Oseltamivir (BioDeep_00000398255)
Main id: BioDeep_00000002213
代谢物信息卡片
Oseltamivir
化学式: C16H28N2O4 (312.20489680000003)
中文名称: 奥司他韦
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(CC)OC1C=C(CC(C1NC(=O)C)N)C(=O)OCC
InChI: InChI=1S/C16H28N2O4/c1-5-12(6-2)22-14-9-11(16(20)21-7-3)8-13(17)15(14)18-10(4)19/h9,12-15H,5-8,17H2,1-4H3,(H,18,19)/t13-,14+,15+/m0/s1
描述信息
A cyclohexenecarboxylate ester that is the ethyl ester of oseltamivir acid. An antiviral prodrug (it is hydrolysed to the active free carboxylic acid in the liver), it is used to slow the spread of influenza.
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AH - Neuraminidase inhibitors
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C254 - Anti-Infective Agent > C281 - Antiviral Agent
D004791 - Enzyme Inhibitors
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Disclaimer: While authors make an effort to ensure that the content of this record is accurate, the authors make no representations or warranties in relation to the accuracy or completeness of the record. This record do not reflect any viewpoints of the affiliation and organization to which the authors belong.
同义名列表
1 个代谢物同义名
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:7798
- KEGG: C08092
- KEGGdrug: D08306
- PubChem: 65028
- DrugBank: DB00198
- ChEMBL: CHEMBL1229
- MeSH: Oseltamivir
- CAS: 196618-13-0
- CAS: 182367-47-1
- MoNA: FFF00285
- MoNA: FFF00284
- MoNA: FFF00283
- MetaboLights: MTBLC7798
- PubChem: 10292
- NIKKAJI: J871.765F
- RefMet: Oseltamivir
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 161756 Isatis tinctoria: 10.1021/NP3002833
- 161756 Isatis tinctoria: 10.1021/NP3002833
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Adriána Čelková, Alexander Búcsi, Mária Klacsová, Tomáš Fazekaš, Juan Carlos Martínez, Daniela Uhríková. Oseltamivir phosphate interaction with model membranes.
Biochimica et biophysica acta. Biomembranes.
2024 Mar; 1866(3):184273. doi:
10.1016/j.bbamem.2024.184273. [PMID: 38211646] - Irina Gaisina, Ping Li, Ruikun Du, Qinghua Cui, Meiyue Dong, Chengcheng Zhang, Balaji Manicassamy, Michael Caffrey, Terry Moore, Laura Cooper, Lijun Rong. An orally active entry inhibitor of influenza A viruses protects mice and synergizes with oseltamivir and baloxavir marboxil.
Science advances.
2024 Feb; 10(8):eadk9004. doi:
10.1126/sciadv.adk9004. [PMID: 38394202] - Yuheng Huang, Xiaoxin Guo, Zhen Wang, Cong Yin, Mu Chen, Jiaming Xie, Ning Li, Zhengchao Tu, Juan Li, Jiaqing Cao, Zhengjin Jiang, Weihuan Huang, Haiyan Tian. High-resolution neuraminidase inhibition profiling of Arnebia euchroma (Royle) I.M. Johnst. based on HR-MS and target isolation: An example study of anti-infectious constituents in traditional Chinese medicine.
Journal of ethnopharmacology.
2024 Jan; 319(Pt 1):117074. doi:
10.1016/j.jep.2023.117074. [PMID: 37619859] - Chuanfeng Liu, Ying Zhang, Ping Li, Huinan Jia, Han Ju, Jiwei Zhang, Edeildo Ferreira da Silva-Júnior, Sunanda Samanta, Parimal Kar, Bing Huang, Xinyong Liu, Peng Zhan. Development of chalcone-like derivatives and their biological and mechanistic investigations as novel influenza nuclear export inhibitors.
European journal of medicinal chemistry.
2023 Sep; 261(?):115845. doi:
10.1016/j.ejmech.2023.115845. [PMID: 37804770] - Philip W Melchert, Qingchen Zhang, Sushobhan Mukhopadhyay, Siva Rama Raju Kanumuri, Christopher R McCurdy, John S Markowitz. An in vitro evaluation of kratom (Mitragyna speciosa) on the catalytic activity of carboxylesterase 1 (CES1).
Chemico-biological interactions.
2023 Sep; ?(?):110715. doi:
10.1016/j.cbi.2023.110715. [PMID: 37716419] - Xinfeng Bai, Suya Xi, Guiyan Chen, Xiaoying Fan, Kaiwei Wang, Yong Li, Yang Zhao, Weizhan Wang, Yingping Tian. Multicenter, randomized controlled, open label evaluation of the efficacy and safety of arbidol hydrochloride tablets in the treatment of influenza-like cases.
BMC infectious diseases.
2023 Sep; 23(1):585. doi:
10.1186/s12879-023-08570-9. [PMID: 37674112] - Qiang Ding, Chao Ye. Microbial engineering for shikimate biosynthesis.
Enzyme and microbial technology.
2023 Aug; 170(?):110306. doi:
10.1016/j.enzmictec.2023.110306. [PMID: 37598506] - Li-Man Ding, Dao-Wen Yang, Hong-Chun Zhang, Xiao Ma, Zhen-Gang Yan, Sheng-Tang Zhang, Wu-Zhi Ma, Wei-Ge Li, Dong-Xing Wu, Qing-Rong Jiang. [Cost-effectiveness analysis of Chaiyin Granules in treatment of influenza].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Aug; 48(16):4529-4535. doi:
10.19540/j.cnki.cjcmm.20230323.501. [PMID: 37802879] - Xuran Cui, Xibao Liu, Feng Wang, Kun Lou, Junping Hong, Hequn Bai, Rongchu Chen, Yang Yang, Qingquan Liu. Determination of the synergistic anti-influenza effect of Huangqin Su tablet and Oseltamivir and investigation of mechanism of the tablet based on gut microbiota and network pharmacology.
