10-gingerol (BioDeep_00000402893)
Main id: BioDeep_00000000511
natural product PANOMIX_OTCML-2023 Volatile Flavor Compounds
代谢物信息卡片
3-Tetradecanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (S)-
化学式: C21H34O4 (350.24569640000004)
中文名称: 10-姜酚
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCC(CC(=O)CCC1=CC(=C(C=C1)O)OC)O
InChI: InChI=1S/C21H34O4/c1-3-4-5-6-7-8-9-10-18(22)16-19(23)13-11-17-12-14-20(24)21(15-17)25-2/h12,14-15,18,22,24H,3-11,13,16H2,1-2H3/t18-/m0/s1
描述信息
10-Gingerol is a major pungent constituent in the ginger oleoresin from fresh rhizome, with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC50 of 12.1 μM[1][2].
10-Gingerol is a major pungent constituent in the ginger oleoresin from fresh rhizome, with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC50 of 12.1 μM[1][2].
同义名列表
9 个代谢物同义名
3-Tetradecanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (S)-; (5S)-5-hydroxy-1-(4-hydroxy-3-methoxy-phenyl)tetradecan-3-one; (5s)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)tetradecan-3-one; (S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-tetradecanone; (10)-Gingerol; 10-gingerol; 23513-15-7; [10]-Gingerol; (10)-Gingerol
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:81134
- KEGG: C17496
- PubChem: 168115
- ChEMBL: CHEMBL549472
- CAS: 23513-15-7
- MoNA: PM012303
- MoNA: PM012307
- PubChem: 96023842
- KNApSAcK: C00031474
- NIKKAJI: J263.993I
- medchemexpress: HY-N0448
- KNApSAcK: 81134
- LOTUS: LTS0012062
- wikidata: Q27155092
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
6 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yoon-Tae Kim, Jae-Sung Shin, Sang-Jin Ye, Ji Hye Kim, Seok Hyun Eom, Moo-Yeol Baik. Conversion of gingerols to shogaols in ginger (Zingiber officinale roscoe) by puffing.
Food chemistry.
2024 Sep; 452(?):139425. doi:
10.1016/j.foodchem.2024.139425. [PMID: 38744128] - Xiaoliang He, Yingya Zhou, Jingtao Yu, Qinpo Huang, Zhengyuan Chen, Ru Xiao, Changhui Liu, Shuhua Gui, Tianqin Xiong. JiaGaSongTang improves chronic cholestasis via enhancing FXR-mediated bile acid metabolism.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jun; 128(?):155347. doi:
10.1016/j.phymed.2024.155347. [PMID: 38493717] - Ze Peng, Yan Zeng, Qi Tan, Qifeng He, Shang Wang, Jianwei Wang. 6-Gingerol alleviates ectopic lipid deposition in skeletal muscle by regulating CD36 translocation and mitochondrial function.
Biochemical and biophysical research communications.
2024 May; 708(?):149786. doi:
10.1016/j.bbrc.2024.149786. [PMID: 38493545] - Zarrin Basharat, Zainab Murtaza, Aisha Siddiqa, Sulaiman Mohammed Alnasser, Alotaibi Meshal. Therapeutic target mapping from the genome of Kingella negevensis and biophysical inhibition assessment through PNP synthase binding with traditional medicinal compounds.
Molecular diversity.
2024 Apr; 28(2):581-594. doi:
10.1007/s11030-023-10604-y. [PMID: 36645537] - Kitti Pázmándi, Beatrix Ágics, Attila Gábor Szöllősi, Attila Bácsi, Tünde Fekete. Ginger-derived bioactive compounds attenuate the Toll-like receptor mediated responses of human dendritic cells.
European journal of pharmacology.
2024 Mar; 967(?):176399. doi:
10.1016/j.ejphar.2024.176399. [PMID: 38331338] - Eka Munika, Shirly Gunawan, Puspita Eka Wuyung, Vivian Soetikno. Beneficial Effects of 6-Gingerol on Fatty Pancreas Disease in High-Fat High-Fructose Diet-Induced Metabolic Syndrome Rat Model.
Pancreas.
2024 Feb; 53(2):e193-e198. doi:
10.1097/mpa.0000000000002287. [PMID: 38127814] - Zijing Chen, Ling Zhang, Yao Lv, Shenyang Qu, Wenjun Liu, Kai Wang, Song Gao, Feng Zhu, Bili Cao, Kun Xu. A genome assembly of ginger (Zingiber officinale Roscoe) provides insights into genome evolution and 6-gingerol biosynthesis.
The Plant journal : for cell and molecular biology.
2024 Jan; ?(?):. doi:
10.1111/tpj.16625. [PMID: 38251816] - Qingsong Xia, Fuer Lu, Yu Chen, Jingbin Li, Zhaoyi Huang, Ke Fang, Meilin Hu, Yujin Guo, Hui Dong, Lijun Xu, Jing Gong. 6-Gingerol regulates triglyceride and cholesterol biosynthesis to improve hepatic steatosis in MAFLD by activating the AMPK-SREBPs signaling pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2024 Jan; 170(?):116060. doi:
10.1016/j.biopha.2023.116060. [PMID: 38147735] - Fatemeh Pashizeh, Afsoun Mansouri, Saina Bazzazan, Mohammadreza Abdihaji, Mohammad Khaleghian, Saba Bazzazan, Niloufar Rezei, Alireza Eskandari, Farzaneh Mashayekhi, Maryam Heydari, Mohammad Tavakkoli Yaraki. Bioresponsive gingerol-loaded alginate-coated niosomal nanoparticles for targeting intracellular bacteria and cancer cells.
International journal of biological macromolecules.
