Prostaglandin A1 (BioDeep_00000403253)

Main id: BioDeep_00000001681

 

natural product


代谢物信息卡片


9-oxo-15S-hydroxy-10Z,13E-prostadienoic acid

化学式: C20H32O4 (336.23)
中文名称: 前列腺素A1
谱图信息: 最多检出来源 Homo sapiens(lipidomics) 75%

分子结构信息

SMILES: C1C(=O)[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)C=1
InChI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/b14-12+/t16-,17-,18+/m0/s1

描述信息

Prostaglandin A1 is a prostaglandins A. It is a conjugate acid of a prostaglandin A1(1-).

同义名列表

8 个代谢物同义名

PROSTAGLANDIN A1; 9-oxo-15S-hydroxy-10Z,13E-prostadienoic acid; 15a-Hydroxy-9-oxo-10,13E-prostadienoic acid; 15a-Hydroxy-9-oxo-10,13E-prostadienoate; FA 20:4;O2; PGA1; Eicosanoids_PGA1_C20H32O4; (13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dienoate



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ALB, BCL2, CASP3, CDKN1A, HPGD, MYC, NFKB1, NFKBIA, PPARG
Peripheral membrane protein 1 AP1S2
Endoplasmic reticulum membrane 3 BCL2, CD4, HMOX1
Nucleus 11 ALB, BCL2, CASP3, CDKN1A, HMOX1, JUND, MYC, NFKB1, NFKBIA, PPARA, PPARG
cytosol 10 ALB, AP1S2, BCL2, CASP3, CDKN1A, HMOX1, HPGD, NFKB1, NFKBIA, PPARG
nuclear body 1 CDKN1A
centrosome 1 ALB
nucleoplasm 10 CASP3, CDKN1A, HMOX1, HPGD, JUND, MYC, NFKB1, NFKBIA, PPARA, PPARG
RNA polymerase II transcription regulator complex 2 JUND, PPARG
Cell membrane 2 CD4, TNF
Cytoplasmic side 2 AP1S2, HMOX1
cell surface 1 TNF
glutamatergic synapse 1 CASP3
Golgi apparatus 2 ALB, AP1S2
Golgi membrane 2 AP1S2, INS
lysosomal membrane 1 AP1S2
neuronal cell body 2 CASP3, TNF
plasma membrane 5 CD4, IFNLR1, NFKBIA, REN, TNF
Membrane 5 BCL2, HMOX1, IFNLR1, MYC, REN
basolateral plasma membrane 1 HPGD
extracellular exosome 2 ALB, HPGD
endoplasmic reticulum 3 ALB, BCL2, HMOX1
extracellular space 5 ALB, HMOX1, INS, REN, TNF
perinuclear region of cytoplasm 3 CDKN1A, HMOX1, PPARG
mitochondrion 2 BCL2, NFKB1
protein-containing complex 4 ALB, BCL2, CDKN1A, MYC
intracellular membrane-bounded organelle 2 AP1S2, PPARG
postsynaptic density 1 CASP3
Single-pass type I membrane protein 2 CD4, IFNLR1
Secreted 3 ALB, INS, REN
extracellular region 5 ALB, INS, NFKB1, REN, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
anchoring junction 1 ALB
transcription regulator complex 2 JUND, NFKB1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 CD4, TNF
nucleolus 2 CDKN1A, MYC
Early endosome 2 AP1S2, CD4
Membrane, clathrin-coated pit 1 AP1S2
apical part of cell 1 REN
clathrin-coated pit 1 AP1S2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 2 CD4, TNF
pore complex 1 BCL2
receptor complex 1 PPARG
ciliary basal body 1 ALB
chromatin 5 JUND, MYC, NFKB1, PPARA, PPARG
phagocytic cup 1 TNF
centriole 1 ALB
Nucleus, nucleolus 1 MYC
spindle pole 1 ALB
blood microparticle 1 ALB
nuclear envelope 1 MYC
Endomembrane system 1 AP1S2
endosome lumen 1 INS
Cytoplasmic vesicle membrane 1 AP1S2
Nucleus, nucleoplasm 1 MYC
myelin sheath 1 BCL2
trans-Golgi network membrane 1 AP1S2
secretory granule lumen 2 INS, NFKB1
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, CD4, INS
transcription repressor complex 1 JUND
platelet alpha granule lumen 1 ALB
specific granule lumen 1 NFKB1
transport vesicle 1 INS
RNA polymerase II transcription repressor complex 1 MYC
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Single-pass type IV membrane protein 1 HMOX1
clathrin-coated endocytic vesicle membrane 1 CD4
death-inducing signaling complex 1 CASP3
AP-type membrane coat adaptor complex 1 AP1S2
membrane coat 1 AP1S2
Rough endoplasmic reticulum 1 MYC
AP-1 adaptor complex 1 AP1S2
cyclin-dependent protein kinase holoenzyme complex 1 CDKN1A
transcription factor AP-1 complex 1 JUND
Myc-Max complex 1 MYC
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD4
BAD-BCL-2 complex 1 BCL2
PCNA-p21 complex 1 CDKN1A
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 2 NFKB1, NFKBIA
NF-kappaB p50/p65 complex 1 NFKB1
ciliary transition fiber 1 ALB
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
nucleoplasmic reticulum 1 MYC


