Phenazone (BioDeep_00000402572)

   


代谢物信息卡片


antipyrine

化学式: C11H12N2O (188.095)
中文名称: 安替比林
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC(=O)N(N1C)C2=CC=CC=C2
InChI: InChI=1S/C11H12N2O/c1-9-8-11(14)13(12(9)2)10-6-4-3-5-7-10/h3-8H,1-2H3

描述信息

CONFIDENCE standard compound; INTERNAL_ID 347; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6322; ORIGINAL_PRECURSOR_SCAN_NO 6320
N - Nervous system > N02 - Analgesics > N02B - Other analgesics and antipyretics > N02BB - Pyrazolones
S - Sensory organs > S02 - Otologicals > S02D - Other otologicals > S02DA - Analgesics and anesthetics
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
CONFIDENCE standard compound; INTERNAL_ID 347; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6343; ORIGINAL_PRECURSOR_SCAN_NO 6341
CONFIDENCE standard compound; INTERNAL_ID 347; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6369; ORIGINAL_PRECURSOR_SCAN_NO 6367
CONFIDENCE standard compound; INTERNAL_ID 347; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6347; ORIGINAL_PRECURSOR_SCAN_NO 6344
CONFIDENCE standard compound; INTERNAL_ID 347; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6363; ORIGINAL_PRECURSOR_SCAN_NO 6361
CONFIDENCE standard compound; INTERNAL_ID 347; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6409; ORIGINAL_PRECURSOR_SCAN_NO 6408
CONFIDENCE standard compound; INTERNAL_ID 347; HBM4EU - science and policy for a healthy future (https://www.hbm4eu.eu)
INTERNAL_ID 347; CONFIDENCE standard compound; HBM4EU - science and policy for a healthy future (https://www.hbm4eu.eu)
CONFIDENCE Reference Standard (Level 1); HBM4EU - science and policy for a healthy future (https://www.hbm4eu.eu); Flow Injection
CONFIDENCE Reference Standard (Level 1); HBM4EU - science and policy for a healthy future (https://www.hbm4eu.eu)
HBM4EU - science and policy for a healthy future (https://www.hbm4eu.eu); CONFIDENCE Reference Standard (Level 1)
Flow Injection; CONFIDENCE Reference Standard (Level 1); HBM4EU - science and policy for a healthy future (https://www.hbm4eu.eu)
CONFIDENCE standard compound; INTERNAL_ID 2652
CONFIDENCE standard compound; INTERNAL_ID 8546