2023 Dec; 258(Pt 2):128957. doi:
10.1016/j.ijbiomac.2023.128957. [PMID: 38154726] - Zhimin Song, Hongbin Fang, Xiaojuan Zhang, Yong-Ming Yan, Yufei Liu, Jingjing Miao, Huiying Niu, Weisheng Feng, Yong-Xian Cheng, Yanzhi Wang. Renoprotective Glycoside Derivatives from Zingiber officinale (Ginger) Peels.
Journal of agricultural and food chemistry.
2023 Oct; ?(?):. doi:
10.1021/acs.jafc.3c05224. [PMID: 37811859] - Wenlin Zhang, Yang Yang, Xuedong Zhu, Suyu Yang, Ximei Liao, Honglei Li, Zhexin Li, Qinhong Liao, Jianmin Tang, Guohua Zhao, Lin Wu. Integrated analyses of metabolomics and transcriptomics reveal the potential regulatory roles of long non-coding RNAs in gingerol biosynthesis.
BMC genomics.
2023 Aug; 24(1):490. doi:
10.1186/s12864-023-09553-5. [PMID: 37633894] - Anita Chando, Vivek Basudkar, Sankalp Gharat, Munira Momin, Tabassum Khan. Development and preclinical assessment of nanoemulgel loaded with phytoconstituents for the management of rheumatoid arthritis.
Drug delivery and translational research.
2023 Aug; ?(?):. doi:
10.1007/s13346-023-01416-6. [PMID: 37606759] - Jisheng Li, Qiqi Wang, Yao Wang, Mencuo La, Ruisha Mian, Liangliang He, Ji Suonan, Denglang Zou. An efficient strategy for large-scale preparation of low polarity gingerols directly from ginger crude extract by high-speed countercurrent chromatography with different rotation mode.
Journal of separation science.
2023 Aug; ?(?):e2300320. doi:
10.1002/jssc.202300320. [PMID: 37541285] - Yajing Wang, Tao Zhang, Jie Liu, Xianfeng Huang, Xiaojing Yan. Investigations of the gingerol oil colon targeting pellets for the treatment of ulcerative colitis.
Fitoterapia.
2023 Jul; ?(?):105607. doi:
10.1016/j.fitote.2023.105607. [PMID: 37442485] - Zahra Asghari Lalami, Farzaneh Tafvizi, Vahid Naseh, Masoud Salehipour. Fabrication, optimization, and characterization of pH-responsive PEGylated nanoniosomes containing gingerol for enhanced treatment of breast cancer.
Naunyn-Schmiedeberg's archives of pharmacology.
2023 Jun; ?(?):. doi:
10.1007/s00210-023-02579-2. [PMID: 37368028] - Youdong Hu, Tingting Liu, Guangzhen Zheng, Li Zhou, Ke Ma, Xiaolian Xiong, Cheng Zheng, Jin Li, Yong Zhu, Wenhui Bian, Xiangde Zheng, Qingping Xiong, Jiafeng Lin. Mechanism exploration of 6-Gingerol in the treatment of atherosclerosis based on network pharmacology, molecular docking and experimental validation.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Apr; 115(?):154835. doi:
10.1016/j.phymed.2023.154835. [PMID: 37121058] - Monisha A, Praveena A, Monisha Baby B. Investigation on the Anticancer Activity of [6]-Gingerol of Zingiber officinale and its Structural Analogs against Skin Cancer.
Current computer-aided drug design.
2023 Apr; ?(?):. doi:
10.2174/1573409919666230418095105. [PMID: 37076965] - Suparna Ghosh, Bhaskar Das, Pallab Kanti Haldar, Amit Kar, Sushil K Chaudhary, Keithellakpam Ojit Singh, Pardeep K Bhardwaj, Nanaocha Sharma, Pulok K Mukherjee. 6-Gingerol contents of several ginger varieties of Northeast India and correlation of their antioxidant activity in respect to phenolics and flavonoids contents.
Phytochemical analysis : PCA.
2023 Apr; 34(3):259-268. doi:
10.1002/pca.3201. [PMID: 36594354] - Yuzhe Liu, Dong Li, Shang Wang, Ze Peng, Qi Tan, Qifeng He, Jianwei Wang. 6-Gingerol Ameliorates Hepatic Steatosis, Inflammation and Oxidative Stress in High-Fat Diet-Fed Mice through Activating LKB1/AMPK Signaling.
International journal of molecular sciences.
2023 Mar; 24(7):. doi:
10.3390/ijms24076285. [PMID: 37047258] - Shou-Jia Wang, Wen Ye, Wan-Yi Li, Wen Tian, Meng Zhang, Yang Sun, Ying-Da Feng, Chen-Xu Liu, Shao-Yuan Liu, Wei Cao, Jing-Ru Meng, Xiao-Qiang Li. Effects and mechanisms of Xiaochaihu Tang against liver fibrosis: An integration of network pharmacology, molecular docking and experimental validation.
Journal of ethnopharmacology.
2023 Mar; 303(?):116053. doi:
10.1016/j.jep.2022.116053. [PMID: 36529247] - Quanli Pan, Peng Liu, Min Wan. 6-Gingerol attenuates sepsis-induced acute lung injury by suppressing NLRP3 inflammasome through Nrf2 activation.
Folia histochemica et cytobiologica.
2023 Feb; ?(?):. doi:
10.5603/fhc.a2023.0002. [PMID: 36734635] - Clarissa Garza-Cadena, Daniela Marian Ortega-Rivera, Gerson Machorro-García, Eloy Mauricio Gonzalez-Zermeño, Diego Homma-Dueñas, Maksymilian Plata-Gryl, Roberto Castro-Muñoz. A comprehensive review on Ginger (Zingiber officinale) as a potential source of nutraceuticals for food formulations: Towards the polishing of gingerol and other present biomolecules.