文献列表

  • Qinglong Li, Xiaomin Wang, Yang Lei, Yanling Wang, Bilang Li, Xiayan Liu, Lijun An, Fei Yu, Yafei Qi. Chloroplast envelope ATPase PGA1/AtFtsH12 is required for chloroplast protein accumulation and cytosol-chloroplast protein homeostasis in Arabidopsis. The Journal of biological chemistry. 2022 10; 298(10):102489. doi: 10.1016/j.jbc.2022.102489. [PMID: 36113581]
  • Y Sajiki, S Konnai, Y Ikenaka, T Okagawa, N Maekawa, C Logullo, I da Silva Vaz, S Murata, K Ohashi. Prostaglandin-related immune suppression in cattle. Veterinary immunology and immunopathology. 2021 Jun; 236(?):110238. doi: 10.1016/j.vetimm.2021.110238. [PMID: 33857743]
  • Guo-Biao Xu, Liu-Qing Yang, Pei-Pei Guan, Zhan-You Wang, Pu Wang. Prostaglandin A1 Inhibits the Cognitive Decline of APP/PS1 Transgenic Mice via PPARγ/ABCA1-dependent Cholesterol Efflux Mechanisms. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2019 04; 16(2):505-522. doi: 10.1007/s13311-018-00704-1. [PMID: 30627958]
  • Lúcio Ayres Caldas, Tânia Rosária Pereira Freitas, Renata Campos Azevedo, Wanderley de Souza. Prostaglandin A1 inhibits the replication of bovine viral diarrhea virus. Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]. 2018 Oct; 49(4):785-789. doi: 10.1016/j.bjm.2017.12.010. [PMID: 29544983]
  • Simone Findling, Henrik U Stotz, Maria Zoeller, Markus Krischke, Mark Zander, Christiane Gatz, Susanne Berger, Martin J Mueller. TGA2 signaling in response to reactive electrophile species is not dependent on cysteine modification of TGA2. PloS one. 2018; 13(4):e0195398. doi: 10.1371/journal.pone.0195398. [PMID: 29608605]
  • Beatriz Díez-Dacal, Francisco J Sánchez-Gómez, Pedro A Sánchez-Murcia, Ivana Milackova, Tahl Zimmerman, Jana Ballekova, Elena García-Martín, José A G Agúndez, Severine Gharbi, Federico Gago, Milan Stefek, Dolores Pérez-Sala. Molecular Interactions and Implications of Aldose Reductase Inhibition by PGA1 and Clinically Used Prostaglandins. Molecular pharmacology. 2016 Jan; 89(1):42-52. doi: 10.1124/mol.115.100693. [PMID: 26487510]
  • Stefania Carta, Simone La Frazia, Isabella Donatelli, Simona Puzelli, Antonio Rossi, M Gabriella Santoro. Prostaglandin A1 inhibits avian influenza virus replication at a postentry level: Effect on virus protein synthesis and NF-κB activity. Prostaglandins, leukotrienes, and essential fatty acids. 2014 Dec; 91(6):311-23. doi: 10.1016/j.plefa.2014.07.009. [PMID: 25151089]
  • Henrik U Stotz, Stefan Mueller, Maria Zoeller, Martin J Mueller, Susanne Berger. TGA transcription factors and jasmonate-independent COI1 signalling regulate specific plant responses to reactive oxylipins. Journal of experimental botany. 2013 Feb; 64(4):963-75. doi: 10.1093/jxb/ers389. [PMID: 23349138]
  • Joseph Antoun, Sophie Goulitquer, Yolande Amet, Yvonne Dreano, Jean-Pierre Salaun, Laurent Corcos, Emmanuelle Plée-Gautier. CYP4F3B is induced by PGA1 in human liver cells: a regulation of the 20-HETE synthesis. Journal of lipid research. 2008 Oct; 49(10):2135-41. doi: 10.1194/jlr.m800043-jlr200. [PMID: 18566475]
  • David W Stanley, Cynthia Goodman, Shiheng An, Arthur McIntosh, Qisheng Song. Prostaglandins A1 and E1 influence gene expression in an established insect cell line (BCIRL-HzAM1 cells). Insect biochemistry and molecular biology. 2008 Mar; 38(3):275-84. doi: 10.1016/j.ibmb.2007.11.004. [PMID: 18252242]
  • Woo Jae Kim, Joon Hyun Kim, Sung Key Jang. Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A. The EMBO journal. 2007 Dec; 26(24):5020-32. doi: 10.1038/sj.emboj.7601920. [PMID: 18034160]
  • Javier Gayarre, David Sánchez, Francisco J Sánchez-Gómez, María C Terrón, Oscar Llorca, Dolores Pérez-Sala. Addition of electrophilic lipids to actin alters filament structure. Biochemical and biophysical research communications. 2006 Nov; 349(4):1387-93. doi: 10.1016/j.bbrc.2006.09.005. [PMID: 16979589]
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  • Carla Amici, Giuseppe Belardo, Carmela Rozera, Daniela Bernasconi, M Gabriella Santoro. Inhibition of herpesvirus-induced HIV-1 replication by cyclopentenone prostaglandins: role of IkappaB kinase (IKK). AIDS (London, England). 2004 Jun; 18(9):1271-80. doi: 10.1097/00002030-200406180-00005. [PMID: 15362659]
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  • Philip J Moos, Kornelia Edes, Pamela Cassidy, Edmond Massuda, F A Fitzpatrick. Electrophilic prostaglandins and lipid aldehydes repress redox-sensitive transcription factors p53 and hypoxia-inducible factor by impairing the selenoprotein thioredoxin reductase. The Journal of biological chemistry. 2003 Jan; 278(2):745-50. doi: 10.1074/jbc.m211134200. [PMID: 12424231]
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