1-Methylnicotinamide (BioDeep_00000405645)
Main id: BioDeep_00000003002
PANOMIX_OTCML-2023 BioNovoGene_Lab2019
代谢物信息卡片
1-Methylnicotinamide
化学式: C7H9N2O+ (137.0715)
中文名称: 1-甲基烟酰胺氯化物
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C[N+]1=CC=CC(=C1)C(=O)N
InChI: InChI=1S/C7H8N2O/c1-9-4-2-3-6(5-9)7(8)10/h2-5H,1H3,(H-,8,10)/p+1
描述信息
A pyridinium ion comprising nicotinamide having a methyl group at the 1-position. It is a metabolite of nicotinamide which was initially considered to be biologically inactive but has emerged as an anti-thrombotic and anti-inflammatory agent.
COVID info from COVID-19 Disease Map, clinicaltrial, clinicaltrials, clinical trial, clinical trials
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
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SARS
同义名列表
2 个代谢物同义名
数据库引用编号
24 个数据库交叉引用编号
- ChEBI: CHEBI:16797
- KEGG: C02918
- PubChem: 457
- DrugBank: DB11710
- ChEMBL: CHEMBL1209652
- ChEMBL: CHEMBL71733
- CAS: 3106-60-3
- MoNA: MoNA038567
- MoNA: MoNA037176
- MoNA: MoNA036062
- MoNA: MoNA036058
- MoNA: MoNA036056
- MoNA: MoNA032131
- MoNA: MoNA032130
- MoNA: MoNA032128
- MoNA: FiehnHILIC001602
- MoNA: FiehnHILIC000014
- MetaboLights: MTBLC16797
- PubChem: 5841
- PDB-CCD: 8GC
- 3DMET: B00512
- NIKKAJI: J66.624F
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-240
- KNApSAcK: 16797
分类词条
相关代谢途径
Reactome(9)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 7227 - Drosophila melanogaster: 10.1038/S41467-019-11933-Z
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiaojing Wei, Yutian Tan, Jiaqi Huang, Ximing Dong, Weijie Feng, Tanglin Liu, Zhao Yang, Guiying Yang, Xiao Luo. N1-methylnicotinamide impairs gestational glucose tolerance in mice.
Journal of molecular endocrinology.
2024 Feb; 72(2):. doi:
10.1530/jme-23-0126. [PMID: 38029302] - Mayuko Yoda, Rin Mizuno, Yoshihiro Izumi, Masatomo Takahashi, Takeshi Bamba, Shinpei Kawaoka. Nicotinamide-N-methyltransferase regulates lipid metabolism via SAM and 1-methylnicotinamide in the AML12 hepatocyte cell line.
Journal of biochemistry.
2023 Apr; ?(?):. doi:
10.1093/jb/mvad028. [PMID: 37014628] - Shanglei Lai, Yue Ma, Liuyi Hao, Qinchao Ding, Kaixin Chang, Hui Zhuge, Jiannan Qiu, Tiantian Xu, Xiaobing Dou, Songtao Li. 1-Methylnicotinamide promotes hepatic steatosis in mice: A potential mechanism in chronic alcohol-induced fatty liver disease.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2023 Apr; 1868(4):159286. doi:
10.1016/j.bbalip.2023.159286. [PMID: 36690322] - Wenying Zhang, Guang Rong, Jinge Gu, Cuiling Fan, Tingting Guo, Tingting Jiang, Weiqian Deng, Jiayu Xie, Zhihua Su, Qimin Yu, Jingyi Mai, Rinan Zheng, Xingling Chen, Xun Tang, Jun Zhang. Nicotinamide N-methyltransferase ameliorates renal fibrosis by its metabolite 1-methylnicotinamide inhibiting the TGF-β1/Smad3 pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2022 03; 36(3):e22084. doi:
10.1096/fj.202100913rrr. [PMID: 35107844] - Hamid Reza Nejabati, Mahsa Ghaffari-Novin, Nazila Fathi-Maroufi, Yousef Faridvand, Hans-Christer Holmberg, Ola Hansson, Saba Nikanfar, Mohammad Nouri. N1-Methylnicotinamide: Is it Time to Consider it as a Dietary Supplement for Athletes?.
Current pharmaceutical design.
2022; 28(10):800-805. doi:
10.2174/1381612828666220211151204. [PMID: 35152860] - Elisa Biliotti, Ottavia Giampaoli, Fabio Sciubba, Federico Marini, Alberta Tomassini, Donatella Palazzo, Giorgio Capuani, Rozenn Esvan, Martina Spaziante, Gloria Taliani, Alfredo Miccheli. Urinary metabolomics of HCV patients with severe liver fibrosis before and during the sustained virologic response achieved by direct acting antiviral treatment.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Nov; 143(?):112217. doi:
10.1016/j.biopha.2021.112217. [PMID: 34560544] - Van Long Nguyen, Roxanne Saldanha, Michael Fitzpatrick. Dual Analysis of N-methyl-2-pyridone-5-carboxamide and N-1-methylnicotinamide in Urine by HPLC with UV Detection.
Journal of chromatographic science.
2021 Aug; 59(8):770-775. doi:
10.1093/chromsci/bmaa134. [PMID: 33442746] - Yu Chen, Jingfan Zhang, Ping Li, Cong Liu, Ling Li. N1‑methylnicotinamide ameliorates insulin resistance in skeletal muscle of type 2 diabetic mice by activating the SIRT1/PGC‑1α signaling pathway.
Molecular medicine reports.