BMC complementary medicine and therapies.
2023 Feb; 23(1):36. doi:
10.1186/s12906-023-03858-4. [PMID: 36739385] - Zhixu Chen, Jincai Wang, Jiaming Yuan, Zhen Wang, Zhengchao Tu, Jacques Crommen, Wenhui Luo, Jialiang Guo, Tingting Zhang, Zhengjin Jiang. Rapid screening of neuraminidase inhibitors using an at-line nanofractionation platform involving parallel oseltamivir-sensitive/resistant neuraminidase bioassays.
Journal of chromatography. A.
2023 Jan; 1687(?):463693. doi:
10.1016/j.chroma.2022.463693. [PMID: 36516530] - Na Jiang, Liqiu Quan, Yan Zhou, Yungyi Cheng, Hongmei Li, Xuanqin Chen, Rongtao Li, Dan Liu. Exploring the anti-influenza virus activity of novel triptolide derivatives targeting nucleoproteins.
Bioorganic chemistry.
2022 12; 129(?):106118. doi:
10.1016/j.bioorg.2022.106118. [PMID: 36067538] - Yanyan Bao, Yujing Shi, Lirun Zhou, Shuangrong Gao, Rongmei Yao, Shanshan Guo, Zihan Geng, Lei Bao, Ronghua Zhao, Xiaolan Cui. MicroRNA-205-5p: A potential therapeutic target for influenza A.
Journal of cellular and molecular medicine.
2022 12; 26(23):5917-5928. doi:
10.1111/jcmm.17615. [PMID: 36403222] - Mengjie Xiao, Fei Cao, Tao Huang, Yun-Sang Tang, Xin Zhao, Pang-Chui Shaw. Urolithin M5 from the Leaves of Canarium album (Lour.) DC. Inhibits Influenza Virus by Targeting Neuraminidase.
Molecules (Basel, Switzerland).
2022 Sep; 27(17):. doi:
10.3390/molecules27175724. [PMID: 36080488] - Xiao-Lan Ye, Chen-Chen Tang, Hui Liu, You Hu, Tian-Nan Xiang, Yue-Juan Zheng. [Reduning Injection protects flu-infected mice by inhibiting infiltration of inflammatory cells in lung and down-regulating cytokine storm].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Sep; 47(17):4698-4706. doi:
10.19540/j.cnki.cjcmm.20220427.402. [PMID: 36164877] - Wei-Feng Li, Chan-Chan Hu, Ya-Li Ding, Bin Yuan. [Overview of Meta-analysis of Lianhua Qingwen preparations in treatment of viral diseases].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Aug; 47(16):4505-4516. doi:
10.19540/j.cnki.cjcmm.20220510.501. [PMID: 36046880] - Yu-Meng Yan, Xiao-Jing Yang, Chun-Xia Zhao, Ze-Yu Li, Guo-Zhen Zhao, Yu-Hong Guo, Bo Li, Qing-Quan Liu. [Systematic review and Meta-analysis of Lianhua Qingwen preparations combined with Oseltamivir in treatment of influenza].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Aug; 47(15):4238-4247. doi:
10.19540/j.cnki.cjcmm.20220512.501. [PMID: 36046914] - Vladimir V Zarubaev, Angelica V Garshinina, Alexandrina S Volobueva, Alexander V Slita, Olga I Yarovaya, Vladimir V Bykov, Klim A Leonov, Valery S Motov, Veniamin A Khazanov, Nariman F Salakhutdinov. Optimization of application schedule of camphecene, a novel anti-influenza compound, based on its pharmacokinetic characteristics.
Fundamental & clinical pharmacology.
2022 Jun; 36(3):518-525. doi:
10.1111/fcp.12750. [PMID: 34984730] - David Calderón Guzmán, Norma Osnaya Brizuela, Maribel Ortiz Herrera, Hugo Juárez Olguín, Quetzalli Veloz Corona, Lulu Sanchez Reyes, Armando Valenzuela Peraza, Gerardo Barragán Mejía. Oseltamivir induces favorable response on oxidative damage in the brain of rats treated with Bezafibrate.
The International journal of neuroscience.
2022 Jun; 132(6):574-581. doi:
10.1080/00207454.2020.1828882. [PMID: 32976735] - Jie Wang-Jairaj, Irene Miller, Aditya Joshi, Tharaka Jayabalan, Amanda Peppercorn, Peter Zammit-Tabona, Amanda Oliver. Zanamivir aqueous solution in severe influenza: A global Compassionate Use Program, 2009-2019.
Influenza and other respiratory viruses.
2022 05; 16(3):542-551. doi:
10.1111/irv.12947. [PMID: 34939702] - Agustín Pijierro Amador, Alba Suárez Cordero, Pedro Sánchez Risco. Acute intermittent porphyria: is oseltamivir safe in these patients?.
Clinical medicine (London, England).
2022 05; 22(3):280-281. doi:
10.7861/clinmed.2022-0100. [PMID: 35584827] - Gareth Iacobucci. Covid-19: Stockpiling antivirals risks repeating Tamiflu mistakes, experts warn.
BMJ (Clinical research ed.).
2022 04; 377(?):o1053. doi:
10.1136/bmj.o1053. [PMID: 35477692] - Philip W Melchert, Yuli Qian, Qingchen Zhang, Brandon O Klee, Chengguo Xing, John S Markowitz. In vitro inhibition of carboxylesterase 1 by Kava (Piper methysticum) Kavalactones.
