Platycodin_D (BioDeep_00000000386)
PANOMIX_OTCML-2023
代谢物信息卡片
Olean-12-en-28-oic acid, 3-(beta-D-glucopyranosyloxy)-2,16,23,24-tetrahydroxy-, O-D-apio-beta-D-furanosyl-(1-3)-O-beta-D-xylopyranosyl-(1-4)-O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-L-arabinopyranosyl ester, (2beta,3beta,16alpha)-
化学式: C57H92O28 (1224.5774832)
中文名称: 桔梗皂苷 D, 桔梗皂苷D, 桔梗皂苷 D
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C(C(C(C(O1)OC2C(C(COC2OC(=O)C34CCC(CC3C5=CCC6C(C5(CC4O)C)(CCC7C6(CC(C(C7(CO)CO)OC8C(C(C(C(O8)CO)O)O)O)O)C)C)(C)C)O)O)O)O)OC9C(C(C(CO9)O)OC1C(C(CO1)(CO)O)O)O
InChI: InChI=1S/C57H92O28/c1-23-40(81-45-39(72)41(28(64)18-76-45)82-49-43(73)56(75,21-61)22-78-49)36(69)38(71)46(79-23)83-42-33(66)27(63)17-77-48(42)85-50(74)57-12-11-51(2,3)13-25(57)24-7-8-30-52(4)14-26(62)44(84-47-37(70)35(68)34(67)29(16-58)80-47)55(19-59,20-60)31(52)9-10-53(30,5)54(24,6)15-32(57)65/h7,23,25-49,58-73,75H,8-22H2,1-6H3/t23-,25-,26-,27-,28+,29+,30+,31+,32+,33-,34+,35-,36-,37+,38+,39+,40-,41-,42+,43-,44-,45-,46-,47-,48-,49-,52+,53+,54+,56+,57+/m0/s1
描述信息
Platycodin D is a triterpenoid saponin. It has a role as a metabolite.
Platycodin D is a natural product found in Platycodon grandiflorus with data available.
A natural product found in Platycodon grandiflorum.
Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D[1][2].
Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D[1][2].
Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D[1][2].
同义名列表
10 个代谢物同义名
Olean-12-en-28-oic acid, 3-(beta-D-glucopyranosyloxy)-2,16,23,24-tetrahydroxy-, O-D-apio-beta-D-furanosyl-(1-3)-O-beta-D-xylopyranosyl-(1-4)-O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-L-arabinopyranosyl ester, (2beta,3beta,16alpha)-; SINGLEEX PLATYCODIN D 98; PLATYCODIN D [INCI]; UNII-CWJ06TA2GI; Platycodin-D; Platycodin D; PlatycodinD; Platycodin; CWJ06TA2GI; LS-15514
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:70436
- KEGG: C17410
- PubChem: 162859
- PubChem: 75251600
- Metlin: METLIN71670
- ChEMBL: CHEMBL1641859
- Wikipedia: Platycodin_D
- MeSH: platycodin D
- ChemIDplus: 0058479688
- chemspider: 142975
- CAS: 58479-68-8
- medchemexpress: HY-N1411
- PMhub: MS000025776
- MetaboLights: MTBLC70436
- PubChem: 96023760
- NIKKAJI: J936.354H
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
6 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Weichen Xu, Shasha Han, Wenying Wang, Zichen Luo, Xuan Wang, Chen Shi, Jinjun Shan. Analysis of gut microbiota metabolites of platycodin D and activity verification.
Journal of pharmaceutical and biomedical analysis.
2024 May; 242(?):116016. doi:
10.1016/j.jpba.2024.116016. [PMID: 38367521] - Tan Yang, Xiaotong Zhao, Qing Sun, Yanqing Zhang, Junbo Xie. Elucidating the anti-inflammatory activity of platycodins in lung inflammation through pulmonary distribution dynamics and grey relational analysis of cytokines.
Journal of ethnopharmacology.
2024 Apr; 323(?):117706. doi:
10.1016/j.jep.2024.117706. [PMID: 38176670] - Yanmin Song, Peilin Lv, Jingni Yu. Platycodin D inhibits diabetic retinopathy via suppressing TLR4/MyD88/NF-κB signaling pathway and activating Nrf2/HO-1 signaling pathway.
Chemical biology & drug design.
2024 Jan; 103(1):e14419. doi:
10.1111/cbdd.14419. [PMID: 38230792] - Peiting Li, Ying Huang, Ju Wang, Jiashun Zeng, Long Li. Platycodin D relieves rheumatoid arthritis by promoting apoptosis of mitochondria to inhibit activation of hedgehog pathway.
Autoimmunity.
2023 Dec; 56(1):2205053. doi:
10.1080/08916934.2023.2205053. [PMID: 37138547] - Meixi Zhang, Yushu Xing, Jiannan Ma, Ying Zhang, Juan Yu, Xiaoqin Wang, Xin Jia. Investigation of the response of Platycodongrandiflorus (Jacq.) A. DC to salt stress using combined transcriptomics and metabolomics.
