taurodeoxycholic acid (BioDeep_00000405394)
Main id: BioDeep_00000003498
natural product PANOMIX_OTCML-2023 Bile acids
代谢物信息卡片
taurodeoxycholic acid
化学式: C26H45NO6S (499.2967)
中文名称: 牛磺脱氧氯酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C1(C(CC3C2CCC4C3(CCC(C4)O)C)O)C
InChI: InChI=1S/C26H45NO6S/c1-16(4-9-24(30)27-12-13-34(31,32)33)20-7-8-21-19-6-5-17-14-18(28)10-11-25(17,2)22(19)15-23(29)26(20,21)3/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-/m1/s1
描述信息
D005765 - Gastrointestinal Agents > D002756 - Cholagogues and Choleretics
D005765 - Gastrointestinal Agents > D001647 - Bile Acids and Salts
D005765 - Gastrointestinal Agents > D002793 - Cholic Acids
D013501 - Surface-Active Agents > D003902 - Detergents
A bile acid taurine conjugate of deoxycholic acid.
Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD)[1][2][3][4].
Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD)[1][2][3][4].
同义名列表
1 个代谢物同义名
数据库引用编号
22 个数据库交叉引用编号
- ChEBI: CHEBI:9410
- PubChem: 2733768
- ChEMBL: CHEMBL412272
- MeSH: Taurodeoxycholic Acid
- CAS: 516-50-7
- CAS: ?516-50-7
- MoNA: CCMSLIB00005435485
- MoNA: CCMSLIB00005435486
- MoNA: CCMSLIB00005435487
- MoNA: CCMSLIB00005435567
- MoNA: CCMSLIB00005435568
- MoNA: CCMSLIB00005435569
- MoNA: CCMSLIB00005435570
- MoNA: CCMSLIB00005435571
- MoNA: CCMSLIB00005435572
- MoNA: CCMSLIB00005435573
- MoNA: HMDB0000896_ms_ms_1267
- MoNA: HMDB0000896_ms_ms_1266
- MoNA: HMDB0000896_ms_ms_1265
- MetaboLights: MTBLC9410
- RefMet: Taurodeoxycholic acid
- medchemexpress: HY-B1899
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
- 40674 - Animals: -
- 3039 - Euglena gracilis: 10.3389/FBIOE.2021.662655
- 9606 - Homo sapiens:
- 1827580 - Streptomyces nigra: 10.3389/FMICB.2018.01587
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Da-Xin Chen, Jian-Feng Chu, Shan Lin, Ling Zhang, Hong-Wei Chen, Zhi-Wei Sun, Jian-Feng Xu, Qiao-Yan Cai, Li-Li Wang, Jun Peng. Therapeutic Effects of Different Animal Bile Powders on Lipid Metabolism Disorders and Their Composition Analysis.
Chinese journal of integrative medicine.
2022 Oct; 28(10):918-923. doi:
10.1007/s11655-021-3441-3. [PMID: 33609233] - Shouli Wang, Junliang Kuang, Hongwei Zhang, Wenlian Chen, Xiaojiao Zheng, Jieyi Wang, Fengjie Huang, Kun Ge, Mengci Li, Mingliang Zhao, Cynthia Rajani, Jinshui Zhu, Aihua Zhao, Wei Jia. Bile Acid-Microbiome Interaction Promotes Gastric Carcinogenesis.
Advanced science (Weinheim, Baden-Wurttemberg, Germany).
2022 05; 9(16):e2200263. doi:
10.1002/advs.202200263. [PMID: 35285172] - Yue Li, Dongming Yan, Jingyi Jin, Bo Tan, Xi Chen, Bin Zou, Guochao Song, Fengyi Weng, Chenghai Liu, Furong Qiu. Clarify the potential cholestatic hepatotoxicity components from Chinese Herb Medicine and metabolism's role via hBSEP vesicles and S9/hBSEP vesicles.
Toxicology in vitro : an international journal published in association with BIBRA.
2022 Apr; 80(?):105324. doi:
10.1016/j.tiv.2022.105324. [PMID: 35101544] - Suzhen Lei, Lu Liu, Linyu Ding, Yi Zhang, Hongliang Zeng. Lotus seed resistant starch affects the conversion of sodium taurocholate by regulating the intestinal microbiota.
International journal of biological macromolecules.
2021 Sep; 186(?):227-236. doi:
10.1016/j.ijbiomac.2021.07.031. [PMID: 34245735] - Yanlin Tao, Fang Zheng, Donghong Cui, Fei Huang, Xiaojun Wu. A combination of three plasma bile acids as a putative biomarker for schizophrenia.
