N-Nitrosodiethylamine (BioDeep_00000396956)
Secondary id: BioDeep_00000002955
PANOMIX_OTCML-2023 Volatile Flavor Compounds
代谢物信息卡片
InChI=1/C4H10N2O/c1-3-6(4-2)5-7/h3-4H2,1-2H
化学式: C4H10N2O (102.07930900000001)
中文名称: N-亚硝基二乙胺, N-二乙基亚硝胺
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 6.06%
分子结构信息
SMILES: CCN(CC)N=O
InChI: InChI=1S/C4H10N2O/c1-3-6(4-2)5-7/h3-4H2,1-2H3
描述信息
N-nitrosodiethylamine is a clear slightly yellow liquid. Boiling point 175-177 °C. Can reasonably be anticipated to be a carcinogen. Used as a gasoline and lubricant additive and as an antioxidant and stabilizer in plastics.
N-nitrosodiethylamine is a nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom. It has a role as a mutagen, a hepatotoxic agent and a carcinogenic agent.
N-Nitrosodiethylamine is a synthetic light-sensitive, volatile, clear yellow oil that is soluble in water, lipids, and other organic solvents. It is used as gasoline and lubricant additive, antioxidant, and stabilizer for industry materials. When heated to decomposition, N-nitrosodiethylamine emits toxic fumes of nitrogen oxides. N-Nitrosodiethylamine affects DNA integrity, probably by alkylation, and is used in experimental research to induce liver tumorigenesis. It is considered to be reasonably anticipated to be a human carcinogen. (NCI05)
A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
D009676 - Noxae > D000477 - Alkylating Agents
N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.
同义名列表
54 个代谢物同义名
InChI=1/C4H10N2O/c1-3-6(4-2)5-7/h3-4H2,1-2H; N-Nitrosodiethylamine 0.1 mg/ml in Methanol; N-Nitrosodiethylamine, analytical standard; N-Nitrosodiethylamine, >=99.0\\% (GC); N-Nitrosodiethylamine, ISOPAC(R); N-Nitroso-diaethylamine [German]; N-NITROSODIETHYLAMINE [USP-RS]; Ethanamine, N-ethyl-N-nitroso-; N-Nitrosodiethylamine, liquid; N-NITROSODIETHYLAMINE [HSDB]; N-Ethyl-N-nitroso-ethanamine; N-Ethyl-N-nitroso-ethylamine; N-NITROSODIETHYLAMINE [IARC]; 1,1-Diethyl-2-oxohydrazine #; N-Ethyl-N-nitrosoethanamine; Diaethylnitrosamin [German]; N-Nitroso-N,N-diethylamine; N-Nitrosodiethyl-d10-amine; N-NITROSODIETHYLAMINE [MI]; 1,1-Diethyl-2-oxohydrazine; N,N-diethylnitrous amide; Ethylamine, N-nitrosodi-; Diethylamine, N-nitroso-; N-Nitrosodiethylamine-d4; N,N-Diethylnitrosoamine; Diaethylnitrosamin;NDMA; N-Nitroso-diaethylamine; n-nitroso-diethylamine; N,N-Diethylnitrosamine; N Nitrosodiethylamine; diethyl-nitroso-amine; Nitrosamine, diethyl-; N-Nitrosodiethylamine; diethyl(nitroso)amine; N-Nitrosodiethlamine; N-Diethylnitrosamine; Nitrosodiethylamine; Diethylnitrosoamine; Diethylnitrosamide; Diaethylnitrosamin; Diethylnitrosamine; UNII-3IQ78TTX1A; DEN (mutagen); Tox21_300533; Tox21_201255; WLN: ONN2&2; CAS-55-18-5; 3IQ78TTX1A; AI3-62031; NDEA; DENA; DEN; N-Nitrosodiethylamine; N-nitrosodiethylamine
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:34873
- KEGG: C14422
- PubChem: 5921
- ChEMBL: CHEMBL164290
- Wikipedia: N-Nitrosodiethylamine
- MeSH: Diethylnitrosamine
- ChemIDplus: 0000055185
- CAS: 1346603-41-5
- CAS: 55-18-5
- medchemexpress: HY-N7434
- PubChem: 17395422
- NIKKAJI: J1.373K
- RefMet: N-Nitrosodiethylamine
- KNApSAcK: 34873
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mohamed S Abdel-Bakky, Hamdoon A Mohammed, Nesreen I Mahmoud, Elham Amin, Mansour Alsharidah, Osamah Al Rugaie, Mohamed G Ewees. Targeting the PI3K/pAKT/mTOR/NF-κB/FOXO3a signaling pathway for suppressing the development of hepatocellular carcinoma in rats: Role of the natural remedic Suaeda vermiculata forssk.
Environmental toxicology.
2024 Jun; 39(6):3666-3678. doi:
10.1002/tox.24217. [PMID: 38506534] - Xuerao Lan, Haiyan Huang, Jianjun Liu, Jing Zhao, Guowei Li, Mingyang Zuo, Xiumei Xing, Xiaohu Ren. Compromised very-low density lipoprotein induced polyunsaturated triglyceride accumulation in N-nitrosodiethylamine-induced hepatic steatosis.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2024 Apr; 186(?):114519. doi:
10.1016/j.fct.2024.114519. [PMID: 38369053] - Obeid Shanab, Laila Mostafa, Ahmed Abdeen, Rania Atia, Ahmed Y Nassar, Mohammed Youssef, Samah F Ibrahim, Zainab M Maher, Florin Imbrea, Liana Fericean, Khaled Ghareeb, Tabinda Hasan, Heba I Ghamry, Reem T Atawia, Omar Sadeq, Afaf Abdelkader. Modulatory mechanisms of copperII-albumin complex toward N-nitrosodiethylamine-induced neurotoxicity in mice via regulating oxidative damage, inflammatory, and apoptotic signaling pathways.
Ecotoxicology and environmental safety.
2024 Jan; 270(?):115841. doi:
10.1016/j.ecoenv.2023.115841. [PMID: 38113799] - Peter Waziri, Richard Auta, Mustapha U Imam, Ben A Chindo, Zakari Ladan, Zainab Mohammed, Samson Wayah, Ja'afar Mohammed, Mohammed I Tahir, Abdurrahman E Ahmad, Yusuf Alhassan, Daniel Tyoapine, Abel S Agbaji. In Vivo Anti-Hepatocellular Carcinoma Effects of the Chloroform Root Extract of Clausena excavata Burm.