BMC plant biology.
2023 Nov; 23(1):589. doi:
10.1186/s12870-023-04536-w. [PMID: 38001405] - Linlin Jiang, Hui Niu, Yuan Chen, Xing Li, Yulian Zhao, Chunhong Zhang, Minhui Li. Quality control of Platycodon grandiflorum (Jacq.) A. DC. based on value chains and food chain analysis.
Scientific reports.
2023 Aug; 13(1):14048. doi:
10.1038/s41598-023-41013-8. [PMID: 37640759] - Xia Jiang, Ye Lin, Mengting Zhao, Youhong Li, Peipei Ye, Renzhi Pei, Ying Lu, Lei Jiang. Platycodin D induces apoptotic cell death through PI3K/AKT and MAPK/ERK pathways and synergizes with venetoclax in acute myeloid leukemia.
European journal of pharmacology.
2023 Aug; 956(?):175957. doi:
10.1016/j.ejphar.2023.175957. [PMID: 37541375] - Qin Si, Longga Su, Dong Wang, Bao-Jun De, Risu Na, Nagongbilige He, Tserentsoo Byambaa, Tserendagva Dalkh, Xilinqiqige Bao, Letai Yi. An evaluation of the qualitative superiority of the Mongolian medicinal herb hurdan-tsagaan (Platycodi Radix) from five different geographic origins based on anti-inflammatory effects.
Journal of ethnopharmacology.
2023 Jun; 310(?):116331. doi:
10.1016/j.jep.2023.116331. [PMID: 36931411] - Yongming Lv, Wenhong Wang, Yanfei Liu, Ben Yi, Tianhao Chu, Zhiqiang Feng, Jun Liu, Xuehua Wan, Yijia Wang. Platycodin D represses β-catenin to suppress metastasis of cetuximab-treated KRAS wild-type colorectal cancer cells.
Clinical & experimental metastasis.
2023 Jun; ?(?):. doi:
10.1007/s10585-023-10218-6. [PMID: 37326719] - Qiong Shen, Si-Min Qi, Jing-Tian Zhang, Ming-Han Li, Ying-Ping Wang, Zi Wang, Wei Li. Platycodin D inhibits HFD/STZ-induced diabetic nephropathy via inflammatory and apoptotic signaling pathways in C57BL/6 mice.
Journal of ethnopharmacology.
2023 May; ?(?):116596. doi:
10.1016/j.jep.2023.116596. [PMID: 37146841] - Yuan-Han Zhong, Jian Liang, Qian Qin, Yu-Jie Wang, Yi-Ming Peng, Ting Zhang, Fang-Yuan Liu, Xin-Yu Zhang, Jun-Wei He, Shou-Wen Zhang, Guo-Yue Zhong, Hui-Lian Huang, Jin-Xiang Zeng. The activities and mechanisms of intestinal microbiota metabolites of TCM herbal ingredients could be illustrated by a strategy integrating spectrum-effects, network pharmacology, metabolomics and molecular docking analysis: Platycodin D as an example.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Apr; 115(?):154831. doi:
10.1016/j.phymed.2023.154831. [PMID: 37094423] - Yiyi Ye, Ying Xie, Lixia Pei, Ziwei Jiang, Chunyu Wu, Sheng Liu. Platycodin D induces neutrophil apoptosis by downregulating PD-L1 expression to inhibit breast cancer pulmonary metastasis.
International immunopharmacology.
2023 Feb; 115(?):109733. doi:
10.1016/j.intimp.2023.109733. [PMID: 37724959] - Qiong Shen, Yu-Te Zhong, Xiang-Xiang Liu, Jun-Nan Hu, Si-Min Qi, Ke Li, Zi Wang, Hong-Yan Zhu, Xin-Dian Li, Ying-Ping Wang, Wei Li. Platycodin D ameliorates hyperglycaemia and liver metabolic disturbance in HFD/STZ-induced type 2 diabetic mice.
Food & function.
2023 Jan; 14(1):74-86. doi:
10.1039/d2fo03308a. [PMID: 36504256] - Koki Matsuda, Yuka Tanaka, Kazuo Ozaki, Osamu Iida, Makio Shibano. Seasonal variation in the total saponin content of platycodon roots cultivated in Japan.
Journal of natural medicines.
2023 Jan; 77(1):64-72. doi:
10.1007/s11418-022-01646-x. [PMID: 35972637] - Jin Lei, Jian Zhao, Meng-Yi-Chen Long, Xue-Wei Cao, Fu-Jun Wang. In addition to its endosomal escape effect, platycodin D also synergizes with ribosomal inactivation protein to induce apoptosis in hepatoma cells through AKT and MAPK signaling pathways.
Chemico-biological interactions.