2021 04; 23(4):. doi:
10.3892/mmr.2021.11909. [PMID: 33576435] - Mei Ji, Na Na, Shaochun Lin. Diagnostic Value of Serum N1-Methylnicotinamide in Cervical Cancer Patients.
Clinical laboratory.
2021 Feb; 67(2):. doi:
10.7754/clin.lab.2020.200422. [PMID: 33616317] - Carolien P J Deen, Anna van der Veen, António W Gomes-Neto, Johanna M Geleijnse, Karin J Borgonjen-van den Berg, M Rebecca Heiner-Fokkema, Ido P Kema, Stephan J L Bakker. Urinary Excretion of N1-Methylnicotinamide and N1-Methyl-2-Pyridone-5-Carboxamide and Mortality in Kidney Transplant Recipients.
Nutrients.
2020 Jul; 12(7):. doi:
10.3390/nu12072059. [PMID: 32664445] - Hamid Reza Nejabati, Nasser Samadi, Vahideh Shahnazi, Aynaz Mihanfar, Amir Fattahi, Zeinab Latifi, Zahra Bahrami-Asl, Leila Roshangar, Mohammad Nouri. Nicotinamide and its metabolite N1-Methylnicotinamide alleviate endocrine and metabolic abnormalities in adipose and ovarian tissues in rat model of Polycystic Ovary Syndrome.
Chemico-biological interactions.
2020 Jun; 324(?):109093. doi:
10.1016/j.cbi.2020.109093. [PMID: 32298659] - Shiva Kalantari, Saeed Chashmniam, Mohsen Nafar, Shiva Samavat, Danial Rezaie, Nooshin Dalili. A Noninvasive Urine Metabolome Panel as Potential Biomarkers for Diagnosis of T Cell-Mediated Renal Transplant Rejection.
Omics : a journal of integrative biology.
2020 03; 24(3):140-147. doi:
10.1089/omi.2019.0158. [PMID: 32176594] - Jingfan Zhang, Yu Chen, Cong Liu, Ling Li, Ping Li. N1-Methylnicotinamide Improves Hepatic Insulin Sensitivity via Activation of SIRT1 and Inhibition of FOXO1 Acetylation.
Journal of diabetes research.
2020; 2020(?):1080152. doi:
10.1155/2020/1080152. [PMID: 32280711] - Kenji Takeuchi, Chie Yokouchi, Hirohiko Goto, Ken Umehara, Hideyuki Yamada, Yuji Ishii. Alleviation of fatty liver in a rat model by enhancing N1-methylnicotinamide bioavailability through aldehyde oxidase inhibition.
Biochemical and biophysical research communications.
2018 12; 507(1-4):203-210. doi:
10.1016/j.bbrc.2018.11.008. [PMID: 30446221] - Hamid Reza Nejabati, Aynaz Mihanfar, Masoud Pezeshkian, Amir Fattahi, Zeinab Latifi, Naser Safaie, Mohammad Valiloo, Ahmad Reza Jodati, Mohammad Nouri. N1-methylnicotinamide (MNAM) as a guardian of cardiovascular system.
Journal of cellular physiology.
2018 10; 233(10):6386-6394. doi:
10.1002/jcp.26636. [PMID: 29741779] - Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics.
Scientific reports.
2018 07; 8(1):10056. doi:
10.1038/s41598-018-28477-9. [PMID: 29968805] - Ming Liu, Anxia He, Jihong Chu, Chao Chen, Siqi Zhang, Yun He, Weiwei Tao, Meijuan Lu, Mulian Hua, Wenzheng Ju, Zhuyuan Fang. Serum N1-methylnicotinamide is Associated with Left Ventricular Systolic Dysfunction in Chinese.
Scientific reports.
2018 06; 8(1):8581. doi:
10.1038/s41598-018-26956-7. [PMID: 29872082] - Lina Luo, Jared Kay, Jenny Zhang, Christopher L Holliman, A David Rodrigues, Martin Dowty, Christopher Banfield, Ragu Ramanathan. LC-MS/MS assay for N1-methylnicotinamide in humans, an endogenous probe for renal transporters.
Bioanalysis.
2018 May; 10(9):673-689. doi:
10.4155/bio-2017-0272. [PMID: 29749253] - Magdalena A Zabielska, Jan Adamus, Robert Kowalski, Jerzy Gebicki, Ewa M Slominska, Zain Khalpey, Ryszard T Smolenski. Cardioprotective effect of N-methylnicotinamide salt of pyruvate in experimental model of cardiac hypoxia.
Pharmacological reports : PR.
2018 Apr; 70(2):378-384. doi:
10.1016/j.pharep.2017.09.011. [PMID: 29477947] - Kristoffer Ström, David Morales-Alamo, Filip Ottosson, Anna Edlund, Line Hjort, Sine W Jörgensen, Peter Almgren, Yuedan Zhou, Marcos Martin-Rincon, Carl Ekman, Alberto Pérez-López, Ola Ekström, Ismael Perez-Suarez, Markus Mattiasson, Pedro de Pablos-Velasco, Nikolay Oskolkov, Emma Ahlqvist, Nils Wierup, Lena Eliasson, Allan Vaag, Leif Groop, Karin G Stenkula, Céline Fernandez, Jose A L Calbet, Hans-Christer Holmberg, Ola Hansson. N1-methylnicotinamide is a signalling molecule produced in skeletal muscle coordinating energy metabolism.
Scientific reports.
