Mahanimbine (BioDeep_00000395594)

natural product PANOMIX_OTCML-2023

代谢物信息卡片

Mahanimbine

化学式: C23H25NO (331.1936)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)=CCCC1(C)C=Cc2c(c(C)cc3c2[nH]c2ccccc23)O1
InChI: InChI=1S/C23H25NO/c1-15(2)8-7-12-23(4)13-11-18-21-19(14-16(3)22(18)25-23)17-9-5-6-10-20(17)24-21/h5-6,8-11,13-14,24H,7,12H2,1-4H3

描述信息

同义名列表

2 个代谢物同义名

Mahanimbine; Mahanimbine

数据库引用编号

14 个数据库交叉引用编号

ChEBI: CHEBI:6646
KEGG: C09220
PubChem: 167963
ChEMBL: CHEMBL495873
CAS: 24948-14-9
CAS: 21104-28-9
MoNA: Bruker_HCD_library000735
medchemexpress: HY-124557
PubChem: 11411
KNApSAcK: C00001745
3DMET: B05337
NIKKAJI: J15.919K
KNApSAcK: 6646
LOTUS: LTS0232887

分类词条

Carbazole alkaloids

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

42 个相关的物种来源信息

2478535 - Bergera: LTS0232887
76958 - Clausena: LTS0232887
76959 - Clausena excavata: 10.1248/CPB.45.48
76959 - Clausena excavata: LTS0232887
2759 - Eukaryota: LTS0232887
3398 - Magnoliopsida: LTS0232887
43710 - Murraya: LTS0232887
1224773 - Murraya euchrestifolia:
1224773 - Murraya euchrestifolia: 10.1002/(SICI)1099-1573(1998)12:1+3.0.CO;2-#
1224773 - Murraya euchrestifolia: 10.1016/0031-9422(91)85313-O
1224773 - Murraya euchrestifolia: 10.1016/0031-9422(95)00447-F
1224773 - Murraya euchrestifolia: 10.1016/0031-9422(95)00794-6
1224773 - Murraya euchrestifolia: 10.1248/CPB.33.4132
1224773 - Murraya euchrestifolia: 10.1248/CPB.39.1668
1224773 - Murraya euchrestifolia: 10.1248/CPB.40.230
1224773 - Murraya euchrestifolia: LTS0232887
159059 - Murraya exotica: 10.1016/0031-9422(91)85313-O
2901850 - Murraya exotica: LTS0232887
159030 - Murraya koenigii:
159030 - Murraya koenigii: 10.1002/CHIN.199808206
159030 - Murraya koenigii: 10.1002/PTR.3023
159030 - Murraya koenigii: 10.1016/0031-9422(91)85313-O
159030 - Murraya koenigii: 10.1016/0031-9422(92)83651-E
159030 - Murraya koenigii: 10.1016/J.BMC.2013.01.012
159030 - Murraya koenigii: 10.1016/J.PHYTOCHEM.2005.05.001
159030 - Murraya koenigii: 10.1016/S0031-9422(00)90494-1
159030 - Murraya koenigii: 10.1016/S0040-4020(01)92976-X
159030 - Murraya koenigii: 10.1016/S0378-8741(01)00247-1
159030 - Murraya koenigii: 10.1021/JF010621R
159030 - Murraya koenigii: 10.1021/JF9805808
159030 - Murraya koenigii: 10.1021/NP990570G
159030 - Murraya koenigii: 10.1248/CPB.41.2096
159030 - Murraya koenigii: 10.3390/MOLECULES16119651
159030 - Murraya koenigii: LTS0232887
43711 - Murraya paniculata: 10.1016/0031-9422(91)85313-O
43711 - Murraya paniculata: LTS0232887
159029 - Murraya siamensis: 10.1021/NP990570G
159029 - Murraya siamensis: LTS0232887
23513 - Rutaceae: LTS0232887
35493 - Streptophyta: LTS0232887
58023 - Tracheophyta: LTS0232887
33090 - Viridiplantae: LTS0232887