Journal of evidence-based integrative medicine.
2024 Jan; 29(?):2515690X241251558. doi:
10.1177/2515690x241251558. [PMID: 38689490] - Esraa S Habiba, Sahar A Harby, Norhan S El-Sayed, Eman M Omar, Basant A Bakr, Maria Augustyniak, Lamia M El-Samad, Mohamed A Hassan. Sericin and melatonin mitigate diethylnitrosamine-instigated testicular impairment in mice: Implications of oxidative stress, spermatogenesis, steroidogenesis, and modulation of Nrf2/WT1/SF-1 signaling pathways.
Life sciences.
2023 Oct; 334(?):122220. doi:
10.1016/j.lfs.2023.122220. [PMID: 37898455] - Miaoqing Ye, Chunyan Liu, Jiaojiao Liu, Fenping Lu, Jingdong Xue, Fenping Li, Yinghui Tang. Scoparone inhibits the development of hepatocellular carcinoma by modulating the p38 MAPK/Akt/NF-κB signaling in nonalcoholic fatty liver disease mice.
Environmental toxicology.
2023 Jul; ?(?):. doi:
10.1002/tox.23851. [PMID: 37436232] - Jaime Sánchez-Meza, Marina Campos-Valdez, José Alfredo Domínguez-Rosales, Juliana Marisol Godínez-Rubí, Sarai Citlalic Rodríguez-Reyes, Erika Martínez-López, Guillermo M Zúñiga-González, Laura Verónica Sánchez-Orozco. Chronic Administration of Diethylnitrosamine and 2-Acetylaminofluorene Induces Hepatocellular Carcinoma in Wistar Rats.
International journal of molecular sciences.
2023 May; 24(9):. doi:
10.3390/ijms24098387. [PMID: 37176094] - Asmaa I Owis, Noheir H Sherif, Asmaa A Hassan, El-Moataz Bellah El-Naggar, Iman H El-Khashab, El-Sayed El-Ghaly. Tropaeolum majus L. and low dose gamma radiation suppress liver carcinoma development via EGFR-HER2 signaling pathway.
Natural product research.
2023 Mar; 37(6):1030-1035. doi:
10.1080/14786419.2022.2098958. [PMID: 35834717] - Fauzia Jamal, Ghufran Ahmed, Mohammad Farazuddin, Ishrat Altaf, Saba Farheen, Qamar Zia, Asim Azhar, Hira Ahmad, Aijaz Ahmed Khan, Satyanarayana Somavarapu, Anshu Agrawal, Mohammad Owais. Potential of siRNA-Bearing Subtilosomes in the Treatment of Diethylnitrosamine-Induced Hepatocellular Carcinoma.
Molecules (Basel, Switzerland).
2023 Feb; 28(5):. doi:
10.3390/molecules28052191. [PMID: 36903437] - Fatma Sayed Abdel-Aal Farag, Hend Mohamed Anwar, Tarek Aboushousha, Hala Sh Mohammed, Lotfi Diab Mousa Ismail. Ameliorative Effects of Thunbergia erecta L. Leaves Against the Initiation of Hepatocarcinogenesis Induced by Diethylnitrosamine in the Rat Model.
Applied biochemistry and biotechnology.
2023 Jan; ?(?):. doi:
10.1007/s12010-022-04292-x. [PMID: 36708488] - Hany Khalil, Alaa H Nada, Hoda Mahrous, Amr Hassan, Patricia Rijo, Ibrahim A Ibrahim, Dalia D Mohamed, Fawziah A Al-Salmi, Doaa D Mohamed, Ahmed I Abd Elmaksoud. Amelioration effect of 18β-Glycyrrhetinic acid on methylation inhibitors in hepatocarcinogenesis -induced by diethylnitrosamine.
Frontiers in immunology.
2023; 14(?):1206990. doi:
10.3389/fimmu.2023.1206990. [PMID: 38322013] - Mohammed S Abdel-Hamid, Ahmed M Mansour, Memy H Hassan, Rasha Abdelhady, Bakheet E M Elsadek, El-Sayed M El-Sayed, Salama A Salama. Estrogen Attenuates Diethylnitrosamine-Induced Hepatocellular Carcinoma in Female Rats via Modulation of Estrogen Receptor/FASN/CD36/IL-6 Axis.
Biological & pharmaceutical bulletin.
2023; 46(11):1558-1568. doi:
10.1248/bpb.b23-00342. [PMID: 37914358] - Fan Yang, Xiaoqiang Shi, Weidong Yang, Chao Gao, Zhenyu Cui, Wentao Wang. Pueraria montana (Kudzu vine) Ameliorate the Inflammation and Oxidative Stress against Fe-NTA Induced Renal Cancer.
Journal of oleo science.
2022 Sep; 71(10):1481-1492. doi:
10.5650/jos.ess22151. [PMID: 36089399] - Haiyang Shen, Qian Li, Youtao Yu. Chemoprotective Effect of Decalactone on Hepatic Cancer via Diminishing the Inflammatory Response and Oxidative Stress.
Journal of oleo science.
2022 Sep; 71(9):1327-1335. doi:
10.5650/jos.ess22033. [PMID: 35965085] - Suphunwadee Sawong, Dumrongsak Pekthong, Pennapha Suknoppakit, Thanwarat Winitchaikul, Worasak Kaewkong, Julintorn Somran, Chaidan Intapa, Supawadee Parhira, Piyarat Srisawang. Calotropis gigantea stem bark extracts inhibit liver cancer induced by diethylnitrosamine.
Scientific reports.
2022 07; 12(1):12151. doi:
10.1038/s41598-022-16321-0. [PMID: 35840761] - Charatda Punvittayagul, Theerapat Luangsuphabool, Rawiwan Wongpoomchai. Protocatechuic acid as a potent anticarcinogenic compound in purple rice bran against diethylnitrosamine-initiated rat hepatocarcinogenesis.
Scientific reports.
2022 06; 12(1):10548. doi:
10.1038/s41598-022-14888-2. [PMID: 35732709] - Osama M Ahmed, Hanaa I Fahim, Eman E Mohamed, Adel Abdel-Moneim. Protective effects of Persea americana fruit and seed extracts against chemically induced liver cancer in rats by enhancing their antioxidant, anti-inflammatory, and apoptotic activities.