同义名列表

4 个代谢物同义名

antipyrine; Phenazone; Antipyrine; Antipyrine



数据库引用编号

69 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ABCB1, ALB, CYP2C9, CYP2D6, CYP3A4, PTGS1, PTGS2, XDH
Peripheral membrane protein 2 PTGS1, PTGS2
Endosome membrane 1 TF
Endoplasmic reticulum membrane 6 CYP1A2, CYP2C9, CYP2D6, CYP3A4, PTGS1, PTGS2
Nucleus 1 ALB
cytosol 5 ALB, ATP12A, GART, GPT, XDH
centrosome 1 ALB
nucleoplasm 1 ATP2B1
Cell membrane 3 ABCB1, ATP2B1, TNF
Multi-pass membrane protein 4 ABCB1, ATP12A, ATP2B1, CACNA1I
Synapse 1 ATP2B1
cell surface 3 ABCB1, TF, TNF
glutamatergic synapse 1 ATP2B1
Golgi apparatus 2 ALB, PTGS1
Golgi membrane 1 INS
neuronal cell body 1 TNF
presynaptic membrane 1 ATP2B1
plasma membrane 9 ABCB1, ATP12A, ATP2B1, BCHE, CACNA1I, CYP2C9, IFNLR1, TF, TNF
synaptic vesicle membrane 1 ATP2B1
Membrane 6 ABCB1, ATP2B1, CACNA1I, CYP2D6, CYP3A4, IFNLR1
apical plasma membrane 3 ABCB1, ATP12A, TF
basolateral plasma membrane 2 ATP12A, ATP2B1
caveola 1 PTGS2
extracellular exosome 7 ABCB1, ALB, ATP2B1, GART, GPT, PTGS1, TF
endoplasmic reticulum 3 ALB, CYP2D6, PTGS2
extracellular space 7 ALB, BCHE, IL6, INS, TF, TNF, XDH
perinuclear region of cytoplasm 1 TF
mitochondrion 1 CYP2D6
protein-containing complex 2 ALB, PTGS2
intracellular membrane-bounded organelle 6 ATP2B1, CYP1A2, CYP2C9, CYP2D6, CYP3A4, PTGS1
Microsome membrane 6 CYP1A2, CYP2C9, CYP2D6, CYP3A4, PTGS1, PTGS2
Single-pass type I membrane protein 1 IFNLR1
Secreted 5 ALB, BCHE, IL6, INS, TF
extracellular region 6 ALB, BCHE, IL6, INS, TF, TNF
Single-pass membrane protein 1 CYP2D6
basal part of cell 1 TF
anchoring junction 1 ALB
photoreceptor outer segment 1 PTGS1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 1 TNF
actin cytoskeleton 1 ATP12A
cytoplasmic vesicle 1 TF
Early endosome 1 TF
clathrin-coated pit 1 TF
recycling endosome 2 TF, TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 TF
Apical cell membrane 2 ABCB1, ATP12A
Membrane raft 1 TNF
Peroxisome 1 XDH
sarcoplasmic reticulum 1 XDH
lateral plasma membrane 1 ATP2B1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Late endosome 1 TF
neuron projection 2 PTGS1, PTGS2
ciliary basal body 1 ALB
cell projection 1 ATP2B1
phagocytic cup 1 TNF
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 3 ALB, BCHE, TF
Basolateral cell membrane 1 ATP2B1
Endomembrane system 1 PTGS1
endosome lumen 1 INS
Presynaptic cell membrane 1 ATP2B1
basal plasma membrane 1 TF
secretory granule lumen 2 INS, TF
HFE-transferrin receptor complex 1 TF
Golgi lumen 1 INS
endoplasmic reticulum lumen 6 ALB, BCHE, IL6, INS, PTGS2, TF
platelet alpha granule lumen 1 ALB
voltage-gated calcium channel complex 1 CACNA1I
endocytic vesicle 1 TF
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 ATP2B1
nuclear envelope lumen 1 BCHE
clathrin-coated endocytic vesicle membrane 1 TF
external side of apical plasma membrane 1 ABCB1
vesicle coat 1 TF
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
photoreceptor ribbon synapse 1 ATP2B1
potassium:proton exchanging ATPase complex 1 ATP12A
ciliary transition fiber 1 ALB
dense body 1 TF
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Toru Yamashita, Koji Abe. Update on Antioxidant Therapy with Edaravone: Expanding Applications in Neurodegenerative Diseases. International journal of molecular sciences. 2024 Mar; 25(5):. doi: 10.3390/ijms25052945. [PMID: 38474192]