Chemico-biological interactions.
2022 Apr; 357(?):109883. doi:
10.1016/j.cbi.2022.109883. [PMID: 35278473] - Qasim M Zeeshan, Shuang Qiu, Jia Gu, Abdul-Wahab Abbew, Zhengshuai Wu, Zhipeng Chen, Sai Xu, Shijian Ge. Unravelling multiple removal pathways of oseltamivir in wastewater by microalgae through experimentation and computation.
Journal of hazardous materials.
2022 04; 427(?):128139. doi:
10.1016/j.jhazmat.2021.128139. [PMID: 34983009] - Uli Schmitz, Swami Swaminathan. Discovery and development of oseltamivir at Gilead Sciences.
Antiviral therapy.
2022 04; 27(2):13596535211067598. doi:
10.1177/13596535211067598. [PMID: 35499178] - Basiru Aliyu, Yakubu Egigogo Raji, Hui-Yee Chee, Mui-Yun Wong, Zamberi Bin Sekawi. Systematic review and meta-analysis of the efficacy and safety of oseltamivir (Tamiflu) in the treatment of Coronavirus Disease 2019 (COVID-19).
PloS one.
2022; 17(12):e0277206. doi:
10.1371/journal.pone.0277206. [PMID: 36454880] - Ryuichi Kambayashi, Ai Goto, Mayu Onozato, Hiroko Izumi-Nakaseko, Yoshinori Takei, Akio Matsumoto, Shinichi Kawai, Takeshi Fukushima, Atsushi Sugiyama. Simultaneous analyses of hemodynamic and electrophysiological effects of oseltamivir along with its pharmacokinetic profile using the canine paroxysmal atrial fibrillation model.
Journal of pharmacological sciences.
2022 Jan; 148(1):179-186. doi:
10.1016/j.jphs.2021.11.002. [PMID: 34924124] - Brian I Grajeda, Atasi De Chatterjee, Carmen M Villalobos, Breanna C Pence, Cameron C Ellis, Vanessa Enriquez, Sourav Roy, Sukla Roychowdhury, Aaron K Neumann, Igor C Almeida, Steven E Patterson, Siddhartha Das. Giardial lipid rafts share virulence factors with secreted vesicles and participate in parasitic infection in mice.
Frontiers in cellular and infection microbiology.
2022; 12(?):974200. doi:
10.3389/fcimb.2022.974200. [PMID: 36081774] - Xiaona Li, Bin Liu, Naifan Duan, Yibai Xiong, Yan Zhang, Chi Zhang, Cheng Lu, Li Li. Clinical Efficacy and Safety of Chinese Patent Medicine Combined with Oseltamivir for the Treatment of Adult Influenza: A Systematic Review and Meta-Analysis.
The American journal of Chinese medicine.
2022; 50(4):1043-1061. doi:
10.1142/s0192415x22500422. [PMID: 35475973] - Rahajeng N Tunjungputri, Silvita Fitri Riswari, Setyo G Pramudo, Lydia Kuntjoro, Bachti Alisjahbana, Harry Galuh Nugraha, Andre van der Ven, Muhammad Hussein Gasem, Quirijn de Mast. Effect of oseltamivir phosphate versus placebo on platelet recovery and plasma leakage in adults with dengue and thrombocytopenia; a phase 2, multicenter, double-blind, randomized trial.
PLoS neglected tropical diseases.
2022 Jan; 16(1):e0010051. doi:
10.1371/journal.pntd.0010051. [PMID: 34995275] - Gülsel Yurtdaş-Kırımlıoğlu, Kadri Güleç, Şennur Görgülü, Hülya Tuba Kıyan. Oseltamivir phosphate loaded pegylated-Eudragit nanoparticles for lung cancer therapy: Characterization, prolonged release, cytotoxicity profile, apoptosis pathways and in vivo anti-angiogenic effect by using CAM assay.
Microvascular research.
2022 01; 139(?):104251. doi:
10.1016/j.mvr.2021.104251. [PMID: 34520775] - Xiao-Yan Liu, Gui-Yun Cao, Yi Luo, Zhao-Qing Meng, You-Bo Zhang. Anti-pandemic influenza A (H1N1) virus potential of Xilingjiedu capsule in vitro.
Pakistan journal of pharmaceutical sciences.
2022 Jan; 35(1):123-128. doi:
". [PMID: 35221280] - Han Ju, N Arul Murugan, Lingxin Hou, Ping Li, Laura Guizzo, Ying Zhang, Chiara Bertagnin, Xiujie Kong, Dongwei Kang, Ruifang Jia, Xiuli Ma, Ruikun Du, Vasanthanathan Poongavanam, Arianna Loregian, Bing Huang, Xinyong Liu, Peng Zhan. Identification of C5-NH2 Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability.
Journal of medicinal chemistry.
2021 12; 64(24):17992-18009. doi:
10.1021/acs.jmedchem.1c01366. [PMID: 34735766] - Kübra Demir Önder, Ayşegül Seremet Keskin, Hande Berk, Derya Seyman, Nefise Öztoprak. Retrospective evaluation of seven different treatment protocols in hospitalized COVID-19 patients.
Turkish journal of medical sciences.
2021 12; 51(6):2835-2849. doi:
10.3906/sag-2106-114. [PMID: 34418000] - C Joaquín Cáceres, Yanmei Hu, Stivalis Cárdenas-García, Xiangmeng Wu, Haozhou Tan, Silvia Carnaccini, L Claire Gay, Ginger Geiger, Chunlong Ma, Qing-Yu Zhang, Daniela Rajao, Daniel R Perez, Jun Wang. Rational design of a deuterium-containing M2-S31N channel blocker UAWJ280 with in vivo antiviral efficacy against both oseltamivir sensitive and -resistant influenza A viruses.
