Tramadol (BioDeep_00000397917)
Main id: BioDeep_00000001585
代谢物信息卡片
(R,R)-tramadol
化学式: C16H25NO2 (263.1885)
中文名称: (+)-曲马多, 曲马多
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CC1CCCCC1(C2=CC(=CC=C2)OC)O
InChI: InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3
描述信息
A racemate consisting of equal amounts of (R,R)- and (S,S)-tramadol. A centrally acting synthetic opioid analgesic, used (as the hydrochloride salt) to treat moderately severe pain. The (R,R)-enantiomer exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. Subsequently isolated from the root bark of Nauclea latifolia
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent
D002491 - Central Nervous System Agents > D000700 - Analgesics
N - Nervous system > N02 - Analgesics > N02A - Opioids
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
CONFIDENCE Reference Standard (Level 1)
同义名列表
4 个代谢物同义名
数据库引用编号
26 个数据库交叉引用编号
- ChEBI: CHEBI:9648
- ChEBI: CHEBI:75725
- KEGG: C07153
- KEGGdrug: D08623
- PubChem: 33741
- DrugBank: DB00193
- ChEMBL: CHEMBL201531
- ChEMBL: CHEMBL1066
- MeSH: Tramadol
- CAS: 181289-58-7
- CAS: 123154-38-1
- CAS: 27203-92-5
- MoNA: WA002510
- MoNA: WA002509
- MoNA: WA002508
- MoNA: WA002507
- MoNA: FiehnHILIC002375
- MoNA: FiehnHILIC000809
- MoNA: TUE00733
- MoNA: TUE00732
- MoNA: TUE00731
- MetaboLights: MTBLC9648
- PubChem: 9362
- NIKKAJI: J244.454B
- RefMet: Tramadol
- KNApSAcK: 75725
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Anna Detzlhofer, Christian Grechhamer, Lawrence Madikizela, Markus Himmelsbach, Franz Mlynek, Wolfgang Buchberger, Christian W Klampfl. Uptake, translocation, and metabolization of amitriptyline, lidocaine, orphenadrine, and tramadol by cress and pea.
Environmental science and pollution research international.
2024 Mar; 31(13):19649-19657. doi:
10.1007/s11356-024-32379-x. [PMID: 38363510] - Afe Taiwo, Alabi Akinyinka, Agbaje Esther, Ale Ayotunde, Ajayi Abayomi, Oluwatoyin Fasesan, Ogunsemi Olawale. Neuro-protective effect of pre-treatment with Sorghum bicolor and vitamin C on tramadol induced brain oxidative stress and anxiety-like behaviour in male albino rats.
Pakistan journal of pharmaceutical sciences.
2024 Jan; 37(1):53-63. doi:
". [PMID: 38741400] - Amir Hossein Behnoush, Nafiseh Alizadeh, Mahdi Emami, Elham Bazmi, Yousef Alimohamadi, Behnam Behnoush. Effects of Intravenous Lipid Emulsion Administration in Acute Tramadol Poisoning: A Randomized Controlled Trial.
The Journal of emergency medicine.
2023 Nov; ?(?):. doi:
10.1016/j.jemermed.2023.11.004. [PMID: 38309983] - Radka Kodešová, Helena Švecová, Aleš Klement, Miroslav Fér, Antonín Nikodem, Ganna Fedorova, Oleksandra Rieznyk, Martin Kočárek, Alina Sadchenko, Alica Chroňáková, Roman Grabic. Contamination of water, soil, and plants by micropollutants from reclaimed wastewater and sludge from a wastewater treatment plant.
The Science of the total environment.
2023 Oct; 907(?):167965. doi:
10.1016/j.scitotenv.2023.167965. [PMID: 37866592] - Mohammad Shabani, Zhaleh Jamali, Aida Naserian, Saleh Khezri, Ahmad Salimi. Maintenance of mitochondrial function by sinapic acid protects against tramadol-induced toxicity in isolated mitochondria obtained from rat brain.
Naunyn-Schmiedeberg's archives of pharmacology.
2023 Aug; ?(?):. doi:
10.1007/s00210-023-02648-6. [PMID: 37526689] - Pradeep Kumkar, Chandani R Verma, Štěpán Hýsek, Manoj Pise, Sonia Źółtowska, Sachin M Gosavi, Filip Mercl, Matěj Božik, Lukáš Praus, Kateřina Hanková, Radek Rinn, Pavel Klouček, Miloslav Petrtýl, Lukáš Kalous. Contaminants and their ecological risk assessment in beach sediments and water along the Maharashtra coast of India: A comprehensive approach using microplastics, heavy metal(loid)s, pharmaceuticals, personal care products and plasticizers.
The Science of the total environment.
2023 Jun; ?(?):164712. doi:
10.1016/j.scitotenv.2023.164712. [PMID: 37301381] - Mohamed M ELseweidy, Sousou I Ali, Laila Sabik, Salma E Sewilam. 10-dehydrogingerdione amends tramadol-elicited neurotransmitters disturbance and apoptosis in the brain of male rats by repleting non-enzymatic antioxidants.
Journal of chemical neuroanatomy.
2023 Jun; 132(?):102302. doi:
10.1016/j.jchemneu.2023.102302. [PMID: 37301525] - Michael R Fettiplace, Guy Weinberg. Lipid emulsion for xenobiotic overdose: PRO.
British journal of clinical pharmacology.