2022 Sep; 364(?):110058. doi:
10.1016/j.cbi.2022.110058. [PMID: 35872048] - Jinzhong Huang, Gangyi Chen, Jilei Wang, Shibin Liu, Jing Su. Platycodin D regulates high glucose-induced ferroptosis of HK-2 cells through glutathione peroxidase 4 (GPX4).
Bioengineered.
2022 03; 13(3):6627-6637. doi:
10.1080/21655979.2022.2045834. [PMID: 35226829] - Qianqian Li, Tan Yang, Shuang Zhao, Qifeng Zheng, Yaxin Li, Zhiyuan Zhang, Xiuyan Sun, Yan Liu, Yanqing Zhang, Junbo Xie. Distribution, Biotransformation, Pharmacological Effects, Metabolic Mechanism and Safety Evaluation of Platycodin D: A Comprehensive Review.
Current drug metabolism.
2022; 23(1):21-29. doi:
10.2174/1389200223666220202090137. [PMID: 35114917] - Jinyang Shen, Yuexia Zhu, Bingxue Zhou, Li Kong, Ye Jin, Di Zhang, Zhiling Cao, Jing Ji, Jiaojiao Li. In vitro and in vivo evaluation of a water-in-oil microemulsion of platycodin D.
Archiv der Pharmazie.
2021 Aug; 354(8):e2000497. doi:
10.1002/ardp.202000497. [PMID: 33844326] - Yongcan Wu, Demei Huang, Xiaomin Wang, Caixia Pei, Wei Xiao, Fei Wang, Zhenxing Wang. Suppression of NLRP3 inflammasome by Platycodin D via the TLR4/MyD88/NF-κB pathway contributes to attenuation of lipopolysaccharide induced acute lung injury in rats.
International immunopharmacology.
2021 Jul; 96(?):107621. doi:
10.1016/j.intimp.2021.107621. [PMID: 33872850] - Tai Young Kim, Sangeun Jeon, Youngho Jang, Lizaveta Gotina, Joungha Won, Yeon Ha Ju, Sunpil Kim, Minwoo Wendy Jang, Woojin Won, Mingu Gordon Park, Ae Nim Pae, Sunkyu Han, Seungtaek Kim, C Justin Lee. Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion.
Experimental & molecular medicine.
2021 05; 53(5):956-972. doi:
10.1038/s12276-021-00624-9. [PMID: 34035463] - Katarzyna Stępnik. Biomimetic Chromatographic Studies Combined with the Computational Approach to Investigate the Ability of Triterpenoid Saponins of Plant Origin to Cross the Blood-Brain Barrier.
International journal of molecular sciences.
2021 Mar; 22(7):. doi:
10.3390/ijms22073573. [PMID: 33808219] - Jing Zhang, Na Song, Yuzhi Liu, Junwei Guo. Platycodin D Inhibits β-Amyloid-Induced Inflammation and Oxidative Stress in BV-2 Cells Via Suppressing TLR4/NF-κB Signaling Pathway and Activating Nrf2/HO-1 Signaling Pathway.
Neurochemical research.
2021 Mar; 46(3):638-647. doi:
10.1007/s11064-020-03198-6. [PMID: 33394221] - Wei-Chung Hsu, Samiraj Ramesh, Marthandam Asokan Shibu, Ming-Cheng Chen, Tso-Fu Wang, Cecilia Hsuan Day, Ray-Jade Chen, V Vijaya Padma, Chi-Cheng Li, Yu-Chen Tseng, Chih-Yang Huang. Platycodin D reverses histone deacetylase inhibitor resistance in hepatocellular carcinoma cells by repressing ERK1/2-mediated cofilin-1 phosphorylation.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Feb; 82(?):153442. doi:
10.1016/j.phymed.2020.153442. [PMID: 33412494] - Jun-Nan Hu, Jing Leng, Qiong Shen, Ying Liu, Xin-Dian Li, Shi-Han Wang, Hui-Ping Li, Zi Wang, Ying-Ping Wang, Wei Li. Platycodin D suppresses cisplatin-induced cytotoxicity by suppressing ROS-mediated oxidative damage, apoptosis, and inflammation in HEK-293 cells.
Journal of biochemical and molecular toxicology.
2021 Jan; 35(1):e22624. doi:
10.1002/jbt.22624. [PMID: 32881195] - Yu-Jeong Choi, Sol Ji Lee, Hyo In Kim, Hee Jung Lee, So Jung Kang, Tai Young Kim, Chunhoo Cheon, Seong-Gyu Ko. Platycodin D enhances LDLR expression and LDL uptake via down-regulation of IDOL mRNA in hepatic cells.
Scientific reports.
2020 11; 10(1):19834. doi:
10.1038/s41598-020-76224-w. [PMID: 33199761] - Christian Bailly, Gérard Vergoten. Proposed mechanisms for the extracellular release of PD-L1 by the anticancer saponin platycodin D.
International immunopharmacology.