Food chemistry.
2023 Feb; 413(?):135629. doi:
10.1016/j.foodchem.2023.135629. [PMID: 36753787] - Kanta Keosaeng, Weerasak Songoen, Thitaree Yooboon, Vasakorn Bullangpoti, Wanchai Pluempanupat. Insecticidal activity of isolated gingerols and shogaols from Zingiber officinale Roscoe rhizomes against Spodoptera spp. (Lepidoptera: Noctuidae).
Natural product research.
2023 Feb; 37(4):669-674. doi:
10.1080/14786419.2022.2078818. [PMID: 35608145] - Muhamad Syafiq Hakimi Kamaruddin, Gun Hean Chong, Nurizzati Mohd Daud, Nicky Rahmana Putra, Liza Md Salleh, Norhidayah Suleiman. Bioactivities and green advanced extraction technologies of ginger oleoresin extracts: A review.
Food research international (Ottawa, Ont.).
2023 Feb; 164(?):112283. doi:
10.1016/j.foodres.2022.112283. [PMID: 36737895] - Jiasheng Li, Ying Zhang, Shurui Liu, Wangjun Li, Yue Sun, Hui Cao, Shumei Wang, Jiang Meng. A network pharmacology integrated pharmacokinetics strategy to investigate the pharmacological mechanism of absorbed components from crude and processed Zingiberis Rhizoma on deficiency-cold and hemorrhagic syndrome.
Journal of ethnopharmacology.
2023 Jan; 301(?):115754. doi:
10.1016/j.jep.2022.115754. [PMID: 36195301] - Yuto Nishidono, Ken Tanaka. Effect of drying and processing on diterpenes and other chemical constituents of ginger.
Journal of natural medicines.
2023 Jan; 77(1):118-127. doi:
10.1007/s11418-022-01652-z. [PMID: 36209453] - Xiao-Juan Zhang, Zhi-Min Song, Pei-Pei Yuan, Yan-Zhi Wang, Man-Qian Li, Yu-Fei Liu, Xue-Yu Hu, Wei-Sheng Feng. Five new compounds from Zingiberis Rhizoma Recens and their anti-apoptotic activity.
Journal of Asian natural products research.
2023 Jan; 25(1):1-10. doi:
10.1080/10286020.2022.2026335. [PMID: 35023415] - Samridhi Sharma, Monu Kumar Shukla, Krishan Chander Sharma, Tirath, Lokender Kumar, Jasha Momo H Anal, Santosh Kumar Upadhyay, Sanjib Bhattacharyya, Deepak Kumar. Revisiting the therapeutic potential of gingerols against different pharmacological activities.
Naunyn-Schmiedeberg's archives of pharmacology.
2022 Dec; ?(?):. doi:
10.1007/s00210-022-02372-7. [PMID: 36585999] - Imran Kazmi, Syed Sarim Imam, Fahad A Al-Abbasi, Muhammad Afzal, Muhammad Shahid Nadeem, Sultan Alshehri. Environment friendly green synthesis method based natural bioactive functional "catechin and gingerol" loaded nanomedicine for the management of obesity.
International journal of pharmaceutics.
2022 Nov; 628(?):122340. doi:
10.1016/j.ijpharm.2022.122340. [PMID: 36341920] - Ngouana Moffo A Ivane, Fopa Kue Roméo Elysé, Suleiman A Haruna, Ngwasiri Pride, Ejoh Richard, Anuanwen Claris Foncha, Munir Abba Dandago. The anti-oxidative potential of ginger extract and its constituent on meat protein isolate under induced Fenton oxidation.
Journal of proteomics.
2022 10; 269(?):104723. doi:
10.1016/j.jprot.2022.104723. [PMID: 36096434] - Jun Dang, Yue Lv, Chengzhao Li, Yan Fang, Gang Li, Qilan Wang. Integrated chromatographic approach for the discovery of gingerol antioxidants from Dracocephalum heterophyllum and their potential targets.
Analytical methods : advancing methods and applications.
2022 10; 14(41):4133-4145. doi:
10.1039/d2ay01282k. [PMID: 36226573] - Yuge Gao, Yujia Lu, Na Zhang, Chibuike C Udenigwe, Yuhao Zhang, Yu Fu. Preparation, pungency and bioactivity of gingerols from ginger (Zingiber officinale Roscoe): a review.
Critical reviews in food science and nutrition.
2022 Sep; ?(?):1-26. doi:
10.1080/10408398.2022.2124951. [PMID: 36135317] - S I Othman, M N Bin-Jumah, R S Suliman, S S Althobaiti, E A Alqhtani, S A Gabr. Gingerol fractions bioactivity against butanone cytotoxicity induced in newborns of mice.
European review for medical and pharmacological sciences.
2022 09; 26(18):6512-6522. doi:
10.26355/eurrev_202209_29750. [PMID: 36196700] - Fei Gao, Fei Zhou, Shuai Gan, Ya-Lan Chen, Shu Fu, Mei-Si Lin, Chao-Mei Fu. [Comparative study on intestinal absorption kinetics of main active components in Sini Decoction and its separated recipes].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Sep; 47(18):5064-5070. doi:
10.19540/j.cnki.cjcmm.20220421.701. [PMID: 36164916] - Wenni Tian, Haonan Wang, Ying Zhu, Qun Wang, Mingyue Song, Yong Cao, Jie Xiao. Intervention effects of delivery vehicles on the therapeutic efficacy of 6-gingerol on colitis.
Journal of controlled release : official journal of the Controlled Release Society.