2023 06; 89(6):1708-1718. doi:
10.1111/bcp.15620. [PMID: 36454165] - David Mamdouh Khalaf, Catarina Cruzeiro, Roberto Siani, Susanne Kublik, Peter Schröder. Resilience of barley (Hordeum vulgare) plants upon exposure to tramadol: Implication for the root-associated bacterial community and the antioxidative plant defence system.
The Science of the total environment.
2023 May; ?(?):164260. doi:
10.1016/j.scitotenv.2023.164260. [PMID: 37209727] - Houman Kamranian, Hadi Asoudeh, Roya Kamrani Sharif, Fereshteh Taheri, A Wallace Hayes, Mina Gholami, Ahmad Alavi, Majid Motaghinejad. Neuroprotective potential of trimetazidine against tramadol-induced neurotoxicity: role of PI3K/Akt/mTOR signaling pathways.
Toxicology mechanisms and methods.
2023 Apr; ?(?):1-17. doi:
10.1080/15376516.2023.2202785. [PMID: 37051630] - Marwa E A El-Shamarka, Gihan F Asaad, Noha A Mowaad, Magy R Kozman. In vivo assessment of inflammatory cytokines induced oxidative stress signalling, and troponin I gene dysregulation in cardiac tissue associated with chronic administration of boldenone and tramadol, alone or in combination.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2023 Mar; ?(?):1-8. doi:
10.1080/1354750x.2023.2193357. [PMID: 36932833] - Y Nomier, G Khuwaja, S R Penakalapati, S Alshahrani, Z Rehman, R Khawaji, W Alhazmi, A Mubarak, M F Alam, T Anwer, H Rashid, E Shaheen, K Alkashef. Ethnopharmacological evaluation of Poppy seed oil in combination with Tramadol on behavioral paradigm and on dopamine, and cytokines levels.
European review for medical and pharmacological sciences.
2023 Mar; 27(5):2077-2090. doi:
10.26355/eurrev_202303_31579. [PMID: 36930507] - Tim Boogaerts, Maarten Quireyns, Hans De Loof, Xander Bertels, Natan Van Wichelen, Bram Pussig, Jan Saevels, Lies Lahousse, Pauline Bonmariage, Wouter Hamelinck, Bert Aertgeerts, Adrian Covaci, Alexander L N van Nuijs. Do the lockdown-imposed changes in a wastewater treatment plant catchment's socio-demographics impact longitudinal temporal trends in psychoactive pharmaceutical use?.
The Science of the total environment.
2023 Feb; ?(?):162342. doi:
10.1016/j.scitotenv.2023.162342. [PMID: 36842581] - Ling Yang, Hai-Jun Yao, Jian-Shu Ni, Jing Xia, Wei-Hong Chen, Li-Li Hou, Yan Zhao. [Electrophysiological appropriateness technique based on TCM meridian theory for postoperative pain after urethral reconstruction: A real-world study].
Zhonghua nan ke xue = National journal of andrology.
2023 Feb; 29(2):174-180. doi:
". [PMID: 37847090] - Fei Liu, Liu-Lin Xiong, Ting-Ting Li, Yan-Jun Chen, Wei Ma, Qi-Jun Li, Qian Li, Ting-Hua Wang. Analgesic Effects and Adverse Reactions of Lidocaine for Patient-Controlled Intravenous Analgesia on Patients Undergoing Open Hepatectomy: A Retrospective Analysis.
Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses.
2023 Feb; 38(1):39-44. doi:
10.1016/j.jopan.2022.05.069. [PMID: 35989234] - Yihong Liu, Brian H May, Anna J Hyde, Yihan He, Xinfeng Guo, Anthony Lin Zhang, Chuanjian Lu, Charlie Changli Xue, Haibo Zhang. Topical Traditional Chinese Medicines for Cancer Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Integrative cancer therapies.
2023 Jan; 22(?):15347354231210870. doi:
10.1177/15347354231210870. [PMID: 37962002] - Vasiliki G Beretsou, Maria-Christina Nika, Kyriakos Manoli, Costas Michael, Qian Sui, Lian Lundy, D Michael Revitt, Nikolaos S Thomaidis, Despo Fatta-Kassinos. Multiclass target analysis of contaminants of emerging concern including transformation products, soil bioavailability assessment and retrospective screening as tools to evaluate risks associated with reclaimed water reuse.
The Science of the total environment.
2022 Dec; 852(?):158391. doi:
10.1016/j.scitotenv.2022.158391. [PMID: 36049679] - Mariana N Miranda, Ana R Lado Ribeiro, Adrián M T Silva, M Fernando R Pereira. Can aged microplastics be transport vectors for organic micropollutants? - Sorption and phytotoxicity tests.
The Science of the total environment.
2022 Dec; 850(?):158073. doi:
10.1016/j.scitotenv.2022.158073. [PMID: 35981591] - Noha A Mowaad, Marwa E A El-Shamarka, Yasser A Khadrawy. The Behavioral and Neurochemical Changes Induced by Boldenone and/or Tramadol in Adult Male Rats.
Neurochemical research.
2022 Nov; ?(?):. doi:
10.1007/s11064-022-03827-2. [PMID: 36449200] - Meng-Si Luo, Guan-Jiang Huang. The effect of peritonsillar infiltration of tramadol vs dexmedetomidine on post‑tonsillectomy pain.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery.
2022 11; 279(11):5467-5468. doi:
10.1007/s00405-021-07212-7. [PMID: 35001165] - Anik Banik, Sheikh Rashel Ahmed, Emran Hossain Sajib, Anamika Deb, Shiuly Sinha, Kazi Faizul Azim. Identification of potential inhibitory analogs of metastasis tumor antigens (MTAs) using bioactive compounds: revealing therapeutic option to prevent malignancy.