2018 02; 8(1):3016. doi:
10.1038/s41598-018-21099-1. [PMID: 29445118] - Mackenzie C Bergagnini-Kolev, Mary F Hebert, Thomas R Easterling, Yvonne S Lin. Pregnancy Increases the Renal Secretion of N1-methylnicotinamide, an Endogenous Probe for Renal Cation Transporters, in Patients Prescribed Metformin.
Drug metabolism and disposition: the biological fate of chemicals.
2017 03; 45(3):325-329. doi:
10.1124/dmd.116.073841. [PMID: 28069720] - Ming Liu, Jihong Chu, Yang Gu, Haibo Shi, Rusheng Zhang, Lingzhun Wang, Jiandong Chen, Le Shen, Peng Yu, Xiaohu Chen, Wenzheng Ju, Zhenxing Wang. Serum N1-Methylnicotinamide is Associated With Coronary Artery Disease in Chinese Patients.
Journal of the American Heart Association.
2017 02; 6(2):. doi:
10.1161/jaha.116.004328. [PMID: 28174167] - Andrzej Fedorowicz, Łukasz Mateuszuk, Grzegorz Kopec, Tomasz Skórka, Barbara Kutryb-Zając, Agnieszka Zakrzewska, Maria Walczak, Andrzej Jakubowski, Magdalena Łomnicka, Ewa Słomińska, Stefan Chlopicki. Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension.
Respiratory research.
2016 08; 17(1):108. doi:
10.1186/s12931-016-0423-7. [PMID: 27581040] - Katarzyna Majzner, Stefan Chlopicki, Malgorzata Baranska. Lipid droplets formation in human endothelial cells in response to polyunsaturated fatty acids and 1-methyl-nicotinamide (MNA); confocal Raman imaging and fluorescence microscopy studies.
Journal of biophotonics.
2016 Apr; 9(4):396-405. doi:
10.1002/jbio.201500134. [PMID: 25966299] - Lukasz Mateuszuk, Agnieszka Jasztal, Edyta Maslak, Marlena Gasior-Glogowska, Malgorzata Baranska, Barbara Sitek, Renata Kostogrys, Agnieszka Zakrzewska, Agnieszka Kij, Maria Walczak, Stefan Chlopicki. Antiatherosclerotic Effects of 1-Methylnicotinamide in Apolipoprotein E/Low-Density Lipoprotein Receptor-Deficient Mice: A Comparison with Nicotinic Acid.
The Journal of pharmacology and experimental therapeutics.
2016 Feb; 356(2):514-24. doi:
10.1124/jpet.115.228643. [PMID: 26631491] - Grietje Bouma, Martijn van Faassen, Gursah Kats-Ugurlu, Elisabeth G E de Vries, Ido P Kema, Annemiek M E Walenkamp. Niacin (Vitamin B3) Supplementation in Patients with Serotonin-Producing Neuroendocrine Tumor.
Neuroendocrinology.
2016; 103(5):489-94. doi:
10.1159/000440621. [PMID: 26335390] - Martin G Thomas, Roxanne M Marwood, Anna E Parsons, Richard B Parsons. The effect of foetal bovine serum supplementation upon the lactate dehydrogenase cytotoxicity assay: Important considerations for in vitro toxicity analysis.
Toxicology in vitro : an international journal published in association with BIBRA.
2015 Dec; 30(1 Pt B):300-8. doi:
10.1016/j.tiv.2015.10.007. [PMID: 26498060] - Yuki Tanaka, Shinji Kume, Hisazumi Araki, Jun Nakazawa, Masami Chin-Kanasaki, Shin-ichi Araki, Fumiyuki Nakagawa, Daisuke Koya, Masakazu Haneda, Hiroshi Maegawa, Takashi Uzu. 1-Methylnicotinamide ameliorates lipotoxicity-induced oxidative stress and cell death in kidney proximal tubular cells.
Free radical biology & medicine.
2015 Dec; 89(?):831-41. doi:
10.1016/j.freeradbiomed.2015.10.414. [PMID: 26482866] - Magdalena Sternak, Andrzej Jakubowski, Elzbieta Czarnowska, Ewa M Slominska, Ryszard T Smolenski, Malgorzata Szafarz, Maria Walczak, Barbara Sitek, Tomasz Wojcik, Agnieszka Jasztal, Karol Kaminski, Stefan Chlopicki. Differential involvement of IL-6 in the early and late phase of 1-methylnicotinamide (MNA) release in Concanavalin A-induced hepatitis.
International immunopharmacology.
2015 Sep; 28(1):105-14. doi:
10.1016/j.intimp.2015.04.053. [PMID: 25976094] - Ming Liu, Lihua Li, Jihong Chu, Boyu Zhu, Qingtao Zhang, Xueyan Yin, Weimin Jiang, Guoliang Dai, Wenzheng Ju, Zhenxing Wang, Qin Yang, Zhuyuan Fang. Serum N(1)-Methylnicotinamide Is Associated With Obesity and Diabetes in Chinese.
The Journal of clinical endocrinology and metabolism.
2015 Aug; 100(8):3112-7. doi:
10.1210/jc.2015-1732. [PMID: 26066674] - André Luiz Maltos, Guilherme Vannucchi Portari, Giselle Vanessa Moraes, Marina Casteli Rodrigues Monteiro, Helio Vannucchi, Daniel Ferreira da Cunha. Niacin metabolism and indoleamine 2,3-dioxygenase activation in malnourished patients with flaky paint dermatosis.
Nutrition (Burbank, Los Angeles County, Calif.).
2015 Jun; 31(6):890-2. doi:
10.1016/j.nut.2014.12.023. [PMID: 25933499] - Aimo Kannt, Anja Pfenninger, Lenore Teichert, Anke Tönjes, Arne Dietrich, Michael R Schön, Nora Klöting, Matthias Blüher. Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance.
