Tellimagrandin II (BioDeep_00000397300)

Main id: BioDeep_00000007948

Secondary id: BioDeep_00000897269

human metabolite PANOMIX_OTCML-2023 Chemicals and Drugs


代谢物信息卡片


3,4,5,21,22,23-Hexahydroxy-8,18-dioxo-12,13-bis(3,4,5-trihydroxybenzoyloxy)-9,14,17-trioxatetracyclo[17.4.0.0²,⁷.0¹⁰,¹⁵]tricosa-1(23),2,4,6,19,21-hexaen-11-yl 3,4,5-trihydroxybenzoic acid

化学式: C41H30O26 (938.1025)
中文名称: 丁子芽鞣素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C2C(C(C(C(O2)OC(=O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O)OC(=O)C5=CC(=C(C(=C5)O)O)O)OC(=O)C6=CC(=C(C(=C6C7=C(C(=C(C=C7C(=O)O1)O)O)O)O)O)O
InChI: InChI=1S/C41H30O26/c42-15-1-10(2-16(43)26(15)50)36(57)65-34-33-23(9-62-39(60)13-7-21(48)29(53)31(55)24(13)25-14(40(61)64-33)8-22(49)30(54)32(25)56)63-41(67-38(59)12-5-19(46)28(52)20(47)6-12)35(34)66-37(58)11-3-17(44)27(51)18(45)4-11/h1-8,23,33-35,41-56H,9H2

描述信息

Isolated from Eugenia caryophyllata (clove) and Filipendula ulmaria (meadowsweet). Tellimagrandin II is found in many foods, some of which are nance, kelp, komatsuna, and narrowleaf cattail.
Tellimagrandin II is found in acorn. Tellimagrandin II is isolated from Eugenia caryophyllata (clove) and Filipendula ulmaria (meadowsweet).
Tellimagrandin II is a natural product found in Syzygium aromaticum, Tellima grandiflora, and other organisms with data available.
Tellimagrandin II (Eugeniin), the first intermediate in the 4C1-glucose derived series of ellagitannins, also inhibits antibiotic resistance of drug-resistant Staphylococcus aureus[1][2].
Tellimagrandin II (Eugeniin), the first intermediate in the 4C1-glucose derived series of ellagitannins, also inhibits antibiotic resistance of drug-resistant Staphylococcus aureus[1][2].

同义名列表

11 个代谢物同义名

3,4,5,21,22,23-Hexahydroxy-8,18-dioxo-12,13-bis(3,4,5-trihydroxybenzoyloxy)-9,14,17-trioxatetracyclo[17.4.0.0²,⁷.0¹⁰,¹⁵]tricosa-1(23),2,4,6,19,21-hexaen-11-yl 3,4,5-trihydroxybenzoic acid; [3,4,5,21,22,23-Hexahydroxy-8,18-dioxo-12,13-bis[(3,4,5-trihydroxybenzoyl)oxy]-9,14,17-trioxatetracyclo[17.4.0.02,7.010,15]tricosa-1(23),2,4,6,19,21-hexaen-11-yl] 3,4,5-trihydroxybenzoate; 3,4,5,21,22,23-hexahydroxy-8,18-dioxo-11,12-bis(3,4,5-trihydroxybenzoyloxy)-9,14,17-trioxatetracyclo[17.4.0.0²,⁷.0¹⁰,¹⁵]tricosa-1(19),2,4,6,20,22-hexaen-13-yl 3,4,5-trihydroxybenzoate; .beta.-D-Glucopyranose, cyclic 4,6-[(1S)-4,4,5,5,6,6-hexahydroxy[1,1-biphenyl]-2,2-dicarboxylate] 1,2,3-tris(3,4,5-trihydroxybenzoate); beta-D-Glucopyranose, cyclic 4,6-((1S)-4,4,5,5,6,6-hexahydroxy(1,1-biphenyl)-2,2-dicarboxylate) 1,2,3-tris(3,4,5-trihydroxybenzoate); beta-D-Glucopyranose, cyclic 4,6-(4,4,5,5,6,6-hexahydroxy(1,1-biphenyl)-2,2-dicarboxylate) 1,2,3-tris(3,4,5-trihydroxybenzoate); 1,2,3-Tri-O-galloyl-4,6-(S)-hexahydroxydiphenoyl-b-D-glucopyranose; Tellimagrandin II; Cornustannin 2; eugeniin; Eugeniin