Molecular diversity.
2022 Oct; 26(5):2473-2502. doi:
10.1007/s11030-021-10345-w. [PMID: 34743299] - Khadga Raj, G D Gupta, Shamsher Singh. l-Theanine ameliorates motor deficit, mitochondrial dysfunction, and neurodegeneration against chronic tramadol induced rats model of Parkinson's disease.
Drug and chemical toxicology.
2022 Sep; 45(5):2097-2108. doi:
10.1080/01480545.2021.1907909. [PMID: 34210222] - Jonathan L Fu, Michael D Perloff. Pharmacotherapy for Spine-Related Pain in Older Adults.
Drugs & aging.
2022 07; 39(7):523-550. doi:
10.1007/s40266-022-00946-x. [PMID: 35754070] - Hitta Garg, Jeanne Marie-Westhiuzen, Allan Pascoe. COVID 19 unveils tramadol dependence.
The Australian and New Zealand journal of psychiatry.
2022 07; 56(7):869. doi:
10.1177/00048674221077620. [PMID: 35147048] - Frederike Nordmeier, Adrian A Doerr, Stefan Potente, Nadja Walle, Matthias W Laschke, Michael D Menger, Peter H Schmidt, Markus R Meyer, Nadine Schaefer. Perimortem Distribution of U-47700, Tramadol and Their Main Metabolites in Pigs Following Intravenous Administration.
Journal of analytical toxicology.
2022 May; 46(5):479-486. doi:
10.1093/jat/bkab044. [PMID: 33950247] - Monireh Isazad, Maliheh Amirzehni, Maryam Akhgari. Highly efficient dispersive liquid-liquid microextraction assisted by magnetic porous carbon composite-based dispersive micro solid-phase extraction for determination of tramadol and methadone in urine samples by gas chromatography-mass spectrometry.
Journal of chromatography. A.
2022 May; 1670(?):462989. doi:
10.1016/j.chroma.2022.462989. [PMID: 35349917] - Raka Jain, Siddharth Sarkar, Nizamuddin Saifi, Shayani Ghosh. Urinalysis based assessment of compliance and drug use patterns in patients prescribed tramadol: A cross-sectional study from a tertiary care centre.
Asian journal of psychiatry.
2022 May; 71(?):103080. doi:
10.1016/j.ajp.2022.103080. [PMID: 35305452] - Guillaume Bianconi, Isabelle Malissin, Laurence Labat, Nihel Khoudour, Pascal Houzé, Nicolas Pallet, Bruno Mégarbane, Xavier Declèves. Marked and prolonged serotonin toxicity in a tramadol-poisoned patient with a pharmacokinetic study.
Clinical toxicology (Philadelphia, Pa.).
2022 Mar; 60(3):382-385. doi:
10.1080/15563650.2021.1955912. [PMID: 34287102] - Amr Said Shalaby, Amira Mohamed El-Seidy, Mohamed Aly Zayed, Abeer Ragab Allam. Does tramadol dependence impair cognitive functions?.
International clinical psychopharmacology.
2022 03; 37(2):67-71. doi:
10.1097/yic.0000000000000389. [PMID: 35045529] - David Mamdouh Khalaf, Catarina Cruzeiro, Peter Schröder. Removal of tramadol from water using Typha angustifolia and Hordeum vulgare as biological models: Possible interaction with other pollutants in short-term uptake experiments.
The Science of the total environment.
2022 Feb; 809(?):151164. doi:
10.1016/j.scitotenv.2021.151164. [PMID: 34695465] - Kinomi Yomiya. [For the Clinical Use-Clinical Guidelines for Pharmacological Management of Cancer Pain 2020].
Gan to kagaku ryoho. Cancer & chemotherapy.
2022 Feb; 49(2):119-124. doi:
NULL. [PMID: 35249042] - G E Erhabor. The Rise of Tramadol Abuse as Omicron Variant Plateaus.
West African journal of medicine.
2022 Jan; 39(1):1-2. doi:
NULL. [PMID: 35156359] - Gehad M Elnagar, Mohamed M Elseweidy, Yasmin K Mahmoud, Nesreen M I M Elkomy, Ziyad M Althafar, Sultan F Alnomasy, Naif A Al-Gabri, Mohamed Shawky. 10-Dehydrogingerdione Attenuates Tramadol-Induced Nephrotoxicity by Modulating Renal Oxidative Stress, Inflammation and Apoptosis in Experimental Rats: Role of HO-1 Activation and TLR4/NF-κB/ERK Inhibition.
International journal of molecular sciences.
2022 Jan; 23(3):. doi:
10.3390/ijms23031384. [PMID: 35163308] - Andrea Horniaková, Ondrej Štefánik, Ivana Čižmárová, Michaela Matušková, Peter Mikuš, Juraj Piešťanský. Capillary zone electrophoresis in combination with UV detection for simultaneous determination of tramadol and paracetamol in pharmaceutical and biological samples.
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti.
2022; 71(2):67-77. doi:
NULL. [PMID: 35728971] - Muhammad Furqan Akhtar, Sobia Younas, Ammara Saleem, Mirza Muhammad Faran Ashraf Baig, Ali Sharif, Mohamed M Abdel-Daim, Azhar Rasul, Mohammad Saleem. Maternotoxicity and fetotoxicity in Rattus norvegicus albinus exposed to tramadol during the late phase of pregnancy.
