GLUTARIC ACID (BioDeep_00000400407)
Main id: BioDeep_00000001619
natural product PANOMIX_OTCML-2023
代谢物信息卡片
GLUTARIC ACID
化学式: C5H8O4 (132.0422568)
中文名称: 戊二酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CC(=O)O)CC(=O)O
InChI: InChI=1S/C5H8O4/c6-4(7)2-1-3-5(8)9/h1-3H2,(H,6,7)(H,8,9)
描述信息
An alpha,omega-dicarboxylic acid that is a linear five-carbon dicarboxylic acid.
Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].
Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].
同义名列表
1 个代谢物同义名
数据库引用编号
32 个数据库交叉引用编号
- ChEBI: CHEBI:17859
- KEGG: C00489
- KEGGdrug: D70283
- PubChem: 743
- DrugBank: DB03553
- ChEMBL: CHEMBL1162495
- CAS: 68603-87-2
- CAS: 68937-69-9
- CAS: 110-94-1
- MoNA: MoNA038385
- MoNA: MoNA037987
- MoNA: MoNA035600
- MoNA: MoNA035596
- MoNA: MoNA035597
- MoNA: MoNA034348
- MoNA: MoNA034346
- MoNA: MoNA034344
- MoNA: FiehnHILIC002733
- MoNA: FiehnHILIC001222
- MoNA: HMDB0000661_ms_ms_903
- MoNA: HMDB0000661_ms_ms_904
- MoNA: HMDB0000661_ms_ms_905
- MoNA: PT202340
- MetaboLights: MTBLC17859
- PubChem: 3772
- LipidMAPS: LMFA01170046
- KNApSAcK: C00001184
- PDB-CCD: GUA
- 3DMET: B01263
- NIKKAJI: J40.077G
- RefMet: Glutaric acid
- medchemexpress: HY-W008820
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 569774 金线莲: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ayoob Obaid Alfalahi, Marwa Shakib Alrawi, Rashid Mushrif Theer, Kutaiba Farhan Dawood, Saoulajan Charfi, Ali F Almehemdi. Phytochemical analysis and antifungal potential of two Launaea mucronata (Forssk.) Muschl and Launaea nudicaulis (L.) Hook.fil. wildly growing in Anbar province, Iraq.
Journal of ethnopharmacology.
2023 Jul; 318(Pt A):116965. doi:
10.1016/j.jep.2023.116965. [PMID: 37506779] - Zhixin Niu, Xiaojun Li, Mohammad Mahamood. Accumulation Potential Cadmium and Lead by Sunflower (Helianthus annuus L.) under Citric and Glutaric Acid-Assisted Phytoextraction.
International journal of environmental research and public health.
2023 Feb; 20(5):. doi:
10.3390/ijerph20054107. [PMID: 36901118] - Kuan-Wei Peng, Allison Klotz, Arcan Guven, Kayleigh Gray, Tracey Friss, Shobha Ravipaty, Rangaprasad Sarangarajan, Vladimir Tolstikov, Mark D Kellogg, Niven R Narain, Michael A Kiebish. Multiplexed LC-MS/MS analysis of methylsuccinic acid, ethylmalonic acid, and glutaric acid in plasma and urine.
Analytical biochemistry.
2022 05; 645(?):114604. doi:
10.1016/j.ab.2022.114604. [PMID: 35217005] - Tanyel Zubarioglu, Saffa Ahmadzada, Cengiz Yalcinkaya, Ertugrul Kiykim, Cigdem Aktuglu-Zeybek. COVID-19 triggered encephalopathic crisis in a patient with glutaric aciduria type 1.
Journal of pediatric endocrinology & metabolism : JPEM.
2021 Dec; 34(12):1611-1614. doi:
10.1515/jpem-2021-0474. [PMID: 34517439] - Mary Gonzalez Melo, Andrea Orlando Fontana, David Viertl, Gilles Allenbach, John O Prior, Samuel Rotman, René Günther Feichtinger, Johannes Adalbert Mayr, Michele Costanzo, Marianna Caterino, Margherita Ruoppolo, Olivier Braissant, Frederic Barbey, Diana Ballhausen. A knock-in rat model unravels acute and chronic renal toxicity in glutaric aciduria type I.
Molecular genetics and metabolism.
2021 12; 134(4):287-300. doi:
10.1016/j.ymgme.2021.10.003. [PMID: 34799272] - E M Charlotte Märtner, Eva Thimm, Philipp Guder, Katharina A Schiergens, Frank Rutsch, Sylvia Roloff, Iris Marquardt, Anibh M Das, Peter Freisinger, Sarah C Grünert, Johannes Krämer, Matthias R Baumgartner, Skadi Beblo, Claudia Haase, Andrea Dieckmann, Martin Lindner, Andrea Näke, Georg F Hoffmann, Chris Mühlhausen, Magdalena Walter, Sven F Garbade, Esther M Maier, Stefan Kölker, Nikolas Boy. The biochemical subtype is a predictor for cognitive function in glutaric aciduria type 1: a national prospective follow-up study.
Scientific reports.
2021 09; 11(1):19300. doi:
10.1038/s41598-021-98809-9. [PMID: 34588557] - Guido Linari, Francesco Dondi, Sofia Segatore, Kateryna Vasylyeva, Nikolina Linta, Marco Pietra, Rodolfo O Leal, Federico Fracassi. Evaluation of 1,2-O-dilauryl-rac-glycero glutaric acid-(6'-methylresorufin) ester (DGGR) and 1,2-diglyceride lipase assays in dogs with naturally occurring hypercortisolism.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.