Diabetologia.
2015 Apr; 58(4):799-808. doi:
10.1007/s00125-014-3490-7. [PMID: 25596852] - Kamil Przyborowski, Marta Wojewoda, Barbara Sitek, Agnieszka Zakrzewska, Agnieszka Kij, Krystyna Wandzel, Jerzy Andrzej Zoladz, Stefan Chlopicki. Effects of 1-Methylnicotinamide (MNA) on Exercise Capacity and Endothelial Response in Diabetic Mice.
PloS one.
2015; 10(6):e0130908. doi:
10.1371/journal.pone.0130908. [PMID: 26115505] - Fabian Müller, Constanza A Pontones, Bertold Renner, Maren Mieth, Eva Hoier, Daniel Auge, Renke Maas, Oliver Zolk, Martin F Fromm. N(1)-methylnicotinamide as an endogenous probe for drug interactions by renal cation transporters: studies on the metformin-trimethoprim interaction.
European journal of clinical pharmacology.
2015 Jan; 71(1):85-94. doi:
10.1007/s00228-014-1770-2. [PMID: 25552403] - Nimzing G Ladep, Anthony C Dona, Matthew R Lewis, Mary M E Crossey, Maud Lemoine, Edith Okeke, Yusuke Shimakawa, Mary Duguru, Harr F Njai, Haddy K S Fye, Makie Taal, John Chetwood, Ben Kasstan, Shahid A Khan, Deborah A Garside, Anisha Wijeyesekera, Andrew V Thillainayagam, Edmund Banwat, Mark R Thursz, Jeremy K Nicholson, Ramou Njie, Elaine Holmes, Simon D Taylor-Robinson. Discovery and validation of urinary metabotypes for the diagnosis of hepatocellular carcinoma in West Africans.
Hepatology (Baltimore, Md.).
2014 Oct; 60(4):1291-301. doi:
10.1002/hep.27264. [PMID: 24923488] - Yuji Nobuoka, Ryuichi Ogawa, Hirotoshi Echizen. Simultaneous determination of N(1)-methylnicotinamide, L-carnitine, and creatinine in human plasma and urine by liquid chromatography with mass spectrometry for assessing the activities of multiple renal cationic transporters.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Sep; 967(?):240-4. doi:
10.1016/j.jchromb.2014.07.034. [PMID: 25129409] - Da Li, Yan-Jie Tian, Jing Guo, Wu-Ping Sun, Yong-Zhi Lun, Ming Guo, Ning Luo, Yu Cao, Ji-Min Cao, Xiao-Jie Gong, Shi-Sheng Zhou. Nicotinamide supplementation induces detrimental metabolic and epigenetic changes in developing rats.
The British journal of nutrition.
2013 Dec; 110(12):2156-64. doi:
10.1017/s0007114513001815. [PMID: 23768418] - Yan-Jie Tian, Da Li, Qiang Ma, Xin-Yi Gu, Ming Guo, Yong-Zhi Lun, Wu-Ping Sun, Xin-Yuan Wang, Yu Cao, Shi-Sheng Zhou. Excess nicotinamide increases plasma serotonin and histamine levels.
Sheng li xue bao : [Acta physiologica Sinica].
2013 Feb; 65(1):33-8. doi:
. [PMID: 23426511] - Katsumi Shibata, Nobuya Morita, Yoshika Shibata, Tsutomu Fukuwatari. Enzymes that control the conversion of L-tryptophan-nicotinamide and the urinary excretion ratio (N(1)-methyl-2-pyridone-5-carboxamide + N(1)-methyl-4-pyridone-3-carboxamide)/N(1)-methylnicotinamide in mice.
Bioscience, biotechnology, and biochemistry.
2013; 77(10):2105-11. doi:
10.1271/bbb.130467. [PMID: 24096677] - Da Li, Ning Luo, Qiang Ma, Shu-Zhuang Li, Qiang Shi, Yu Cao, Shi-Sheng Zhou. Excessive nicotinic acid increases methyl consumption and hydrogen peroxide generation in rats.
Pharmaceutical biology.
2013 Jan; 51(1):8-12. doi:
10.3109/13880209.2012.697175. [PMID: 22971213] - Tomasz Przygodzki, Bartlomiej Grobelski, Piotr Kazmierczak, Cezary Watala. N-Methyl-2-pyridone-5-carboxamide is 1-methylnicotinamide metabolite of low cyclooxygenase-dependent vasodilating activity.
Journal of physiology and biochemistry.
2012 Sep; 68(3):329-34. doi:
10.1007/s13105-012-0144-4. [PMID: 22247034] - Ibrahim Abdel Aziz Ibrahim, Yusof Kamisah, Mohd Ismail Nafeeza, Mohd Fahami Nur Azlina. The effects of palm vitamin E on stress hormone levels and gastric lesions in stress-induced rats.
Archives of medical science : AMS.
2012 Feb; 8(1):22-9. doi:
10.5114/aoms.2012.27276. [PMID: 22457670] - Wu-Ping Sun, Da Li, Yong-Zhi Lun, Xiao-Jie Gong, Shen-Xia Sun, Ming Guo, Li-Xin Jing, Li-Bin Zhang, Fu-Cheng Xiao, Shi-Sheng Zhou. Excess nicotinamide inhibits methylation-mediated degradation of catecholamines in normotensives and hypertensives.
Hypertension research : official journal of the Japanese Society of Hypertension.