Birth defects research.
2021 11; 113(19):1407-1421. doi:
10.1002/bdr2.1957. [PMID: 34553514] - Myoung Hwa Kim, Jeong-Rim Lee, Ki-Joon Kim, Ji Hae Jun, Hye Jeong Hwang, Wootaek Lee, Seung Hyun Nam, Ju Eun Oh, Young Chul Yoo. Identification for antitumor effects of tramadol in a xenograft mouse model using orthotopic breast cancer cells.
Scientific reports.
2021 11; 11(1):22113. doi:
10.1038/s41598-021-01701-9. [PMID: 34764420] - Assad Bio-Sya, Henri Joël Gandjo, Elvyre T E Klikpo, Odile Kouglenou, Arnaud C Agbanlinsou, Georgia Barikissou Damien, Adolphe C Kpatchavi, Aurel C Allabi. Nonmedical use of tramadol among secondary school students in Benin, Africa.
The American journal of drug and alcohol abuse.
2021 11; 47(6):746-752. doi:
10.1080/00952990.2021.1955897. [PMID: 34402343] - Mahedeh Samadi, Fatemeh Shaki, Behnaz Bameri, Marjan Fallah, Nematollah Ahangar, Hamidreza Mohammadi. Caffeine attenuates seizure and brain mitochondrial disruption induced by Tramadol: the role of adenosinergic pathway.
Drug and chemical toxicology.
2021 Nov; 44(6):613-619. doi:
10.1080/01480545.2019.1643874. [PMID: 31368376] - O Yoo, E K Y Tang, M N Nguyen, S Salman, A J Hua, B S von Ungern Sternberg, L Y Lim. HPLC-UV assay of tramadol and O-desmethyltramadol in human plasma containing other drugs potentially co-administered to participants in a paediatric population pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Nov; 1184(?):122971. doi:
10.1016/j.jchromb.2021.122971. [PMID: 34649173] - Samaneh Nakhaee, Khadijeh Farrokhfall, Ebrahim Miri-Moghaddam, Mohsen Foadoddini, Masoumeh Askari, Omid Mehrpour. The effects of quercetin on seizure, inflammation parameters and oxidative stress in acute on chronic tramadol intoxication.
BMC pharmacology & toxicology.
2021 10; 22(1):59. doi:
10.1186/s40360-021-00532-8. [PMID: 34666816] - Gang Li, Changxi Zhang, Congyi Wang, Ling Xiao. Acupuncture against chronic postsurgical pain in non-small cell lung cancer patients: A protocol of randomized controlled trial.
Medicine.
2021 Oct; 100(40):e27461. doi:
10.1097/md.0000000000027461. [PMID: 34622872] - Narges Hedayati, Seyed Mohammad Taghdisi, Rezvan Yazdian-Robati, Atena Mansouri, Khalil Abnous, Seyed Ahmad Mohajeri. Selection of DNA aptamers for tramadol through the systematic evolution of ligands by exponential enrichment method for fabrication of a sensitive fluorescent aptasensor based on graphene oxide.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2021 Oct; 259(?):119840. doi:
10.1016/j.saa.2021.119840. [PMID: 33965888] - Lauren A Aldrich, James K Roush, Butch KuKanich. Plasma concentrations of tramadol after transdermal application of a single metered dose of a compounded tramadol gel to cats.
American journal of veterinary research.
2021 Oct; 82(10):840-845. doi:
10.2460/ajvr.82.10.840. [PMID: 34554876] - Florence Isabella Ogili, Daoud Ali, Gerald N Attamah, Uduak Aletan, Henrietta Ijeoma Kelle, Maureen N Chukwu, Christopher D Nwani. Morphometric, hematological and oxidative stress changes in Clarias gariepinus following sub-chronic exposure to tramadol.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2021 Oct; 248(?):109096. doi:
10.1016/j.cbpc.2021.109096. [PMID: 34090974] - Marwa H Bakr, Eman Radwan, Asmaa S Shaltout, Alshaimaa A Farrag, Amany Refaat Mahmoud, Tarek Hamdy Abd-Elhamid, Maha Ali. Chronic exposure to tramadol induces cardiac inflammation and endothelial dysfunction in mice.
Scientific reports.
2021 09; 11(1):18772. doi:
10.1038/s41598-021-98206-2. [PMID: 34548593] - Ashley M Gesseck, Michelle R Peace, Carrol R Nanco, Carl E Wolf, Karen D Hendricks-Muñoz, Jie Xu, Justin L Poklis. Neonatal Exposure to Tramadol through Mother's Breast Milk.
Journal of analytical toxicology.
2021 Sep; 45(8):840-846. doi:
10.1093/jat/bkab055. [PMID: 34037761] - Safa Khelifi, Khadija Saad, Ariadni Vonaparti, Souhila Mahieddine, Sofia Salama, Amal Saleh, Maryam Al-Mohannadi, Hussain Al-Thaiban, Arjen Lommen, Peter Horvatovich, Alka Beotra, Wadha Abushareeda, Mohammed Al Maadheed, Costas Georgakopoulos. Ultra-fast retroactive processing by MetAlign of liquid chromatography/high-resolution full-scan Orbitrap mass spectrometry data in WADA Human Urine Sample Monitoring Program.
Rapid communications in mass spectrometry : RCM.