2021 Sep; 33(5):817-824. doi:
10.1177/10406387211021345. [PMID: 34078197] - João Leandro, Aaron Bender, Tetyana Dodatko, Carmen Argmann, Chunli Yu, Sander M Houten. Glutaric aciduria type 3 is a naturally occurring biochemical trait in inbred mice of 129 substrains.
Molecular genetics and metabolism.
2021 02; 132(2):139-145. doi:
10.1016/j.ymgme.2021.01.004. [PMID: 33483254] - Santosh L Gawali, Sandeep B Shelar, Jagriti Gupta, K C Barick, P A Hassan. Immobilization of protein on Fe3O4 nanoparticles for magnetic hyperthermia application.
International journal of biological macromolecules.
2021 Jan; 166(?):851-860. doi:
10.1016/j.ijbiomac.2020.10.241. [PMID: 33161076] - Ruixue Wang, Lianyun Lin, Yiqiang Zheng, Peng Cao, Zhiguang Yuchi, Hui-Yuan Wu. Identification of 2-PMPA as a novel inhibitor of cytosolic carboxypeptidases.
Biochemical and biophysical research communications.
2020 12; 533(4):1393-1399. doi:
10.1016/j.bbrc.2020.10.029. [PMID: 33092792] - Fernanda Silva Rodrigues, Angela Patrícia França, Núbia Broetto, Ana Flávia Furian, Mauro Schneider Oliveira, Adair Roberto Soares Santos, Luiz Fernando Freire Royes, Michele Rechia Fighera. Sustained glial reactivity induced by glutaric acid may be the trigger to learning delay in early and late phases of development: Involvement of p75NTR receptor and protection by N-acetylcysteine.
Brain research.
2020 12; 1749(?):147145. doi:
10.1016/j.brainres.2020.147145. [PMID: 33035499] - Taylan B Morcol, Konrad Wysocki, Renuka P Sankaran, Paul D Matthews, Edward J Kennelly. UPLC-QTof-MSE Metabolomics Reveals Changes in Leaf Primary and Secondary Metabolism of Hop (Humulus lupulus L.) Plants under Drought Stress.
Journal of agricultural and food chemistry.
2020 Dec; 68(49):14698-14708. doi:
10.1021/acs.jafc.0c05987. [PMID: 33236890] - Sue Yee Lim, Panagiotis G Xenoulis, Evangelia M Stavroulaki, Jonathan A Lidbury, Jan S Suchodolski, Frédéric Carrière, Jörg M Steiner. The 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6'-methylresorufin) ester (DGGR) lipase assay in cats and dogs is not specific for pancreatic lipase.
Veterinary clinical pathology.
2020 Dec; 49(4):607-613. doi:
10.1111/vcp.12906. [PMID: 33111388] - João Leandro, Tetyana Dodatko, Robert J DeVita, Hongjie Chen, Brandon Stauffer, Chunli Yu, Sander M Houten. Deletion of 2-aminoadipic semialdehyde synthase limits metabolite accumulation in cell and mouse models for glutaric aciduria type 1.
Journal of inherited metabolic disease.
2020 11; 43(6):1154-1164. doi:
10.1002/jimd.12276. [PMID: 32567100] - Beatriz Mendoza, Maria Joana Dias, Telmo Nunes, Maria Alexandra Basso, Juan Hernandez, Rodolfo Oliveira Leal. Effect of prednisolone therapy on serum levels of 1,2-O-dilauryl-rac-glycero glutaric acid-(6'-methylresorufin) ester lipase in dogs.
Journal of veterinary internal medicine.
2020 Nov; 34(6):2330-2336. doi:
10.1111/jvim.15946. [PMID: 33146921] - Juliette Bouchereau, Manuel Schiff. Inherited Disorders of Lysine Metabolism: A Review.
The Journal of nutrition.
2020 10; 150(Suppl 1):2556S-2560S. doi:
10.1093/jn/nxaa112. [PMID: 33000154] - Anne-Sophie Bua, Carolyn Grimes, Guy Beauchamp, Marilyn E Dunn. Evaluation of 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6'-methylresorufin) ester lipase concentrations in cats with kidney disease and with normal SNAP fPL.
The Canadian veterinary journal = La revue veterinaire canadienne.
2020 07; 61(7):743-748. doi:
NULL. [PMID: 32655158] - Boda Zhou, Yipeng Du, Yajun Xue, Guobin Miao, Taotao Wei, Ping Zhang. Identification of Malonylation, Succinylation, and Glutarylation in Serum Proteins of Acute Myocardial Infarction Patients.
Proteomics. Clinical applications.
2020 01; 14(1):e1900103. doi:
10.1002/prca.201900103. [PMID: 31532912] - Muntaj Shaik, Kruthika-Vinod T P, Mahesh Kamate, Vedamurthy A B. Is Expanded Newborn Screening Adequate to Detect Indian Biochemical Low Excretor Phenotype Patients of Glutaric Aciduria Type I?.
Indian journal of pediatrics.
2019 11; 86(11):995-1001. doi:
10.1007/s12098-019-03017-z. [PMID: 31302874] - Hao Liu, Jing-Kun Miao, Chao-Wen Yu, Ke-Xing Wan, Juan Zhang, Zhao-Jian Yuan, Jing Yang, Dong-Juan Wang, Yan Zeng, Lin Zou. Severe clinical manifestation of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency associated with two novel mutations: a case report.