Emerging microbes & infections.
2021 Dec; 10(1):1832-1848. doi:
10.1080/22221751.2021.1972769. [PMID: 34427541] - Nour K Younis, Rana O Zareef, Ghina Fakhri, Fadi Bitar, Ali H Eid, Mariam Arabi. COVID-19: potential therapeutics for pediatric patients.
Pharmacological reports : PR.
2021 Dec; 73(6):1520-1538. doi:
10.1007/s43440-021-00316-1. [PMID: 34458951] - Mario Karolyi, Erich Pawelka, Hasan Kelani, Georg Christian Funk, Boris Lindner, Christoph Porpaczy, Sabine Publig, Sara Omid, Tamara Seitz, Marianna Traugott, Michael Turner, Alexander Zoufaly, Christoph Wenisch. Management of hospitalized influenza A patients during the season 2018/19 : Comparison of three medical departments and the effect on outcome and antibiotic usage.
Wiener klinische Wochenschrift.
2021 Dec; 133(23-24):1310-1317. doi:
10.1007/s00508-021-01950-8. [PMID: 34613478] - Burcu Ucar, Tayfun Acar, Pelin Pelit Arayici, Serap Derman. A nanotechnological approach in the current therapy of COVID-19: model drug oseltamivir-phosphate loaded PLGA nanoparticles targeted with spike protein binder peptide of SARS-CoV-2.
Nanotechnology.
2021 Sep; 32(48):. doi:
10.1088/1361-6528/ac1c22. [PMID: 34375967] - Jing Tang, Rongbao Gao, Liqi Liu, Shuxia Zhang, Jia Liu, Xiyan Li, Qiongqiong Fang, Zhaomin Feng, Cuiling Xu, Weijuan Huang, Dayan Wang. Substitution of I222L-E119V in neuraminidase from highly pathogenic avian influenza H7N9 virus exhibited synergistic resistance effect to oseltamivir in mice.
Scientific reports.
2021 08; 11(1):16293. doi:
10.1038/s41598-021-95771-4. [PMID: 34381119] - Mengwei Li, Yuxu Wang, Jing Jin, Jie Dou, Qinglong Guo, Xue Ke, Changlin Zhou, Min Guo. Inhibitory Activity of Honeysuckle Extracts against Influenza A Virus In Vitro and In Vivo.
Virologica Sinica.
2021 Jun; 36(3):490-500. doi:
10.1007/s12250-020-00302-6. [PMID: 33044658] - Angelita Pusparani, Joshua Henrina, Alius Cahyadi. Co-infection of COVID-19 and recurrent malaria.
Journal of infection in developing countries.
2021 05; 15(5):625-629. doi:
10.3855/jidc.13793. [PMID: 34106884] - Olivier Bocquet, Amandine Wahart, Thomas Sarazin, Elise Vincent, Christophe Schneider, Anne Fougerat, Stéphanie Gayral, Aubéri Henry, Sébastien Blaise, Béatrice Romier-Crouzet, Camille Boulagnon, Stéphane Jaisson, Philippe Gillery, Amar Bennasroune, Hervé Sartelet, Muriel Laffargue, Laurent Martiny, Laurent Duca, Pascal Maurice. Adverse Effects of Oseltamivir Phosphate Therapy on the Liver of LDLR-/- Mice Without Any Benefit on Atherosclerosis and Thrombosis.
Journal of cardiovascular pharmacology.
2021 05; 77(5):660-672. doi:
10.1097/fjc.0000000000001002. [PMID: 33760798] - Eda Ferahkaya. Oseltamivir-Induced Mania in a Patient With Influenza A.
Clinical neuropharmacology.
2021 May; 44(3):106-107. doi:
10.1097/wnf.0000000000000446. [PMID: 33811194] - L Anedda, L Bianchini, L Cuzzolin, G Finco, V Fanos, M A Marcialis. What if COVID-19 affects the child: which weapons and how to use them.
European review for medical and pharmacological sciences.
2021 Apr; 25(8):3325-3337. doi:
10.26355/eurrev_202104_25744. [PMID: 33928620] - Tiago da Silva Arouche, Anderson Yuri Martins, Teodorico de Castro Ramalho, Raul Nunes Carvalho Júnior, Fabio Luiz Paranhos Costa, Tarciso Silva de Andrade Filho, Antonio Maia Jesus Chaves Neto. Molecular Docking of Azithromycin, Ritonavir, Lopinavir, Oseltamivir, Ivermectin and Heparin Interacting with Coronavirus Disease 2019 Main and Severe Acute Respiratory Syndrome Coronavirus-2 3C-Like Proteases.
Journal of nanoscience and nanotechnology.
2021 04; 21(4):2075-2089. doi:
10.1166/jnn.2021.19029. [PMID: 33500022] - Satoru Chiba. Effect of early oseltamivir on outpatients without hypoxia with suspected COVID-19.
Wiener klinische Wochenschrift.
2021 Apr; 133(7-8):292-297. doi:
10.1007/s00508-020-01780-0. [PMID: 33296027] - Nisha Muralidharan, R Sakthivel, D Velmurugan, M Michael Gromiha. Computational studies of drug repurposing and synergism of lopinavir, oseltamivir and ritonavir binding with SARS-CoV-2 protease against COVID-19.
Journal of biomolecular structure & dynamics.
