protriptyline (BioDeep_00000408796)

Main id: BioDeep_00000002057

 


代谢物信息卡片


protriptyline

化学式: C19H21N (263.16739060000003)
中文名称: 普罗替林
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CNCCCC(c21)c(c3)c(ccc3)C=Cc(cccc2)1
InChI: InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3

描述信息

N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AA - Non-selective monoamine reuptake inhibitors
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent > C94727 - Tricyclic Antidepressant
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D049990 - Membrane Transport Modulators

同义名列表

1 个代谢物同义名

protriptyline



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Jin Ryeol An, Hojung Kang, Hongliang Li, Mi Seon Seo, Hee Seok Jung, Won-Kyo Jung, Il-Whan Choi, Sook Won Ryu, Hongzoo Park, Young Min Bae, Se Min Ryu, Won Sun Park. Protriptyline, a tricyclic antidepressant, inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells. Acta biochimica et biophysica Sinica. 2020 Mar; 52(3):320-327. doi: 10.1093/abbs/gmz159. [PMID: 32060505]
  • He-Hsiung Cheng, Chiang-Ting Chou, Wei-Zhe Liang, Chun-Chi Kuo, Pochuen Shieh, Jue-Long Wang, Chung-Ren Jan. Effect of Protriptyline on [Ca²⁺]i and Viability in MDCK Renal Tubular Cells. The Chinese journal of physiology. 2017 Apr; 60(2):114-123. doi: 10.4077/cjp.2017.baf459. [PMID: 28468029]
  • Luke R Odell, Mohammed K Abdel-Hamid, Timothy A Hill, Ngoc Chau, Kelly A Young, Fiona M Deane, Jennette A Sakoff, Sofia Andersson, James A Daniel, Phillip J Robinson, Adam McCluskey. Pyrimidine-Based Inhibitors of Dynamin I GTPase Activity: Competitive Inhibition at the Pleckstrin Homology Domain. Journal of medicinal chemistry. 2017 01; 60(1):349-361. doi: 10.1021/acs.jmedchem.6b01422. [PMID: 27997171]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Gabriela Mladenova, Subhash C Annedi, Jailall Ramnauth, Shawn P Maddaford, Suman Rakhit, John S Andrews, Dongqin Zhang, Frank Porreca. First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain. Journal of medicinal chemistry. 2012 Apr; 55(7):3488-501. doi: 10.1021/jm300138g. [PMID: 22420844]
  • Kamisha L Johnson-Davis, Joetta M Juenke, Rebecka Davis, Gwendolyn A McMillin. Quantification of tricyclic antidepressants using UPLC-MS/MS. Methods in molecular biology (Clifton, N.J.). 2012; 902(?):175-84. doi: 10.1007/978-1-61779-934-1_16. [PMID: 22767118]
  • Gerile, Chiharu Sogawa, Kazumi Ohyama, Takashi Masuko, Tadashi Kusama, Katsuya Morita, Norio Sogawa, Shigeo Kitayama. Inhibitory action of antidepressants on mouse Betaine/GABA transporter (BGT1) heterologously expressed in cell cultures. International journal of molecular sciences. 2012; 13(3):2578-2589. doi: 10.3390/ijms13032578. [PMID: 22489112]
  • Carl E Wolf, Sara J Kester-Florin, Alphonse Poklis. A HPLC-MS method to detect and quantify guanfacine in urine. Clinical chemistry and laboratory medicine. 2011 Nov; 50(3):535-7. doi: 10.1515/cclm.2011.803. [PMID: 22112053]
  • Gbolagade Sunmaila Akintomide, Hugh Rickards. Narcolepsy: a review. Neuropsychiatric disease and treatment. 2011; 7(?):507-18. doi: 10.2147/ndt.s23624. [PMID: 21931493]