2022 09; 349(?):51-66. doi:
10.1016/j.jconrel.2022.06.058. [PMID: 35792187] - Alieh Alipour, Vafa Baradaran Rahimi, Vahid Reza Askari. Promising influences of gingerols against metabolic syndrome: A mechanistic review.
BioFactors (Oxford, England).
2022 Sep; 48(5):993-1004. doi:
10.1002/biof.1892. [PMID: 36191294] - Miaomaio Liu, Yakun Yang, Muqing Zhang, Yucong Xue, Bin Zheng, Yuanyuan Zhang, Yu Liu, Xi Chu, Zhenqing Sun, Xue Han. Inhibition of human ether-à-go-go-related gene K+ currents expressed in HEK293 cells by three gingerol components from ginger.
The Journal of pharmacy and pharmacology.
2022 Aug; 74(8):1133-1139. doi:
10.1093/jpp/rgac029. [PMID: 35511715] - Shuwei Zhang, Emily DiMango, Yingdong Zhu, Tarnjot K Saroya, Charles W Emala, Shengmin Sang. Pharmacokinetics of Gingerols, Shogaols, and Their Metabolites in Asthma Patients.
Journal of agricultural and food chemistry.
2022 Aug; 70(31):9674-9683. doi:
10.1021/acs.jafc.2c03150. [PMID: 35916113] - Priyadharshini Thangavelu, Viswanathan Sundaram, Kaavya Gunasekaran, Bonaventure Mujyambere, Sowndarya Raju, Arya Kannan, Ashok Arasu, Kadirvelu Krishna, Jayaraj Ramamoorthi, Sivasamy Ramasamy, Thirunavukkarasu Velusamy, Suja Samiappan. Development of optimized novel liposome loaded with 6-gingerol and assessment of its therapeutic activity against NSCLC In vitro and In vivo experimental models.
Chemistry and physics of lipids.
2022 07; 245(?):105206. doi:
10.1016/j.chemphyslip.2022.105206. [PMID: 35483420] - Xiaohong Deng, Dandan Chen, Xianjun Sun, Jingcheng Dong, Jianhua Huang. Effects of ginger extract and its major component 6-gingerol on anti-tumor property through mitochondrial biogenesis in CD8+ T cells.
Journal of food science.
2022 Jul; 87(7):3307-3317. doi:
10.1111/1750-3841.16228. [PMID: 35708209] - Min Su, Xueqin Wang, Gang Cao, Li Sun, Rodney J Y Ho, Yanquan Han, Yan Hong, Deling Wu. Prediction of the potential mechanism of compound gingerol against liver cancer based on network pharmacology and experimental verification.
The Journal of pharmacy and pharmacology.
2022 Jun; 74(6):869-886. doi:
10.1093/jpp/rgac002. [PMID: 35429380] - Xue Han, Panpan Liu, Bin Zheng, Muqing Zhang, Yuanyuan Zhang, Yucong Xue, Chenxu Liu, Xi Chu, Xiangting Wang, Shijiang Sun, Li Chu. 6-Gingerol exerts a protective effect against hypoxic injury through the p38/Nrf2/HO-1 and p38/NF-κB pathway in H9c2 cells.
The Journal of nutritional biochemistry.
2022 06; 104(?):108975. doi:
10.1016/j.jnutbio.2022.108975. [PMID: 35245652] - Nantaporn Promdam, Pissared Khuituan, Pharkphoom Panichayupakaranant. Effects of standardized [6]-gingerol extracts and [6]-gingerol on isolated ileum and lower esophageal sphincter contractions in mice.
Food chemistry.
2022 Jun; 378(?):132077. doi:
10.1016/j.foodchem.2022.132077. [PMID: 35042108] - Wanlin Zhong, Jiaqing Zhu, Juanjuan Yi, Changcheng Zhao, Yanling Shi, Qiaozhen Kang, Jinyong Huang, Limin Hao, Jike Lu. Biochemical analysis reveals the systematic response of motion sickness mice to ginger (Zingiber officinale) extract's amelioration effect.
Journal of ethnopharmacology.
2022 May; 290(?):115077. doi:
10.1016/j.jep.2022.115077. [PMID: 35131339] - Bo Deng, Xiao-Li Jiang, You-Cai Xu, Si Chen, Min Cai, Sui-Hui Deng, Wen-Jun Ding, Hong-Lin Xu, Shuang-Wei Zhang, Zhang-Bin Tan, Rui-Xue Chen, Bin Liu, Jing-Zhi Zhang. 10-Gingerol, a natural AMPK agonist, suppresses neointimal hyperplasia and inhibits vascular smooth muscle cell proliferation.
Food & function.
2022 Mar; 13(6):3234-3246. doi:
10.1039/d1fo03610f. [PMID: 35213678] - Li Zhong, Rui Wang, Qin-Hui Wen, Jian Li, Jia-Wei Lin, Xin-An Zeng. The interaction between bovine serum albumin and [6]-,[8]- and [10]-gingerol: An effective strategy to improve the solubility and stability of gingerol.
Food chemistry.
2022 Mar; 372(?):131280. doi:
10.1016/j.foodchem.2021.131280. [PMID: 34818732] - Quan-Cao Zhan, Yu-Zhe Liu, Yu-Meng Xi, Yan Zeng, Jia-Yu Tian, Li Liu, Dong Li, Yamahara Johji, Jian-Wei Wang. [6-Gingerol ameliorates adipose tissue insulin resistance in aging rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Mar; 47(6):1642-1649. doi:
10.19540/j.cnki.cjcmm.20211008.702. [PMID: 35347963] - Chwan-Li Shen, Rui Wang, Guangchen Ji, Moamen M Elmassry, Masoud Zabet-Moghaddam, Heather Vellers, Abdul N Hamood, Xiaoxia Gong, Parvin Mirzaei, Shengmin Sang, Volker Neugebauer. Dietary supplementation of gingerols- and shogaols-enriched ginger root extract attenuate pain-associated behaviors while modulating gut microbiota and metabolites in rats with spinal nerve ligation.