2021 04; 39(7):2673-2678. doi:
10.1080/07391102.2020.1752802. [PMID: 32248766] - Hany M Dabbous, Manal H El-Sayed, Gihan El Assal, Hesham Elghazaly, Fatma F S Ebeid, Ahmed F Sherief, Maha Elgaafary, Ehab Fawzy, Sahar M Hassany, Ahmed R Riad, Mohamed A TagelDin. Safety and efficacy of favipiravir versus hydroxychloroquine in management of COVID-19: A randomised controlled trial.
Scientific reports.
2021 03; 11(1):7282. doi:
10.1038/s41598-021-85227-0. [PMID: 33790308] - Zerrin Orbak, Fuat Laloglu, Hulya Akat. Effectiveness of lopinavir/ritonavir on COVID-19-related pneumonia in a child with COVID-19-associated Kawasaki disease.
Cardiology in the young.
2021 Mar; 31(3):507-510. doi:
10.1017/s1047951120004291. [PMID: 33183365] - Nader Bakheet, Rabab Fouad, Abdel Meguid Kassem, Wessam Hussin, Mostafa El-Shazly. Persistent hiccup: A rare presentation of COVID-19.
Respiratory investigation.
2021 Mar; 59(2):263-265. doi:
10.1016/j.resinv.2020.11.003. [PMID: 33309013] - Jiahong Tan, Yuan Yuan, Cheng Xu, Chunyan Song, Dan Liu, Ding Ma, Qinglei Gao. A retrospective comparison of drugs against COVID-19.
Virus research.
2021 03; 294(?):198262. doi:
10.1016/j.virusres.2020.198262. [PMID: 33333102] - Burcu Uğurlu Ilgın, İrem Müge Akbulut Koyuncu, Emrullah Kızıltunç. Effect of triple antimicrobial therapy on electrocardiography parameters in patients with mild-to-moderate coronavirus disease 2019.
Anatolian journal of cardiology.
2021 03; 25(3):184-190. doi:
10.14744/anatoljcardiol.2020.79138. [PMID: 33690133] - Gianna Milano. [Scientific research in times of pandemics.].
Recenti progressi in medicina.
2021 03; 112(3):173-181. doi:
10.1701/3565.35454. [PMID: 33687354] - Weiyin Lin, Zhiwei Xie, Yueping Li, Liya Li, Chunyan Wen, Yi Cao, Xiaoting Chen, Xu Ou, Fengyu Hu, Feng Li, Xiaoping Tang, Weiping Cai, Linghua Li. Association between detectable SARS-COV-2 RNA in anal swabs and disease severity in patients with coronavirus disease 2019.
Journal of medical virology.
2021 02; 93(2):794-802. doi:
10.1002/jmv.26307. [PMID: 32672840] - Terry E Jones. Oseltamivir-Current Dosing Recommendations Reduce the Therapeutic Benefit in Patients With Mild to Moderate Renal Function and/or Large Body Mass: A Review of the Literature With Recommendations to Optimize Dosing, Including the Use of Therapeutic Drug Monitoring.
Therapeutic drug monitoring.
2021 02; 43(1):103-107. doi:
10.1097/ftd.0000000000000797. [PMID: 32947554] - Leila Simani, Mahtab Ramezani, Ilad Alavi Darazam, Mastooreh Sagharichi, Mohammad Amin Aalipour, Fatemeh Ghorbani, Hossein Pakdaman. Prevalence and correlates of chronic fatigue syndrome and post-traumatic stress disorder after the outbreak of the COVID-19.
Journal of neurovirology.
2021 02; 27(1):154-159. doi:
10.1007/s13365-021-00949-1. [PMID: 33528827] - Maziar Emamikhah, Mansoureh Babadi, Mehrnoush Mehrabani, Mehdi Jalili, Maryam Pouranian, Peyman Daraie, Fahimeh Mohaghegh, Sharmin Aghavali, Maryam Zaribafian, Mohammad Rohani. Opsoclonus-myoclonus syndrome, a post-infectious neurologic complication of COVID-19: case series and review of literature.
Journal of neurovirology.
2021 02; 27(1):26-34. doi:
10.1007/s13365-020-00941-1. [PMID: 33492608] - Y Nong, J T Lin, X W Sun, J Wang, X Ma, X P Liu, H Q Wang, R T Zha, D P Shen, S J Jiang, S K Luo, Q Zhao, L Meng, W P Wang, J Fang, L M Han, G B Lu, W Zhang, G F Li, H Wang, Z Y Zhao, W Zhou, B L Wei, Y D Yuan, L P Peng, X L Lu, G F Pang, F H Li, L Li, H Zhen. [Efficacy and safety of Kangbingdu granules in the treatment of influenza: a randomized, double-blind, double-dummy, positive-drug parallel control multicenter clinical trial].
Zhonghua yi xue za zhi.
2021 Jan; 101(3):205-211. doi:
10.3760/cma.j.cn112137-20201122-03166. [PMID: 33370867] - Jesús Arturo Ruíz-Quiñonez, Crystell Guadalupe Guzmán-Priego, Germán Alberto Nolasco-Rosales, Carlos Alfonso Tovilla-Zarate, Oscar Israel Flores-Barrientos, Víctor Narváez-Osorio, Guadalupe Del Carmen Baeza-Flores, Thelma Beatriz Gonzalez-Castro, Carlos Ramón López-Brito, Carlos Alberto Denis-García, Agustín Pérez-García, Isela Esther Juárez-Rojop. Features of patients that died for COVID-19 in a hospital in the south of Mexico: A observational cohort study.
PloS one.
2021; 16(2):e0245394. doi:
10.1371/journal.pone.0245394. [PMID: 33606711] - Vassilis Athanassoglou, Lauren A Wilson, Jiabin Liu, Jashvant Poeran, Haoyan Zhong, Stavros G Memtsoudis. The Impact of Immunization and Use of Oseltamivir on Influenza-Related Hospitalizations: A Population-Based Study.