2012 Feb; 35(2):180-5. doi:
10.1038/hr.2011.151. [PMID: 21918528] - Stefan Chłopicki, Marta Kurdziel, Magdalena Sternak, Małgorzata Szafarz, Joanna Szymura-Oleksiak, Karol Kamiński, Jerzy A Żołądź. Single bout of endurance exercise increases NNMT activity in the liver and MNA concentration in plasma; the role of IL-6.
Pharmacological reports : PR.
2012; 64(2):369-76. doi:
10.1016/s1734-1140(12)70777-6. [PMID: 22661188] - Zuzana Országhová, Ol'ga Uličná, Anna Liptáková, Ingrid Zitňanová, Jana Muchová, Cezary Watala, Zdeňka Duračková. Effects of N1-methylnicotinamide on oxidative and glycooxidative stress markers in rats with streptozotocin-induced diabetes mellitus.
Redox report : communications in free radical research.
2012; 17(1):1-7. doi:
10.1179/1351000211y.0000000016. [PMID: 22340509] - Xing-Xing Liu, Chang-Bin Sun, Ting-Tong Yang, Da Li, Chun-Yan Li, Yan-Jie Tian, Ming Guo, Yu Cao, Shi-Sheng Zhou. Decreased skin-mediated detoxification contributes to oxidative stress and insulin resistance.
Experimental diabetes research.
2012; 2012(?):128694. doi:
10.1155/2012/128694. [PMID: 22899900] - S U Munshi, S Taneja, N S Bhavesh, J Shastri, R Aggarwal, S Jameel. Metabonomic analysis of hepatitis E patients shows deregulated metabolic cycles and abnormalities in amino acid metabolism.
Journal of viral hepatitis.
2011 Oct; 18(10):e591-602. doi:
10.1111/j.1365-2893.2011.01488.x. [PMID: 21914081] - James B Adams, Tapan Audhya, Sharon McDonough-Means, Robert A Rubin, David Quig, Elizabeth Geis, Eva Gehn, Melissa Loresto, Jessica Mitchell, Sharon Atwood, Suzanne Barnhouse, Wondra Lee. Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity.
Nutrition & metabolism.
2011 Jun; 8(1):34. doi:
10.1186/1743-7075-8-34. [PMID: 21651783] - Seok-Min Kang, Jong-Chul Park, Min-Jeong Shin, Hyeran Lee, Jaewon Oh, Do Hyun Ryu, Geum-Sook Hwang, Ji Hyung Chung. ¹H nuclear magnetic resonance based metabolic urinary profiling of patients with ischemic heart failure.
Clinical biochemistry.
2011 Mar; 44(4):293-9. doi:
10.1016/j.clinbiochem.2010.11.010. [PMID: 21167146] - Jia V Li, Jasmina Saric, Yulan Wang, Jürg Utzinger, Elaine Holmes, Oliver Balmer. Metabonomic investigation of single and multiple strain Trypanosoma brucei brucei infections.
The American journal of tropical medicine and hygiene.
2011 Jan; 84(1):91-8. doi:
10.4269/ajtmh.2011.10-0402. [PMID: 21212208] - Cimen Karasu. Glycoxidative stress and cardiovascular complications in experimentally-induced diabetes: effects of antioxidant treatment.
The open cardiovascular medicine journal.
2010 Nov; 4(?):240-56. doi:
10.2174/1874192401004010240. [PMID: 21270942] - Magdalena Sternak, Tamara I Khomich, Andrzej Jakubowski, Małgorzata Szafarz, Wojciech Szczepański, Magdalena Białas, Marta Stojak, Joanna Szymura-Oleksiak, Stefan Chłopicki. Nicotinamide N-methyltransferase (NNMT) and 1-methylnicotinamide (MNA) in experimental hepatitis induced by concanavalin A in the mouse.
Pharmacological reports : PR.
2010 May; 62(3):483-93. doi:
10.1016/s1734-1140(10)70304-2. [PMID: 20631412] - Susan C Connor, Michael K Hansen, Adam Corner, Randall F Smith, Terence E Ryan. Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes.
Molecular bioSystems.
2010 May; 6(5):909-21. doi:
10.1039/b914182k. [PMID: 20567778] - Malgorzata Szafarz, Magdalena Lomnicka, Magdalena Sternak, Stefan Chlopicki, Joanna Szymura-Oleksiak. Simultaneous determination of nicotinic acid and its four metabolites in rat plasma using high performance liquid chromatography with tandem mass spectrometric detection (LC/MS/MS).
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Apr; 878(11-12):895-902. doi:
10.1016/j.jchromb.2010.02.009. [PMID: 20223714] - M N Khodosovskiĭ, V V Zinchuk, S Chlopicki. [Effect of 1-methylnicotinamide on prooxidant-antioxidant balance parameters in rats during hepatic ischemia-reperfusion].
Eksperimental'naia i klinicheskaia farmakologiia.
2010 Apr; 73(4):11-3. doi:
NULL. [PMID: 20486552] - Tamara Kuchmerovska, Ihor Shymanskyy, Stefan Chlopicki, Arkady Klimenko. 1-methylnicotinamide (MNA) in prevention of diabetes-associated brain disorders.
Neurochemistry international.
2010 Jan; 56(2):221-8. doi:
10.1016/j.neuint.2009.10.004. [PMID: 19837120] - Shi-Sheng Zhou, Da Li, Wu-Ping Sun, Ming Guo, Yong-Zhi Lun, Yi-Ming Zhou, Fu-Cheng Xiao, Li-Xin Jing, Shen-Xia Sun, Li-Bin Zhang, Ning Luo, Fu-Ning Bian, Wei Zou, Lai-Bin Dong, Zhi-Gang Zhao, Sheng-Fan Li, Xiao-Jie Gong, Zeng-Guo Yu, Chang-Bin Sun, Cong-Long Zheng, Dong-Ju Jiang, Zheng-Ning Li. Nicotinamide overload may play a role in the development of type 2 diabetes.