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AIMP2, AKR1B1, BCL2, BDNF, FASN, GFAP, NOS2, NTRK2, PIK3CA, PTGS2
Peripheral membrane protein 3 GORASP1, HSD17B6, PTGS2
Endosome membrane 2 BACE1, NTRK2
Endoplasmic reticulum membrane 2 BCL2, PTGS2
Nucleus 7 AIMP2, BCL2, CA9, FOS, JUN, NOS2, PARP1
cytosol 10 AIMP2, AKR1B1, BCL2, FASN, FOS, GFAP, NOS2, NTRK2, PARP1, PIK3CA
dendrite 3 BACE1, BDNF, NTRK2
nuclear body 1 PARP1
trans-Golgi network 1 BACE1
nucleoplasm 6 AKR1B1, ATP2B1, FOS, JUN, NOS2, PARP1
RNA polymerase II transcription regulator complex 2 FOS, JUN
Cell membrane 4 ATP2B1, BACE1, CA9, NTRK2
Cytoplasmic side 1 GORASP1
lamellipodium 1 PIK3CA
Cell projection, axon 2 BACE1, NTRK2
Early endosome membrane 2 HSD17B6, NTRK2
Multi-pass membrane protein 1 ATP2B1
Golgi apparatus membrane 1 GORASP1
Synapse 1 ATP2B1
cell surface 1 BACE1
glutamatergic synapse 1 ATP2B1
Golgi apparatus 3 BACE1, FASN, GORASP1
Golgi membrane 1 GORASP1
lysosomal membrane 1 GAA
neuronal cell body 1 BACE1
presynaptic membrane 1 ATP2B1
synaptic vesicle 2 BACE1, BDNF
Cytoplasm, cytosol 3 AIMP2, NOS2, PARP1
Lysosome 2 BACE1, GAA
endosome 1 BACE1
plasma membrane 8 ATP2B1, BACE1, CA9, FASN, GAA, NOS2, NTRK2, PIK3CA
synaptic vesicle membrane 1 ATP2B1
terminal bouton 1 NTRK2
Membrane 11 AIMP2, ATP2B1, BACE1, BCL2, BDNF, CA9, FASN, GAA, HGF, NTRK2, PARP1
axon 3 BACE1, BDNF, NTRK2
basolateral plasma membrane 2 ATP2B1, CA9
caveola 1 PTGS2
extracellular exosome 4 AKR1B1, ATP2B1, FASN, GAA
Lysosome membrane 1 GAA
Lumenal side 1 HSD17B6
endoplasmic reticulum 5 BACE1, BCL2, FOS, HSD17B6, PTGS2
extracellular space 3 AKR1B1, BDNF, HGF
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 4 BDNF, NOS2, NTRK2, PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 3 AKR1B1, BCL2, PARP1
protein-containing complex 3 BCL2, PARP1, PTGS2
intracellular membrane-bounded organelle 3 ATP2B1, GAA, HSD17B6
Microsome membrane 2 HSD17B6, PTGS2
postsynaptic density 1 NTRK2
Single-pass type I membrane protein 3 BACE1, CA9, NTRK2
Secreted 2 BDNF, GAA
extracellular region 3 BDNF, GAA, HGF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
astrocyte end-foot 1 GFAP
hippocampal mossy fiber to CA3 synapse 1 BACE1
transcription regulator complex 2 JUN, PARP1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
multivesicular body 1 BACE1
dendritic spine 1 NTRK2
nucleolus 2 CA9, PARP1
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
Early endosome 2 BACE1, NTRK2
recycling endosome 1 BACE1
Cytoplasm, perinuclear region 2 NOS2, NTRK2
Membrane raft 1 BACE1
pore complex 1 BCL2
cis-Golgi network 1 GORASP1
Peroxisome 1 NOS2
peroxisomal matrix 1 NOS2
intermediate filament 1 GFAP
lateral plasma membrane 1 ATP2B1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Late endosome 1 BACE1
receptor complex 1 NTRK2
neuron projection 1 PTGS2
chromatin 3 FOS, JUN, PARP1
cell projection 2 ATP2B1, GFAP
Chromosome 1 PARP1
Golgi apparatus, trans-Golgi network 1 BACE1
Nucleus, nucleolus 2 CA9, PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
nuclear chromosome 1 JUN
Basolateral cell membrane 1 ATP2B1
Cell projection, microvillus membrane 1 CA9
microvillus membrane 1 CA9
site of double-strand break 1 PARP1
nuclear envelope 1 PARP1
Endomembrane system 1 BACE1
Cytoplasmic vesicle membrane 1 BACE1
Cell projection, dendrite 2 BACE1, NTRK2
tertiary granule membrane 1 GAA
Melanosome 1 FASN
euchromatin 1 JUN
Presynaptic cell membrane 1 ATP2B1
cell body 1 GFAP
myelin sheath 1 BCL2
intermediate filament cytoskeleton 1 GFAP
endoplasmic reticulum lumen 3 BACE1, BDNF, PTGS2
nuclear matrix 1 FOS
platelet alpha granule lumen 1 HGF
axon terminus 1 NTRK2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
azurophil granule membrane 1 GAA
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
immunological synapse 1 ATP2B1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
protein-DNA complex 2 FOS, PARP1
ficolin-1-rich granule membrane 1 GAA
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
site of DNA damage 1 PARP1
cytoplasmic side of lysosomal membrane 1 GFAP
transcription factor AP-1 complex 2 FOS, JUN
cortical cytoskeleton 1 NOS2
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
photoreceptor ribbon synapse 1 ATP2B1
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
glycogen granule 1 FASN
Golgi-associated vesicle lumen 1 BACE1