Journal of primary care & community health.
2021 Jan; 12(?):21501327211005906. doi:
10.1177/21501327211005906. [PMID: 33829910] - Ambedkar Kumar Yadav, Siwan Wen, Xianghuai Xu, Li Yu. Antiviral treatment in COVID-19: which is the most promising?-a narrative review.
Annals of palliative medicine.
2021 Jan; 10(1):707-720. doi:
10.21037/apm-20-1755. [PMID: 33440983] - Setareh Mamishi, Ameneh Navaeian, Reza Shabanian. Acute aortic dissection in a patient with Williams syndrome infected by COVID-19.
Cardiology in the young.
2021 Jan; 31(1):132-134. doi:
10.1017/s1047951120003236. [PMID: 33040742] - Aurora Salamanca, Paula Almodóvar, Irene Jarama, Daniel González-Hedström, Marin Prodanov, Antonio Manuel Inarejos-García. Anti-influenza virus activity of the elenolic acid rich olive leaf (Olea europaea L.) extract Isenolic®.
Antiviral chemistry & chemotherapy.
2021 Jan; 29(?):20402066211063391. doi:
10.1177/20402066211063391. [PMID: 34839747] - Hülya Gamze Çelik, Şiran Keske, Ülker Şener, Müge Tekbaş, Mahir Kapmaz, Şükrü Taylan Şahin, Aslı Özyıldırım, Saide Aytekin, Vedat Aytekin, Önder Ergönül. Why we should be more careful using hydroxychloroquine in influenza season during COVID-19 pandemic?.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2021 Jan; 102(?):389-391. doi:
10.1016/j.ijid.2020.10.080. [PMID: 33130195] - Sana Rehman, Umi Lela. Pharmacological treatment during CoViD-19 and mental health issues.
Rivista di psichiatria.
2021 Jan; 56(1):53-55. doi:
10.1708/3546.35221. [PMID: 33560276] - L Nováková, M Havlíčková. Monitoring influenza virus oseltamivir resistance - our experience to date.
Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti J.E. Purkyne.
2021; 70(4):241-246. doi:
NULL. [PMID: 35073702] - Diana Laila Ramatillah, Suri Isnaini. Treatment profiles and clinical outcomes of COVID-19 patients at private hospital in Jakarta.
PloS one.
2021; 16(4):e0250147. doi:
10.1371/journal.pone.0250147. [PMID: 33861777] - Ensieh Vahedi, Mostafa Ghanei, Ali Ghazvini, Hossein Azadi, Morteza Izadi, Yunes Panahi, Saeid Fathi, Mahmood Salesi, Seyed Hassan Saadat, Amir Hossein Ghazale, Mohammad Rezapour, Abolfazl Mozafari, Nahid Zand, Mohammadreza Raesi Parsaei, Mohammad Hossein Ranjkesh, Ramezan Jafari, Fatemeh Movaseghi, Enayat Darabi. The clinical value of two combination regimens in the Management of Patients Suffering from Covid-19 pneumonia: a single centered, retrospective, observational study.
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences.
2020 Dec; 28(2):507-516. doi:
10.1007/s40199-020-00353-w. [PMID: 32562159] - Alem Zekarias, Sarah Watson, Sara Hedfors Vidlin, Birgitta Grundmark. Sex Differences in Reported Adverse Drug Reactions to COVID-19 Drugs in a Global Database of Individual Case Safety Reports.
Drug safety.
2020 12; 43(12):1309-1314. doi:
10.1007/s40264-020-01000-8. [PMID: 32978702] - Yeming Wang, Wu Zhong, Alex Salam, Joel Tarning, Qingyuan Zhan, Jian-An Huang, Heng Weng, Changqing Bai, Yanhong Ren, Koichi Yamada, Dayan Wang, Qiang Guo, Qiongqiong Fang, Sakurai Tsutomu, Xiaohui Zou, Haibo Li, Annelies Gillesen, Lyndsey Castle, Cheng Chen, Hongyan Li, Jing Zhen, Binghuai Lu, Jun Duan, Liping Guo, Jinfang Jiang, Ruiyuan Cao, Guohui Fan, Jintong Li, Frederick G Hayden, Chen Wang, Peter Horby, Bin Cao. Phase 2a, open-label, dose-escalating, multi-center pharmacokinetic study of favipiravir (T-705) in combination with oseltamivir in patients with severe influenza.
EBioMedicine.
2020 Dec; 62(?):103125. doi:
10.1016/j.ebiom.2020.103125. [PMID: 33232871] - Z Ahmadinejad, R Assari, N Ayoobi Yazdi, S-H Mazloomi, P Javanshayani, H Khalili Afousi, V Ziaee. COVID-19 pandemic and biological therapy in rheumatologic disorders: how to deal with?.
Reumatismo.
2020 Nov; 72(3):173-177. doi:
10.4081/reumatismo.2020.1289. [PMID: 33213130] - Lei Zhao, Jinjing Che, Qian Zhang, Yiming Li, Xiaojia Guo, Lixia Chen, Hua Li, Ruiyuan Cao, Xingzhou Li. Identification of Novel Influenza Polymerase PB2 Inhibitors Using a Cascade Docking Virtual Screening Approach.
Molecules (Basel, Switzerland).
2020 Nov; 25(22):. doi:
10.3390/molecules25225291. [PMID: 33202790] - Fuying Hu, Gang Yin, Youping Chen, Jiangqin Song, Maosong Ye, Jie Liu, Cuicui Chen, Yuanlin Song, Xinjun Tang, Yong Zhang. Corticosteroid, oseltamivir and delayed admission are independent risk factors for prolonged viral shedding in patients with Coronavirus Disease 2019.