  • José Manuel Cruz-Rubio, Renate Loeppert, Werner Praznik. Monosaccharide Analysis After One-Pot Derivatization Followed by Reverse-Phase Liquid Chromatography Separation and UV/Vis Detection. Methods in molecular biology (Clifton, N.J.). 2024; 2788(?):67-79. doi: 10.1007/978-1-0716-3782-1_5. [PMID: 38656509]
  • İsmet Yılmaz, Zeynep Maraş, Yılmaz Uğur, Mustafa Erkan Özgür, Murat Durmaz, Halil İbrahim Ulusoy, Selim Erdoğan. Pharmacokinetic Profiles of Metamizole Metabolites after Intramuscular and Intravenous Administration in Healthy Arabian Horses. Journal of veterinary pharmacology and therapeutics. 2021 Nov; 44(6):927-936. doi: 10.1111/jvp.13003. [PMID: 34431528]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Hany Ibrahim, Abdallah M Hamdy, Hanan A Merey, Ahmed S Saad. Simultaneous Determination of Paracetamol, Propyphenazone and Caffeine in Presence of Paracetamol Impurities Using Dual-Mode Gradient HPLC and TLC Densitometry Methods. Journal of chromatographic science. 2021 Jan; 59(2):140-147. doi: 10.1093/chromsci/bmaa088. [PMID: 33221830]
  • Aleksandra Nikitina, Geliia Gildeeva, Alexander Grigoriev, Alla Sidorova. 4-Methylamino antipyrine determination in human plasma by high-performance liquid chromatography tandem mass spectrometry. Biomedical chromatography : BMC. 2020 Oct; 34(10):e4913. doi: 10.1002/bmc.4913. [PMID: 32510593]
  • Yasuyuki Ohta, Toru Yamashita, Emi Nomura, Nozomi Hishikawa, Ken Ikegami, Yosuke Osakada, Namiko Matsumoto, Yuko Kawahara, Taijun Yunoki, Yoshiaki Takahashi, Motonori Takamiya, Koh Tadokoro, Ryo Sasaki, Yumiko Nakano, Keiichiro Tsunoda, Kota Sato, Yoshio Omote, Mami Takemoto, Koji Abe. Improvement of a decreased anti-oxidative activity by edaravone in amyotrophic lateral sclerosis patients. Journal of the neurological sciences. 2020 Aug; 415(?):116906. doi: 10.1016/j.jns.2020.116906. [PMID: 32446009]
  • Yury I Chernyak, Jean A Grassman. Impact of AhRR (565C > G) polymorphism on dioxin dependent CYP1A2 induction. Toxicology letters. 2020 Mar; 320(?):58-63. doi: 10.1016/j.toxlet.2019.12.002. [PMID: 31805342]
  • Yu I Chernyak, A P Merinova. CYP3A Polymorphism and Chronic Mercury Intoxication. Bulletin of experimental biology and medicine. 2020 Feb; 168(4):492-495. doi: 10.1007/s10517-020-04738-4. [PMID: 32146629]
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  • Chizu Oba, Mitsuru Kashiwagi, Takuya Tanabe, Shohei Nomura, Motoko Ogino, Takuya Matsuda, Shinya Murata, Michiko Nakamura, Akihiko Shirasu, Keisuke Inoue, Keisuke Okasora, Hiroshi Tamai. Prognostic factors in the early phase of acute encephalopathy. Pediatrics international : official journal of the Japan Pediatric Society. 2018 Mar; 60(3):270-275. doi: 10.1111/ped.13492. [PMID: 29280262]
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  • Katsunori Tsuda, Licht Miyamoto, Shuichi Hamano, Yuri Morimoto, Yumi Kangawa, Chika Fukue, Yoko Kagawa, Yuya Horinouchi, Wenting Xu, Yasumasa Ikeda, Toshiaki Tamaki, Koichiro Tsuchiya. Mechanisms of the pH- and Oxygen-Dependent Oxidation Activities of Artesunate. Biological & pharmaceutical bulletin. 2018; 41(4):555-563. doi: 10.1248/bpb.b17-00855. [PMID: 29607928]