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位		关联基因列表
Cytoplasm	10	ANXA5, BCL2, CASP3, CASP7, CASP9, DCTN4, ESR1, MTOR, PTGS2, STAT3
Peripheral membrane protein	4	ANXA5, ESR1, MTOR, PTGS2
Endoplasmic reticulum membrane	3	BCL2, MTOR, PTGS2
Nucleus	8	BCL2, CASP3, CASP7, CASP9, DCTN4, ESR1, MTOR, STAT3
autophagosome	1	MAP1LC3A
cytosol	10	ANXA5, BCL2, CASP3, CASP7, CASP9, DCTN4, ESR1, MAP1LC3A, MTOR, STAT3
dendrite	1	MTOR
phagocytic vesicle	1	MTOR
centrosome	1	DCTN4
nucleoplasm	6	ATP2B1, CASP3, CASP7, ESR1, MTOR, STAT3
RNA polymerase II transcription regulator complex	1	STAT3
Cell membrane	2	ATP2B1, ESR1
Lipid-anchor	1	MAP1LC3A
Cytoplasmic side	2	ESR1, MTOR
Early endosome membrane	1	GPNMB
Multi-pass membrane protein	1	ATP2B1
Golgi apparatus membrane	1	MTOR
Synapse	1	ATP2B1
cell cortex	1	DCTN4
glutamatergic synapse	3	ATP2B1, CASP3, MAP1LC3A
Golgi apparatus	1	ESR1
Golgi membrane	2	INS, MTOR
lysosomal membrane	1	MTOR
neuronal cell body	1	CASP3
presynaptic membrane	1	ATP2B1
sarcolemma	1	ANXA5
Cytoplasm, cytosol	1	CASP7
Lysosome	1	MTOR
plasma membrane	4	ATP2B1, ESR1, GPNMB, STAT3
synaptic vesicle membrane	1	ATP2B1
Membrane	6	ANXA5, ATP2B1, BCL2, ESR1, GPNMB, MTOR
basolateral plasma membrane	1	ATP2B1
caveola	1	PTGS2
extracellular exosome	2	ANXA5, ATP2B1
Lysosome membrane	1	MTOR
endoplasmic reticulum	2	BCL2, PTGS2
extracellular space	3	CASP7, INS, PNLIP
mitochondrion	2	BCL2, CASP9
protein-containing complex	4	BCL2, CASP9, ESR1, PTGS2
intracellular membrane-bounded organelle	2	ATP2B1, MAP1LC3A
Microsome membrane	2	MTOR, PTGS2
postsynaptic density	1	CASP3
TORC1 complex	1	MTOR
TORC2 complex	1	MTOR
Single-pass type I membrane protein	1	GPNMB
Secreted	3	HTRA3, INS, PNLIP
extracellular region	4	ANXA5, HTRA3, INS, PNLIP
Mitochondrion outer membrane	2	BCL2, MTOR
Single-pass membrane protein	1	BCL2
mitochondrial outer membrane	2	BCL2, MTOR
transcription regulator complex	2	ESR1, STAT3
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome	1	DCTN4
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane	1	ATP2B1
Nucleus membrane	1	BCL2
Bcl-2 family protein complex	1	BCL2
nuclear membrane	1	BCL2
external side of plasma membrane	1	ANXA5
Melanosome membrane	1	GPNMB
pore complex	1	BCL2
Cytoplasm, cytoskeleton	2	DCTN4, MAP1LC3A
focal adhesion	2	ANXA5, DCTN4
microtubule	1	MAP1LC3A
Nucleus, PML body	1	MTOR
PML body	1	MTOR
collagen-containing extracellular matrix	1	ANXA5
lateral plasma membrane	1	ATP2B1
Nucleus inner membrane	1	PTGS2
Nucleus outer membrane	1	PTGS2
nuclear inner membrane	1	PTGS2
nuclear outer membrane	1	PTGS2
Cytoplasm, myofibril, sarcomere	1	DCTN4
Late endosome	1	MAP1LC3A
sarcomere	1	DCTN4
Zymogen granule membrane	1	ANXA5
neuron projection	1	PTGS2
chromatin	2	ESR1, STAT3
Cytoplasmic vesicle, autophagosome membrane	1	MAP1LC3A
autophagosome membrane	1	MAP1LC3A
cell projection	1	ATP2B1
Secreted, extracellular space	1	CASP7
spindle pole	1	DCTN4
Cytoplasm, cell cortex	1	DCTN4
Basolateral cell membrane	1	ATP2B1
organelle membrane	1	MAP1LC3A
nuclear envelope	1	MTOR
Endomembrane system	2	MAP1LC3A, MTOR
endosome lumen	1	INS
euchromatin	1	ESR1
Presynaptic cell membrane	1	ATP2B1
myelin sheath	1	BCL2
stress fiber	1	DCTN4
secretory granule lumen	1	INS
Golgi lumen	1	INS
endoplasmic reticulum lumen	2	INS, PTGS2
dynactin complex	1	DCTN4
kinetochore	1	DCTN4
transport vesicle	1	INS
Endoplasmic reticulum-Golgi intermediate compartment membrane	1	INS
immunological synapse	1	ATP2B1
cytoplasmic dynein complex	1	DCTN4
apoptosome	1	CASP9
vesicle membrane	1	ANXA5
Cytoplasm, cytoskeleton, stress fiber	1	DCTN4
[Isoform 1]: Nucleus	1	ESR1
death-inducing signaling complex	1	CASP3
Cytoplasmic vesicle, phagosome	1	MTOR
Autolysosome	1	MAP1LC3A
endothelial microparticle	1	ANXA5
BAD-BCL-2 complex	1	BCL2
photoreceptor ribbon synapse	1	ATP2B1
caspase complex	1	CASP9