Environmental science and pollution research international.
2022 Jun; 29(29):43858-43873. doi:
10.1007/s11356-022-18902-y. [PMID: 35122196] - Yuan Lu, Yanli Wang, Yan He, Jie Pan, Yang Jin, Lin Zheng, Yong Huang, Yongjun Li, Wen Liu. Aidi injection altered the activity of CYP2D4, CYP1A2, CYP2C19, CYP3A2, CYP2E1 and CYP2C11 in normal and diethylnitrosamine-induced hepatocellular carcinoma in rats.
Journal of ethnopharmacology.
2022 Mar; 286(?):114930. doi:
10.1016/j.jep.2021.114930. [PMID: 34952190] - Chao Liu, Han Yu, Xia Li, Yanju Gong, Peijie Wu, Quan-Sheng Feng. Anti-hepatocellular carcinoma efficacy of Fuzheng Xiaozheng prescription and its interventional mechanism studies.
Journal of ethnopharmacology.
2022 Mar; 285(?):114913. doi:
10.1016/j.jep.2021.114913. [PMID: 34910953] - Magda I Mohamad, Islam A Desoky, Kamelia Ahmed Zaki, Doaa R Sadek, Samar Kamal Kassim, Dalia Abdel-Wahab Mohamed. Pterostilbene ameliorates the disrupted Adars expression and improves liver fibrosis in DEN-induced liver injury in Wistar rats: A novel potential effect.
Gene.
2022 Mar; 813(?):146124. doi:
10.1016/j.gene.2021.146124. [PMID: 34921950] - Ting Zhang, Hong-Wei Gu, Jin-Xing Gao, Yu-Sang Li, He-Bin Tang. Ethanol supernatant extracts of Gynura procumbens could treat nanodiethylnitrosamine-induced mouse liver cancer by interfering with inflammatory factors for the tumor microenvironment.
Journal of ethnopharmacology.
2022 Mar; 285(?):114917. doi:
10.1016/j.jep.2021.114917. [PMID: 34919988] - Xia Li, Han Yu, Yanju Gong, Peijie Wu, Quansheng Feng, Chao Liu. Fuzheng Xiaozheng prescription relieves rat hepatocellular carcinoma through improving anti-inflammation capacity and regulating lipid related metabolisms.
Journal of ethnopharmacology.
2022 Feb; 284(?):114801. doi:
10.1016/j.jep.2021.114801. [PMID: 34748868] - P Amudha, M Jayalakshmi, R Vidya, B N Poojitha. Chemopreventive and Therapeutic Efficacy of Enhalus acoroides against Diethylnitrosamine Induced Hepatocellular Carcinoma in Wistar Albino Rats.
Applied biochemistry and biotechnology.
2022 Feb; ?(?):. doi:
10.1007/s12010-022-03832-9. [PMID: 35106713] - Hee Jeong Chun, Yeon Joo Shim, Young Hye Kwon. Cholic acid supplementation accelerates the progression of nonalcoholic fatty liver disease to the procarcinogenic state in mice fed a high-fat and high-cholesterol diet.
The Journal of nutritional biochemistry.
2022 02; 100(?):108869. doi:
10.1016/j.jnutbio.2021.108869. [PMID: 34563665] - Ke-Xin Wang, Guan-Hua Du, Xue-Mei Qin, Li Gao. 1H-NMR-based metabolomics reveals the biomarker panel and molecular mechanism of hepatocellular carcinoma progression.
Analytical and bioanalytical chemistry.
2022 Feb; 414(4):1525-1537. doi:
10.1007/s00216-021-03768-9. [PMID: 35024914] - Satoshi Kidoguchi, Kento Kitada, Kazuki Nakajima, Daisuke Nakano, Hiroyuki Ohsaki, Wararat Kittikulsuth, Hideki Kobara, Tsutomu Masaki, Takashi Yokoo, Kazuo Takahashi, Jens Titze, Akira Nishiyama. Hepatocellular carcinoma induces body mass loss in parallel with osmolyte and water retention in rats.
Life sciences.
2022 Jan; 289(?):120192. doi:
10.1016/j.lfs.2021.120192. [PMID: 34871664] - Gaber Ali, Hany Omar, Fatema Hersi, Amira Abo-Youssef, Osama Ahmed, Wafaa Mohamed. The Protective Role of Etoricoxib Against Diethylnitrosamine/2-acetylaminofluorene- Induced Hepatocarcinogenesis in Wistar Rats: The Impact of NF-κB/COX-2/PGE2 Signaling.
Current molecular pharmacology.
2022; 15(1):252-262. doi:
10.2174/1874467214666210708103752. [PMID: 34238176] - Renata L Goto, Mariana B Tablas, Gabriel B Prata, Sara G Espírito Santo, Ana Angélica H Fernandes, Bruno Cogliati, Luis F Barbisan, Guilherme R Romualdo. Vitamin D3 supplementation alleviates chemically-induced cirrhosis-associated hepatocarcinogenesis.
The Journal of steroid biochemistry and molecular biology.
2022 01; 215(?):106022. doi:
10.1016/j.jsbmb.2021.106022. [PMID: 34774723] - Khairy M A Zoheir, Mohamed A Abdelhafez, Ahmed M Darwish, Karima F Mahrous. New Approach about the Signaling Crosstalk between IQGAPs/ NF- κB/IL-8 and PDCD5/p53/TRAIL Pathways that Modulate Malignant Transformation in Hepatocellular Carcinoma.
Asian Pacific journal of cancer prevention : APJCP.
2022 Jan; 23(1):271-279. doi:
10.31557/apjcp.2022.23.1.271. [PMID: 35092397] - Nabil Mohie Abdel-Hamid, Sara Gamal Abd Allah, Mohamed K Hassan, Amal A M Ahmed, Nahla H Anber, Ibrahim Adel Faried. Possible Protective Potency of Argun Nut (Medemia argun - An Ancient Egyptian Palm) against Hepatocellular Carcinoma in Rats.
Nutrition and cancer.
2022; 74(2):527-538. doi:
10.1080/01635581.2021.1883683. [PMID: 33570439] - R Vidya, K Kalaivani, P Amudha. Therapeutic Potential of Cucumis melo (L.) Fruit Extract and Its Silver Nanopartciles Against DEN-Induced Hepatocellular Cancer in Rats.
Applied biochemistry and biotechnology.