2020 Aug; 85(?):106675. doi:
10.1016/j.intimp.2020.106675. [PMID: 32531711] - Yong-Mei Liu, Shuo Cong, Zhuo Cheng, Ya-Xin Hu, Yu Lei, Li-Li Zhu, Xue-Ke Zhao, Mao Mu, Bao-Fang Zhang, Lin-da Fan, Lei Yu, Ming-Liang Cheng. Platycodin D alleviates liver fibrosis and activation of hepatic stellate cells by regulating JNK/c-JUN signal pathway.
European journal of pharmacology.
2020 Jun; 876(?):172946. doi:
10.1016/j.ejphar.2020.172946. [PMID: 31996320] - Kyung-Chul Shin, Dae Wook Kim, Hyun Sim Woo, Deok-Kun Oh, Yeong-Su Kim. Conversion of Glycosylated Platycoside E to Deapiose-Xylosylated Platycodin D by Cytolase PCL5.
International journal of molecular sciences.
2020 Feb; 21(4):. doi:
10.3390/ijms21041207. [PMID: 32054089] - Chenyang Shi, Qin Li, Xinyue Zhang. Platycodin D Protects Human Fibroblast Cells from Premature Senescence Induced by H2O2 through Improving Mitochondrial Biogenesis.
Pharmacology.
2020; 105(9-10):598-608. doi:
10.1159/000505593. [PMID: 32008007] - Di Wu, Wei Zhang, Ying Chen, Hong Ma, Mengchang Wang. Platycodin D inhibits proliferation, migration and induces chemosensitization through inactivation of the NF-κB and JAK2/STAT3 pathways in multiple myeloma cells.
Clinical and experimental pharmacology & physiology.
2019 12; 46(12):1194-1200. doi:
10.1111/1440-1681.13145. [PMID: 31347196] - Mu-Yang Huang, Xiao-Ming Jiang, Yu-Lian Xu, Luo-Wei Yuan, Yu-Chi Chen, Guozhen Cui, Run-Yue Huang, Bo Liu, Yitao Wang, Xiuping Chen, Jin-Jian Lu. Platycodin D triggers the extracellular release of programed death Ligand-1 in lung cancer cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2019 Sep; 131(?):110537. doi:
10.1016/j.fct.2019.05.045. [PMID: 31150782] - Tae-Geun Kil, Su-Hwan Kang, Tae-Hun Kim, Kyung-Chul Shin, Deok-Kun Oh. Enzymatic Biotransformation of Balloon Flower Root Saponins into Bioactive Platycodin D by Deglucosylation with Caldicellulosiruptor bescii β-Glucosidase.
International journal of molecular sciences.
2019 Aug; 20(16):. doi:
10.3390/ijms20163854. [PMID: 31394870] - Su-Hwan Kang, Tae-Hun Kim, Kyung-Chul Shin, Yoon-Joo Ko, Deok-Kun Oh. Biotransformation of Food-Derived Saponins, Platycosides, into Deglucosylated Saponins Including Deglucosylated Platycodin D and Their Anti-Inflammatory Activities.
Journal of agricultural and food chemistry.
2019 Feb; 67(5):1470-1477. doi:
10.1021/acs.jafc.8b06399. [PMID: 30652865] - Yiyi Ye, Lixia Pei, Jing Ding, Chunyu Wu, Chenping Sun, Sheng Liu. Effects of Platycodin D on S100A8/A9-induced inflammatory response in murine mammary carcinoma 4T1 cells.
International immunopharmacology.
2019 Feb; 67(?):239-247. doi:
10.1016/j.intimp.2018.12.008. [PMID: 30562685] - Hye-Lin Kim, Jinbong Park, Yunu Jung, Kwang Seok Ahn, Jae-Young Um. Platycodin D, a novel activator of AMP-activated protein kinase, attenuates obesity in db/db mice via regulation of adipogenesis and thermogenesis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Jan; 52(?):254-263. doi:
10.1016/j.phymed.2018.09.227. [PMID: 30599906] - Yao Peng, Jing-Ying Fan, Jian Xiong, Yu Lou, Ying Zhu. miR-34a Enhances the Susceptibility of Gastric Cancer to Platycodin D by Targeting Survivin.
Pathobiology : journal of immunopathology, molecular and cellular biology.
2019; 86(5-6):296-305. doi:
10.1159/000502913. [PMID: 31711057] - Mingxin Zhang, Taofeng Du, Feixiang Long, Xia Yang, Yankuo Sun, Mubing Duan, Guihong Zhang, Yahong Liu, En-Min Zhou, Weisan Chen, Jianxin Chen. Platycodin D Suppresses Type 2 Porcine Reproductive and Respiratory Syndrome Virus In Primary and Established Cell Lines.
Viruses.