World journal of gastroenterology.
2009 Dec; 15(45):5674-84. doi:
10.3748/wjg.15.5674. [PMID: 19960564] - Monika Riederer, Wolfgang Erwa, Robert Zimmermann, Sasa Frank, Rudolf Zechner. Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine.
Atherosclerosis.
2009 Jun; 204(2):412-7. doi:
10.1016/j.atherosclerosis.2008.09.015. [PMID: 18996527] - Carolyn M Slupsky, Andriy Cheypesh, Danny V Chao, Hao Fu, Kathryn N Rankin, Thomas J Marrie, Paige Lacy. Streptococcus pneumoniae and Staphylococcus aureus pneumonia induce distinct metabolic responses.
Journal of proteome research.
2009 Jun; 8(6):3029-36. doi:
10.1021/pr900103y. [PMID: 19368345] - Łukasz Mateuszuk, Tamara I Khomich, Ewa Słomińska, Mariusz Gajda, Luiza Wójcik, Magdalena Łomnicka, Pawel Gwóźdź, Stefan Chłopicki. Activation of nicotinamide N-methyltrasferase and increased formation of 1-methylnicotinamide (MNA) in atherosclerosis.
Pharmacological reports : PR.
2009 Jan; 61(1):76-85. doi:
10.1016/s1734-1140(09)70009-x. [PMID: 19307695] - Cezary Watała, Piotr Kaźmierczak, Marcin Dobaczewski, Tomasz Przygodzki, Magdalena Bartuś, Magdalena Łomnicka, Ewa M Słomińska, Zdena Durackova, Stefan Chłopicki. Anti-diabetic effects of 1-methylnicotinamide (MNA) in streptozocin-induced diabetes in rats.
Pharmacological reports : PR.
2009 Jan; 61(1):86-98. doi:
10.1016/s1734-1140(09)70010-6. [PMID: 19307696] - Shigeyuki Kitamura, Kayoko Nitta, Yoshitaka Tayama, Chiaki Tanoue, Kazumi Sugihara, Tae Inoue, Toru Horie, Shigeru Ohta. Aldehyde oxidase-catalyzed metabolism of N1-methylnicotinamide in vivo and in vitro in chimeric mice with humanized liver.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1202-5. doi:
10.1124/dmd.107.019075. [PMID: 18332084] - Tomasz Brzozowski, Peter C Konturek, Stefan Chlopicki, Zbigniew Sliwowski, Michal Pawlik, Agata Ptak-Belowska, Slawomir Kwiecien, Danuta Drozdowicz, Robert Pajdo, Ewa Slonimska, Stanislaw J Konturek, Wieslaw W Pawlik. Therapeutic potential of 1-methylnicotinamide against acute gastric lesions induced by stress: role of endogenous prostacyclin and sensory nerves.
The Journal of pharmacology and experimental therapeutics.
2008 Jul; 326(1):105-16. doi:
10.1124/jpet.108.136457. [PMID: 18385449] - Magdalena Bartuś, Magdalena Łomnicka, Renata B Kostogrys, Piotr Kaźmierczak, Cezary Watała, Ewa M Słominska, Ryszard T Smoleński, Paweł M Pisulewski, Jan Adamus, Jerzy Gebicki, Stefan Chlopicki. 1-Methylnicotinamide (MNA) prevents endothelial dysfunction in hypertriglyceridemic and diabetic rats.
Pharmacological reports : PR.
2008 Jan; 60(1):127-38. doi:
. [PMID: 18276994] - Francois-Pierre J Martin, Yulan Wang, Norbert Sprenger, Ivan K S Yap, Serge Rezzi, Ziad Ramadan, Emma Peré-Trepat, Florence Rochat, Christine Cherbut, Peter van Bladeren, Laurent B Fay, Sunil Kochhar, John C Lindon, Elaine Holmes, Jeremy K Nicholson. Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model.
Molecular systems biology.
2008; 4(?):205. doi:
10.1038/msb.2008.40. [PMID: 18628745] - Paul I Creeke, Filippo Dibari, Edith Cheung, Tina van den Briel, Eustace Kyroussis, Andrew J Seal. Whole blood NAD and NADP concentrations are not depressed in subjects with clinical pellagra.
The Journal of nutrition.
2007 Sep; 137(9):2013-7. doi:
10.1093/jn/137.9.2013. [PMID: 17709435] - Yueying Zhen, Kristopher W Krausz, Chi Chen, Jeffrey R Idle, Frank J Gonzalez. Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation.
Molecular endocrinology (Baltimore, Md.).
2007 Sep; 21(9):2136-51. doi:
10.1210/me.2007-0150. [PMID: 17550978] - Yulan Wang, Dennis Lawler, Brian Larson, Ziad Ramadan, Sunil Kochhar, Elaine Holmes, Jeremy K Nicholson. Metabonomic investigations of aging and caloric restriction in a life-long dog study.
Journal of proteome research.
2007 May; 6(5):1846-54. doi:
10.1021/pr060685n. [PMID: 17411081] - Mark W Ruddock, David G Hirst. Metabolites of the radiosensitizer nicotinamide are unlikely to contribute to the degree of emesis observed with the parent drug.
Oncology research.