Acta neuropsychiatrica.
2021 Feb; 33(1):51-54. doi:
10.1017/neu.2020.42. [PMID: 33222705] - Iván L Csanaky, Andrew J Lickteig, Youcai Zhang, Curtis D Klaassen. Effects of patent ductus venosus on bile acid homeostasis in aryl hydrocarbon receptor (AhR)-null mice.
Toxicology and applied pharmacology.
2020 09; 403(?):115136. doi:
10.1016/j.taap.2020.115136. [PMID: 32679164] - Abir Ben Bacha, Ikram Jemel, Ramesa Shafi Bhat, Mona Awad Onizi. Inhibitory effects of various solvent extracts from Rhamnus frangula leaves on some inflammatory and metabolic enzymes.
Cellular and molecular biology (Noisy-le-Grand, France).
2018 Oct; 64(13):55-62. doi:
10.14715/cmb/2018.64.13.11. [PMID: 30403596] - Takumi Kawaguchi, Dan Nakano, Tetsuharu Oriishi, Takuji Torimura. Effects of isomaltulose on insulin resistance and metabolites in patients with non‑alcoholic fatty liver disease: A metabolomic analysis.
Molecular medicine reports.
2018 Aug; 18(2):2033-2042. doi:
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2018 05; 128(5):1157-1162. doi:
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Chinese journal of natural medicines.
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Food & function.
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PloS one.
2015; 10(7):e0131010. doi:
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World journal of gastroenterology.
2013 Oct; 19(37):6228-36. doi:
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Hepatology (Baltimore, Md.).
2012 Dec; 56(6):2387-97. doi:
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2012 Feb; 16(1):25-30. doi:
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Hepatology (Baltimore, Md.).
2012 Jan; 55(1):267-76. doi:
10.1002/hep.24681. [PMID: 21932398] - Barbara Renga, Andrea Mencarelli, Claudio D'Amore, Sabrina Cipriani, Maria Valeria D'Auria, Valentina Sepe, Maria Giovanna Chini, Maria Chiara Monti, Giuseppe Bifulco, Angela Zampella, Stefano Fiorucci. Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis.
PloS one.
2012; 7(1):e30443. doi:
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Biochimica et biophysica acta.
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Experimental diabetes research.
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PloS one.
2012; 7(4):e34522. doi:
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Toxicological sciences : an official journal of the Society of Toxicology.
2011 Dec; 124(2):251-60. doi:
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European journal of pharmacology.
2011 Nov; 670(1):229-35. doi:
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Analytical and bioanalytical chemistry.
2011 Nov; 401(9):2899-907. doi:
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Plant foods for human nutrition (Dordrecht, Netherlands).
2011 Mar; 66(1):34-40. doi:
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Chemical communications (Cambridge, England).
2011 Feb; 47(6):1806-8. doi:
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Yao xue xue bao = Acta pharmaceutica Sinica.
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PloS one.
2011; 6(10):e25482. doi:
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PloS one.
2011; 6(7):e22094. doi:
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2010 Jul; 16(27):3411-7. doi:
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International journal of molecular sciences.
2010 Jun; 11(6):2499-522. doi:
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Pharmaceutical research.
2010 May; 27(5):823-31. doi:
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American journal of physiology. Gastrointestinal and liver physiology.
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Toxicological sciences : an official journal of the Society of Toxicology.
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2010 Mar; 105(3):585-95. doi:
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Pancreas.
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Analytical chemistry.
2007 Sep; 79(17):6455-64. doi:
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Journal of lipid research.
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Vascular pharmacology.
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Journal of pediatric gastroenterology and nutrition.
2007 Mar; 44(3):300-11. doi:
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Molecular systems biology.
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Research in microbiology.
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Journal of proteome research.
2006 Sep; 5(9):2135-43. doi:
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American journal of physiology. Gastrointestinal and liver physiology.
2006 Sep; 291(3):G414-23. doi:
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Journal of lipid research.
2006 Sep; 47(9):1959-66. doi:
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The Journal of biological chemistry.
2006 Mar; 281(12):7793-800. doi:
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European journal of pharmacology.
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Biochemical pharmacology.
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International journal of pharmaceutics.
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Journal of veterinary science.
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Analytical biochemistry.
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Journal of medical microbiology.
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The Journal of biological chemistry.
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American journal of physiology. Gastrointestinal and liver physiology.
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Fundamental & clinical pharmacology.
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