BMC pediatrics.
2019 10; 19(1):344. doi:
10.1186/s12887-019-1747-5. [PMID: 31597564] - Wenjie Wang, Jianping Yang, Jinjie Xue, Wenjuan Mu, Xiaogang Zhang, Wang Wu, Mengnan Xu, Yuyan Gong, Yiqian Liu, Yu Zhang, Xiaobing Xie, Weiyue Gu, Jigeng Bai, David S Cram. A comprehensive multiplex PCR based exome-sequencing assay for rapid bloodspot confirmation of inborn errors of metabolism.
BMC medical genetics.
2019 01; 20(1):3. doi:
10.1186/s12881-018-0731-5. [PMID: 30612563] - Ayesha Hafeez, Safia Fatima, Nayyar Chaudhry, Muhammad Tahir Khadim. Dyskinesia in a Child: A Concern for a Rare Neuro-Metabolic Disorder.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2019 Jan; 29(1):84-86. doi:
10.29271/jcpsp.2019.01.84. [PMID: 30630579] - Jyotindra Narayan Goswami, Ananthanarayanan Kasinathan, Naveen Sankhyan, Sameer Vyas, Pratibha Singhi. Siblings with L2 Hydroxy Glutaric Aciduria.
Indian journal of pediatrics.
2018 Nov; 85(11):1040-1041. doi:
10.1007/s12098-018-2701-5. [PMID: 29777465] - Chawanphat Muangnoi, Ponsiree Jithavech, Pahweenvaj Ratnatilaka Na Bhuket, Wiwat Supasena, Wisut Wichitnithad, Pasarapa Towiwat, Nuansri Niwattisaiwong, Ian S Haworth, Pornchai Rojsitthisak. A curcumin-diglutaric acid conjugated prodrug with improved water solubility and antinociceptive properties compared to curcumin.
Bioscience, biotechnology, and biochemistry.
2018 Aug; 82(8):1301-1308. doi:
10.1080/09168451.2018.1462694. [PMID: 29678124] - Carmen Regla Vargas, Graziela Schmitt Ribas, Janine Machado da Silva, Angela Sitta, Marion Deon, Daniella de Moura Coelho, Moacir Wajner. Selective Screening of Fatty Acids Oxidation Defects and Organic Acidemias by Liquid Chromatography/tandem Mass Spectrometry Acylcarnitine Analysis in Brazilian Patients.
Archives of medical research.
2018 04; 49(3):205-212. doi:
10.1016/j.arcmed.2018.08.004. [PMID: 30119976] - Na Yang, Sijia Li, Caixia Yan, Runbin Sun, Jun He, Yuan Xie, Ying Peng, Guangji Wang, Jiye Aa. Inhibitory Effects of Endogenous Linoleic Acid and Glutaric Acid on the Renal Glucuronidation of Berberrubine in Mice and on Recombinant Human UGT1A7, 1A8, and 1A9.
Molecular pharmacology.
2018 03; 93(3):216-227. doi:
10.1124/mol.117.110668. [PMID: 29351921] - Jaime Fernández-Bravo, Fernando de Andrés, Mohammed Zougagh, Ángel Ríos. Selective screening of glutaric acid acidurias by capillary electrophoresis-mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2017 Oct; 145(?):40-45. doi:
10.1016/j.jpba.2017.06.037. [PMID: 28648786] - Katia Sayyed, Marc Le Vee, Ziad Abdel-Razzak, Olivier Fardel. Inhibition of organic anion transporter (OAT) activity by cigarette smoke condensate.
Toxicology in vitro : an international journal published in association with BIBRA.
2017 Oct; 44(?):27-35. doi:
10.1016/j.tiv.2017.06.014. [PMID: 28629854] - Agnes Hackl, Katrin Mehler, Ingo Gottschalk, Anne Vierzig, Marcus Eydam, Jan Hauke, Bodo B Beck, Max C Liebau, Regina Ensenauer, Lutz T Weber, Sandra Habbig. Disorders of fatty acid oxidation and autosomal recessive polycystic kidney disease-different clinical entities and comparable perinatal renal abnormalities.
Pediatric nephrology (Berlin, Germany).
2017 05; 32(5):791-800. doi:
10.1007/s00467-016-3556-5. [PMID: 28083701] - Igor Linhart, Michal Himl, Monika Židková, Marie Balíková, Eva Lhotková, Tomáš Páleníček. Metabolic profile of mephedrone: Identification of nor-mephedrone conjugates with dicarboxylic acids as a new type of xenobiotic phase II metabolites.
Toxicology letters.
2016 Jan; 240(1):114-21. doi:
10.1016/j.toxlet.2015.10.025. [PMID: 26541208] - A L Colín-González, A L Paz-Loyola, I N Serratos, B Seminotti, C A J Ribeiro, G Leipnitz, D O Souza, M Wajner, A Santamaría. The effect of WIN 55,212-2 suggests a cannabinoid-sensitive component in the early toxicity induced by organic acids accumulating in glutaric acidemia type I and in related disorders of propionate metabolism in rat brain synaptosomes.
Neuroscience.
2015 Dec; 310(?):578-88. doi:
10.1016/j.neuroscience.2015.09.043. [PMID: 26431622] - A L Colín-González, A L Paz-Loyola, I Serratos, B Seminotti, C A J Ribeiro, G Leipnitz, D O Souza, M Wajner, A Santamaría. Toxic synergism between quinolinic acid and organic acids accumulating in glutaric acidemia type I and in disorders of propionate metabolism in rat brain synaptosomes: Relevance for metabolic acidemias.
