-thioguanine and dasatinib as three important anticancer drugs using nanostructure voltammetric sensor employing Pt/MWCNTs and 1-butyl-3-methylimidazolium hexafluoro phosphate.
Biosensors & bioelectronics.
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Dec; 1038(?):88-94. doi:
10.1016/j.jchromb.2016.10.035. [PMID: 27802917] - Hadi Beitollahi, Susan Ghofrani Ivari, Masoud Torkzadeh-Mahani. Voltammetric determination of 6-thioguanine and folic acid using a carbon paste electrode modified with ZnO-CuO nanoplates and modifier.
Materials science & engineering. C, Materials for biological applications.
2016 Dec; 69(?):128-33. doi:
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2015 Jan; 5(1):82-95. doi:
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2014 Sep; 29(6):689-94. doi:
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Molecular genetics and genomics : MGG.
2014 Apr; 289(2):215-23. doi:
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10.1080/15257771003730052. [PMID: 20544508] - Juan Sun, Yanxin Hu, Shanping Cao, Guozhong Zhang, Lun-Quan Sun, Ming Wang. Acute, multiple-dose dermal and genetic toxicity of Nu-3: a novel antimicrobial agent.
Journal of biomedicine & biotechnology.
2010; 2010(?):. doi:
10.1155/2010/362524. [PMID: 20706607] - Farhat L Khanim, Rachel E Hayden, Jane Birtwistle, Alessia Lodi, Stefano Tiziani, Nicholas J Davies, Jon P Ride, Mark R Viant, Ulrich L Gunther, Joanne C Mountford, Heinrich Schrewe, Richard M Green, Jim A Murray, Mark T Drayson, Chris M Bunce. Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia.
PloS one.
2009 Dec; 4(12):e8147. doi:
10.1371/journal.pone.0008147. [PMID: 19997560] - Peng Qu, Hua Lu, Xiaoyu Ding, Yi Tao, Zuhong Lu. Influences of urea and guanidine hydrochloride on the interaction of 6-thioguanine with bovine serum albumin.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2009 Dec; 74(5):1224-8. doi:
10.1016/j.saa.2009.09.040. [PMID: 19875331] - Ahmed F Hawwa, Jeff S Millership, Paul S Collier, Anthony McCarthy, Sid Dempsey, Carole Cairns, James C McElnay. The development of an objective methodology to measure medication adherence to oral thiopurines in paediatric patients with acute lymphoblastic leukaemia--an exploratory study.
European journal of clinical pharmacology.
2009 Nov; 65(11):1105-12. doi:
10.1007/s00228-009-0700-1. [PMID: 19636546] - Krzysztof Kuśmierek, Grazyna Chwatko, Rafał Głowacki, Edward Bald. Determination of endogenous thiols and thiol drugs in urine by HPLC with ultraviolet detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Oct; 877(28):3300-8. doi:
10.1016/j.jchromb.2009.03.038. [PMID: 19386557] - Lingzhi Bao, An Xu, Liping Tong, Shaopeng Chen, Lingyan Zhu, Ye Zhao, Guoping Zhao, Erkang Jiang, Jun Wang, Lijun Wu. Activated toxicity of diesel particulate extract by ultraviolet a radiation in mammalian cells: role of singlet oxygen.
Environmental health perspectives.
2009 Mar; 117(3):436-41. doi:
10.1289/ehp.0800029. [PMID: 19337519] - Luke H Stockwin, Sherry X Yu, Howard Stotler, Melinda G Hollingshead, Dianne L Newton. ARC (NSC 188491) has identical activity to Sangivamycin (NSC 65346) including inhibition of both P-TEFb and PKC.
BMC cancer.
2009 Feb; 9(?):63. doi:
10.1186/1471-2407-9-63. [PMID: 19232100] - Ahmed F Hawwa, Jeff S Millership, Paul S Collier, James C McElnay. Development and validation of an HPLC method for the rapid and simultaneous determination of 6-mercaptopurine and four of its metabolites in plasma and red blood cells.
Journal of pharmaceutical and biomedical analysis.
2009 Feb; 49(2):401-9. doi:
10.1016/j.jpba.2008.10.045. [PMID: 19095392] - Yukihiko Kawasaki. Mizoribine: a new approach in the treatment of renal disease.
Clinical & developmental immunology.