2022 Jan; 194(1):368-381. doi:
10.1007/s12010-021-03765-9. [PMID: 34792748] - Vichununt Kerdput, Kritsakorn Kanjanapongkul, Arunporn Itharat, Ratchadaporn Pramong, Wouter H Lamers, Theodorus B M Hakvoort, Aldo Jongejan, Wisuit Pradidarcheep. Molecular Changes Following Induction of Hepatocellular Carcinoma by Diethylnitrosamine and Thioacetamide, and Subsequent Treatment with Dioscorea membranacea Extract.
International journal of medical sciences.
2022; 19(12):1806-1815. doi:
10.7150/ijms.72987. [PMID: 36313224] - Ashish Kumar, Manisha Naithani, Nitesh Kumar, Neha Singh, Shruti Agrawal, Ambika Sharma, Surabhi Thapliyal, Jagjit Singh, Shailendra Handu. Piperlongumine inhibits diethylnitrosamine induced hepatocellular carcinoma in rats.
Human & experimental toxicology.
2022 Jan; 41(?):9603271211073593. doi:
10.1177/09603271211073593. [PMID: 35113675] - Osama M Ahmed, Adel A Ahmed, Hanaa I Fahim, Mohamed Y Zaky. Quercetin and naringenin abate diethylnitrosamine/acetylaminofluorene-induced hepatocarcinogenesis in Wistar rats: the roles of oxidative stress, inflammation and cell apoptosis.
Drug and chemical toxicology.
2022 Jan; 45(1):262-273. doi:
10.1080/01480545.2019.1683187. [PMID: 31665932] - Ryo Ichikawa, Sosuke Masuda, Junta Nakahara, Mio Kobayashi, Risako Yamashita, Suzuka Uomoto, Ohshima Kanami, Erika Hara, Yuko Ito, Makoto Shibutani, Toshinori Yoshida. Inhibition of autophagy with expression of NADPH oxidase subunit p22phox in preneoplastic lesions in a high-fat diet and streptozotocin-related hepatocarcinogenesis rat model.
The Journal of toxicological sciences.
2022; 47(7):289-300. doi:
10.2131/jts.47.289. [PMID: 35786680] - Hongwu Huang, Zhenzhen Liu, Xiaoru Qi, Nailong Gao, Jianguo Chang, Miaomiao Yang, Sha Na, Yanyan Liu, Rui Song, Lu Li, Guangliang Chen, Hui Zhou. Rhubarb granule promotes diethylnitrosamine-induced liver tumorigenesis by activating the oxidative branch of pentose phosphate pathway via G6PD in rats.
Journal of ethnopharmacology.
2021 Dec; 281(?):114479. doi:
10.1016/j.jep.2021.114479. [PMID: 34343647] - María José Rodríguez, Matías Sabaj, Gerardo Tolosa, Francisca Herrera Vielma, María José Zúñiga, Daniel R González, Jessica Zúñiga-Hernández. Maresin-1 Prevents Liver Fibrosis by Targeting Nrf2 and NF-κB, Reducing Oxidative Stress and Inflammation.
Cells.
2021 12; 10(12):. doi:
10.3390/cells10123406. [PMID: 34943914] - Nahed Abdel-Aziz, Sawsan M El-Sonbaty, Marwa G A Hegazy. Ameliorative potential of manganese nanoparticles with low-level ionizing radiation against experimentally induced hepatocarcinogenesis.
Environmental science and pollution research international.
2021 Dec; 28(46):65474-65486. doi:
10.1007/s11356-021-15571-1. [PMID: 34322790] - Shanshan Li, Yang Li, Hongjian Sun, Yang Jiang, Keming Pan, Yue Su, Nan Bu. Mulberry fruit polysaccharides alleviate diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis in vivo: the roles of cell apoptosis and inflammation.
Bioengineered.
2021 12; 12(2):11599-11611. doi:
10.1080/21655979.2021.1993716. [PMID: 34866538] - Gopalakrishnan Balaraman, Jagan Sundaram, Ashok Mari, Palanisamy Krishnan, Sharmila Salam, Nirmala Subramaniam, Immaduddin Sirajduddin, Devaki Thiruvengadam. Farnesol alleviates diethyl nitrosamine induced inflammation and protects experimental rat hepatocellular carcinoma.
Environmental toxicology.
2021 Dec; 36(12):2467-2474. doi:
10.1002/tox.23359. [PMID: 34473392] - Sang R Lee, Su Hee Jeong, Jun H Heo, Seong Lae Jo, Je-Won Ko, Hyo-Jung Kwun, Eui-Ju Hong. Dietary Intake of 17α-Ethinylestradiol Promotes HCC Progression in Humanized Male Mice Expressing Sex Hormone-Binding Globulin.
International journal of molecular sciences.
2021 Nov; 22(22):. doi:
10.3390/ijms222212557. [PMID: 34830439] - Kenta Yamamoto, Takashi Honda, Shinya Yokoyama, Lingyun Ma, Asuka Kato, Takanori Ito, Yoji Ishizu, Teiji Kuzuya, Masanao Nakamura, Hiroki Kawashima, Masatoshi Ishigami, Noriko M Tsuji, Mitsuhiro Fujishiro. Microbiome, fibrosis and tumor networks in a non-alcoholic steatohepatitis model of a choline-deficient high-fat diet using diethylnitrosamine.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.
2021 Nov; 53(11):1443-1450. doi:
10.1016/j.dld.2021.02.013. [PMID: 33726979] - Huiying Fu, Xia Liu, Lu Jin, Jiali Lang, Zhiming Hu, Wen Mao, Changpei Cheng, Qiyang Shou. Safflower yellow reduces DEN-induced hepatocellular carcinoma by enhancing liver immune infiltration through promotion of collagen degradation and modulation of gut microbiota.
Food & function.
2021 Nov; 12(21):10632-10643. doi:
10.1039/d1fo01321a. [PMID: 34585698] - Elisabeth M Haberl, Rebekka Pohl, Lisa Rein-Fischboeck, Marcus Höring, Sabrina Krautbauer, Gerhard Liebisch, Christa Buechler. Accumulation of cholesterol, triglycerides and ceramides in hepatocellular carcinomas of diethylnitrosamine injected mice.
Lipids in health and disease.