Neuroscience.
2015 Nov; 308(?):64-74. doi:
10.1016/j.neuroscience.2015.09.002. [PMID: 26343296] - D Spitzer, B Risse, F Schnell, V Pichot, M Klaumünzer, M R Schaefer. Continuous engineering of nano-cocrystals for medical and energetic applications.
Scientific reports.
2014 Oct; 4(?):6575. doi:
10.1038/srep06575. [PMID: 25300652] - P S Bindu, A B Taly, K Sonam, C Govindaraju, H R Arvinda, N Gayathri, M M Srinivas Bharath, D Ranjith, M Nagappa, S Sinha, N A Khan, K Thangaraj. Bilateral hypertrophic olivary nucleus degeneration on magnetic resonance imaging in children with Leigh and Leigh-like syndrome.
The British journal of radiology.
2014 Feb; 87(1034):20130478. doi:
10.1259/bjr.20130478. [PMID: 24470583] - Qi Liu, Yi-Ping Chen. [Glutaric aciduria type I: a report of 2 cases].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics.
2014 Jan; 16(1):87-90. doi:
NULL. [PMID: 24461187] - Palash Sanphui, Srinu Tothadi, Somnath Ganguly, Gautam R Desiraju. Salt and cocrystals of sildenafil with dicarboxylic acids: solubility and pharmacokinetic advantage of the glutarate salt.
Molecular pharmaceutics.
2013 Dec; 10(12):4687-97. doi:
10.1021/mp400516b. [PMID: 24168322] - Bastian Thies, Catherine Meyer-Schwesinger, Jessica Lamp, Michaela Schweizer, David M Koeller, Kurt Ullrich, Thomas Braulke, Chris Mühlhausen. Acute renal proximal tubule alterations during induced metabolic crises in a mouse model of glutaric aciduria type 1.
Biochimica et biophysica acta.
2013 Oct; 1832(10):1463-72. doi:
10.1016/j.bbadis.2013.04.019. [PMID: 23623985] - Hiroshi Ashihara, Wei-Wei Deng. Pyridine metabolism in tea plants: salvage, conjugate formation and catabolism.
Journal of plant research.
2012 Nov; 125(6):781-91. doi:
10.1007/s10265-012-0490-x. [PMID: 22527843] - Krista Viau, Sharon L Ernst, Rena J Vanzo, Lorenzo D Botto, Marzia Pasquali, Nicola Longo. Glutaric acidemia type 1: outcomes before and after expanded newborn screening.
Molecular genetics and metabolism.
2012 Aug; 106(4):430-8. doi:
10.1016/j.ymgme.2012.05.024. [PMID: 22728054] - Ronke Yemisi Aderinboye, Chryss Friday Ijeoma Onwuka, Oluwasanmi Moses Arigbede, Oluseyi Olutosin Oduguwa, Ayobami Bukola Joseph Aina. Effect of dietary monensin inclusion on performance, nutrient utilisation, rumen volatile fatty acid concentration and blood status of West African dwarf bucks fed with basal diets of forages.
Tropical animal health and production.
2012 Jun; 44(5):1079-87. doi:
10.1007/s11250-011-0043-7. [PMID: 22201011] - Valentina Citton, Alberto Burlina, Claudio Baracchini, Massimo Gallucci, Alessia Catalucci, Sandro Dal Pos, Alessandro Burlina, Renzo Manara. Apparent diffusion coefficient restriction in the white matter: going beyond acute brain territorial ischemia.
Insights into imaging.
2012 Apr; 3(2):155-64. doi:
10.1007/s13244-011-0114-3. [PMID: 22696041] - C Reveneau, S K R Karnati, E R Oelker, J L Firkins. Interaction of unsaturated fat or coconut oil with monensin in lactating dairy cows fed 12 times daily. I. Protozoal abundance, nutrient digestibility, and microbial protein flow to the omasum.
Journal of dairy science.
2012 Apr; 95(4):2046-60. doi:
10.3168/jds.2011-4887. [PMID: 22459850] - Peter Kämpfer, Stefanie Wellner, Kerstin Lohse, Karin Martin, Nicole Lodders. Duganella phyllosphaerae sp. nov., isolated from the leaf surface of Trifolium repens and proposal to reclassify Duganella violaceinigra into a novel genus as Pseudoduganella violceinigra gen. nov., comb. nov.
Systematic and applied microbiology.
2012 Feb; 35(1):19-23. doi:
10.1016/j.syapm.2011.10.003. [PMID: 22169565] - Stewart Frankel, Blanka Rogina. Indy mutants: live long and prosper.
Frontiers in genetics.
2012; 3(?):13. doi:
10.3389/fgene.2012.00013. [PMID: 22363340] - Huihui Zhao, Jianxin Chen, Qi Shi, Xueling Ma, Yi Yang, Liangtao Luo, Shuzhen Guo, Yong Wang, Jing Han, Wei Wang. Metabolomics-based study of clinical and animal plasma samples in coronary heart disease with blood stasis syndrome.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):638723. doi:
10.1155/2012/638723. [PMID: 22675387] - Fabien J Cousin, Sandrine Jouan-Lanhouet, Marie-Thérèse Dimanche-Boitrel, Laurent Corcos, Gwénaël Jan. Milk fermented by Propionibacterium freudenreichii induces apoptosis of HGT-1 human gastric cancer cells.