文献列表

Yahya Hasan Hobani. Cytotoxicity of Mahanimbine from Curry Leaves in Human Breast Cancer Cells (MCF-7) via Mitochondrial Apoptosis and Anti-Angiogenesis. Molecules (Basel, Switzerland). 2022 Feb; 27(3):. doi: 10.3390/molecules27030971. [PMID: 35164236]
Chenlin Pei, Qun He, Shuai Liang, Xuejun Gong. Mahanimbine Exerts Anticancer Effects on Human Pancreatic Cancer Cells by Triggering Cell Cycle Arrest, Apoptosis, and Modulation of AKT/Mammalian Target of Rapamycin (mTOR) and Signal Transducer and Activator of Transcription 3 (STAT3) Signalling Pathways. Medical science monitor : international medical journal of experimental and clinical research. 2018 Oct; 24(?):6975-6983. doi: 10.12659/msm.911013. [PMID: 30273298]
Pragya Sharma, Sonali Batra, Ashwani Kumar, Anupam Sharma. In vivo antianxiety and antidepressant activity of Murraya paniculata leaf extracts. Journal of integrative medicine. 2017 07; 15(4):320-325. doi: 10.1016/s2095-4964(17)60352-2. [PMID: 28659237]
Sneha Jagtap, Pragyanshu Khare, Priyanka Mangal, Kanthi Kiran Kondepudi, Mahendra Bishnoi, Kamlesh Kumar Bhutani. Effect of mahanimbine, an alkaloid from curry leaves, on high-fat diet-induced adiposity, insulin resistance, and inflammatory alterations. BioFactors (Oxford, England). 2017 Mar; 43(2):220-231. doi: 10.1002/biof.1333. [PMID: 27663177]
Jyoti Dahiya, Jitender Singh, Ashwani Kumar, Anupam Sharma. Isolation, characterization and quantification of an anxiolytic constituent - mahanimbine, from Murraya koenigii Linn. Spreng Leaves. Journal of ethnopharmacology. 2016 Dec; 193(?):706-711. doi: 10.1016/j.jep.2016.10.014. [PMID: 27737817]
Seikou Nakamura, Souichi Nakashima, Yoshimi Oda, Nami Yokota, Katsuyoshi Fujimoto, Takahiro Matsumoto, Tomoe Ohta, Keiko Ogawa, Sayuri Maeda, Shino Nishida, Hisashi Matsuda, Masayuki Yoshikawa. Alkaloids from Sri Lankan curry-leaf (Murraya koenigii) display melanogenesis inhibitory activity: structures of karapinchamines A and B. Bioorganic & medicinal chemistry. 2013 Mar; 21(5):1043-9. doi: 10.1016/j.bmc.2013.01.012. [PMID: 23376010]
Thilahgavani Nagappan, Thirukanthan Chandra Segaran, Mohd Effendy Abdul Wahid, Perumal Ramasamy, Charles S Vairappan. Efficacy of carbazole alkaloids, essential oil and extract of Murraya koenigii in enhancing subcutaneous wound healing in rats. Molecules (Basel, Switzerland). 2012 Dec; 17(12):14449-63. doi: 10.3390/molecules171214449. [PMID: 23519245]
Subrata Pandit, Mythies Kumar, S Ponnusankar, B C Pal, Pulok K Mukherjee. RP-HPLC-DAD for simultaneous estimation of mahanine and mahanimbine in Murraya koenigii. Biomedical chromatography : BMC. 2011 Sep; 25(9):959-62. doi: 10.1002/bmc.1561. [PMID: 21381062]
Rahul Birari, Vishal Javia, Kamlesh Kumar Bhutani. Antiobesity and lipid lowering effects of Murraya koenigii (L.) Spreng leaves extracts and mahanimbine on high fat diet induced obese rats. Fitoterapia. 2010 Dec; 81(8):1129-33. doi: 10.1016/j.fitote.2010.07.013. [PMID: 20655993]
J D Coonrod, R P Leach. Antigenemia in fulminant pneumococcemia. Annals of internal medicine. 1976 May; 84(5):561-3. doi: 10.7326/0003-4819-84-5-561. [PMID: 5936]