2009; 2009(?):681482. doi:
10.1155/2009/681482. [PMID: 20052390] - L A Hogarth, C P F Redfern, J M Teodoridis, A G Hall, H Anderson, M C Case, S A Coulthard. The effect of thiopurine drugs on DNA methylation in relation to TPMT expression.
Biochemical pharmacology.
2008 Oct; 76(8):1024-35. doi:
10.1016/j.bcp.2008.07.026. [PMID: 18708030] - Ahmed F Hawwa, Jeff S Millership, Paul S Collier, Koen Vandenbroeck, Anthony McCarthy, Sid Dempsey, Carole Cairns, John Collins, Colin Rodgers, James C McElnay. Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine.
British journal of clinical pharmacology.
2008 Oct; 66(4):517-28. doi:
10.1111/j.1365-2125.2008.03248.x. [PMID: 18662289] - Mi Ra Yoon, Seok Hyun Nam, Mi Young Kang. Antioxidative and antimutagenic activities of 70\% ethanolic extracts from four fungal mycelia-fermented specialty rices.
Journal of clinical biochemistry and nutrition.
2008 Sep; 43(2):118-25. doi:
10.3164/jcbn.2008056. [PMID: 18818745] - Robert Zakrzewski. Application of the iodine-azide postcolumn reaction in RP-HPLC for the determination of thioguanine in urine.
Journal of separation science.
2008 Jul; 31(12):2199-205. doi:
10.1002/jssc.200800056. [PMID: 18615825] - Kazi Mirajul Hoque, Linxi Chen, George P H Leung, Chung-Ming Tse. A purine-selective nucleobase/nucleoside transporter in PK15NTD cells.
American journal of physiology. Regulatory, integrative and comparative physiology.
2008 Jun; 294(6):R1988-95. doi:
10.1152/ajpregu.00016.2008. [PMID: 18417653] - Sukirti Kalra, Gopabandhu Jena, Kulbhushan Tikoo, Anup Kumar Mukhopadhyay. Preferential inhibition of xanthine oxidase by 2-amino-6-hydroxy-8-mercaptopurine and 2-amino-6-purine thiol.
BMC biochemistry.
2007 May; 8(?):8. doi:
10.1186/1471-2091-8-8. [PMID: 17511860] - Jung-Feng Hsieh, Shih-Hsiung Wu, Yu-Liang Yang, Kee-Fong Choong, Shui-Tein Chen. The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors.
Bioorganic & medicinal chemistry.
2007 May; 15(10):3450-6. doi:
10.1016/j.bmc.2007.03.010. [PMID: 17379526] - Maria Chrzanowska, Mateusz Kurzawski, Marek Droździk, Marta Mazik, Andrzej Oko, Stanisław Czekalski. Thiopurine S-methyltransferase phenotype-genotype correlation in hemodialyzed patients.
Pharmacological reports : PR.
2006 Nov; 58(6):973-8. doi:
NULL. [PMID: 17220558] - Li Jiang, Yi Zhong, Shinya Akatsuka, Yu-Ting Liu, Khokon Kumar Dutta, Wen-Hua Lee, Janice Onuki, Ken-ichi Masumura, Takehiko Nohmi, Shinya Toyokuni. Deletion and single nucleotide substitution at G:C in the kidney of gpt delta transgenic mice after ferric nitrilotriacetate treatment.
Cancer science.
2006 Nov; 97(11):1159-67. doi:
10.1111/j.1349-7006.2006.00301.x. [PMID: 16925583] - Susanne Mueller, Stefan Holdenrieder, Petra Stieber, Torsten Haferlach, Andreas Schalhorn, Jan Braess, Dorothea Nagel, Dietrich Seidel. Early prediction of therapy response in patients with acute myeloid leukemia by nucleosomal DNA fragments.
BMC cancer.
2006 May; 6(?):143. doi:
10.1186/1471-2407-6-143. [PMID: 16734907] - Nikola Tanic, Gordana Brkic, Bogomir Dimitrijevic, Nasta Dedovic-Tanic, Nir Gefen, Daniel Benharroch, Jacob Gopas. Identification of differentially expressed mRNA transcripts in drug-resistant versus parental human melanoma cell lines.
Anticancer research.
2006 May; 26(3A):2137-42. doi:
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Current opinion in gastroenterology.