PloS one.
2012; 7(3):e31892. doi:
10.1371/journal.pone.0031892. [PMID: 22442660] - Jolanta Zuwała-Jagiello, Monika Pazgan-Simon, Krzysztof Simon, Maria Warwas. Picolinic acid in patients with chronic hepatitis C infection: a preliminary report.
Mediators of inflammation.
2012; 2012(?):762863. doi:
10.1155/2012/762863. [PMID: 22701277] - Maria G Beconi, David Howland, Larry Park, Kathryn Lyons, Joseph Giuliano, Celia Dominguez, Ignacio Munoz-Sanjuan, Robert Pacifici. Pharmacokinetics of memantine in rats and mice.
PLoS currents.
2011 Dec; 3(?):RRN1291. doi:
10.1371/currents.rrn1291. [PMID: 22307216] - Wisut Wichitnithad, Ubonthip Nimmannit, Patrick S Callery, Pornchai Rojsitthisak. Effects of different carboxylic ester spacers on chemical stability, release characteristics, and anticancer activity of mono-PEGylated curcumin conjugates.
Journal of pharmaceutical sciences.
2011 Dec; 100(12):5206-18. doi:
10.1002/jps.22716. [PMID: 21850703] - A O Oni, C F I Onwuka, O M Arigbede, U Y Anele, O O Oduguwa, O S Onifade, Z L Tan. Chemical composition and nutritive value of four varieties of cassava leaves grown in South-Western Nigeria.
Journal of animal physiology and animal nutrition.
2011 Oct; 95(5):583-90. doi:
10.1111/j.1439-0396.2010.01086.x. [PMID: 21091552] - T L Felix, S C Loerch. Effects of haylage and monensin supplementation on performance, carcass characteristics, and ruminal metabolism of feedlot cattle fed diets containing 60\% dried distillers grains.
Journal of animal science.
2011 Aug; 89(8):2614-23. doi:
10.2527/jas.2010-3716. [PMID: 21454865] - Andrej Kochevenko, Alisdair R Fernie. The genetic architecture of branched-chain amino acid accumulation in tomato fruits.
Journal of experimental botany.
2011 Jul; 62(11):3895-906. doi:
10.1093/jxb/err091. [PMID: 21436187] - R Song, D N Foster, G C Shurson. Effects of feeding diets containing bacitracin methylene disalicylate to heat-stressed finishing pigs.
Journal of animal science.
2011 Jun; 89(6):1830-43. doi:
10.2527/jas.2010-3218. [PMID: 21297060] - Katja Brauburger, Gerhard Burckhardt, Birgitta C Burckhardt. The sodium-dependent di- and tricarboxylate transporter, NaCT, is not responsible for the uptake of D-, L-2-hydroxyglutarate and 3-hydroxyglutarate into neurons.
Journal of inherited metabolic disease.
2011 Apr; 34(2):477-82. doi:
10.1007/s10545-010-9268-2. [PMID: 21264516] - Mireia Marin, Virginie Lhiaubet-Vallet, Miguel Angel Miranda. Site-dependent photo-fries rearrangement within serum albumins.
The journal of physical chemistry. B.
2011 Mar; 115(12):2910-5. doi:
10.1021/jp2009463. [PMID: 21384817] - Yuichi Mushimoto, Seiji Fukuda, Yuki Hasegawa, Hironori Kobayashi, Jamiyan Purevsuren, Hong Li, Takeshi Taketani, Seiji Yamaguchi. Clinical and molecular investigation of 19 Japanese cases of glutaric acidemia type 1.
Molecular genetics and metabolism.
2011 Mar; 102(3):343-8. doi:
10.1016/j.ymgme.2010.11.159. [PMID: 21176883] - Wagner L Araújo, Adriano Nunes-Nesi, Sonia Osorio, Björn Usadel, Daniela Fuentes, Réka Nagy, Ilse Balbo, Martin Lehmann, Claudia Studart-Witkowski, Takayuki Tohge, Enrico Martinoia, Xavier Jordana, Fábio M Damatta, Alisdair R Fernie. Antisense inhibition of the iron-sulphur subunit of succinate dehydrogenase enhances photosynthesis and growth in tomato via an organic acid-mediated effect on stomatal aperture.
The Plant cell.
2011 Feb; 23(2):600-27. doi:
10.1105/tpc.110.081224. [PMID: 21307286] - Annet M Bosch, Nico G G M Abeling, Lodewijk Ijlst, Hennie Knoester, W Ludo van der Pol, Alida E M Stroomer, Ronald J Wanders, Gepke Visser, Frits A Wijburg, Marinus Duran, Hans R Waterham. Brown-Vialetto-Van Laere and Fazio Londe syndrome is associated with a riboflavin transporter defect mimicking mild MADD: a new inborn error of metabolism with potential treatment.
Journal of inherited metabolic disease.
2011 Feb; 34(1):159-64. doi:
10.1007/s10545-010-9242-z. [PMID: 21110228] - Osama Y Al-Dirbashi, Stefan Kölker, Dione Ng, Lawrence Fisher, Tony Rupar, Nathalie Lepage, Mohamed S Rashed, Tomofumi Santa, Stephen I Goodman, Michael T Geraghty, Johannes Zschocke, Ernst Christensen, Georg F Hoffmann, Pranesh Chakraborty. Diagnosis of glutaric aciduria type 1 by measuring 3-hydroxyglutaric acid in dried urine spots by liquid chromatography tandem mass spectrometry.
