1-Hydroxyisoquinoline (BioDeep_00000003967)

 

Secondary id: BioDeep_00001868896

human metabolite blood metabolite


代谢物信息卡片


1,2-dihydroisoquinolin-1-one

化学式: C9H7NO (145.0528)
中文名称: 2H-异喹啉-1-酮, 异喹诺酮
谱图信息: 最多检出来源 Homo sapiens(blood) 26.64%

分子结构信息

SMILES: C1=CC=C2C(=C1)C=CNC2=O
InChI: InChI=1S/C9H7NO/c11-9-8-4-2-1-3-7(8)5-6-10-9/h1-6H,(H,10,11)

描述信息

CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 70
COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

7 个代谢物同义名

1,2-dihydroisoquinolin-1-one; ISOQUINOLIN-1(2H)-ONE; 1-Hydroxyisoquinoline; 1(2H)-Isoquinolinone; Isocarbostyril; Isoquinolone; Isocarbostyril



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 CASP3, MDM2, PDE4D, PIK3CA, TFDP3, TNKS, TNKS2
Peripheral membrane protein 3 ACHE, PTPMT1, TNKS
Nucleus 11 ACHE, CASP3, MDM2, NR5A1, PARP1, PDE4B, PDE4D, PTPMT1, TFDP3, TNKS, TNKS2
cytosol 9 CASP3, MDM2, NR5A1, PARP1, PDE4B, PDE4D, PIK3CA, TNKS, TNKS2
dendrite 2 HTR2A, HTR2C
nuclear body 3 LPAR4, PARP1, TNKS
centrosome 2 PDE4B, PDE4D
nucleoplasm 5 CASP3, MDM2, NR5A1, PARP1, TNKS
RNA polymerase II transcription regulator complex 1 NR5A1
Cell membrane 8 ACHE, HTR2A, HTR2C, ITGAM, KCNH2, LPAR5, PDE4B, TNF
lamellipodium 1 PIK3CA
Cell projection, axon 1 HTR2A
Multi-pass membrane protein 4 HTR2A, HTR2C, KCNH2, LPAR5
Golgi apparatus membrane 1 TNKS
Synapse 2 ACHE, HTR2C
cell surface 4 ACHE, ITGAM, KCNH2, TNF
dendritic shaft 1 HTR2A
glutamatergic synapse 3 CASP3, HTR2A, MDM2
Golgi apparatus 2 ACHE, TNKS
Golgi membrane 2 TNKS, TNKS2
mitochondrial inner membrane 1 PTPMT1
neuromuscular junction 1 ACHE
neuronal cell body 3 CASP3, HTR2A, TNF
presynaptic membrane 1 HTR2A
synaptic vesicle 1 PDE4B
Cytoplasm, cytosol 1 PARP1
Presynapse 1 HTR2A
plasma membrane 11 ACHE, HTR2A, HTR2C, ITGAM, KCNH2, LPAR4, LPAR5, MDM2, PDE4D, PIK3CA, TNF
Membrane 6 ACHE, ITGAM, KCNH2, LPAR5, PARP1, PDE4D
apical plasma membrane 1 PDE4D
axon 1 HTR2A
caveola 1 HTR2A
extracellular exosome 1 ITGAM
extracellular space 4 ACHE, CTRL, ITGAM, TNF
perinuclear region of cytoplasm 6 ACHE, KCNH2, PDE4B, PDE4D, PIK3CA, TNKS2
intercalated disc 1 PIK3CA
mitochondrion 2 PARP1, PTPMT1
protein-containing complex 2 MDM2, PARP1
intracellular membrane-bounded organelle 1 LPAR4
postsynaptic density 3 CASP3, MDM2, PDE4B
Single-pass type I membrane protein 1 ITGAM
Secreted 1 ACHE
extracellular region 2 ACHE, TNF
excitatory synapse 1 PDE4B
Extracellular side 1 ACHE
transcription regulator complex 2 PARP1, TFDP3
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 PDE4D, TNKS
nuclear membrane 1 TNKS
external side of plasma membrane 2 ITGAM, TNF
dendritic spine 1 PDE4B
Z disc 1 PDE4B
cytoplasmic vesicle 1 HTR2A
nucleolus 2 MDM2, PARP1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 HTR2A
Apical cell membrane 1 PDE4D
Mitochondrion inner membrane 1 PTPMT1
Matrix side 1 PTPMT1
Membrane raft 2 ITGAM, TNF
Cytoplasm, cytoskeleton 1 PDE4D
basement membrane 1 ACHE
chromatin 3 NR5A1, PARP1, TFDP3
phagocytic cup 1 TNF
Chromosome 1 PARP1
Nucleus, nucleolus 2 MDM2, PARP1
nuclear replication fork 1 PARP1
Chromosome, telomere 2 TNKS, TNKS2
chromosome, telomeric region 3 PARP1, TNKS, TNKS2
Lipid-anchor, GPI-anchor 1 ACHE
site of double-strand break 1 PARP1
Cytoplasm, cytoskeleton, spindle pole 1 TNKS
Nucleus, nuclear pore complex 1 TNKS
nuclear envelope 2 PARP1, TNKS2
nuclear pore 1 TNKS
Membrane, caveola 1 HTR2A
monoatomic ion channel complex 1 KCNH2
cell body fiber 1 HTR2A
Nucleus, nucleoplasm 1 MDM2
Cell projection, dendrite 1 HTR2A
specific granule membrane 1 ITGAM
tertiary granule membrane 1 ITGAM
side of membrane 1 ACHE