2006 May; 22(3):234-40. doi:
10.1097/01.mog.0000218959.48064.7f. [PMID: 16550037] - Diane M Stearns, Monica Yazzie, Andrew S Bradley, Virginia H Coryell, Jake T Shelley, Adam Ashby, Craig S Asplund, R Clark Lantz. Uranyl acetate induces hprt mutations and uranium-DNA adducts in Chinese hamster ovary EM9 cells.
Mutagenesis.
2005 Nov; 20(6):417-23. doi:
10.1093/mutage/gei056. [PMID: 16195314] - Chung-Pu Wu, Anna Maria Calcagno, Stephen B Hladky, Suresh V Ambudkar, Margery A Barrand. Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5).
The FEBS journal.
2005 Sep; 272(18):4725-40. doi:
10.1111/j.1742-4658.2005.04888.x. [PMID: 16156793] - Mateusz Kurzawski, Krzysztof Dziewanowski, Barbara Gawrońska-Szklarz, Leszek Domański, Marek Droździk. The impact of thiopurine s-methyltransferase polymorphism on azathioprine-induced myelotoxicity in renal transplant recipients.
Therapeutic drug monitoring.
2005 Aug; 27(4):435-41. doi:
10.1097/01.ftd.0000164393.09402.c9. [PMID: 16044099] - Chun-Chi Wang, Shyh-Shin Chiou, Shou-Mei Wu. Determination of mercaptopurine and its four metabolites by large-volume sample stacking with polarity switching in capillary electrophoresis.
Electrophoresis.
2005 Jun; 26(13):2637-42. doi:
10.1002/elps.200500003. [PMID: 15934057] - Susan Pratt, Robert L Shepard, Ramani A Kandasamy, Paul A Johnston, William Perry, Anne H Dantzig. The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites.
Molecular cancer therapeutics.
2005 May; 4(5):855-63. doi:
10.1158/1535-7163.mct-04-0291. [PMID: 15897250] - Carolina Rumbo, Benjamin L Shneider, Sukru H Emre. Utility of azathioprine metabolite measurements in post-transplant recurrent autoimmune and immune-mediated hepatitis.
Pediatric transplantation.
2004 Dec; 8(6):571-5. doi:
10.1111/j.1399-3046.2004.00230.x. [PMID: 15598326] - M Ottey, S-Y Han, T Druck, B L Barnoski, K A McCorkell, C M Croce, C Raventos-Suarez, C R Fairchild, Y Wang, K Huebner. Fhit-deficient normal and cancer cells are mitomycin C and UVC resistant.
British journal of cancer.
2004 Nov; 91(9):1669-77. doi:
10.1038/sj.bjc.6602058. [PMID: 15494723] - Sunita Shastri, Marla C Dubinsky, F Fred Poordad, Eric A Vasiliauskas, Stephen A Geller. Early nodular hyperplasia of the liver occurring with inflammatory bowel diseases in association with thioguanine therapy.
Archives of pathology & laboratory medicine.
2004 Jan; 128(1):49-53. doi:
10.5858/2004-128-49-enhotl. [PMID: 14692812] - Eiichi Furusawa, Anne Hirazumi, Stephen Story, Jarakae Jensen. Antitumour potential of a polysaccharide-rich substance from the fruit juice of Morinda citrifolia (Noni) on sarcoma 180 ascites tumour in mice.
Phytotherapy research : PTR.
2003 Dec; 17(10):1158-64. doi:
10.1002/ptr.1307. [PMID: 14669249] - R Hast, E Hellström-Lindberg, L Ohm, M Björkholm, F Celsing, I-M Dahl, I Dybedal, G Gahrton, G Lindberg, R Lerner, O Linder, E Löfvenberg, H Nilsson-Ehle, C Paul, J Samuelsson, J-M Tangen, U Tidefelt, I Turesson, A Wahlin, J Wallvik, I Winquist, G Oberg, P Bernell. No benefit from adding GM-CSF to induction chemotherapy in transforming myelodysplastic syndromes: better outcome in patients with less proliferative disease.
Leukemia.
2003 Sep; 17(9):1827-33. doi:
10.1038/sj.leu.2403035. [PMID: 12970783] - P Deibert, K Dilger, C Fischer, U Hofmann, S Nauck, S Stoelben, W Kreisel. High variation of tioguanine absorption in patients with chronic active Crohn's disease.