The Journal of nutritional biochemistry.
2022 02; 100(?):108904. doi:
10.1016/j.jnutbio.2021.108904. [PMID: 34748918] - Xiao-Xuan Guo, Yun-Dan Zhang, Tian-Cai Wang, Xin-Lu Wang, Yan-Yang Xu, Yong Wang, Jing Qiu. Ginger and 6-gingerol prevent lipopolysaccharide-induced intestinal barrier damage and liver injury in mice.
Journal of the science of food and agriculture.
2022 Feb; 102(3):1066-1075. doi:
10.1002/jsfa.11442. [PMID: 34309869] - Zhe Cheng, Xinyu Xiong, Yi Zhou, Fan Wu, Qingqing Shao, Ruolan Dong, Qiong Liu, Lingli Li, Guang Chen. 6-gingerol ameliorates metabolic disorders by inhibiting hypertrophy and hyperplasia of adipocytes in high-fat-diet induced obese mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Feb; 146(?):112491. doi:
10.1016/j.biopha.2021.112491. [PMID: 34896967] - Li Liu, Nan Yu, Wei Leng, Yun Lu, Xinxin Xia, Hui Yuan. 6-Gingerol, a functional polyphenol of ginger, reduces pulmonary fibrosis by activating Sirtuin1.
Allergologia et immunopathologia.
2022; 50(2):104-114. doi:
10.15586/aei.v50i2.533. [PMID: 35257553] - Babatunde Joseph Oso, Akinwunmi Oluwaseun Adeoye, Ige Francis Olaoye. Pharmacoinformatics and hypothetical studies on allicin, curcumin, and gingerol as potential candidates against COVID-19-associated proteases.
Journal of biomolecular structure & dynamics.
2022 Jan; 40(1):389-400. doi:
10.1080/07391102.2020.1813630. [PMID: 32876538] - Tamilvelan Manjunathan, Ajay Guru, Jesu Arokiaraj, Pushparathinam Gopinath. 6-Gingerol and Semisynthetic 6-Gingerdione Counteract Oxidative Stress Induced by ROS in Zebrafish.
Chemistry & biodiversity.
2021 Dec; 18(12):e2100650. doi:
10.1002/cbdv.202100650. [PMID: 34599795] - Huali Qian, Zhe Xu, Kun Cong, Xinyan Zhu, Lei Zhang, Junfeng Wang, Jiankun Wei, Pengzhang Ji. Transcriptomic responses to drought stress in Polygonatum kingianum tuber.
BMC plant biology.
2021 Nov; 21(1):537. doi:
10.1186/s12870-021-03297-8. [PMID: 34781887] - Nazanin Momeni Roudsari, Naser-Aldin Lashgari, Saeideh Momtaz, Basil Roufogalis, Amir Hossein Abdolghaffari, Amirhossein Sahebkar. Ginger: A complementary approach for management of cardiovascular diseases.
BioFactors (Oxford, England).
2021 Nov; 47(6):933-951. doi:
10.1002/biof.1777. [PMID: 34388275] - Roghayeh Yahyazadeh, Vafa Baradaran Rahimi, Ahmad Yahyazadeh, Seyed Ahmad Mohajeri, Vahid Reza Askari. Promising effects of gingerol against toxins: A review article.
BioFactors (Oxford, England).
2021 Nov; 47(6):885-913. doi:
10.1002/biof.1779. [PMID: 34418196] - Giovanni Schepici, Valentina Contestabile, Andrea Valeri, Emanuela Mazzon. Ginger, a Possible Candidate for the Treatment of Dementias?.
Molecules (Basel, Switzerland).
2021 Sep; 26(18):. doi:
10.3390/molecules26185700. [PMID: 34577171] - Kapil Rai, Narayansing Chhanwal, Nirali N Shah, Rekha S Singhal. Encapsulation of ginger oleoresin in co-crystallized sucrose: development, characterization and storage stability.
Food & function.
2021 Sep; 12(17):7964-7974. doi:
10.1039/d1fo00565k. [PMID: 34254624] - Niramon Utama-Ang, Sirinapa Sida, Phenphichar Wanachantararak, Arthitaya Kawee-Ai. Development of edible Thai rice film fortified with ginger extract using microwave-assisted extraction for oral antimicrobial properties.
Scientific reports.
2021 07; 11(1):14870. doi:
10.1038/s41598-021-94430-y. [PMID: 34290338] - Kinga Gawel, Wirginia Kukula-Koch, Nancy Saana Banono, Dorota Nieoczym, Katarzyna M Targowska-Duda, Lidia Czernicka, Jolanta Parada-Turska, Camila V Esguerra. 6-Gingerol, a Major Constituent of Zingiber officinale Rhizoma, Exerts Anticonvulsant Activity in the Pentylenetetrazole-Induced Seizure Model in Larval Zebrafish.
International journal of molecular sciences.
2021 Jul; 22(14):. doi:
10.3390/ijms22147745. [PMID: 34299361] - Ulrike Breitinger, Heinrich Sticht, Hans-Georg Breitinger. Modulation of recombinant human alpha 1 glycine receptor by flavonoids and gingerols.
Biological chemistry.
2021 06; 402(7):825-838. doi:
10.1515/hsz-2020-0360. [PMID: 33752269] - Mai T Abdo, Sherweit H El-Ahmady, Haidy A Gad. Quality control and long-term stability study of ginger from different geographical origins using chemometrics.