Journal of inherited metabolic disease.
2011 Feb; 34(1):173-80. doi:
10.1007/s10545-010-9223-2. [PMID: 20978942] - Maria Vinaixa, Miguel Angel Rodriguez, Sara Samino, Marta Díaz, Antoni Beltran, Roger Mallol, Cinta Bladé, Lourdes Ibañez, Xavier Correig, Oscar Yanes. Metabolomics reveals reduction of metabolic oxidation in women with polycystic ovary syndrome after pioglitazone-flutamide-metformin polytherapy.
PloS one.
2011; 6(12):e29052. doi:
10.1371/journal.pone.0029052. [PMID: 22194988] - Johannes Häberle. Role of carglumic acid in the treatment of acute hyperammonemia due to N-acetylglutamate synthase deficiency.
Therapeutics and clinical risk management.
2011; 7(?):327-32. doi:
10.2147/tcrm.s12703. [PMID: 21941437] - Sven W Sauer, Silvana Opp, Georg F Hoffmann, David M Koeller, Jürgen G Okun, Stefan Kölker. Therapeutic modulation of cerebral L-lysine metabolism in a mouse model for glutaric aciduria type I.
Brain : a journal of neurology.
2011 Jan; 134(Pt 1):157-70. doi:
10.1093/brain/awq269. [PMID: 20923787] - Ariel A Bazzini, Carlos A Manacorda, Takayuki Tohge, Gabriela Conti, Maria C Rodriguez, Adriano Nunes-Nesi, Sofía Villanueva, Alisdair R Fernie, Fernando Carrari, Sebastian Asurmendi. Metabolic and miRNA profiling of TMV infected plants reveals biphasic temporal changes.
PloS one.
2011; 6(12):e28466. doi:
10.1371/journal.pone.0028466. [PMID: 22174812] - Makoto Takei, Yosuke Ando, Wataru Saitoh, Tomoe Tanimoto, Naoki Kiyosawa, Sunao Manabe, Atsushi Sanbuissho, Osamu Okazaki, Haruo Iwabuchi, Takashi Yamoto, Klaus-Peter Adam, James E Weiel, John A Ryals, Michael V Milburn, Lining Guo. Ethylene glycol monomethyl ether-induced toxicity is mediated through the inhibition of flavoprotein dehydrogenase enzyme family.
Toxicological sciences : an official journal of the Society of Toxicology.
2010 Dec; 118(2):643-52. doi:
10.1093/toxsci/kfq211. [PMID: 20616209] - Amlan K Patra. Meta-analyses of effects of phytochemicals on digestibility and rumen fermentation characteristics associated with methanogenesis.
Journal of the science of food and agriculture.
2010 Dec; 90(15):2700-8. doi:
10.1002/jsfa.4143. [PMID: 20740549] - Hui Sun, Alla Lapidus, Matt Nolan, Susan Lucas, Tijana Glavina Del Rio, Hope Tice, Jan-Fang Cheng, Roxane Tapia, Cliff Han, Lynne Goodwin, Sam Pitluck, Ioanna Pagani, Natalia Ivanova, Konstantinos Mavromatis, Natalia Mikhailova, Amrita Pati, Amy Chen, Krishna Palaniappan, Miriam Land, Loren Hauser, Yun-Juan Chang, Cynthia D Jeffries, Olivier Duplex Ngatchou Djao, Manfred Rohde, Johannes Sikorski, Markus Göker, Tanja Woyke, James Bristow, Jonathan A Eisen, Victor Markowitz, Philip Hugenholtz, Nikos C Kyrpides, Hans-Peter Klenk. Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509).
Standards in genomic sciences.
2010 Nov; 3(3):325-36. doi:
10.4056/sigs.1363462. [PMID: 21304737] - Chia-Cheng Li, Tin-Yun Ho, Chia-Hung Kao, Shih-Lu Wu, Ji-An Liang, Chien-Yun Hsiang. Conserved charged amino acid residues in the extracellular region of sodium/iodide symporter are critical for iodide transport activity.
Journal of biomedical science.
2010 Nov; 17(?):89. doi:
10.1186/1423-0127-17-89. [PMID: 21092238] - V A Corriher, G M Hill, J K Bernard, T C Jenkins, J W West, B G Mullinix. Pigeon peas as a supplement for lactating dairy cows fed corn silage-based diets.
Journal of dairy science.
2010 Nov; 93(11):5309-17. doi:
10.3168/jds.2010-3182. [PMID: 20965347] - Ching-Hui Yang, Kyle P Glover, Xing Han. Characterization of cellular uptake of perfluorooctanoate via organic anion-transporting polypeptide 1A2, organic anion transporter 4, and urate transporter 1 for their potential roles in mediating human renal reabsorption of perfluorocarboxylates.
Toxicological sciences : an official journal of the Society of Toxicology.
2010 Oct; 117(2):294-302. doi:
10.1093/toxsci/kfq219. [PMID: 20639259] - George van der Watt, Elizabeth P Owen, Peter Berman, Surita Meldau, Nicholas Watermeyer, Simon E Olpin, Nigel J Manning, Ingrid Baumgarten, Felicity Leisegang, Howard Henderson. Glutaric aciduria type 1 in South Africa-high incidence of glutaryl-CoA dehydrogenase deficiency in black South Africans.
Molecular genetics and metabolism.