2007; 16(12):569-74. doi:
10.3727/000000007783629990. [PMID: 18351131] - Satohiro Masuda, Tomohiro Terada, Atsushi Yonezawa, Yuko Tanihara, Koshiro Kishimoto, Toshiya Katsura, Osamu Ogawa, Ken-ichi Inui. Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2.
Journal of the American Society of Nephrology : JASN.
2006 Aug; 17(8):2127-35. doi:
10.1681/asn.2006030205. [PMID: 16807400] - Mohamed Abdelfattah El Dawya, Mokhtar Mohamed Mabrouk, Riad Ahmed El Barbary. Spectrofluorimetric determination of drugs containing active methylene group using N1-methyl nicotinamide chloride as a fluorigenic agent.
Chemical & pharmaceutical bulletin.
2006 Jul; 54(7):1026-9. doi:
10.1248/cpb.54.1026. [PMID: 16819224] - Kazumi Sugihara, Yoshitaka Tayama, Kazuhiro Shimomiya, Daisuke Yoshimoto, Shigeru Ohta, Shigeyuki Kitamura. Estimation of aldehyde oxidase activity in vivo from conversion ratio of N1-methylnicotinamide to pyridones, and intraspecies variation of the enzyme activity in rats.
Drug metabolism and disposition: the biological fate of chemicals.
2006 Feb; 34(2):208-12. doi:
10.1124/dmd.105.006544. [PMID: 16299165] - Paul I Creeke, Andrew J Seal. Quantitation of the niacin metabolites 1-methylnicotinamide and l-methyl-2-pyridone-5-carboxamide in random spot urine samples, by ion-pairing reverse-phase HPLC with UV detection, and the implications for the use of spot urine samples in the assessment of niacin status.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Mar; 817(2):247-53. doi:
10.1016/j.jchromb.2004.12.012. [PMID: 15686992] - Mohamed A El Dawy, Mokhtar M Mabrouk, Riad A El Barbary. Spectrofluorimetric determination of warfarin sodium by using N1-methylnicotinamide chloride as a fluorigenic agent.
Journal of AOAC International.
2005 Mar; 88(2):455-61. doi:
10.1093/jaoac/88.2.455. [PMID: 15859071] - Stephanie Ringeissen, Susan C Connor, H Roger Brown, Brian C Sweatman, Mark P Hodson, Steve P Kenny, Richard I Haworth, Paul McGill, Mark A Price, Mike C Aylott, Derek J Nunez, John N Haselden, Catherine J Waterfield. Potential urinary and plasma biomarkers of peroxisome proliferation in the rat: identification of N-methylnicotinamide and N-methyl-4-pyridone-3-carboxamide by 1H nuclear magnetic resonance and high performance liquid chromatography.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2003 May; 8(3-4):240-71. doi:
10.1080/1354750031000149124. [PMID: 12944176] - Tetsuhito Fukushima. [Elucidation of paraquat poisoning mechanism and development of the neuronal death model].
Nihon eiseigaku zasshi. Japanese journal of hygiene.
2002 Apr; 57(1):83-6. doi:
". [PMID: 11928321] - Tetsuhito Fukushima, Akihiko Kaetsu, Heejin Lim, Masaki Moriyama. Possible role of 1-methylnicotinamide in the pathogenesis of Parkinson's disease.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2002 Feb; 53(6):469-73. doi:
10.1078/0940-2993-00214. [PMID: 11926289] - C Musfeld, J Biollaz, N Bélaz, U W Kesselring, L A Decosterd. Validation of an HPLC method for the determination of urinary and plasma levels of N1-methylnicotinamide, an endogenous marker of renal cationic transport and plasma flow.
Journal of pharmaceutical and biomedical analysis.
2001 Jan; 24(3):391-404. doi:
10.1016/s0731-7085(00)00425-8. [PMID: 11199218] - X Wu, W Huang, M E Ganapathy, H Wang, R Kekuda, S J Conway, F H Leibach, V Ganapathy. Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney.
American journal of physiology. Renal physiology.
2000 Sep; 279(3):F449-58. doi:
10.1152/ajprenal.2000.279.3.f449. [PMID: 10966924] - R Orlando, M Floreani, E Napoli, R Padrini, P Palatini. Renal clearance of N(1)-methylnicotinamide: a sensitive marker of the severity of liver dysfunction in cirrhosis.
Nephron.
2000 Jan; 84(1):32-9. doi:
10.1159/000045536. [PMID: 10644906] - D H Sweet, J B Pritchard. rOCT2 is a basolateral potential-driven carrier, not an organic cation/proton exchanger.
The American journal of physiology.
1999 12; 277(6):F890-8. doi:
10.1152/ajprenal.1999.277.6.f890. [PMID: 10600936] - K Mawatari, F Iinuma, M Watanabe. Determination of N1-methylnicotinamide by HPLC postcolumn photoirradiation.
Advances in experimental medicine and biology.
1999; 467(?):817-9. doi:
10.1007/978-1-4615-4709-9_103. [PMID: 10721134] - J Bernier, M R Stratford, J Denekamp, M F Dennis, S Bieri, F Hagen, O Kocagöncü, M Bolla, A Rojas. Pharmacokinetics of nicotinamide in cancer patients treated with accelerated radiotherapy: the experience of the Co-operative Group of Radiotherapy of the European Organization for Research and Treatment of Cancer.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
1998 Aug; 48(2):123-33. doi:
10.1016/s0167-8140(98)00048-6. [PMID: 9783883] - K Shibata, T Kondo, A Miki. Increased conversion ratio of tryptophan to niacin in severe food restriction.