The clinical respiratory journal.
2020 Nov; 14(11):1067-1075. doi:
10.1111/crj.13243. [PMID: 32750201] - Defang Ding, Caisong Zhu, Weiwu Yao. A Cured Patient With 2019-nCoV Pneumonia.
The American journal of medicine.
2020 11; 133(11):1291-1292. doi:
10.1016/j.amjmed.2020.02.023. [PMID: 32205073] - Liqian Zhou, Juanjuan Wang, Guangyi Liu, Qingqing Lu, Ruyi Dong, Geng Tian, Jialiang Yang, Lihong Peng. Probing antiviral drugs against SARS-CoV-2 through virus-drug association prediction based on the KATZ method.
Genomics.
2020 11; 112(6):4427-4434. doi:
10.1016/j.ygeno.2020.07.044. [PMID: 32745502] - Rong Deng, Gaohong She, Mauricio Maia, Jeremy J Lim, Melicent C Peck, Jacqueline M McBride, Priya Kulkarni, Priscilla Horn, Aide Castro, Elizabeth Newton, Jorge A Tavel, William D Hanley. Pharmacokinetics of the Monoclonal Antibody MHAA4549A Administered in Combination With Oseltamivir in Patients Hospitalized With Severe Influenza A Infection.
Journal of clinical pharmacology.
2020 11; 60(11):1509-1518. doi:
10.1002/jcph.1652. [PMID: 32621543] - Qi Tan, Limin Duan, YanLing Ma, Feng Wu, Qi Huang, Kaimin Mao, Wenjing Xiao, Hui Xia, Shujing Zhang, E Zhou, Pei Ma, Siwei Song, YuMei Li, Zilin Zhao, Yice Sun, Zeyu Li, Wei Geng, Zengrong Yin, Yang Jin. Is oseltamivir suitable for fighting against COVID-19: In silico assessment, in vitro and retrospective study.
Bioorganic chemistry.
2020 11; 104(?):104257. doi:
10.1016/j.bioorg.2020.104257. [PMID: 32927129] - Prina Patel, Vincent Matt Laurich, Sharon Smith, Jesse Sturm. Point-of-Care Influenza Testing in the Pediatric Emergency Department.
Pediatric emergency care.
2020 Nov; 36(11):515-518. doi:
10.1097/pec.0000000000002250. [PMID: 33065674] - Mitsutaka Kitano, Takanobu Matsuzaki, Ryoko Oka, Kaoru Baba, Takahiro Noda, Yuki Yoshida, Kenji Sato, Kohei Kiyota, Tohru Mizutare, Ryu Yoshida, Akihiko Sato, Hiroshi Kamimori, Takao Shishido, Akira Naito. The antiviral effects of baloxavir marboxil against influenza A virus infection in ferrets.
Influenza and other respiratory viruses.
2020 11; 14(6):710-719. doi:
10.1111/irv.12760. [PMID: 32533654] - Lu Zheng, Lina Zhang, Jiamin Huang, Kutty Selva Nandakumar, Shuwen Liu, Kui Cheng. Potential treatment methods targeting 2019-nCoV infection.
European journal of medicinal chemistry.
2020 Nov; 205(?):112687. doi:
10.1016/j.ejmech.2020.112687. [PMID: 32771797] - Liva Checkmahomed, Blandine Padey, Andrés Pizzorno, Olivier Terrier, Manuel Rosa-Calatrava, Yacine Abed, Mariana Baz, Guy Boivin. In Vitro Combinations of Baloxavir Acid and Other Inhibitors against Seasonal Influenza A Viruses.
Viruses.
2020 10; 12(10):. doi:
10.3390/v12101139. [PMID: 33049959] - Rui Xiong, Leike Zhang, Shiliang Li, Yuan Sun, Minyi Ding, Yong Wang, Yongliang Zhao, Yan Wu, Weijuan Shang, Xiaming Jiang, Jiwei Shan, Zihao Shen, Yi Tong, Liuxin Xu, Yu Chen, Yingle Liu, Gang Zou, Dimitri Lavillete, Zhenjiang Zhao, Rui Wang, Lili Zhu, Gengfu Xiao, Ke Lan, Honglin Li, Ke Xu. Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.
Protein & cell.
2020 10; 11(10):723-739. doi:
10.1007/s13238-020-00768-w. [PMID: 32754890] - Y Zhao, Z Xia, W Liang, J Li, L Liu, D Huang, X Xu, J He. SARS-CoV-2 persisted in lung tissue despite disappearance in other clinical samples.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2020 10; 26(10):1424-1425. doi:
10.1016/j.cmi.2020.05.013. [PMID: 32447048] - Yechun Xu, Hualiang Jiang. Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase.
Protein & cell.
2020 10; 11(10):699-702. doi:
10.1007/s13238-020-00769-9. [PMID: 32761523] - Yuli Qian, John S Markowitz. Natural Products as Modulators of CES1 Activity.
Drug metabolism and disposition: the biological fate of chemicals.
2020 10; 48(10):993-1007. doi:
10.1124/dmd.120.000065. [PMID: 32591414] - Fatemeh Dehghani Firouzabadi, Mohammad Dehghani Firouzabadi, Babak Ghalehbaghi, Hesam Jahandideh, Maryam Roomiani, Sogand Goudarzi. Have the symptoms of patients with COVID-19 changed over time during hospitalization?.
Medical hypotheses.