2010 Oct; 101(2-3):178-82. doi:
10.1016/j.ymgme.2010.07.018. [PMID: 20732827] - Findy Au, Lisa E McKeown, Tim A McAllister, Alexandre V Chaves. Fermentation characteristics of corn-, triticale-, and wheat-based dried distillers' grains with solubles in barley-based diets determined using continuous and batch culture systems.
Journal of the science of food and agriculture.
2010 Sep; 90(12):2074-82. doi:
10.1002/jsfa.4054. [PMID: 20597102] - M Agle, A N Hristov, S Zaman, C Schneider, P M Ndegwa, V K Vaddella. Effect of dietary concentrate on rumen fermentation, digestibility, and nitrogen losses in dairy cows.
Journal of dairy science.
2010 Sep; 93(9):4211-22. doi:
10.3168/jds.2009-2977. [PMID: 20723695] - Yohannes Hagos, Natascha A Wolff. Assessment of the role of renal organic anion transporters in drug-induced nephrotoxicity.
Toxins.
2010 08; 2(8):2055-82. doi:
10.3390/toxins2082055. [PMID: 22069672] - André Quincozes-Santos, Rafael Borba Rosa, Guilhian Leipnitz, Daniela Fraga de Souza, Bianca Seminotti, Moacir Wajner, Carlos Alberto Gonçalves. Induction of S100B secretion in C6 astroglial cells by the major metabolites accumulating in glutaric acidemia type I.
Metabolic brain disease.
2010 Jun; 25(2):191-8. doi:
10.1007/s11011-010-9203-0. [PMID: 20437086] - Sven W Sauer, Silvana Opp, Anne Mahringer, Marcin M Kamiński, Christian Thiel, Jürgen G Okun, Gert Fricker, Marina A Morath, Stefan Kölker. Glutaric aciduria type I and methylmalonic aciduria: simulation of cerebral import and export of accumulating neurotoxic dicarboxylic acids in in vitro models of the blood-brain barrier and the choroid plexus.
Biochimica et biophysica acta.
2010 Jun; 1802(6):552-60. doi:
10.1016/j.bbadis.2010.03.003. [PMID: 20302929] - Susan C Connor, Michael K Hansen, Adam Corner, Randall F Smith, Terence E Ryan. Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes.
Molecular bioSystems.
2010 May; 6(5):909-21. doi:
10.1039/b914182k. [PMID: 20567778] - Judith L Flanagan, Peter A Simmons, Joseph Vehige, Mark Dp Willcox, Qian Garrett. Role of carnitine in disease.
Nutrition & metabolism.
2010 Apr; 7(?):30. doi:
10.1186/1743-7075-7-30. [PMID: 20398344] - E Molina-Alcaide, A I Martín-García, A Moumen, M D Carro. Ruminal fermentation, microbial growth and amino acid flow in single-flow continuous culture fermenters fed a diet containing olive leaves.
Journal of animal physiology and animal nutrition.
2010 Apr; 94(2):227-36. doi:
10.1111/j.1439-0396.2008.00905.x. [PMID: 19175451] - Amlan Kumar Patra, Devki Nandan Kamra, Neeta Agarwal. Effects of extracts of spices on rumen methanogenesis, enzyme activities and fermentation of feeds in vitro.
Journal of the science of food and agriculture.
2010 Feb; 90(3):511-20. doi:
10.1002/jsfa.3849. [PMID: 20355074] - Matthias Rödiger, Xiaohong Zhang, Bernhard Ugele, Nikolaus Gersdorff, Stephen H Wright, Gerhard Burckhardt, Andrew Bahn. Organic anion transporter 3 (OAT3) and renal transport of the metal chelator 2,3-dimercapto-1-propanesulfonic acid (DMPS).
Canadian journal of physiology and pharmacology.
2010 Feb; 88(2):141-6. doi:
10.1139/y09-123. [PMID: 20237588] - Anibh M Das, Ulrike Steuerwald, Sabine Illsinger. Inborn errors of energy metabolism associated with myopathies.
Journal of biomedicine & biotechnology.
2010; 2010(?):340849. doi:
10.1155/2010/340849. [PMID: 20589068] - I Höliner, B Simma, A Reiter, J O Sass, J Zschocke, Martina Huemer. Compliance to clinical guidelines determines outcome in glutaric aciduria type I in the era of newborn screening.
Klinische Padiatrie.
2010 Jan; 222(1):35-7. doi:
10.1055/s-0029-1239525. [PMID: 20084589] - Kimiyoshi Ichida. What lies behind serum urate concentration? Insights from genetic and genomic studies.
Genome medicine.
2009 Dec; 1(12):118. doi:
10.1186/gm118. [PMID: 20090896] - Julia B Hennermann, Sylvia Roloff, Jutta Gellermann, Annette Grüters, Jeannette Klein. False-positive newborn screening mimicking glutaric aciduria type I in infants with renal insufficiency.
Journal of inherited metabolic disease.
2009 Dec; 32 Suppl 1(?):S355-9. doi:
10.1007/s10545-009-9017-6. [PMID: 20033292] - Fenja Klevenhusen, Stefano M Bernasconi, Thomas B Hofstetter, Jakov Bolotin, Carmen Kunz, Carla R Soliva. Efficiency of monolaurin in mitigating ruminal methanogenesis and modifying C-isotope fractionation when incubating diets composed of either C3 or C4 plants in a rumen simulation technique (Rusitec) system.
The British journal of nutrition.