2021 Sep; 35(17):e9141. doi:
10.1002/rcm.9141. [PMID: 34106497] - Samaneh Nakhaee, Khadijeh Farrokhfall, Ebrahim Miri-Moghaddam, Masoumeh Askari, Alireza Amirabadizadeh, Mohsen Foadoddini, Omid Mehrpour. Effects of naloxone and diazepam on blood glucose levels in tramadol overdose using generalized estimating equation (GEE) model; (an experimental study).
BMC endocrine disorders.
2021 Sep; 21(1):180. doi:
10.1186/s12902-021-00847-x. [PMID: 34488743] - Aymen A Al-Qurain, Desmond B Williams, Lorraine Mackenzie, Michael S Roberts, Michael D Wiese. Simultaneous LC-MS/MS quantification of oxycodone, tramadol and fentanyl and their metabolites (noroxycodone, oxymorphone, O- desmethyltramadol, N- desmethyltramadol, and norfentanyl) in human plasma and whole blood collected via venepuncture and volumetric absorptive micro sampling.
Journal of pharmaceutical and biomedical analysis.
2021 Sep; 203(?):114171. doi:
10.1016/j.jpba.2021.114171. [PMID: 34087551] - Elizabeth Ortega Molina, Maria Josefa Bernad Bernad, Jesus Gracia Mora, Dinorah Vargas Estrada, Luis Ocampo Camberos. In vitro release of new designs of modified-release tramadol hydrochloride included in a polymer matrix.
Pakistan journal of pharmaceutical sciences.
2021 Sep; 34(5):1783-1790. doi:
NULL. [PMID: 34803016] - Tomoyuki Hioki, Haruhiko Tokuda, Kumiko Tanabe, Woo Kim, Junko Tachi, Shinobu Yamaguchi, Rie Matsushima-Nishiwaki, Osamu Kozawa, Hiroki Iida. Amplification by tramadol of PGD2-induced osteoprotegerin synthesis in osteoblasts: Involvement of μ-opioid receptor and 5-HT transporter.
Prostaglandins, leukotrienes, and essential fatty acids.
2021 09; 172(?):102323. doi:
10.1016/j.plefa.2021.102323. [PMID: 34392133] - Dac Teoli, Virginia Thompson, Jessica Wright, Ivana Ho, Brittany Vlaminck, Gina Miller, Molly Feely. Acute Pain Crisis Caused by Tramadol Remdesivir Drug-Drug Interaction.
Journal of palliative medicine.
2021 Sep; 24(10):1582-1584. doi:
10.1089/jpm.2021.0123. [PMID: 34152842] - Omaima I Abdel Hamid, Laila M E Sabik, Karima F Abdelfadeel, Sahar F Shaban. Tramadol aggravates cardiovascular toxicity in a rat model of alcoholism: Involvement of intermediate microfilament proteins and immune-expressed osteopontin.
Journal of biochemical and molecular toxicology.
2021 Jun; 35(6):1-15. doi:
10.1002/jbt.22748. [PMID: 33645892] - Jung Hyun Cho, Han-Gon Choi. Acetaminophen and tramadol hydrochloride-loaded soft gelatin capsule: preparation, dissolution and pharmacokinetics in beagle dogs.
Pharmaceutical development and technology.
2021 Jun; 26(5):576-581. doi:
10.1080/10837450.2021.1903036. [PMID: 33719822] - Vishal Duggal, I-Chun Thomas, Maria E Montez-Rath, Glenn M Chertow, Manjula Kurella Tamura. National Estimates of CKD Prevalence and Potential Impact of Estimating Glomerular Filtration Rate Without Race.
Journal of the American Society of Nephrology : JASN.
2021 06; 32(6):1454-1463. doi:
10.1681/asn.2020121780. [PMID: 33958490] - Andressa Nunes Mouta, Isabelle de Oliveira Lima, Maria Gláucia Carlos de Oliveira, Letícia Pereira Alves, Luã Barbalho de Macêdo, Gabriel Araujo-Silva, José Pérez-Urizar, Valéria Veras de Paula. Pharmacokinetic properties of tramadol and M1 metabolite in Northeast Brazilian donkeys (Equus asinus).
Journal of veterinary pharmacology and therapeutics.
2021 May; 44(3):318-325. doi:
10.1111/jvp.12935. [PMID: 33280136] - Miriam Saiz-Rodríguez, Sarahí Valdez-Acosta, Alberto M Borobia, Miguel Burgueño, María Ángeles Gálvez-Múgica, Julio Acero, Teresa Cabaleiro, Mario Fernando Muñoz-Guerra, Miguel Puerro, Lucia Llanos, Dolores Martínez-Pérez, Dolores Ochoa, Antonio J Carcas, Francisco Abad-Santos. Influence of Genetic Polymorphisms on the Response to Tramadol, Ibuprofen, and the Combination in Patients With Moderate to Severe Pain After Dental Surgery.
Clinical therapeutics.
2021 05; 43(5):e86-e102. doi:
10.1016/j.clinthera.2021.03.005. [PMID: 33812699] - Piotr J Rudzki, Katarzyna Jarus-Dziedzic, Monika Filist, Edyta Gilant, Katarzyna Buś-Kwaśnik, Andrzej Leś, Małgorzata Sasinowska-Motyl, Łukasz Nagraba, Magdalena Bujalska-Zadrożny. Evaluation of tramadol human pharmacokinetics and safety after co-administration of magnesium ions in randomized, single- and multiple-dose studies.
Pharmacological reports : PR.