2020 10; 143(?):110067. doi:
10.1016/j.mehy.2020.110067. [PMID: 32634735] - Sherief Abd-Elsalam, Eslam Saber Esmail, Mai Khalaf, Ehab Fawzy Abdo, Mohammed A Medhat, Mohamed Samir Abd El Ghafar, Ossama Ashraf Ahmed, Shaimaa Soliman, Ghada N Serangawy, Mohamed Alboraie. Hydroxychloroquine in the Treatment of COVID-19: A Multicenter Randomized Controlled Study.
The American journal of tropical medicine and hygiene.
2020 10; 103(4):1635-1639. doi:
10.4269/ajtmh.20-0873. [PMID: 32828135] - Chen Chen, Ling He. Advances in research of spirodienone and its derivatives: Biological activities and synthesis methods.
European journal of medicinal chemistry.
2020 Oct; 203(?):112577. doi:
10.1016/j.ejmech.2020.112577. [PMID: 32698113] - Giulio Nittari, Graziano Pallotta, Francesco Amenta, Seyed Khosrow Tayebati. Current pharmacological treatments for SARS-COV-2: A narrative review.
European journal of pharmacology.
2020 Sep; 882(?):173328. doi:
10.1016/j.ejphar.2020.173328. [PMID: 32603692] - Zohreh Esam. Protective potential of expectorants against COVID-19.
Medical hypotheses.
2020 09; 142(?):109844. doi:
". [PMID: 32930097] - Guoguang Lu, Jing Wang. Dynamic changes in routine blood parameters of a severe COVID-19 case.
Clinica chimica acta; international journal of clinical chemistry.
2020 Sep; 508(?):98-102. doi:
10.1016/j.cca.2020.04.034. [PMID: 32405079] - Alpay Medetalibeyoğlu, Naci Şenkal, Gazi Çapar, Murat Köse, Tufan Tükek. Characteristics of the initial patients hospitalized for COVID-19: a single-center report.
Turkish journal of medical sciences.
2020 Aug; 50(5):1436-1439. doi:
10.3906/sag-2004-98. [PMID: 32490641] - Javed Akram, Shehnoor Azhar, Muhammad Shahzad, Waqas Latif, Khalid Saeed Khan. Pakistan Randomized and Observational Trial to Evaluate Coronavirus Treatment (PROTECT) of Hydroxychloroquine, Oseltamivir and Azithromycin to treat newly diagnosed patients with COVID-19 infection who have no comorbidities like diabetes mellitus: A structured summary of a study protocol for a randomized controlled trial.
Trials.
2020 Aug; 21(1):702. doi:
10.1186/s13063-020-04616-4. [PMID: 32771032] - Danielle Tilmanis, Paulina Koszalka, Ian G Barr, Jean-Francois Rossignol, Edin Mifsud, Aeron C Hurt. Host-targeted nitazoxanide has a high barrier to resistance but does not reduce the emergence or proliferation of oseltamivir-resistant influenza viruses in vitro or in vivo when used in combination with oseltamivir.
Antiviral research.
2020 08; 180(?):104851. doi:
10.1016/j.antiviral.2020.104851. [PMID: 32544408] - Maryam Daneshpazhooh, Tahereh Soori, Ahdie Isazade, Pedram Noormohammadpour. Mucous membrane pemphigoid and COVID-19 treated with high-dose intravenous immunoglobulins: a case report.
The Journal of dermatological treatment.
2020 Aug; 31(5):446-447. doi:
10.1080/09546634.2020.1764472. [PMID: 32363963] - Kristin R Smith, William E Bryan, Mary L Townsend, Amy E Randolph, Adam J Vanderman, Catherine L Woodard, Jamie N Brown. Impact of prophylactic oseltamivir on INR in patients on stable warfarin therapy.
Journal of thrombosis and thrombolysis.
2020 Aug; 50(2):452-456. doi:
10.1007/s11239-019-02016-3. [PMID: 31898274] - Emre Arpali, Basak Akyollu, Berna Yelken, Suda Tekin, Aydin Turkmen, Burak Kocak. Case report: A kidney transplant patient with mild COVID-19.
Transplant infectious disease : an official journal of the Transplantation Society.
2020 Aug; 22(4):e13296. doi:
10.1111/tid.13296. [PMID: 32301198] - Beatriz Vidaña, Pamela Martínez-Orellana, Jaime M Martorell, Massimiliano Baratelli, Jorge Martínez, Lourdes Migura-Garcia, Lorena Córdoba, Mónica Pérez, Inmaculada Casas, Francisco Pozo, Lorenzo Fraile, Natàlia Majó, María Montoya. Differential Viral-Host Immune Interactions Associated with Oseltamivir-Resistant H275Y and Wild-Type H1N1 A(pdm09) Influenza Virus Pathogenicity.
Viruses.
2020 07; 12(8):. doi:
10.3390/v12080794. [PMID: 32721992] - Guangwei Wu, Guihong Yu, Yunjia Yu, Shuang Yang, Zhongwei Duan, Wei Wang, Yankai Liu, Rilei Yu, Jing Li, Tianjiao Zhu, Qianqun Gu, Dehai Li. Chemoreactive-Inspired Discovery of Influenza A Virus Dual Inhibitor to Block Hemagglutinin-Mediated Adsorption and Membrane Fusion.
Journal of medicinal chemistry.
2020 07; 63(13):6924-6940. doi:
10.1021/acs.jmedchem.0c00312. [PMID: 32520560] - Muayad A Merza, Azad A Haleem Al Mezori, Hakar Mustafa Mohammed, Deldar Morad Abdulah. COVID-19 outbreak in Iraqi Kurdistan: The first report characterizing epidemiological, clinical, laboratory, and radiological findings of the disease.
Diabetes & metabolic syndrome.
2020 Jul; 14(4):547-554. doi:
10.1016/j.dsx.2020.04.047. [PMID: 32408119]