Journal of the science of food and agriculture.
2021 Jun; 101(8):3429-3438. doi:
10.1002/jsfa.10973. [PMID: 33289094] - Akalesh Kumar Verma, Vikas Kumar, Sweta Singh, Bhabesh Ch Goswami, Ihosvany Camps, Aishwarya Sekar, Sanghwa Yoon, Keun Woo Lee. Repurposing potential of Ayurvedic medicinal plants derived active principles against SARS-CoV-2 associated target proteins revealed by molecular docking, molecular dynamics and MM-PBSA studies.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 May; 137(?):111356. doi:
10.1016/j.biopha.2021.111356. [PMID: 33561649] - Man-Qian Li, Xue-Yu Hu, Yan-Zhi Wang, Xiao-Juan Zhang, Jian-Peng Li, Zhi-Min Song, Yu-Fei Liu, Wei-Sheng Feng. Qualitative analysis on chemical constituents from different polarity extracted fractions of the pulp and peel of ginger rhizomes by ultra-high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2021 Apr; 35(8):e9029. doi:
10.1002/rcm.9029. [PMID: 33326132] - Yugang Sun, Jinmin Ren, Fang Wang. [6]-Gingerol impedes 7,12-dimethylbenz(a)anthracene-induced inflammation and cell proliferation-associated hamster buccal pouch carcinogenesis through modulating Nrf2 signaling events.
Journal of biochemical and molecular toxicology.
2021 Apr; 35(4):e22689. doi:
10.1002/jbt.22689. [PMID: 33347680] - Hui Yan, Peng-Hui Li, Gui-Sheng Zhou, Ying-Jun Wang, Bei-Hua Bao, Qi-Nan Wu, Shen-Liang Huang. Rapid and practical qualitative and quantitative evaluation of non-fumigated ginger and sulfur-fumigated ginger via Fourier-transform infrared spectroscopy and chemometric methods.
Food chemistry.
2021 Mar; 341(Pt 1):128241. doi:
10.1016/j.foodchem.2020.128241. [PMID: 33038774] - Parinaz Zivarpour, Elhameh Nikkhah, Parisa Maleki Dana, Zatollah Asemi, Jamal Hallajzadeh. Molecular and biological functions of gingerol as a natural effective therapeutic drug for cervical cancer.
Journal of ovarian research.
2021 Mar; 14(1):43. doi:
10.1186/s13048-021-00789-x. [PMID: 33706784] - Rida Siddique, Faqir Muhammad, Bilal Aslam, M Naeem Faisal. Characterization and in vivo evaluation of nanoformulations in FCA induced rheumatoid arthritis in rats.
Pakistan journal of pharmaceutical sciences.
2021 Mar; 34(2(Supplementary)):787-793. doi:
". [PMID: 34275816] - Hassan S Alamri, Jawaher Alsughayyir, Maaged Akiel, Yazeed A Al-Sheikh, Ahmed M Basudan, Ayed Dera, Tlili Barhoumi, Abdulrahman M Basuwdan, Mohammad A Alfhili. Stimulation of calcium influx and CK1α by NF-κB antagonist [6]-Gingerol reprograms red blood cell longevity.
Journal of food biochemistry.
2021 01; 45(1):e13545. doi:
10.1111/jfbc.13545. [PMID: 33145778] - Mohammed A Alsahli, Saleh A Almatroodi, Ahmad Almatroudi, Amjad Ali Khan, Shehwaz Anwar, Abdulmajeed G Almutary, Faris Alrumaihi, Arshad Husain Rahmani. 6-Gingerol, a Major Ingredient of Ginger Attenuates Diethylnitrosamine-Induced Liver Injury in Rats through the Modulation of Oxidative Stress and Anti-Inflammatory Activity.
Mediators of inflammation.
2021; 2021(?):6661937. doi:
10.1155/2021/6661937. [PMID: 33531877] - Shan Xu, Haibao Zhang, Tianjie Liu, Zixi Wang, Wenjie Yang, Tao Hou, Xinyang Wang, Dalin He, Pengsheng Zheng. 6-Gingerol suppresses tumor cell metastasis by increasing YAPser127 phosphorylation in renal cell carcinoma.
Journal of biochemical and molecular toxicology.
2021 Jan; 35(1):e22609. doi:
10.1002/jbt.22609. [PMID: 32926756] - Seong-A Ju, Quang-Tam Nguyen, Thu-Ha T Nguyen, Jae-Hee Suh, Won G An, Zak Callaway, Yeonsoo Joe, Hun Taeg Chung, Byung-Sam Kim. Pretreatment with 6-Gingerol Ameliorates Sepsis-Induced Immune Dysfunction by Regulating the Cytokine Balance and Reducing Lymphocyte Apoptosis.
Oxidative medicine and cellular longevity.
2021; 2021(?):5427153. doi:
10.1155/2021/5427153. [PMID: 35003518] - Jiyun Ahn, Hyunjung Lee, Chang Hwa Jung, Seung Yeon Ha, Hyo-Deok Seo, Young In Kim, Taeyoul Ha. 6-Gingerol Ameliorates Hepatic Steatosis via HNF4α/miR-467b-3p/GPAT1 Cascade.
Cellular and molecular gastroenterology and hepatology.
2021; 12(4):1201-1213. doi:
10.1016/j.jcmgh.2021.06.007. [PMID: 34139323] - Jing Wang, Yong Chen, Xiaosong Hu, Fengqin Feng, Luyun Cai, Fang Chen. Assessing the Effects of Ginger Extract on Polyphenol Profiles and the Subsequent Impact on the Fecal Microbiota by Simulating Digestion and Fermentation In Vitro.