2018 11; 10(11):. doi:
10.3390/v10110657. [PMID: 30469357] - Cheng-Lin Fu, Ying Liu, Jing Leng, Jing Zhang, Yu-Fang He, Chen Chen, Zi Wang, Wei Li. Platycodin D protects acetaminophen-induced hepatotoxicity by inhibiting hepatocyte MAPK pathway and apoptosis in C57BL/6J mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Nov; 107(?):867-877. doi:
10.1016/j.biopha.2018.08.082. [PMID: 30257399] - Hyung Jin Ahn, Hyun Ju You, Myung Su Park, Tony V Johnston, Seockmo Ku, Geun Eog Ji. Biocatalysis of Platycoside E and Platycodin D3 Using Fungal Extracellular β-Glucosidase Responsible for Rapid Platycodin D Production.
International journal of molecular sciences.
2018 Sep; 19(9):. doi:
10.3390/ijms19092671. [PMID: 30205574] - Su-Yeon Cho, Chang-Hyun Song, Ji-Eun Lee, Seong Hun Choi, Sae-Kwang Ku, Soo-Jin Park. Effects of Platycodin D on Reflux Esophagitis due to Modulation of Antioxidant Defense Systems.
Evidence-based complementary and alternative medicine : eCAM.
2018; 2018(?):7918034. doi:
10.1155/2018/7918034. [PMID: 29770154] - Ting Li, Xin Chen, Xiao-Yang Dai, Bin Wei, Qin-Jie Weng, Xiuping Chen, De-Fang Ouyang, Ru Yan, Zhang-Jian Huang, Hu-Lin Jiang, Hong Zhu, Jin-Jian Lu. Novel Hsp90 inhibitor platycodin D disrupts Hsp90/Cdc37 complex and enhances the anticancer effect of mTOR inhibitor.
Toxicology and applied pharmacology.
2017 09; 330(?):65-73. doi:
10.1016/j.taap.2017.07.006. [PMID: 28711525] - Jaeyoung Kwon, Hyaemin Lee, Nahyun Kim, Je-Hyun Lee, Mi Hee Woo, Jinwoong Kim, Yeong Shik Kim, Dongho Lee. Effect of processing method on platycodin D content in Platycodon grandiflorum roots.
Archives of pharmacal research.
2017 Sep; 40(9):1087-1093. doi:
10.1007/s12272-017-0946-6. [PMID: 28852980] - Yuan-Chuan Lin, Chih-Hsueh Lin, Hsien-Tsung Yao, Wei-Wen Kuo, Chia-Yao Shen, Yu-Lan Yeh, Tsung-Jung Ho, V Vijaya Padma, Yu-Chen Lin, Chih-Yang Huang, Chih-Yang Huang. Platycodon grandiflorum (PG) reverses angiotensin II-induced apoptosis by repressing IGF-IIR expression.
Journal of ethnopharmacology.
2017 Jun; 205(?):41-50. doi:
10.1016/j.jep.2017.04.028. [PMID: 28473244] - Jae Ho Choi, Younho Han, Yong An Kim, Sun Woo Jin, Gi Ho Lee, Hyung Min Jeong, Hyun Sun Lee, Young Chul Chung, Young Chun Lee, Eun Ju Kim, Kwang Youl Lee, Hye Gwang Jeong. Platycodin D Inhibits Osteoclastogenesis by Repressing the NFATc1 and MAPK Signaling Pathway.
Journal of cellular biochemistry.
2017 04; 118(4):860-868. doi:
10.1002/jcb.25763. [PMID: 27739107] - Yan-Li Meng, Wei-Ming Wang, Dan-Dan Lv, Qiu-Xia An, Wei-Hong Lu, Xin Wang, Guixin Tang. The effect of Platycodin D on the expression of cytoadherence proteins P1 and P30 in Mycoplasma pneumoniae models.
Environmental toxicology and pharmacology.
2017 Jan; 49(?):188-193. doi:
10.1016/j.etap.2017.01.001. [PMID: 28073091] - Yunhe Fu, Zhuoyuan Xin, Bin Liu, Jiaxin Wang, Jingjing Wang, Xu Zhang, Yanan Wang, Fan Li. Platycodin D Inhibits Inflammatory Response in LPS-Stimulated Primary Rat Microglia Cells through Activating LXRα-ABCA1 Signaling Pathway.
Frontiers in immunology.
2017; 8(?):1929. doi:
10.3389/fimmu.2017.01929. [PMID: 29375565] - Ting Li, Xin Chen, Xiuping Chen, Dik Lung Ma, Chung Hang Leung, Jin Jian Lu. Platycodin D potentiates proliferation inhibition and apoptosis induction upon AKT inhibition via feedback blockade in non-small cell lung cancer cells.
Scientific reports.
2016 11; 6(?):37997. doi:
10.1038/srep37997. [PMID: 27897231] - Jing-Tao Wu, Gui-Wen Yang, Cui-Hua Qi, Lei Zhou, Jian-Guo Hu, Mao-Shan Wang. ANTI-INFLAMMATORY ACTIVITY OF PLATYCODIN D ON ALCOHOL-INDUCED FATTY LIVER RATS VIA TLR4-MYD88-NF-κB SIGNAL PATH.