2021 Apr; 73(2):604-614. doi:
10.1007/s43440-021-00239-x. [PMID: 33686610] - Ibrahim A Naguib, Nesma A Ali, Fadwa A Elroby, Mohamed R El Ghobashy, Fatma F Abdallah. Ecologically evaluated and FDA-validated HPTLC method for assay of pregabalin and tramadol in human biological fluids.
Biomedical chromatography : BMC.
2021 Apr; 35(4):e5023. doi:
10.1002/bmc.5023. [PMID: 33169415] - Abigail Duvall, Thomas N Tully, James W Carpenter, Butch KuKanich, Hugues Beaufrère, Geraldine C Magnin. Pilot Study of a Single Dose of Orally Administered Tapentadol Suspension in Hispaniolan Amazon Parrots (Amazona ventralis).
Journal of avian medicine and surgery.
2021 Apr; 35(1):45-50. doi:
10.1647/1082-6742-35.1.45. [PMID: 33892588] - Miao Xu, Liang Zheng, Jin Zeng, Wenwen Xu, Xuehua Jiang, Ling Wang. Physiologically based pharmacokinetic modeling of tramadol to inform dose adjustment and drug-drug interactions according to CYP2D6 phenotypes.
Pharmacotherapy.
2021 03; 41(3):277-290. doi:
10.1002/phar.2494. [PMID: 33316842] - Ghada Abdel Kader, Mahrous A Ibrahim, Athar M Khalifa, Umrana Mirza, Eman K Rashwan, Zinab Abdel-Hady. Evaluation of vitamin C protective effect on the cerebrocortical antioxidant defense, histopathological, pro-apoptotic p53 and anti-apoptotic Bcl2 expressions against tramadol neurotoxicity in rats.
Journal of chemical neuroanatomy.
2021 03; 112(?):101893. doi:
10.1016/j.jchemneu.2020.101893. [PMID: 33276071] - Koji Suzuki, Takafumi Naito, Hironari Tanaka, Kaito Shibata, Yasuhide Yamada, Kunihiko Itoh, Junichi Kawakami. Impact of CYP2D6 activity and cachexia progression on enantiomeric alteration of plasma tramadol and its demethylated metabolites and their relationships with central nervous system symptoms in head and neck cancer patients.
Basic & clinical pharmacology & toxicology.
2021 Mar; 128(3):472-481. doi:
10.1111/bcpt.13528. [PMID: 33131142] - Hongliang Su, Yongjun Li, Miaomiao Wu, Tingting Sun, Weifen Niu, Juan Jia, Zhiwen Wei, Keming Yun. Dynamic Distribution and Postmortem Redistribution of Tramadol in Poisoned Rats.
Journal of analytical toxicology.
2021 Feb; 45(2):203-210. doi:
10.1093/jat/bkaa035. [PMID: 32451554] - Alassane Diouf, Youssra Aghoutane, Hakan Burhan, Fatih Sen, Benachir Bouchikhi, Nezha El Bari. Tramadol sensing in non-invasive biological fluids using a voltammetric electronic tongue and an electrochemical sensor based on biomimetic recognition.
International journal of pharmaceutics.
2021 Jan; 593(?):120114. doi:
10.1016/j.ijpharm.2020.120114. [PMID: 33253800] - Ting Li, Tian Wang, Linlin Wang, Rongxia Liu, Leiming Zhang, Rong Zhai, Fenghua Fu. Antinociceptive effects of rotigotine-loaded microspheres and its synergistic interactions with analgesics in inflammatory pain in rats.
European journal of pharmacology.
2021 Jan; 891(?):173693. doi:
10.1016/j.ejphar.2020.173693. [PMID: 33160937] - Shukun Jiang, Guojie Liu, Huiya Yuan, Enyu Xu, Wei Xia, Xiaoyu Zhang, Junting Liu, Lina Gao. Changes on proteomic and metabolomic profile in serum of mice induced by chronic exposure to tramadol.
Scientific reports.
2021 01; 11(1):1454. doi:
10.1038/s41598-021-81109-7. [PMID: 33446901] - Nahla E El-Ashmawy, Abdel-Halim A Lashin, Kamal M Okasha, Amal M Abo Kamer, Tarek M Mostafa, Mona El-Aasr, Ahmed E Goda, Yusuf A Haggag, Haytham O Tawfik, Mariam A Abo-Saif. The plausible mechanisms of tramadol for treatment of COVID-19.
Medical hypotheses.
2021 Jan; 146(?):110468. doi:
10.1016/j.mehy.2020.110468. [PMID: 33385878] - Benjamin Kimble, Larry Vogelnest, Peter Valtchev, Merran Govendir. Pharmacokinetic profile of injectable tramadol in the koala (Phascolarctos cinereus) and prediction of its analgesic efficacy.
PloS one.
2021; 16(3):e0247546. doi:
10.1371/journal.pone.0247546. [PMID: 33657107] - Qing-Hua Wen, Zheng Zhang, Wen-Ke Cai, Xiao-Qian Lin, Gong-Hao He. The Associations Between CYP2D6*10 C188T Polymorphism and Pharmacokinetics and Clinical Outcomes of Tramadol: A Systematic Review and Meta-analysis.
Pain medicine (Malden, Mass.).
2020 12; 21(12):3679-3690. doi:
10.1093/pm/pnaa140. [PMID: 32488232] - Haytham A Ali, Mohamed Afifi, Taghred M Saber, Arwa A Makki, A T Keshta, Mohammed Baeshen, Ammar Al-Farga. Neurotoxic, Hepatotoxic and Nephrotoxic Effects of Tramadol Administration in Rats.
Journal of molecular neuroscience : MN.