Nutrients.
2020 Oct; 12(10):. doi:
10.3390/nu12103194. [PMID: 33086593] - Mayuri Patwardhan, Mark T Morgan, Vermont Dia, Doris H D'Souza. Heat sensitization of hepatitis A virus and Tulane virus using grape seed extract, gingerol and curcumin.
Food microbiology.
2020 Sep; 90(?):103461. doi:
10.1016/j.fm.2020.103461. [PMID: 32336357] - Shengmin Sang, Hunter D Snook, Fakir Shahidullah Tareq, Yewande Fasina. Precision Research on Ginger: The Type of Ginger Matters.
Journal of agricultural and food chemistry.
2020 Aug; 68(32):8517-8523. doi:
10.1021/acs.jafc.0c03888. [PMID: 32663000] - Asmaa M Magdy, Eman M Fahmy, Abd El-Rahman M F Al-Ansary, Gamal Awad. Improvement of 6-gingerol production in ginger rhizomes (Zingiber officinale Roscoe) plants by mutation breeding using gamma irradiation.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.
2020 Aug; 162(?):109193. doi:
10.1016/j.apradiso.2020.109193. [PMID: 32501232] - Meran Keshawa Ediriweera, Jeong Yong Moon, Yen Thi-Kim Nguyen, Somi Kim Cho. 10-Gingerol Targets Lipid Rafts Associated PI3K/Akt Signaling in Radio-Resistant Triple Negative Breast Cancer Cells.
Molecules (Basel, Switzerland).
2020 Jul; 25(14):. doi:
10.3390/molecules25143164. [PMID: 32664351] - Xue Han, Panpan Liu, Miaomiao Liu, Ziheng Wei, Sen Fan, Xiangting Wang, Shijiang Sun, Li Chu. [6]-Gingerol Ameliorates ISO-Induced Myocardial Fibrosis by Reducing Oxidative Stress, Inflammation, and Apoptosis through Inhibition of TLR4/MAPKs/NF-κB Pathway.
Molecular nutrition & food research.
2020 07; 64(13):e2000003. doi:
10.1002/mnfr.202000003. [PMID: 32438504] - Jianxia Wen, Lu Zhang, Jian Wang, Jiabo Wang, Lifu Wang, Ruilin Wang, Ruisheng Li, Honghong Liu, Shizhang Wei, Haotian Li, Wenjun Zou, Yanling Zhao. Therapeutic effects of higenamine combined with [6]-gingerol on chronic heart failure induced by doxorubicin via ameliorating mitochondrial function.
Journal of cellular and molecular medicine.
2020 04; 24(7):4036-4050. doi:
10.1111/jcmm.15041. [PMID: 32073745] - Chao Wen, Ying Liu, Yuanwei Ye, Zhengguo Tao, Zongjia Cheng, Tian Wang, Yanmin Zhou. Effects of gingerols-rich extract of ginger on growth performance, serum metabolites, meat quality and antioxidant activity of heat-stressed broilers.
Journal of thermal biology.
2020 Apr; 89(?):102544. doi:
10.1016/j.jtherbio.2020.102544. [PMID: 32364987] - Mu-Keng Hong, Lan-Lan Hu, Ya-Xin Zhang, Yu-Ling Xu, Xiao-Yu Liu, Pei-Kun He, Yu-Hua Jia. 6-Gingerol ameliorates sepsis-induced liver injury through the Nrf2 pathway.
International immunopharmacology.
2020 Mar; 80(?):106196. doi:
10.1016/j.intimp.2020.106196. [PMID: 31978803] - Shan Xu, Haibao Zhang, Tianjie Liu, Wenjie Yang, Wei Lv, Dalin He, Peng Guo, Lei Li. 6-Gingerol induces cell-cycle G1-phase arrest through AKT-GSK 3β-cyclin D1 pathway in renal-cell carcinoma.
Cancer chemotherapy and pharmacology.
2020 02; 85(2):379-390. doi:
10.1007/s00280-019-03999-9. [PMID: 31832810] - Alexandra Simon, András Darcsi, Ágnes Kéry, Eszter Riethmüller. Blood-brain barrier permeability study of ginger constituents.
Journal of pharmaceutical and biomedical analysis.
2020 Jan; 177(?):112820. doi:
10.1016/j.jpba.2019.112820. [PMID: 31476432] - Fang-Ling Zhang, Bo-Wei Zhou, Zheng-Zheng Yan, Jin Zhao, Bing-Cheng Zhao, Wei-Feng Liu, Cai Li, Ke-Xuan Liu. 6-Gingerol attenuates macrophages pyroptosis via the inhibition of MAPK signaling pathways and predicts a good prognosis in sepsis.
Cytokine.
2020 01; 125(?):154854. doi:
10.1016/j.cyto.2019.154854. [PMID: 31539844] - Qianqian Cheng, Xiaodi Feng, Qi Meng, Yaqi Li, Siqi Chen, Guoen Wang, Ke Nie. [6]-Gingerol Ameliorates Cisplatin-Induced Pica by Regulating the TPH/MAO-A/SERT/5-HT/5-HT3 Receptor System in Rats.
Drug design, development and therapy.
2020; 14(?):4085-4099. doi:
10.2147/dddt.s270185. [PMID: 33061309] - Jing Wang, Lu Zhang, Li Dong, Xiaosong Hu, Fengqin Feng, Fang Chen. 6-Gingerol, a Functional Polyphenol of Ginger, Promotes Browning through an AMPK-Dependent Pathway in 3T3-L1 Adipocytes.
Journal of agricultural and food chemistry.