African journal of traditional, complementary, and alternative medicines : AJTCAM.
2016; 13(4):176-183. doi:
10.21010/ajtcam.v13i4.23. [PMID: 28852734] - Wei Li, Yu-Hong Tian, Ying Liu, Zi Wang, Shan Tang, Jing Zhang, Ying-Ping Wang. Platycodin D exerts anti-tumor efficacy in H22 tumor-bearing mice via improving immune function and inducing apoptosis.
The Journal of toxicological sciences.
2016; 41(3):417-28. doi:
10.2131/jts.41.417. [PMID: 27193733] - Wei Zhang, Shi-Hui Qian, Da-Wei Qian, Song-Lin Li. Screening of Intestinal Bacterial Metabolites of Platycodin D Using Ultra-Performance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry.
The American journal of Chinese medicine.
2016; 44(4):817-33. doi:
10.1142/s0192415x16500452. [PMID: 27222071] - Hye-Lin Kim, Jinbong Park, Hyewon Park, Yunu Jung, Dong-Hyun Youn, JongWook Kang, Mi-Young Jeong, Jae-Young Um. Platycodon grandiflorum A. De Candolle Ethanolic Extract Inhibits Adipogenic Regulators in 3T3-L1 Cells and Induces Mitochondrial Biogenesis in Primary Brown Preadipocytes.
Journal of agricultural and food chemistry.
2015 Sep; 63(35):7721-30. doi:
10.1021/acs.jafc.5b01908. [PMID: 26244589] - Jin-Jian Lu, De-Zhao Lu, Yu-Fei Chen, Ya-Ting Dong, Jun-Ren Zhang, Ting Li, Zheng-Hai Tang, Zhen Yang. Proteomic analysis of hepatocellular carcinoma HepG2 cells treated with platycodin D.
Chinese journal of natural medicines.
2015 Sep; 13(9):673-9. doi:
10.1016/s1875-5364(15)30065-0. [PMID: 26412427] - Jin-Jun Shan, Jia-Shuang Zou, Tong Xie, An Kang, Wei Zhou, Jian-Ya Xu, Cun-Si Shen, Li-Na Du, Shou-Chuan Wang, Liu-Qing Di. Effects of Gancao on pharmacokinetic profiles of platycodin D and deapio-platycodin D in Jiegeng.
Journal of ethnopharmacology.
2015 Jul; 170(?):50-6. doi:
10.1016/j.jep.2015.04.056. [PMID: 25980422] - Tong Chen, Jin Gao, Pengjun Xiang, Yongde Chen, Jing Ji, Peng Xie, Hui Wu, Wei Xiao, Yidan Wei, Shumin Wang, Li Lan, Hui Ji, Tianhua Yan. Protective effect of platycodin D on liver injury in alloxan-induced diabetic mice via regulation of Treg/Th17 balance.
International immunopharmacology.
2015 Jun; 26(2):338-48. doi:
10.1016/j.intimp.2015.04.001. [PMID: 25887267] - Wei Li, Ying Liu, Zi Wang, Ye Han, Yu-Hong Tian, Gui-Shan Zhang, Yin-Shi Sun, Ying-Ping Wang. Platycodin D isolated from the aerial parts of Platycodon grandiflorum protects alcohol-induced liver injury in mice.
Food & function.
2015 May; 6(5):1418-27. doi:
10.1039/c5fo00094g. [PMID: 25927324] - Haiou Ding, Qianqian Yin, Guang Wan, Xingxing Dai, Xinyuan Shi, Yanjiang Qiao. Solubilization of menthol by platycodin D in aqueous solution: an integrated study of classical experiments and dissipative particle dynamics simulation.
International journal of pharmaceutics.
2015 Mar; 480(1-2):143-51. doi:
10.1016/j.ijpharm.2015.01.033. [PMID: 25615986] - Jae Ho Choi, Sun Woo Jin, Hyung Gyun Kim, Chul Yung Choi, Hyun Sun Lee, Shi Yong Ryu, Young Chul Chung, Young Jung Hwang, Yeon Ji Um, Tae Cheon Jeong, Hye Gwang Jeong. Saponins, especially platyconic acid A, from Platycodon grandiflorum reduce airway inflammation in ovalbumin-induced mice and PMA-exposed A549 cells.
Journal of agricultural and food chemistry.
2015 Feb; 63(5):1468-76. doi:
10.1021/jf5043954. [PMID: 25590691] - Tianzhu Zhang, Shihai Yang, Juan Du, Yao Jinfu, Wang Shumin. Platycodin D Attenuates Airway Inflammation in a Mouse Model of Allergic Asthma by Regulation NF-κB Pathway.