  • Robert J Altenbach, Lawrence A Black, Marina I Strakhova, Arlene M Manelli, Tracy L Carr, Kennan C Marsh, Jill M Wetter, Erica J Wensink, Gin C Hsieh, Prisca Honore, Tiffany Runyan Garrison, Jorge D Brioni, Marlon D Cowart. Diaryldiamines with dual inhibition of the histamine H(3) receptor and the norepinephrine transporter and the efficacy of 4-(3-(methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in pain. Journal of medicinal chemistry. 2010 Nov; 53(21):7869-73. doi: 10.1021/jm100666w. [PMID: 20945906]
  • Marie T Vanier. Niemann-Pick disease type C. Orphanet journal of rare diseases. 2010 Jun; 5(?):16. doi: 10.1186/1750-1172-5-16. [PMID: 20525256]
  • Zaorui Zhao, Han-Ting Zhang, Elianna Bootzin, Mark J Millan, James M O'Donnell. Association of changes in norepinephrine and serotonin transporter expression with the long-term behavioral effects of antidepressant drugs. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2009 May; 34(6):1467-81. doi: 10.1038/npp.2008.183. [PMID: 18923402]
  • Carrie Haglock, Carl Wolf, Alphonse Poklis. A novel method for the determination of guanfacine in urine by gas chromatography-mass spectrometry. Journal of analytical toxicology. 2008 Oct; 32(8):544-6. doi: 10.1093/jat/32.8.544. [PMID: 19007502]
  • Xiao-Pen Lee, Chika Hasegawa, Takeshi Kumazawa, Natsuko Shinmen, Yukiko Shoji, Hiroshi Seno, Keizo Sato. Determination of tricyclic antidepressants in human plasma using pipette tip solid-phase extraction and gas chromatography-mass spectrometry. Journal of separation science. 2008 Jul; 31(12):2265-71. doi: 10.1002/jssc.200700627. [PMID: 18546392]
  • Su-Hyun Jo, Hee-Kyung Hong, Seon Ha Chong, Han Choe. Protriptyline block of the human ether-à-go-go-related gene (HERG) K+ channel. Life sciences. 2008 Jan; 82(5-6):331-40. doi: 10.1016/j.lfs.2007.12.004. [PMID: 18191158]
  • Pekka Suomalainen, Christoffer Johans, Tim Söderlund, Paavo K J Kinnunen. Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry. 2004 Mar; 47(7):1783-8. doi: 10.1021/jm0309001. [PMID: 15027870]
  • Yukari Sudoh, Elaine Elliott Cahoon, Peter Gerner, Ging Kuo Wang. Tricyclic antidepressants as long-acting local anesthetics. Pain. 2003 May; 103(1-2):49-55. doi: 10.1016/s0304-3959(02)00375-5. [PMID: 12749958]
  • M Tatsumi, K Groshan, R D Blakely, E Richelson. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. European journal of pharmacology. 1997 Dec; 340(2-3):249-58. doi: 10.1016/s0014-2999(97)01393-9. [PMID: 9537821]
  • T Miyoshi, R Yamamichi, T Maruyama, A Takadate, M Otagiri. Further characterization of reversal of signs of induced cotton effects of dicumarol derivatives-alpha 1-acid glycoprotein systems by protriptyline. Biochemical pharmacology. 1992 May; 43(10):2161-7. doi: 10.1016/0006-2952(92)90175-i. [PMID: 1376120]
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  • G Fechner, I Magureanu, R Aderjan, G Schmidt. [Fatal poisoning by protriptyline and haloperidol following an extreme overdose]. Zeitschrift fur Rechtsmedizin. Journal of legal medicine. 1986; 97(4):277-83. doi: 10.1007/bf00200607. [PMID: 3577435]
  • H I Trzeciak. Effects of short- and long-term protriptyline treatment on phospholipid metabolism in rat brain. Journal of neurochemistry. 1985 Feb; 44(2):401-5. doi: 10.1111/j.1471-4159.1985.tb05429.x. [PMID: 3965615]
  • J R Shipe, A F Arlinghaus, J Savory, M R Wills, J P DiMarco. Determination of bethanidine in plasma by liquid-chromatography with a microbore reversed-phase column. Clinical chemistry. 1983 Oct; 29(10):1793-5. doi: NULL. [PMID: 6616825]