Alimentary pharmacology & therapeutics.
2003 Jul; 18(2):183-9. doi:
10.1046/j.1365-2036.2003.01652.x. [PMID: 12869078] - Sjofn Gunnarsdottir, Adnan A Elfarra. Distinct tissue distribution of metabolites of the novel glutathione-activated thiopurine prodrugs cis-6-(2-acetylvinylthio)purine and trans-6-(2-acetylvinylthio)guanine and 6-thioguanine in the mouse.
Drug metabolism and disposition: the biological fate of chemicals.
2003 Jun; 31(6):718-26. doi:
10.1124/dmd.31.6.718. [PMID: 12756203] - Thierry Dervieux, Michael L Hancock, Ching-Hon Pui, Gaston K Rivera, John T Sandlund, Raul C Ribeiro, James Boyett, William E Evans, Mary V Relling. Antagonism by methotrexate on mercaptopurine disposition in lymphoblasts during up-front treatment of acute lymphoblastic leukemia.
Clinical pharmacology and therapeutics.
2003 Jun; 73(6):506-16. doi:
10.1016/s0009-9236(03)00063-8. [PMID: 12811360] - Stephen J Rulyak, Michael D Saunders, Scott D Lee. Hepatotoxicity associated with 6-thioguanine therapy for Crohn's disease.
Journal of clinical gastroenterology.
2003 Mar; 36(3):234-7. doi:
10.1097/00004836-200303000-00010. [PMID: 12590235] - P R Wielinga, G Reid, E E Challa, I van der Heijden, L van Deemter, M de Haas, C Mol, A J Kuil, E Groeneveld, J D Schuetz, C Brouwer, R A De Abreu, J Wijnholds, J H Beijnen, P Borst. Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells.
Molecular pharmacology.
2002 Dec; 62(6):1321-31. doi:
10.1124/mol.62.6.1321. [PMID: 12435799] - Sjofn Gunnarsdottir, Marian Rucki, Lynette A Phillips, Karen M Young, Adnan A Elfarra. The glutathione-activated thiopurine prodrugs trans-6-(2-acetylvinylthio)guanine and cis-6-(2-acetylvinylthio)purine cause less in vivo toxicity than 6-thioguanine after single- and multiple-dose regimens.
Molecular cancer therapeutics.
2002 Nov; 1(13):1211-20. doi:
NULL. [PMID: 12479702] - Sally A Coulthard, Linda A Hogarth, Margaret Little, Elizabeth C Matheson, Christopher P F Redfern, Lynne Minto, Andrew G Hall. The effect of thiopurine methyltransferase expression on sensitivity to thiopurine drugs.
Molecular pharmacology.
2002 Jul; 62(1):102-9. doi:
10.1124/mol.62.1.102. [PMID: 12065760] - Chi Y Shin, Olga N Ponomareva, Lanelle Connolly, Mitchell S Turker. A mouse kidney cell line with a G:C --> C:G transversion mutator phenotype.
Mutation research.
2002 Jun; 503(1-2):69-76. doi:
10.1016/s0027-5107(02)00073-8. [PMID: 12052505] - Sjofn Gunnarsdottir, Marian Rucki, Adnan A Elfarra. Novel glutathione-dependent thiopurine prodrugs: evidence for enhanced cytotoxicity in tumor cells and for decreased bone marrow toxicity in mice.
The Journal of pharmacology and experimental therapeutics.
2002 Apr; 301(1):77-86. doi:
10.1124/jpet.301.1.77. [PMID: 11907160] - Tarak Srivastava, J Patrick O'Neill, Majed Dasouki, Ari M Simckes. Childhood hyperuricemia and acute renal failure resulting from a missense mutation in the HPRT gene.
American journal of medical genetics.
2002 Mar; 108(3):219-22. doi:
10.1002/ajmg.10217. [PMID: 11891689] - Lorel M Colgin, Alden F M Hackmann, Mary J Emond, Raymond J Monnat. The unexpected landscape of in vivo somatic mutation in a human epithelial cell lineage.
Proceedings of the National Academy of Sciences of the United States of America.
2002 Feb; 99(3):1437-42. doi:
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Cancer treatment reviews.
2001 Dec; 27(6):351-63. doi:
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