2021 Oct; 20(1):135. doi:
10.1186/s12944-021-01567-w. [PMID: 34629057] - A M Kabel, H H Arab, M A Abd Elmaaboud. Attenuation of diethyl nitrosamine-induced hepatocellular carcinoma by taxifolin and/or alogliptin: The interplay between toll-like receptor 4, transforming growth factor beta-1, and apoptosis.
Human & experimental toxicology.
2021 Oct; 40(10):1710-1720. doi:
10.1177/09603271211008496. [PMID: 33840231] - Tarek Kamal Abouzed, Fayez Althobaiti, Nesreen Adel Abdelkhlek, Ehab Bedir Eldomany, Nasr Elsayed Nasr, Kadry Mohamed Sadek, Samir Ahmed El-Shazly, Khaled A Kahilo, Doaa Abdallha Dorghamm. Antitumor and Antioxidant Activity of S-Methyl Methionine Sulfonium Chloride against Liver Cancer Induced in Wistar Albino Rats by Diethyl Nitrosamine and Carbon Tertrachloride.
International journal of environmental research and public health.
2021 09; 18(18):. doi:
10.3390/ijerph18189726. [PMID: 34574650] - Yuan Lu, Jie Pan, Xiaoqing Zhu, Shuai Zhang, Chunhua Liu, Jia Sun, Yueting Li, Siying Chen, Jing Huang, Chuang Cao, Yonglin Wang, Yongjun Li, Ting Liu. Pharmacokinetic herb-drug interactions between Aidi injection and doxorubicin in rats with diethylnitrosamine-induced hepatocellular carcinoma.
BMC pharmacology & toxicology.
2021 09; 22(1):48. doi:
10.1186/s40360-021-00515-9. [PMID: 34488896] - Adel Abdel-Moneim, Osama M Ahmed, Sanaa M Abd El-Twab, Mohamed Y Zaky, Lamiaa N Bakry. Prophylactic effects of Cynara scolymus L. leaf and flower hydroethanolic extracts against diethylnitrosamine/acetylaminoflourene-induced lung cancer in Wistar rats.
Environmental science and pollution research international.
2021 Aug; 28(32):43515-43527. doi:
10.1007/s11356-021-13391-x. [PMID: 33834342] - Piman Pocasap, Natthida Weerapreeyakul, Rawiwan Wongpoomchai. Chemopreventive Effect of Cratoxylum formosum (Jack) ssp. pruniflorum on Initial Stage Hepatocarcinogenesis in Rats.
Molecules (Basel, Switzerland).
2021 Jul; 26(14):. doi:
10.3390/molecules26144235. [PMID: 34299510] - Hend Mohamed Anwar, Asmaa M Moghazy, Amany Abd Elhameid Osman, Amina A S Abdel Rahman. The Therapeutic Effect of Myrrh (Commiphora molmol) and Doxorubicin on Diethylnitrosamine Induced Hepatocarcinogenesis in Male Albino Rats.
Asian Pacific journal of cancer prevention : APJCP.
2021 Jul; 22(7):2153-2163. doi:
10.31557/apjcp.2021.22.7.2153. [PMID: 34319038] - Mohammad Iqbal, Muhammad Dawood Shah, Senty Vun-Sang, Yasumasa Okazaki, Shigeru Okada. The therapeutic potential of curcumin in alleviating N-diethylnitrosamine and iron nitrilotriacetate induced renal cell tumours in mice via inhibition of oxidative stress: Implications for cancer chemoprevention.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jul; 139(?):111636. doi:
10.1016/j.biopha.2021.111636. [PMID: 33957566] - Yan-Jiao Wang, Hai-Yan Xu, Xin-Hui Huo, Si-En Fan, Xin-Hua Nabi. Multi-stress accelerated liver cancer progression in rats treated with diethylnitrosamine.
Chinese medical journal.
2021 06; 134(14):1762-1764. doi:
10.1097/cm9.0000000000001504. [PMID: 34116526] - Sara Hooshmand, Mohammad Reza Mahdinezhad, Shirin Taraz Jamshidi, Mohammad Soukhtanloo, Farshad Mirzavi, Mehrdad Iranshahi, Maedeh Hasanpour, Ahmad Ghorbani. Morus nigra L. extract prolongs survival of rats with hepatocellular carcinoma.
Phytotherapy research : PTR.
2021 Jun; 35(6):3365-3376. doi:
10.1002/ptr.7056. [PMID: 33624311] - Sachin Shetty, U Anushree, Rajesh Kumar, Sanjay Bharati. Mitochondria-targeted antioxidant, mito-TEMPO mitigates initiation phase of N-Nitrosodiethylamine-induced hepatocarcinogenesis.
Mitochondrion.
2021 05; 58(?):123-130. doi:
10.1016/j.mito.2021.03.001. [PMID: 33711502] - Yulai You, Fengfeng Zhu, Zhenhuan Li, LingFeng Zhang, Yu Xie, Arunachalam Chinnathambi, Tahani Awad Alahmadi, Bei Lu. Phyllanthin prevents diethylnitrosamine (DEN) induced liver carcinogenesis in rats and induces apoptotic cell death in HepG2 cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 May; 137(?):111335. doi:
10.1016/j.biopha.2021.111335. [PMID: 33581648] - Soha A Hassan, Amira A H Ali, Mona Yassine, Dennis Sohn, Martina Pfeffer, Reiner U Jänicke, Horst-Werner Korf, Charlotte von Gall. Relationship between locomotor activity rhythm and corticosterone levels during HCC development, progression, and treatment in a mouse model.
Journal of pineal research.
2021 Apr; 70(3):e12724. doi:
10.1111/jpi.12724. [PMID: 33615553] - Renuka Sharma, Taqveema Ali, Ishwar Negi, Ashim Das, Ajay Duseja, Jyotdeep Kaur. Dietary modulations of folic acid affect the development of diethylnitrosamine induced hepatocellular carcinoma in a rat model.
Journal of molecular histology.
2021 Apr; 52(2):335-350. doi:
10.1007/s10735-020-09955-9. [PMID: 33438102] - Yomna I Mahmoud, Aya M M Shehata, Nagui H Fares, Asmaa A Mahmoud. Spirulina inhibits hepatocellular carcinoma through activating p53 and apoptosis and suppressing oxidative stress and angiogenesis.
Life sciences.
2021 Jan; 265(?):118827. doi:
10.1016/j.lfs.2020.118827. [PMID: 33253720] - Charatda Punvittayagul, Arpamas Chariyakornkul, Paweena Sankam, Rawiwan Wongpoomchai. Inhibitory Effect of Thai Purple Rice Husk Extract on Chemically Induced Carcinogenesis in Rats.