Inflammation.
2015; 38(3):1221-8. doi:
10.1007/s10753-014-0089-6. [PMID: 25578175] - Ruolin Zhao, Meijuan Chen, Zequn Jiang, Fengming Zhao, Beili Xi, Xu Zhang, Haian Fu, Kunfu Zhou. Platycodin-D Induced Autophagy in Non-Small Cell Lung Cancer Cells via PI3K/Akt/mTOR and MAPK Signaling Pathways.
Journal of Cancer.
2015; 6(7):623-31. doi:
10.7150/jca.11291. [PMID: 26078792] - Chong Xu, Guibo Sun, Guangxin Yuan, Rui Wang, Xiaobo Sun. Effects of platycodin D on proliferation, apoptosis and PI3K/Akt signal pathway of human glioma U251 cells.
Molecules (Basel, Switzerland).
2014 Dec; 19(12):21411-23. doi:
10.3390/molecules191221411. [PMID: 25532840] - Jae Ho Choi, Sun Woo Jin, Eun Hee Han, Bong Hwan Park, Hyung Gyun Kim, Tilak Khanal, Yong Pil Hwang, Minh Truong Do, Hyun-Sun Lee, Young Chul Chung, Hee Suk Kim, Tae Cheon Jeong, Hye Gwang Jeong. Platycodon grandiflorum root-derived saponins attenuate atopic dermatitis-like skin lesions via suppression of NF-κB and STAT1 and activation of Nrf2/ARE-mediated heme oxygenase-1.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2014 Jul; 21(8-9):1053-61. doi:
10.1016/j.phymed.2014.04.011. [PMID: 24854572] - Qin Zhan, Feng Zhang, Shou-Hong Gao, Fei Cai, Bo Jiang, Lian-Na Sun, Wan-Sheng Chen. An HPLC-MS/MS method for the quantitative determination of platycodin D in rat plasma and its application to the pharmacokinetics of Platycodi Radix extract.
Chinese journal of natural medicines.
2014 Feb; 12(2):154-60. doi:
10.1016/s1875-5364(14)60026-1. [PMID: 24636069] - Ting Li, Wen-Shan Xu, Guo-Sheng Wu, Xiu-Ping Chen, Yi-Tao Wang, Jin-Jian Lu. Platycodin D induces apoptosis, and inhibits adhesion, migration and invasion in HepG2 hepatocellular carcinoma cells.
Asian Pacific journal of cancer prevention : APJCP.
2014; 15(4):1745-9. doi:
10.7314/apjcp.2014.15.4.1745. [PMID: 24641402] - Yanli Meng, Yang Yang, Weihong Lu, Yingyan Wang, Feng Qian, Xin Wang, Zhihua Zhang, Weiming Wang. The inhibition of Platycodin D on Mycoplasma pneumoniae proliferation and its effect on promoting cell growth after anti-Mycoplasma pneumoniae treatment.
Frontiers in cellular and infection microbiology.
2014; 4(?):192. doi:
10.3389/fcimb.2014.00192. [PMID: 25629010] - Yiyi Ye, Xianghui Han, Baofeng Guo, Zhenping Sun, Sheng Liu. Combination treatment with platycodin D and osthole inhibits cell proliferation and invasion in mammary carcinoma cell lines.
Environmental toxicology and pharmacology.
2013 Jul; 36(1):115-24. doi:
10.1016/j.etap.2013.03.012. [PMID: 23603464] - Yong Pil Hwang, Jae Ho Choi, Hyung Gyun Kim, Tilak Khanal, Gye Young Song, Myoung Soo Nam, Hyun-Sun Lee, Young Chul Chung, Young Chun Lee, Hye Gwang Jeong. Saponins, especially platycodin D, from Platycodon grandiflorum modulate hepatic lipogenesis in high-fat diet-fed rats and high glucose-exposed HepG2 cells.
Toxicology and applied pharmacology.
2013 Mar; 267(2):174-83. doi:
10.1016/j.taap.2013.01.001. [PMID: 23319015] - Tae-Won Kim, Hong-Ki Lee, In-Bae Song, Jong-Hwan Lim, Eun-Sang Cho, Hwa-Young Son, Ju-Young Jung, Hyo-In Yun. Platycodin D attenuates bile duct ligation-induced hepatic injury and fibrosis in mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2013 Jan; 51(?):364-9. doi:
10.1016/j.fct.2012.10.017. [PMID: 23116642] - Jong-Woo Kim, Sang Jin Park, Jong Hwan Lim, Jae Won Yang, Jung Cheul Shin, Sang Wook Lee, Joo Won Suh, Soon B Hwang. Triterpenoid Saponins Isolated from Platycodon grandiflorum Inhibit Hepatitis C Virus Replication.
Evidence-based complementary and alternative medicine : eCAM.