  • Chao He, Wei Zhang, Suobei Li, Wei Ruan, Junmei Xu, Feng Xiao. Edaravone Improves Septic Cardiac Function by Inducing an HIF-1α/HO-1 Pathway. Oxidative medicine and cellular longevity. 2018; 2018(?):5216383. doi: 10.1155/2018/5216383. [PMID: 29765498]
  • Xiong Zhang, Fang Xu, Li Liu, Lili Feng, Xuefeng Wu, Yan Shen, Yang Sun, Xudong Wu, Qiang Xu. (+)-Borneol improves the efficacy of edaravone against DSS-induced colitis by promoting M2 macrophages polarization via JAK2-STAT3 signaling pathway. International immunopharmacology. 2017 Dec; 53(?):1-10. doi: 10.1016/j.intimp.2017.10.002. [PMID: 29028547]
  • Panagiota Tsounapi, Masashi Honda, Fotios Dimitriadis, Bunya Kawamoto, Katsuya Hikita, Kuniyasu Muraoka, Motoaki Saito, Nikolaos Sofikitis, Atsushi Takenaka. Impact of antioxidants on seminal vesicles function and fertilizing potential in diabetic rats. Asian journal of andrology. 2017 Nov; 19(6):639-646. doi: 10.4103/1008-682x.186871. [PMID: 27748317]
  • Ankit Parikh, Krishna Kathawala, Chun Chuan Tan, Sanjay Garg, Xin-Fu Zhou. Lipid-based nanosystem of edaravone: development, optimization, characterization and in vitro/in vivo evaluation. Drug delivery. 2017 Nov; 24(1):962-978. doi: 10.1080/10717544.2017.1337825. [PMID: 28633547]
  • Shingo Tanaka, Takeshi Kanagawa, Kazuo Momma, Satoko Hori, Hiroki Satoh, Takeshi Nagamatsu, Tomoyuki Fujii, Tadashi Kimura, Yasufumi Sawada. Prediction of sustained fetal toxicity induced by ketoprofen based on PK/PD analysis using human placental perfusion and rat toxicity data. British journal of clinical pharmacology. 2017 Nov; 83(11):2503-2516. doi: 10.1111/bcp.13352. [PMID: 28635050]
  • Alexander Kalin, Elvia Medina-Paraiso, Kaoru Ishizaki, Alex Kim, Yannong Zhang, Takanori Saita, Masahiko Wasaki. A safety analysis of edaravone (MCI-186) during the first six cycles (24 weeks) of amyotrophic lateral sclerosis (ALS) therapy from the double-blind period in three randomized, placebo-controlled studies. Amyotrophic lateral sclerosis & frontotemporal degeneration. 2017 Oct; 18(sup1):71-79. doi: 10.1080/21678421.2017.1362440. [PMID: 28872919]
  • Zhengping Zhang, Zhaowen Luo, Aijing Bi, Weidong Yang, Wenji An, Xiaoliang Dong, Rong Chen, Shibao Yang, Huifang Tang, Xiaodong Han, Lan Luo. Compound edaravone alleviates lipopolysaccharide (LPS)-induced acute lung injury in mice. European journal of pharmacology. 2017 Sep; 811(?):1-11. doi: 10.1016/j.ejphar.2017.05.047. [PMID: 28552343]
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  • Xiaoming Qiang, Yan Li, Xia Yang, Li Luo, Rui Xu, Yunxiaozhu Zheng, Zhongcheng Cao, Zhenghuai Tan, Yong Deng. DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy. Bioorganic & medicinal chemistry letters. 2017 02; 27(4):718-722. doi: 10.1016/j.bmcl.2017.01.050. [PMID: 28131710]
  • Alaa Khedr, Soad S Abd El-Hay, Ahmed K Kammoun. Liquid chromatography-tandem mass spectrometric determination of propofol in rat serum and hair at attogram level after derivatization with 3-bromomethyl-propyphenazone. Journal of pharmaceutical and biomedical analysis. 2017 Feb; 134(?):195-202. doi: 10.1016/j.jpba.2016.11.051. [PMID: 27915197]