Molecules (Basel, Switzerland).
2021 Jan; 26(2):. doi:
10.3390/molecules26020360. [PMID: 33445792] - Luis Manuel Sarmiento-Machado, Guilherme Ribeiro Romualdo, Joyce Regina Zapaterini, Mariana Baptista Tablas, Ana Angélica Henrique Fernandes, Fernando Salvador Moreno, Luís Fernando Barbisan. Protective Effects of Dietary Capsaicin on the Initiation Step of a Two-Stage Hepatocarcinogenesis Rat Model.
Nutrition and cancer.
2021; 73(5):817-828. doi:
10.1080/01635581.2020.1764067. [PMID: 32400193] - Yongfang Gong, Dong Li, Lili Li, Juan Yang, Hanyan Ding, Chong Zhang, Guanhua Wen, Chao Wu, Zhirui Fang, Shu Hou, Yan Yang. Smad3 C-terminal phosphorylation site mutation attenuates the hepatoprotective effect of salvianolic acid B against hepatocarcinogenesis.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 Jan; 147(?):111912. doi:
10.1016/j.fct.2020.111912. [PMID: 33290806] - Deepika Singh, Ekta Yadav, Vikas Kumar, Amita Verma. Madhuca longifolia Embedded Silver Nanoparticles Attenuate Diethylnitrosamine (DEN)-Induced Renal Cancer via Regulating Oxidative Stress.
Current drug delivery.
2021; 18(5):634-644. doi:
10.2174/1567201817666200910154301. [PMID: 32914714] - Mohammed A Alsahli, Saleh A Almatroodi, Ahmad Almatroudi, Amjad Ali Khan, Shehwaz Anwar, Abdulmajeed G Almutary, Faris Alrumaihi, Arshad Husain Rahmani. 6-Gingerol, a Major Ingredient of Ginger Attenuates Diethylnitrosamine-Induced Liver Injury in Rats through the Modulation of Oxidative Stress and Anti-Inflammatory Activity.
Mediators of inflammation.
2021; 2021(?):6661937. doi:
10.1155/2021/6661937. [PMID: 33531877] - Amira M Gamal-Eldeen, Hassan Amer, Amani A Alrehaili, Ahmed Saleh, Abd El-Rahman Al Ghamdi, Nahed M Hawsawi, Asma Salman, Bassem M Raafat. Cancer Chemopreventive Properties of Sulfated Enterolobium cyclocarpum Extract.
Nutrition and cancer.
2021; 73(5):856-868. doi:
10.1080/01635581.2020.1773512. [PMID: 32482099] - Arpamas Chariyakornkul, Nichanan Inboot, Sirinya Taya, Rawiwan Wongpoomchai. Low-polar extract from seed of Cleistocalyx nervosum var. paniala modulates initiation and promotion stages of chemically-induced carcinogenesis in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jan; 133(?):110963. doi:
10.1016/j.biopha.2020.110963. [PMID: 33190034] - Elisabeth M Haberl, Rebekka Pohl, Lisa Rein-Fischboeck, Marcus Höring, Sabrina Krautbauer, Gerhard Liebisch, Christa Buechler. Hepatic lipid profile in mice fed a choline-deficient, low-methionine diet resembles human non-alcoholic fatty liver disease.
Lipids in health and disease.
2020 Dec; 19(1):250. doi:
10.1186/s12944-020-01425-1. [PMID: 33298075] - Maria José Rodríguez, Francisca Herrera, Wendy Donoso, Iván Castillo, Roxana Orrego, Daniel R González, Jessica Zúñiga-Hernández. Pro-Resolving Lipid Mediator Resolvin E1 Mitigates the Progress of Diethylnitrosamine-Induced Liver Fibrosis in Sprague-Dawley Rats by Attenuating Fibrogenesis and Restricting Proliferation.
International journal of molecular sciences.
2020 Nov; 21(22):. doi:
10.3390/ijms21228827. [PMID: 33266360] - H E Abo Mansour, M M El-Batsh, N S Badawy, E T Mehanna, N M Mesbah, D M Abo-Elmatty. Effect of co-treatment with doxorubicin and verapamil loaded into chitosan nanoparticles on diethylnitrosamine-induced hepatocellular carcinoma in mice.
Human & experimental toxicology.
2020 Nov; 39(11):1528-1544. doi:
10.1177/0960327120930266. [PMID: 32519553] - Omolara F Yakubu, Damilohun S Metibemu, Isaacson B Adelani, Gbolahan O Adesina, Chidera B Edokwe, Oyinkansola E Oseha, Abiodun H Adebayo. Annona senegalensis extract demonstrates anticancer properties in N-diethylnitrosamine-induced hepatocellular carcinoma in male Wistar rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Nov; 131(?):110786. doi:
10.1016/j.biopha.2020.110786. [PMID: 33152944] - Yanping Tang, Ji Cao, Zhengmin Cai, Huihua An, Yuqun Li, Yan Peng, Ni Chen, Anqiang Luo, Hao Tao, Kezhi Li. Epigallocatechin gallate induces chemopreventive effects on rats with diethylnitrosamine‑induced liver cancer via inhibition of cell division cycle 25A.
Molecular medicine reports.
2020 Nov; 22(5):3873-3885. doi:
10.3892/mmr.2020.11463. [PMID: 33000276] - Steffen Landerer, Sandra Kalthoff, Stefan Paulusch, Christian P Strassburg. UDP-glucuronosyltransferase polymorphisms affect diethylnitrosamine-induced carcinogenesis in humanized transgenic mice.
Cancer science.
2020 Nov; 111(11):4266-4275. doi:
10.1111/cas.14635. [PMID: 32860300] - Brisa Rodope Alarcón-Sánchez, Dafne Guerrero-Escalera, Sandra Rosas-Madrigal, Diana Ivette Aparicio-Bautista, Karina Reyes-Gordillo, M Raj Lakshman, Arturo Ortiz-Fernández, Héctor Quezada, Óscar Medina-Contreras, Saúl Villa-Treviño, Julio Isael Pérez-Carreón, Jaime Arellanes-Robledo. Nucleoredoxin interaction with flightless-I/actin complex is differentially altered in alcoholic liver disease.
Basic & clinical pharmacology & toxicology.