2020 Dec; 70(12):1934-1942. doi:
10.1007/s12031-020-01592-x. [PMID: 32440822] - Qin Cai, Hanlin Gong, Mingbo Fan, Wen Chen, Lun Cai. The analgesic effect of tramadol combined with butorphanol on uterine cramping pain after repeat caesarean section: a randomized, controlled, double-blind study.
Journal of anesthesia.
2020 12; 34(6):825-833. doi:
10.1007/s00540-020-02820-9. [PMID: 32627064] - Douglas M McMillan, Ahmed A El-Sherbeni, Janielle Richards, Rachel F Tyndale. Centrally administered CYP2D inhibitors increase oral tramadol analgesia in rats.
Brain research bulletin.
2020 11; 164(?):400-406. doi:
10.1016/j.brainresbull.2020.09.001. [PMID: 32926950] - Ibrahim A Naguib, Nesma A Ali, Fadwa A Elroby, Mohamed R El Ghobashy, Fatma F Abdallah. US FDA-validated green GC-MS method for analysis of gabapentin, tramadol and/or amitriptyline mixtures in biological fluids.
Bioanalysis.
2020 Nov; 12(21):1521-1533. doi:
10.4155/bio-2020-0217. [PMID: 33118848] - Çetin Erol. COVID-19 and TURKMI, miRNAs in CAD, effects of cannabis and tramadol use, and more.
Anatolian journal of cardiology.
2020 11; 24(5):289. doi:
10.14744/anatoljcardiol.2020.11. [PMID: 33122487] - Serena Marita Lazzarin, Marco Vabanesi, Giordano Cecchetti, Raffaella Fazio, Giovanna Franca Fanelli, Maria Antonietta Volonté, Angela Genchi, Antonino Giordano, Vittorio Martinelli, Sergio Colombo, Paolo Beccaria, Milena Mucci, Jacopo Peccatori, Massimo Filippi, Fabio Minicucci. Refractory anti-NMDAR encephalitis successfully treated with bortezomib and associated movements disorders controlled with tramadol: a case report with literature review.
Journal of neurology.
2020 Aug; 267(8):2462-2468. doi:
10.1007/s00415-020-09988-w. [PMID: 32535682] - Miriam Saiz-Rodríguez, Dolores Ochoa, Manuel Román, Pablo Zubiaur, Dora Koller, Gina Mejía, Francisco Abad-Santos. Involvement of CYP2D6 and CYP2B6 on tramadol pharmacokinetics.
Pharmacogenomics.
2020 07; 21(10):663-675. doi:
10.2217/pgs-2020-0026. [PMID: 32538291] - Medhat M Bassiony, Usama M Youssef, Hayam El-Gohari. Free Testosterone and Prolactin Levels and Sperm Morphology and Function Among Male Patients With Tramadol Abuse: A Case-Control Study.
Journal of clinical psychopharmacology.
2020 Jul; 40(4):405-408. doi:
10.1097/jcp.0000000000001223. [PMID: 32639294] - Alessandra Di Salvo, Maria Beatrice Conti, Sara Nannarone, Antonello Bufalari, Mario Giorgi, Giulia Moretti, Maria Luisa Marenzoni, Giorgia Della Rocca. Pharmacokinetics and analgesic efficacy of intranasal administration of tramadol in dogs after ovariohysterectomy.
Veterinary anaesthesia and analgesia.
2020 Jul; 47(4):557-566. doi:
10.1016/j.vaa.2019.12.011. [PMID: 32513525] - Mahnaz Ahmadimanesh, Mehri Bemani Naeini, Mohammad-Reza Rouini, Shahin Shadnia, Mahmoud Ghazi-Khansari. Assessment of tramadol pharmacokinetics in correlation with CYP2D6 and clinical symptoms.
Drug metabolism and personalized therapy.
2020 06; 35(2):. doi:
10.1515/dmpt-2019-0021. [PMID: 32681776] - Wen-Min Li, Feng-Dao Li, Hua Xu, Li-Chen Sun. Analgesic impact of buprenorphine transdermal patch in total hip arthroplasty: A randomized controlled trial protocol.
Medicine.
2020 Jun; 99(24):e20405. doi:
10.1097/md.0000000000020405. [PMID: 32541462] - Koji Suzuki, Takafumi Naito, Hironari Tanaka, Yasuhide Yamada, Kunihiko Itoh, Junichi Kawakami. A Reversed-Phase Mode LC-MS/MS Method Using a Polysaccharide Chiral Selector for Simultaneous Quantitation of Each Enantiomer of Tramadol and its Metabolites in Human Plasma and Evaluation of CYP-Mediated Stereoselective Demethylation.
Therapeutic drug monitoring.
2020 06; 42(3):503-511. doi:
10.1097/ftd.0000000000000707. [PMID: 31613803] - Amany Mohamed Shalaby, Adel Mohamed Aboregela, Mohamed Ali Alabiad, Dina Fouad El Shaer. Tramadol Promotes Oxidative Stress, Fibrosis, Apoptosis, Ultrastructural and Biochemical alterations in the Adrenal Cortex of Adult Male Rat with Possible Reversibility after Withdrawal.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada.
2020 06; 26(3):509-523. doi:
10.1017/s1431927620001397. [PMID: 32366353] - Clare O'Carroll, Rob Fenwick. Rhabdomyolysis: a case-based critical reflection on its causes and diagnosis.
Emergency nurse : the journal of the RCN Accident and Emergency Nursing Association.