文献列表

  • Mohamed A A Orabi, Hiroshi Sakagami, Naoki Umemura, Hamad S Alyami, Tsutomu Hatano. Two new C-glycosidic ellagitannins and accompanying tannins from Lawsonia inermis leaves and their cytotoxic effects. Fitoterapia. 2021 Sep; 153(?):104925. doi: 10.1016/j.fitote.2021.104925. [PMID: 33984438]
  • Lipeng Du, Zhigang Mei, Yaguang Huang, Wei Tao, Kai Wang, Weifeng Huang, Huajun Zhou, Zhitao Feng. Protection of the Geum japonicum Thunb. var. chinense extracts against oxygen-glucose deprivation and re-oxygenation induced astrocytes injury via BDNF/PI3K/Akt/CREB pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Jul; 127(?):110123. doi: 10.1016/j.biopha.2020.110123. [PMID: 32361162]
  • Yu-Wei Chang, Wan-Chun Huang, Chun-Yu Lin, Wen-Hung Wang, Ling-Chien Hung, Yen-Hsu Chen. Tellimagrandin II, A Type of Plant Polyphenol Extracted from Trapa bispinosa Inhibits Antibiotic Resistance of Drug-Resistant Staphylococcus aureus. International journal of molecular sciences. 2019 Nov; 20(22):. doi: 10.3390/ijms20225790. [PMID: 31752109]
  • Ruver Rodrigues Feitosa Ramalho, João Marcos Gonçalves Barbosa, Pedro Henrique Ferri, Suzana da Costa Santos. Variability of polyphenols and volatiles during fruit development of three pitanga (Eugenia uniflora L.) biotypes. Food research international (Ottawa, Ont.). 2019 05; 119(?):850-858. doi: 10.1016/j.foodres.2018.10.068. [PMID: 30884725]
  • Kenneth T Kongstad, Sileshi G Wubshet, Ane Johannesen, Lasse Kjellerup, Anne-Marie Lund Winther, Anna Katharina Jäger, Dan Staerk. High-resolution screening combined with HPLC-HRMS-SPE-NMR for identification of fungal plasma membrane H(+)-ATPase inhibitors from plants. Journal of agricultural and food chemistry. 2014 Jun; 62(24):5595-602. doi: 10.1021/jf501605z. [PMID: 24830509]
  • Hee-Ju Lee, Yeon-Hee Seong, Ki-Hwan Bae, Soon-Ho Kwon, Hye-Min Kwak, Si-Kab Nho, Kyung-A Kim, Jong-Moon Hur, Kyung Bok Lee, Young-Hwa Kang, Kyung-Sik Song. Beta-secretase (BACE1) inhibitors from Sanguisorbae Radix. Archives of pharmacal research. 2005 Jul; 28(7):799-803. doi: 10.1007/bf02977345. [PMID: 16114494]
  • Ruth Niemetz, Gerhard Schilling, Georg G Gross. Biosynthesis of the dimeric ellagitannin, cornusiin E, in Tellima grandiflora. Phytochemistry. 2003 Sep; 64(1):109-114. doi: 10.1016/s0031-9422(03)00280-2. [PMID: 12946409]
  • Eva Leu, Anja Krieger-Liszkay, Charilaos Goussias, Elisabeth M Gross. Polyphenolic allelochemicals from the aquatic angiosperm Myriophyllum spicatum inhibit photosystem II. Plant physiology. 2002 Dec; 130(4):2011-8. doi: 10.1104/pp.011593. [PMID: 12481084]
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