inward rectifier potassium channel complex 1 KCNH2
voltage-gated potassium channel complex 1 KCNH2
plasma membrane raft 1 ITGAM
transcription repressor complex 1 MDM2
voltage-gated calcium channel complex 2 PDE4B, PDE4D
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endocytic vesicle membrane 1 MDM2
mitotic spindle pole 1 TNKS
neurofilament 1 HTR2A
calcium channel complex 1 PDE4D
synaptic cleft 1 ACHE
protein-DNA complex 1 PARP1
death-inducing signaling complex 1 CASP3
pericentriolar material 2 TNKS, TNKS2
site of DNA damage 1 PARP1
integrin complex 1 ITGAM
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
integrin alphaM-beta2 complex 1 ITGAM
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
[Isoform H]: Cell membrane 1 ACHE
gamma-tubulin complex 1 PDE4B
G protein-coupled serotonin receptor complex 2 HTR2A, HTR2C
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[Isoform PDE4B5]: Cytoplasm 1 PDE4B
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Subhash C Joshi, Chandra S Mathela. Antioxidant and antibacterial activities of the leaf essential oil and its constituents furanodienone and curzerenone from Lindera pulcherrima (Nees.) Benth. ex hook. f. Pharmacognosy research. 2012 Apr; 4(2):80-4. doi: 10.4103/0974-8490.94721. [PMID: 22518079]
  • Andrew J McKenzie, Shirley L Campbell, Alan K Howe. Protein kinase A activity and anchoring are required for ovarian cancer cell migration and invasion. PloS one. 2011; 6(10):e26552. doi: 10.1371/journal.pone.0026552. [PMID: 22028904]
  • Ai Hua Zhang, Nan Jiang, Wen Gu, Jing Ma, Yu Rong Wang, Yong Chun Song, Ren Xiang Tan. Characterization, synthesis and self-aggregation of (-)-alternarlactam: a new fungal cytotoxin with cyclopentenone and isoquinolinone scaffolds. Chemistry (Weinheim an der Bergstrasse, Germany). 2010 Dec; 16(48):14479-85. doi: 10.1002/chem.201002205. [PMID: 21038331]
  • Chanhui Lee, Quincy Teng, Wenlin Huang, Ruiqin Zhong, Zheng-Hua Ye. The Arabidopsis family GT43 glycosyltransferases form two functionally nonredundant groups essential for the elongation of glucuronoxylan backbone. Plant physiology. 2010 Jun; 153(2):526-41. doi: 10.1104/pp.110.155309. [PMID: 20335400]
  • El-Hadi M Ahmed, Bakri Y M Nour, Yousif G Mohammed, Hassan S Khalid. Antiplasmodial Activity of Some Medicinal Plants Used in Sudanese Folk-medicine. Environmental health insights. 2010 02; 4(?):1-6. doi: 10.4137/ehi.s4108. [PMID: 20523878]
  • Axel Teichert, Jürgen Schmidt, Andrea Porzel, Norbert Arnold, Ludger Wessjohann. (Iso)-quinoline alkaloids from fungal fruiting bodies of Cortinarius subtortus. Journal of natural products. 2008 Jun; 71(6):1092-4. doi: 10.1021/np8000859. [PMID: 18447384]
  • Christopher P Regan, Laszlo Kiss, Gary L Stump, Charles J McIntyre, Douglas C Beshore, Nigel J Liverton, Christopher J Dinsmore, Joseph J Lynch. Atrial antifibrillatory effects of structurally distinct IKur blockers 3-[(dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in dogs with underlying heart failure. The Journal of pharmacology and experimental therapeutics. 2008 Jan; 324(1):322-30. doi: 10.1124/jpet.107.127654. [PMID: 17967939]
  • Virginia M Zaleskas, Daniela S Krause, Katherine Lazarides, Nihal Patel, Yiguo Hu, Shaoguang Li, Richard A Van Etten. Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F. PloS one. 2006 Dec; 1(?):e18. doi: 10.1371/journal.pone.0000018. [PMID: 17183644]
  • Chen Xie, Nigel C Veitch, Peter J Houghton, Monique S J Simmonds. Flavonoid glycosides and isoquinolinone alkaloids from Corydalis bungeana. Phytochemistry. 2004 Nov; 65(22):3041-7. doi: 10.1016/j.phytochem.2004.09.009. [PMID: 15504439]