2020 May; 28(3):24-28. doi:
10.7748/en.2020.e2004. [PMID: 32207593] - Somayeh Mohammadi, Mohammad Ali Taher, Hadi Beitollahi. A hierarchical 3D camellia-like molybdenum tungsten disulfide architectures for the determination of morphine and tramadol.
Mikrochimica acta.
2020 05; 187(5):312. doi:
10.1007/s00604-020-4134-x. [PMID: 32367346] - Jacob Bejder, Andreas Breenfeldt Andersen, Thomas Christian Bonne, Jacob Feder Piil, Linn Camilla Hauan Hagen, Yvette Dehnes, Kasper Hvid Eibye, Lars Nybo, Nikolai Baastrup Nordsborg. Tramadol Does Not Improve Performance or Impair Motor Function in Trained Cyclists.
Medicine and science in sports and exercise.
2020 05; 52(5):1169-1175. doi:
10.1249/mss.0000000000002217. [PMID: 31809408] - Lucy Lu, Michael Ryan, Mark Harnett, George J Atiee, Scott A Reines. Comparing the Pharmacokinetics of 2 Novel Intravenous Tramadol Dosing Regimens to Oral Tramadol: A Randomized 3-Arm Crossover Study.
Clinical pharmacology in drug development.
2020 05; 9(4):537-546. doi:
10.1002/cpdd.746. [PMID: 31610100] - Elka Touitou, Shaher Duchi, Hiba Natsheh. A new nanovesicular system for nasal drug administration.
International journal of pharmaceutics.
2020 Apr; 580(?):119243. doi:
10.1016/j.ijpharm.2020.119243. [PMID: 32209370] - Laleh Adlnasab, Parvin Shahdousti, Hamid Ahmar. Layered double hydroxide intercalated with tyrosine for ultrasonic-assisted microextraction of tramadol and methadone from biological samples followed by GC/MS analysis.
Mikrochimica acta.
2020 04; 187(5):265. doi:
10.1007/s00604-020-04237-3. [PMID: 32279132] - E Reza, K Bhuiyan, R I Emon, A Hossain, M H Biplob, S Kader, A Habib, R Hasan, A K Chaudary, T Rahman, S Hasan, A A Nisa. Efficacy of Intra-peritoneal Tramadol Instillation for Postoperative Pain Management after Laparoscopic Cholecystectomy.
Mymensingh medical journal : MMJ.
2020 Apr; 29(2):303-310. doi:
NULL. [PMID: 32506083] - Chenning Zhang, Jialin Qu, Xiaoyuan Lv, Jianbin Zhang, Linlin Fang. A novel open-tubular capillary electrochromatography using carboxymethyl-β-cyclodextrin functionalized gold nanoparticles as chiral stationary phase.
Journal of separation science.
2020 Mar; 43(5):946-953. doi:
10.1002/jssc.201900733. [PMID: 31802622] - Mohamed Khairy, Craig E Banks. A screen-printed electrochemical sensing platform surface modified with nanostructured ytterbium oxide nanoplates facilitating the electroanalytical sensing of the analgesic drugs acetaminophen and tramadol.
Mikrochimica acta.
2020 01; 187(2):126. doi:
10.1007/s00604-020-4118-x. [PMID: 31938885] - Fatma M Minisy, Hossam H Shawki, Abdelfatteh El Omri, Ahmed A Massoud, Enayat A Omara, Fatma G Metwally, Manal A Badawy, Neveen A Hassan, Nabila S Hassan, Hisashi Oishi. Pomegranate Seeds Extract Possesses a Protective Effect against Tramadol-Induced Testicular Toxicity in Experimental Rats.
BioMed research international.
2020; 2020(?):2732958. doi:
10.1155/2020/2732958. [PMID: 32219129] - A K Olaifa, C O Oguntoye. Effects of Castration on Epidural Administration of Lidocaine-Tramadol in West African Dwarf (Wad) Goats.
Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria.
2019 Dec; 34(2):141-147. doi:
NULL. [PMID: 32343265] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Tae Kon Kim. Determination of JW5473 in Rat Plasma by UPLC-MS/MS and its Application to Pharmacokinetic Study of JW5473.
Drug research.
2019 Oct; 69(11):606-611. doi:
10.1055/a-0885-1535. [PMID: 30986883] - Maryam Ezoddin, Laleh Adlnasab, Akram Afshari Kaveh, Mohammad Ali Karimi, Behnaz Mahjoob. Development of air-assisted dispersive micro-solid-phase extraction-based supramolecular solvent-mediated Fe3 O4 @Cu-Fe-LDH for the determination of tramadol in biological samples.
Biomedical chromatography : BMC.
2019 Sep; 33(9):e4572. doi:
10.1002/bmc.4572. [PMID: 31062369] - Sybil Skinner Robertson, Mohamad Samer Mouksassi, France Varin. Population Pharmacokinetic/Pharmacodynamic Modeling of O-Desmethyltramadol in Young and Elderly Healthy Volunteers.
Drugs & aging.
2019 08; 36(8):747-758. doi:
10.1007/s40266-019-00681-w. [PMID: 31161580] - Joanna Porażka, Edyta Szałek, Wojciech Połom, Mateusz Czajkowski, Tomasz Grabowski, Marcin Matuszewski, Edmund Grześkowiak. Influence of Obesity and Type 2 Diabetes Mellitus on the Pharmacokinetics of Tramadol After Single Oral Dose Administration.
European journal of drug metabolism and pharmacokinetics.
2019 Aug; 44(4):579-584. doi:
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