2019 Dec; 67(51):14056-14065. doi:
10.1021/acs.jafc.9b05072. [PMID: 31789021] - Blessing Om Oyedemi, E M Kotsia, Paul D Stapleton, Simon Gibbons. Capsaicin and gingerol analogues inhibit the growth of efflux-multidrug resistant bacteria and R-plasmids conjugal transfer.
Journal of ethnopharmacology.
2019 Dec; 245(?):111871. doi:
10.1016/j.jep.2019.111871. [PMID: 31022566] - Sucai Song, Minyan Dang, Mukresh Kumar. Anti-inflammatory and renal protective effect of gingerol in high-fat diet/streptozotocin-induced diabetic rats via inflammatory mechanism.
Inflammopharmacology.
2019 Dec; 27(6):1243-1254. doi:
10.1007/s10787-019-00569-6. [PMID: 30826930] - Stefano Dall'Acqua, Iztok Grabnar, Roberto Verardo, Enio Klaric, Luigi Marchionni, Eddie Luidy-Imada, Stefania Sut, Chiara Agostinis, Roberta Bulla, Beatrice Perissutti, Dario Voinovich. Combined extracts of Echinacea angustifolia DC. and Zingiber officinale Roscoe in softgel capsules: Pharmacokinetics and immunomodulatory effects assessed by gene expression profiling.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Dec; 65(?):153090. doi:
10.1016/j.phymed.2019.153090. [PMID: 31557666] - Yi Zhang, Yue Ding, Tong Zhang, Xiaoyi Jiang, Yaxiong Yi, Lijuan Zhang, Yi Chen, Ting Li, Ping Kang, Juanjuan Tian. Quantitative Analysis of Twelve Active Components Combined With Chromatographic Fingerprint for Comprehensive Evaluation of Qinma Prescription by Ultra-Performance Liquid Chromatography Coupled With Diode Array Detection.
Journal of chromatographic science.
2019 Oct; 57(9):855-865. doi:
10.1093/chromsci/bmz060. [PMID: 31560746] - Ting Du, Rongjin Sun, Shiming Du, Song Gao, Ming Hu, Yong Zhang, Jing Chen, Guangde Yang. Metabolic profiles of Xiao Chai Hu Tang in mouse plasma, bile and urine by the UHPLC-ESI-Q-TOF/MS technique.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Oct; 1128(?):121767. doi:
10.1016/j.jchromb.2019.121767. [PMID: 31627161] - Richard Osae, Cunshan Zhou, Raphael N Alolga, Baoguo Xu, William Tchabo, Ernest Bonah, Evans Adingba Alenyorege, Haile Ma. Effects of Various Nonthermal Pretreatments on the Physicochemical Properties of Dried Ginger (Zingiber officinale Roscoe) Slices from Two Geographical Locations.
Journal of food science.
2019 Oct; 84(10):2847-2858. doi:
10.1111/1750-3841.14790. [PMID: 31573687] - Federica Tinello, Anna Lante. Valorisation of Ginger and Turmeric Peels as Source of Natural Antioxidants.
Plant foods for human nutrition (Dordrecht, Netherlands).
2019 Sep; 74(3):443-445. doi:
10.1007/s11130-019-00748-4. [PMID: 31183803] - Xiaohong Deng, Siwei Zhang, Junzhen Wu, Xianjun Sun, Ziyin Shen, Jingcheng Dong, Jianhua Huang. Promotion of Mitochondrial Biogenesis via Activation of AMPK-PGC1ɑ Signaling Pathway by Ginger (Zingiber officinale Roscoe) Extract, and Its Major Active Component 6-Gingerol.
Journal of food science.
2019 Aug; 84(8):2101-2111. doi:
10.1111/1750-3841.14723. [PMID: 31369153] - Jianxia Wen, Jian Wang, Pengyan Li, Ruilin Wang, Jiabo Wang, Xuelin Zhou, Lu Zhang, Haotian Li, Shizhang Wei, Huadan Cai, Yanling Zhao. Protective effects of higenamine combined with [6]-gingerol against doxorubicin-induced mitochondrial dysfunction and toxicity in H9c2 cells and potential mechanisms.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Jul; 115(?):108881. doi:
10.1016/j.biopha.2019.108881. [PMID: 31028997] - Babajide O Ajayi, Isaac A Adedara, Ebenezer O Farombi. 6-Gingerol abates benzo[a]pyrene-induced colonic injury via suppression of oxido-inflammatory stress responses in BALB/c mice.
Chemico-biological interactions.
2019 Jul; 307(?):1-7. doi:
10.1016/j.cbi.2019.04.026. [PMID: 31004597] - Mari Morimoto, Mizuki Mitsukawa, Chisato Fujiwara, Yukio Kawamura, Seiji Masuda. Inhibition of mRNA processing activity from ginger-, clove- and cinnamon-extract, and by two ginger constituents, 6-gingerol and 6-shogaol.
Bioscience, biotechnology, and biochemistry.
2019 Mar; 83(3):498-501. doi:
10.1080/09168451.2018.1547107. [PMID: 30426858] - Li Liu, Ling Yao, Shang Wang, Zhiwei Chen, Tingli Han, Peng Ma, Lirong Jiang, Chunlin Yuan, Jinxiu Li, Dazhi Ke, Chunli Li, Johji Yamahara, Yuhao Li, Jianwei Wang. 6-Gingerol Improves Ectopic Lipid Accumulation, Mitochondrial Dysfunction, and Insulin Resistance in Skeletal Muscle of Ageing Rats: Dual Stimulation of the AMPK/PGC-1α Signaling Pathway via Plasma Adiponectin and Muscular AdipoR1.
Molecular nutrition & food research.
2019 03; 63(6):e1800649. doi:
10.1002/mnfr.201800649. [PMID: 30575271]