2020 Nov; 127(5):389-404. doi:
10.1111/bcpt.13451. [PMID: 32524749] - Jie Pan, Yuan Lu, Shuai Zhang, Yueting Li, Jia Sun, Hua Chunhua Liu, Zipeng Gong, Jing Huang, Chuang Cao, Yonglin Wang, Yongjun Li, Ting Liu. Differential changes in the pharmacokinetics of doxorubicin in diethylnitrosamine-induced hepatocarcinoma model rats.
Xenobiotica; the fate of foreign compounds in biological systems.
2020 Oct; 50(10):1251-1257. doi:
10.1080/00498254.2020.1765049. [PMID: 32375563] - S Ali, M Ejaz, K K Dar, S Nasreen, N Ashraf, S F Gillani, N Shafi, S Safeer, M A Khan, S Andleeb, N Akhtar, T A Mughal. Evaluation of chemopreventive and chemotherapeutic effect of Artemisia vulgaris extract against diethylnitrosamine induced hepatocellular carcinogenesis in Balb C mice.
Brazilian journal of biology = Revista brasleira de biologia.
2020 Sep; 80(3):484-496. doi:
10.1590/1519-6984.185979. [PMID: 31691741] - Minghui Feng, Songqi He, Songze Huang, Jiaxin Lin, Huilin Yang, Jiaji Wang, Jie Pang. [Inhibitory effect of Biejiajian pills against diethylnitrosamine-induced hepatocarcinogenesis in rats].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2020 Aug; 40(8):1148-1154. doi:
10.12122/j.issn.1673-4254.2020.08.12. [PMID: 32895174] - Jie Song, Wenbo Ding, Bojia Liu, Dan Liu, Zhi Xia, Li Zhang, Li Cui, Yi Luo, Xiaobin Jia, Liang Feng. Anticancer effect of caudatin in diethylnitrosamine‑induced hepatocarcinogenesis in rats.
Molecular medicine reports.
2020 08; 22(2):697-706. doi:
10.3892/mmr.2020.11135. [PMID: 32626931] - Saman Khan, Atif Zafar, Imrana Naseem. Redox cycling of copper by coumarin-di(2-picolyl)amine hybrid molecule leads to ROS-mediated modulation of redox scavengers, DNA damage and cell death in diethylnitrosamine induced hepatocellular carcinoma.
Bioorganic chemistry.
2020 06; 99(?):103818. doi:
10.1016/j.bioorg.2020.103818. [PMID: 32276135] - Lei Song, Jian-Gang Zhang, Long Zheng, Xu Feng, Jie Hou, Huan-Ling Zhang, Shu-Feng Liu. Establishment of rat liver cancer cell lines with different metastatic potential.
Scientific reports.
2020 05; 10(1):8329. doi:
10.1038/s41598-020-65338-w. [PMID: 32433581] - Yuta Matsuoka, Yoshihiro Izumi, Masatomo Takahashi, Takeshi Bamba, Ken-Ichi Yamada. Method for Structural Determination of Lipid-Derived Radicals.
Analytical chemistry.
2020 05; 92(10):6993-7002. doi:
10.1021/acs.analchem.0c00053. [PMID: 32311262] - Yu-Hsuan Lin, Shuyuan Zhang, Min Zhu, Tianshi Lu, Kenian Chen, Zhuoyu Wen, Shidan Wang, Guanghua Xiao, Danni Luo, Yuemeng Jia, Lin Li, Malcolm MacConmara, Yujin Hoshida, Amit G Singal, Adam Yopp, Tao Wang, Hao Zhu. Mice With Increased Numbers of Polyploid Hepatocytes Maintain Regenerative Capacity But Develop Fewer Hepatocellular Carcinomas Following Chronic Liver Injury.
Gastroenterology.
2020 05; 158(6):1698-1712.e14. doi:
10.1053/j.gastro.2020.01.026. [PMID: 31972235] - Wen-Hao Qin, Zhi-Shi Yang, Mian Li, Yao Chen, Xiao-Fang Zhao, Ying-Yi Qin, Jia-Qi Song, Bi-Bo Wang, Bo Yuan, Xiu-Liang Cui, Feng Shen, Jia He, Yu-Fang Bi, Guang Ning, Jing Fu, Hong-Yang Wang. High Serum Levels of Cholesterol Increase Antitumor Functions of Nature Killer Cells and Reduce Growth of Liver Tumors in Mice.
Gastroenterology.
2020 05; 158(6):1713-1727. doi:
10.1053/j.gastro.2020.01.028. [PMID: 31972238] - Naglaa H M Hassanen, Abdelgawad Fahmi, Engy Shams-Eldin, Mariam Abdur-Rahman. Protective effect of rosemary (Rosmarinus officinalis) against diethylnitrosamine-induced renal injury in rats.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2020 May; 25(3):281-289. doi:
10.1080/1354750x.2020.1737734. [PMID: 32118487] - Velid Unsal, Ergül Belge Kurutaş. Investigation of the Effects of Octreotide Agent on Oxidative Stress, 8-Hydroxy Deoxyguanosine in Experimental Hepatic Carcinogenesis Rat Model.
Folia medica.
2020 03; 62(1):70-75. doi:
10.3897/folmed.62.e47735. [PMID: 32337899] - X B He, M Chen, H Xiao, C B Huang, A Tsung, Y Liu. [High-mobility group protein 1 promotes diethylnitrosamine-induced liver cancer formation in mice by activating mitochondrial biogenesis].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2020 Feb; 28(2):141-146. doi:
10.3760/cma.j.issn.1007-3418.2020.02.008. [PMID: 32164065] - Durgesh Kumar Dwivedi, G B Jena. Diethylnitrosamine and thioacetamide-induced hepatic damage and early carcinogenesis in rats: Role of Nrf2 activator dimethyl fumarate and NLRP3 inhibitor glibenclamide.
Biochemical and biophysical research communications.
2020 02; 522(2):381-387. doi:
10.1016/j.bbrc.2019.11.100. [PMID: 31761320] - Pritha Bose, Mohd Usman M Siddique, Reetuparna Acharya, Venkatesan Jayaprakash, Barij Nayan Sinha, Antonio Lapenna, Shakti P Pattanayak. Quinazolinone derivative BNUA-3 ameliorated [NDEA+2-AAF]-induced liver carcinogenesis in SD rats by modulating AhR-CYP1B1-Nrf2-Keap1 pathway.