Bioscience, biotechnology, and biochemistry.
1998 Mar; 62(3):580-3. doi:
10.1271/bbb.62.580. [PMID: 9571792] - V Gorboulev, J C Ulzheimer, A Akhoundova, I Ulzheimer-Teuber, U Karbach, S Quester, C Baumann, F Lang, A E Busch, H Koepsell. Cloning and characterization of two human polyspecific organic cation transporters.
DNA and cell biology.
1997 Jul; 16(7):871-81. doi:
10.1089/dna.1997.16.871. [PMID: 9260930] - J K Chun, L Zhang, M Piquette-Miller, E Lau, L Q Tong, K M Giacomini. Characterization of guanidine transport in human renal brush border membranes.
Pharmaceutical research.
1997 Jul; 14(7):936-41. doi:
10.1023/a:1012164203648. [PMID: 9244153] - S A Khotimchenko, V M Kodentsova, I A Alekseeva, S G Vlaskina, O A Vrzhesinskaia, A A Sokol'nikov, L A Kharitonchik, I P Aleshko-Ozhevskií, L V Sheviakova. [Influence of lead on metabolism of vitamins B group in alimentary iron deficient rats].
Voprosy meditsinskoi khimii.
1997 May; 43(3):158-64. doi:
NULL. [PMID: 9273779] - H M Vargas, D J Jenden. Elevation of cerebrospinal fluid choline levels by nicotinamide involves the enzymatic formation of N1-methylnicotinamide in brain tissue.
Life sciences.
1996; 58(22):1995-2002. doi:
10.1016/0024-3205(96)00190-7. [PMID: 8637429] - T Fukushima, T Tawara, A Isobe, N Hojo, K Shiwaku, Y Yamane. Radical formation site of cerebral complex I and Parkinson's disease.
Journal of neuroscience research.
1995 Oct; 42(3):385-90. doi:
10.1002/jnr.490420313. [PMID: 8583507] - C David, G Rumrich, K J Ullrich. Luminal transport system for H+/organic cations in the rat proximal tubule. Kinetics, dependence on pH; specificity as compared with the contraluminal organic cation-transport system.
Pflugers Archiv : European journal of physiology.
1995 Aug; 430(4):477-92. doi:
10.1007/bf00373884. [PMID: 7491274] - R Bendayan, B Lo, M Silverman. Characterization of cimetidine transport in LLCPK1 cells.
Journal of the American Society of Nephrology : JASN.
1994 Jul; 5(1):75-84. doi:
10.1681/asn.v5175. [PMID: 7948786] - V M Kodentsova, O A Vrzhesinskaia, L A Kharitonchik, V B Spirichev. [B group vitamin metabolism in duodenal ulcer disease, hypertension, and ischemic heart disease].
Voprosy meditsinskoi khimii.
1994 Mar; 40(2):41-5. doi:
NULL. [PMID: 8160430] - B D Edwards, A Maiza, P T Daley-Yates, R J Chalmers, J B O'Driscoll, R S Lawson, H J Testa, F W Ballardie. Altered clearance of N-1 methylnicotinamide associated with the use of low doses of cyclosporine.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
1994 Jan; 23(1):23-30. doi:
10.1016/s0272-6386(12)80807-9. [PMID: 8285193] - R E Sadykova, V M Kodentsova, A V Dreval'. [Body niacin status in experimental diabetes mellitus; effect of protein level in the ration].
Problemy endokrinologii.
1994 Jan; 40(1):41-3. doi:
10.14341/probl11329. [PMID: 8165215] - K J Ullrich, G Rumrich, C David, G Fritzsch. Bisubstrates: substances that interact with renal contraluminal organic anion and organic cation transport systems. I. Amines, piperidines, piperazines, azepines, pyridines, quinolines, imidazoles, thiazoles, guanidines and hydrazines.
Pflugers Archiv : European journal of physiology.
1993 Nov; 425(3-4):280-99. doi:
10.1007/bf00374179. [PMID: 8309790] - K J Ullrich, G Rumrich, C David, G Fritzsch. Bisubstrates: substances that interact with both, renal contraluminal organic anion and organic cation transport systems. II. Zwitterionic substrates: dipeptides, cephalosporins, quinolone-carboxylate gyrase inhibitors and phosphamide thiazine carboxylates; nonionizable substrates: steroid hormones and cyclophosphamides.
Pflugers Archiv : European journal of physiology.
1993 Nov; 425(3-4):300-12. doi:
10.1007/bf00374180. [PMID: 8309791] - V M Kodentsova, O A Vrzhesinskaia, A A Sokol'nikov, N A Beketova, V B Spirichev. [The effect of riboflavin supply on metabolism of water-soluble vitamins].
Voprosy meditsinskoi khimii.
1993 Sep; 39(5):29-33. doi:
. [PMID: 8279138] - V M Kodentsova, O A Vrzhesinskaia, A A Sokol'nikov, I A Alekseeva, V B Spirichev. [Metabolism of riboflavin and B group vitamins functionally bound to it in insulin-dependent diabetes mellitus].
Voprosy meditsinskoi khimii.
1993 Sep; 39(5):33-6. doi:
. [PMID: 8279139] - R E Sadykova, V M Kodentsova, A A Sokol'nikov, O A Vrzhesinskaia, N A Beketova, A V Dreval', V Iu Spirichev. [Water-soluble vitamin metabolism in rats with streptozotocin-induced diabetes].
Problemy endokrinologii.
1993 May; 39(3):40-2. doi:
NULL. [PMID: 8058681]