  • R L Livingston, D K Zucker, K Isenberg, R D Wetzel. Tricyclic antidepressants and delirium. The Journal of clinical psychiatry. 1983 May; 44(5):173-6. doi: NULL. [PMID: 6853452]
  • F A Beierle, R W Hubbard. Liquid chromatographic separation of antidepressant drugs: I. Tricyclics. Therapeutic drug monitoring. 1983; 5(3):279-92. doi: 10.1097/00007691-198309000-00008. [PMID: 6636256]
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  • S J Bannister, S van der Wal, J W Dolan, L R Snyder. Liquid-chromatographic analysis for common tricyclic antidepressant drugs and their metabolites in serum or plasma with the technicon 'FAST-LC' system. Clinical chemistry. 1981 Jun; 27(6):849-55. doi: NULL. [PMID: 7237764]
  • J Amsterdam, D Brunswick, J Mendels. The clinical application of tricyclic antidepressant pharmacokinetics and plasma levels. The American journal of psychiatry. 1980 Jun; 137(6):653-62. doi: 10.1176/ajp.137.6.653. [PMID: 6990798]
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  • S H Preskorn, B K Hartman. The effect of tricyclic antidepressants on cerebral fluid dynamics. Biological psychiatry. 1979 Apr; 14(2):235-50. doi: . [PMID: 476220]
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  • M van Wijk, J J Meisch, J Korf. Metabolism of 5-hydroxytryptamine and levels of tricyclic antidepressant drugs in rat brain after acute and chronic treatment. Psychopharmacology. 1977 Dec; 55(3):217-23. doi: 10.1007/bf00497851. [PMID: 414282]
  • J T Biggs, V E Ziegler. Protriptyline plasma levels and antidepressant response. Clinical pharmacology and therapeutics. 1977 Sep; 22(3):269-73. doi: 10.1002/cpt1977223269. [PMID: 330075]
  • G Bianchetti, A Bonaccorsi, A Chiodaroli, R Franco, S Garattini, R Gomeni, P L Morselli. Plasma concentrations and cardiotoxic effects of desipramine and protriptyline in the rat. British journal of pharmacology. 1977 May; 60(1):11-9. doi: 10.1111/j.1476-5381.1977.tb16741.x. [PMID: 884382]
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  • H H Tai, C S Hollander. Regulation of prostaglandin metabolism: activation of 15-hydroxyprostaglandin dehydrogenase by chlorpromazine and imipramine related drugs. Biochemical and biophysical research communications. 1976 Feb; 68(3):814-20. doi: 10.1016/0006-291x(76)91218-3. [PMID: 177012]
  • G Belvedere, A Frigerio, C Pantarotto, V Rovei, M Zanol, F Parravicini, G Pifferi. Mass spectrometric identification of 10,11-dihydro-10,11-dihydroxyprotriptyline in rat urine after administration of protriptyline. Il Farmaco; edizione scientifica. 1975 Nov; 30(11):904-16. doi: NULL. [PMID: 1193231]
  • E Elonen, M Linnoila, I Lukkari, M J Mattila. Concentration of tricyclic antidepressants in plasma, heart and skeletal muscle after their intravenous infusion to anaesthetized rabbits. Acta pharmacologica et toxicologica. 1975 Oct; 37(4):274-81. doi: 10.1111/j.1600-0773.1975.tb00845.x. [PMID: 1242609]
  • A Trenchard, P Turner, C M Pare, M Hills. The effects of protriptyline and clomipramine in vitro on the uptake of 5-hydroxytryptamine and dopamine in human platelet-rich plasma. Psychopharmacologia. 1975 Jul; 43(1):89-93. doi: 10.1007/bf00437621. [PMID: 1161997]