Clinical and experimental pharmacology & physiology.
2020 01; 47(1):143-157. doi:
10.1111/1440-1681.13184. [PMID: 31563143] - Chunyang Zhang, Yuhui Chen, Ming Zhang, Chunni Xu, Guojin Gong, Vishnu Priya Veeraraghavan, Srinivasa Rao Bolla, Yandong Li. Vicenin-2 Treatment Attenuated the Diethylnitrosamine-Induced Liver Carcinoma and Oxidative Stress through Increased Apoptotic Protein Expression in Experimental Rats.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer.
2020; 39(2):113-123. doi:
10.1615/jenvironpatholtoxicoloncol.2020031892. [PMID: 32749121] - Shakir Saleem, Imran Kazmi, Aftab Ahmad, Mohammed F Abuzinadah, Ali Samkari, Huda M Alkrathy, Ruqaiyah Khan. Thiamin Regresses the Anticancer Efficacy of Methotrexate in the Amelioration of Diethyl Nitrosamine-Induced Hepatocellular Carcinoma in Wistar Strain Rats.
Nutrition and cancer.
2020; 72(1):170-181. doi:
10.1080/01635581.2019.1614199. [PMID: 31088230] - Elisabeth M Haberl, Rebekka Pohl, Lisa Rein-Fischboeck, Susanne Feder, Christopher J Sinal, Astrid Bruckmann, Marcus Hoering, Sabrina Krautbauer, Gerhard Liebisch, Christa Buechler. Overexpression of Hepatocyte Chemerin-156 Lowers Tumor Burden in a Murine Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma.
International journal of molecular sciences.
2019 Dec; 21(1):. doi:
10.3390/ijms21010252. [PMID: 31905933] - Pranesh Kumar, Aakriti Agarwal, Ashok K Singh, Anurag Kumar Gautam, Sreemoyee Chakraborti, Umesh Kumar, Dinesh Kumar, Bolay Bhattacharya, Parthasarathi Panda, Biswajit Saha, Tabish Qidwai, Biswanath Maity, Sudipta Saha. Antineoplastic properties of zafirlukast against hepatocellular carcinoma via activation of mitochondrial mediated apoptosis.
Regulatory toxicology and pharmacology : RTP.
2019 Dec; 109(?):104489. doi:
10.1016/j.yrtph.2019.104489. [PMID: 31605713] - Nirmala Subramaniam, Pugazhendhi Kannan, Ashokkumar K, Devaki Thiruvengadam. Hepatoprotective effect of boldine against diethylnitrosamine-induced hepatocarcinogenesis in wistar rats.
Journal of biochemical and molecular toxicology.
2019 Dec; 33(12):e22404. doi:
10.1002/jbt.22404. [PMID: 31593341] - Hiroyuki Wakana, Hiroshi Kono, Hisataka Fukushima, Yuuki Nakata, Yoshihiro Akazawa, Suguru Maruyama, Kotaro Hagio, Hideki Fujii, Daisuke Ichikawa. Effects of Medium-chain Triglycerides Administration in Chemically-induced Carcinogenesis in Mice.
Anticancer research.
2019 Dec; 39(12):6653-6660. doi:
10.21873/anticanres.13880. [PMID: 31810930] - Jingjing Li, Qiujie Wang, Yi Yang, Chong Lei, Fan Yang, Li Liang, Chang Chen, Jie Xia, Kai Wang, Ni Tang. GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway.
Journal of experimental & clinical cancer research : CR.
2019 Oct; 38(1):438. doi:
10.1186/s13046-019-1459-6. [PMID: 31666108] - K K Dar, S Ali, M Ejaz, S Nasreen, N Ashraf, S F Gillani, N Shafi, S Safeer, M A Khan, S Andleeb, T A Mughal. In vivo induction of hepatocellular carcinoma by diethylnitrosoamine and pharmacological intervention in Balb C mice using Bergenia ciliata extracts.
Brazilian journal of biology = Revista brasleira de biologia.
2019 Oct; 79(4):629-638. doi:
10.1590/1519-6984.186565. [PMID: 31017181] - Deepika Singh, Ekta Yadav, Neha Falls, Vikas Kumar, Manvendra Singh, Amita Verma. Phytofabricated silver nanoparticles of Phyllanthus emblica attenuated diethylnitrosamine-induced hepatic cancer via knock-down oxidative stress and inflammation.
Inflammopharmacology.
2019 Oct; 27(5):1037-1054. doi:
10.1007/s10787-018-0525-6. [PMID: 30219979] - Dinala Qiarefuhan, Mireayi Yalikun, Tailiaiti Tuerhong, Akilzaman Mamat, Batur Mamtimin. [Effect of diethylnitrosamine on renal metabolic pathway in rats].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2019 Sep; 44(9):990-995. doi:
10.11817/j.issn.1672-7347.2019.180518. [PMID: 31645487] - Uzma Latief, Mohammad Faisal Umar, Riaz Ahmad. Nrf2 protein as a therapeutic target during diethylnitrosamine-induced liver injury ameliorated by β-carotene-reduced graphene oxide (βC-rGO) nanocomposite.
International journal of biological macromolecules.
2019 Sep; 137(?):346-357. doi:
10.1016/j.ijbiomac.2019.06.219. [PMID: 31260769] - Angélique Gougelet, Chiara Sartor, Nadia Senni, Julien Calderaro, Laetitia Fartoux, Marie Lequoy, Dominique Wendum, Jean-Noël Talbot, Aurélie Prignon, Julia Chalaye, Sandrine Imbeaud, Jessica Zucman-Rossi, Thierry Tordjmann, Cécile Godard, Pascale Bossard, Olivier Rosmorduc, Giuliana Amaddeo, Sabine Colnot. Hepatocellular Carcinomas With Mutational Activation of Beta-Catenin Require Choline and Can Be Detected by Positron Emission Tomography.
Gastroenterology.
2019 09; 157(3):807-822. doi:
10.1053/j.gastro.2019.05.069. [PMID: 31194980] - Marwa M Mohammed, Gamal Ramadan, Mona K Zoheiry, Nadia M El-Beih. Antihepatocarcinogenic activity of whey protein concentrate and lactoferrin in diethylnitrosamine-treated male albino mice.
Environmental toxicology.
2019 Sep; 34(9):1025-1033. doi:
10.1002/tox.22773. [PMID: 31087429]