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  • Kiyoshi Kikuchi, Kentaro Setoyama, Ko-Ichi Kawahara, Tomoka Nagasato, Takuto Terashi, Koki Ueda, Kazuki Nakanishi, Shotaro Otsuka, Naoki Miura, Hisayo Sameshima, Kazuya Hosokawa, Yoichiro Harada, Binita Shrestha, Mika Yamamoto, Yoko Morimoto-Yamashita, Haruna Kikuchi, Ryoji Kiyama, Chinatsu Kamikokuryo, Salunya Tancharoen, Harutoshi Sakakima, Motohiro Morioka, Eiichiro Tanaka, Takashi Ito, Ikuro Maruyama. Edaravone, a Synthetic Free Radical Scavenger, Enhances Alteplase-Mediated Thrombolysis. Oxidative medicine and cellular longevity. 2017; 2017(?):6873281. doi: 10.1155/2017/6873281. [PMID: 29259732]
  • Meenu Paliwal, Sucheta, Ruchita, Shilpa Jain, Monika, Himanshu. Synthesis and Biological Evaluation of Mutual Prodrugs of Carboxylic Group Containing Some Non-Steroidal Anti-Inflammatory Drugs and Propyphenazone. Current drug delivery. 2017; 14(8):1213-1224. doi: 10.2174/1567201814666170213153509. [PMID: 28201966]
  • Jean-Baptiste Oudart, Imad Dali Braham, François-Xavier Maquart. Unexpected Creatinine Values. Clinical chemistry. 2016 12; 62(12):1675-1676. doi: 10.1373/clinchem.2016.263038. [PMID: 27899460]
  • Mayuko Morita, Yuji Naito, Toshikazu Yoshikawa, Etsuo Niki. Inhibition of plasma lipid oxidation induced by peroxyl radicals, peroxynitrite, hypochlorite, 15-lipoxygenase, and singlet oxygen by clinical drugs. Bioorganic & medicinal chemistry letters. 2016 11; 26(22):5411-5417. doi: 10.1016/j.bmcl.2016.10.033. [PMID: 27777006]
  • Norio Fujiwara, Angel T Som, Loc-Duyen D Pham, Brian J Lee, Emiri T Mandeville, Eng H Lo, Ken Arai. A free radical scavenger edaravone suppresses systemic inflammatory responses in a rat transient focal ischemia model. Neuroscience letters. 2016 10; 633(?):7-13. doi: 10.1016/j.neulet.2016.08.048. [PMID: 27589890]
  • Tianjiao Zhang, Chuanbao Zhang, Haijian Zhao, Jie Zeng, Jiangtao Zhang, Weiyan Zhou, Ying Yan, Yufei Wang, Mo Wang, Wenxiang Chen. Determination of serum glucose by isotope dilution liquid chromatography-tandem mass spectrometry: a candidate reference measurement procedure. Analytical and bioanalytical chemistry. 2016 Oct; 408(26):7403-11. doi: 10.1007/s00216-016-9817-0. [PMID: 27481169]
  • Ayahisa Watanabe, Kei Mayumi, Kyohei Nishimura, Hiromi Osaki. In vivo use of the CYP inhibitor 1-aminobenzotriazole to increase long-term exposure in mice. Biopharmaceutics & drug disposition. 2016 Sep; 37(6):373-8. doi: 10.1002/bdd.2020. [PMID: 27379984]
  • Guang-Wei Zhang, Tian-Xiang Gu, Xue-Jun Sun, Chunyue Wang, Xun Qi, Xiao-Bing Wang, Jesse Li-Ling. Edaravone promotes activation of resident cardiac stem cells by transplanted mesenchymal stem cells in a rat myocardial infarction model. The Journal of thoracic and cardiovascular surgery. 2016 08; 152(2):570-82. doi: 10.1016/j.jtcvs.2016.02.071. [PMID: 27056755]
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  • Akio Fujisawa, Yorihiro Yamamoto. Edaravone, a potent free radical scavenger, reacts with peroxynitrite to produce predominantly 4-NO-edaravone. Redox report : communications in free radical research. 2016 May; 21(3):98-103. doi: 10.1179/1351000215y.0000000025. [PMID: 26196041]
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