2009 Nov; 102(9):1308-17. doi:
10.1017/s0007114509990262. [PMID: 19505345] - Belén Pérez-Dueñas, Alberto De La Osa, Antoni Capdevila, Aleix Navarro-Sastre, Andy Leist, Antonia Ribes, Angels García-Cazorla, Mercedes Serrano, Mercedes Pineda, Jaume Campistol. Brain injury in glutaric aciduria type I: the value of functional techniques in magnetic resonance imaging.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society.
2009 Nov; 13(6):534-40. doi:
10.1016/j.ejpn.2008.12.002. [PMID: 19167251] - Masashi Niimi, Lian Tao, Shi-Hua Lin, Jun Yin, Xiaoyun Wu, Hiroyuki Fukui, Junichi Kambayashi, Jianping Ye, Bing Sun. Involvement of an alternatively spliced mitochondrial oxodicarboxylate carrier in adipogenesis in 3T3-L1 cells.
Journal of biomedical science.
2009 Oct; 16(?):92. doi:
10.1186/1423-0127-16-92. [PMID: 19825180] - J M Kelzer, P J Kononoff, A M Gehman, L O Tedeschi, K Karges, M L Gibson. Effects of feeding three types of corn-milling coproducts on milk production and ruminal fermentation of lactating Holstein cattle.
Journal of dairy science.
2009 Oct; 92(10):5120-32. doi:
10.3168/jds.2009-2208. [PMID: 19762830] - G N Gozho, J J McKinnon, D A Christensen, V Racz, T Mutsvangwa. Effects of type of canola protein supplement on ruminal fermentation and nutrient flow to the duodenum in beef heifers.
Journal of animal science.
2009 Oct; 87(10):3363-71. doi:
10.2527/jas.2009-1841. [PMID: 19542502] - Nadiya Bakhiya, Volker M Arlt, Andrew Bahn, Gerhard Burckhardt, David H Phillips, Hansruedi Glatt. Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy.
Toxicology.
2009 Oct; 264(1-2):74-9. doi:
10.1016/j.tox.2009.07.014. [PMID: 19643159] - Shiek Ssj Ahmed, Winkins Santosh, Suresh Kumar, Hema T Thanka Christlet. Metabolic profiling of Parkinson's disease: evidence of biomarker from gene expression analysis and rapid neural network detection.
Journal of biomedical science.
2009 Jul; 16(?):63. doi:
10.1186/1423-0127-16-63. [PMID: 19594911] - Masanori Nakakariya, Yoichiro Shima, Yoshiyuki Shirasaka, Keisuke Mitsuoka, Takeo Nakanishi, Ikumi Tamai. Organic anion transporter OAT1 is involved in renal handling of citrulline.
American journal of physiology. Renal physiology.
2009 Jul; 297(1):F71-9. doi:
10.1152/ajprenal.90662.2008. [PMID: 19403644] - Ugur Goktas, Ismail Kati, Osman Cagatay Aytekin. Management of outpatient anesthesia in an unusually case with glutaric aciduria type-1.
Paediatric anaesthesia.
2009 Jun; 19(6):632-3. doi:
10.1111/j.1460-9592.2009.02893.x. [PMID: 19645992] - L Holtshausen, A V Chaves, K A Beauchemin, S M McGinn, T A McAllister, N E Odongo, P R Cheeke, C Benchaar. Feeding saponin-containing Yucca schidigera and Quillaja saponaria to decrease enteric methane production in dairy cows.
Journal of dairy science.
2009 Jun; 92(6):2809-21. doi:
10.3168/jds.2008-1843. [PMID: 19448015] - Mahesh Kamate, V D Patil, Vivek Chetal, Virupaxi Hattiholi. 'Glutaric aciduria type I--an easily diagnosable and treatable metabolic disorder'.
Indian journal of pediatrics.
2009 May; 76(5):562-3. doi:
10.1007/s12098-009-0080-7. [PMID: 19390803] - Verity M McClelland, Daniela B Bakalinova, Chris Hendriksz, Ravi P Singh. Glutaric aciduria type 1 presenting with epilepsy.
Developmental medicine and child neurology.
2009 Mar; 51(3):235-9. doi:
10.1111/j.1469-8749.2008.03240.x. [PMID: 19260933] - K J Vander Pol, M K Luebbe, G I Crawford, G E Erickson, T J Klopfenstein. Performance and digestibility characteristics of finishing diets containing distillers grains, composites of corn processing coproducts, or supplemental corn oil.
Journal of animal science.
2009 Feb; 87(2):639-52. doi:
10.2527/jas.2008-1036. [PMID: 18952733] - Joost T van Dongen, Anja Fröhlich, Santiago J Ramírez-Aguilar, Nicolas Schauer, Alisdair R Fernie, Alexander Erban, Joachim Kopka, Jeremy Clark, Anke Langer, Peter Geigenberger. Transcript and metabolite profiling of the adaptive response to mild decreases in oxygen concentration in the roots of arabidopsis plants.
Annals of botany.
2009 Jan; 103(2):269-80. doi:
10.1093/aob/mcn126. [PMID: 18660497] - Eric A Sherman, Kevin A Strauss, Silvia Tortorelli, Michael J Bennett, Ina Knerr, D Holmes Morton, Erik G Puffenberger. Genetic mapping of glutaric aciduria, type 3, to chromosome 7 and identification of mutations in c7orf10.
American journal of human genetics.
2008 Nov; 83(5):604-9. doi:
10.1016/j.ajhg.2008.09.018. [PMID: 18926513]