2013; 2013(?):560417. doi:
10.1155/2013/560417. [PMID: 24489585] - Zongliang Lu, Leiguang Wang, Rui Zhou, Yi Qiu, Liuna Yang, Chanyu Zhang, Min Cai, Mantian Mi, Hongxia Xu. Evaluation of the spermicidal and contraceptive activity of Platycodin D, a Saponin from Platycodon grandiflorum.
PloS one.
2013; 8(11):e82068. doi:
10.1371/journal.pone.0082068. [PMID: 24303079] - Qin Zhan, Feng Zhang, Lianna Sun, Zhijun Wu, Wansheng Chen. Two new oleanane-type triterpenoids from Platycodi Radix and anti-proliferative activity in HSC-T6 cells.
Molecules (Basel, Switzerland).
2012 Dec; 17(12):14899-907. doi:
10.3390/molecules171214899. [PMID: 23519261] - Tae-Won Kim, In-Bae Song, Hong-Ki Lee, Jong-Hwan Lim, Eun-Sang Cho, Hwa-Young Son, Sang-Jin Park, Jong-Woo Kim, Hyo-In Yun. Platycodin D, a triterpenoid sapoinin from Platycodon grandiflorum, ameliorates cisplatin-induced nephrotoxicity in mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2012 Dec; 50(12):4254-9. doi:
10.1016/j.fct.2012.05.022. [PMID: 22617354] - Qun Dai, Zhe Chen, Yu-qing Ge, Pei Liu, Hai-bing Wang, Xiao-qiong Ma, Bao-hua Wu. [Mechanism of platycodin D-induced apoptosis in A549 human lung cancer cells].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2012 Sep; 37(17):2626-9. doi:
. [PMID: 23236765] - Eun Jeong Lee, Minseok Kang, Yeong Shik Kim. Platycodin D inhibits lipogenesis through AMPKα-PPARγ2 in 3T3-L1 cells and modulates fat accumulation in obese mice.
Planta medica.
2012 Sep; 78(14):1536-42. doi:
10.1055/s-0032-1315147. [PMID: 22872592] - Dae Young Kwon, Young Seob Kim, Shi Yong Ryu, Yeon Hee Choi, Mi-Ran Cha, Hye Jeong Yang, Sunmin Park. Platyconic acid, a saponin from Platycodi radix, improves glucose homeostasis by enhancing insulin sensitivity in vitro and in vivo.
European journal of nutrition.
2012 Aug; 51(5):529-40. doi:
10.1007/s00394-011-0236-x. [PMID: 21847688] - Ji Sun Yu, An Keun Kim. Platycodin D induces reactive oxygen species-mediated apoptosis signal-regulating kinase 1 activation and endoplasmic reticulum stress response in human breast cancer cells.
Journal of medicinal food.
2012 Aug; 15(8):691-9. doi:
10.1089/jmf.2011.2024. [PMID: 22784044] - Young-Min Ahn, Su Kang Kim, Ji-Suck Kang, Byung-Cheol Lee. Platycodon grandiflorum modifies adipokines and the glucose uptake in high-fat diet in mice and L6 muscle cells.
The Journal of pharmacy and pharmacology.
2012 May; 64(5):697-704. doi:
10.1111/j.2042-7158.2012.01455.x. [PMID: 22471365] - Lixia Pei, Yuanwu Bao, Lei Ma, Qiqi Wang, Yiyi Ye, Xianghui Han, Sheng Liu, Xiuping Chen. A sensitive method for determination of platycodin d in rat plasma using liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study.
Planta medica.
2012 Feb; 78(3):244-51. doi:
10.1055/s-0031-1280372. [PMID: 22095263] - Xiang-hui Han, Yi-yi Ye, Bao-feng Guo, Sheng Liu. [Effects of platycodin D in combination with different active ingredients of Chinese herbs on proliferation and invasion of 4T1 and MDA-MB-231 breast cancer cell lines].
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2012 Jan; 10(1):67-75. doi:
10.3736/jcim20120111. [PMID: 22237277] - Wei Li, Li-Chun Zhao, Zi Wang, Yi-Nan Zheng, Jian Liang, Hui Wang. Response surface methodology to optimize enzymatic preparation of Deapio-Platycodin D and Platycodin D from Radix Platycodi.
International journal of molecular sciences.
2012; 13(4):4089-4100. doi:
10.3390/ijms13044089. [PMID: 22605967] - Jingtao Wu, Guiwen Yang, Wenxing Zhu, Wujun Wen, Fumiao Zhang, Jinduo Yuan, Liguo An. Anti-atherosclerotic activity of platycodin D derived from roots of Platycodon grandiflorum in human endothelial cells.
Biological & pharmaceutical bulletin.
2012; 35(8):1216-21. doi:
10.1248/bpb.b-y110129. [PMID: 22863916] - Emma M Twiner, Zhijun Liu, Jeffrey Gimble, Ying Yu, Frank Greenway. Pharmacokinetic pilot study of the antiangiogenic activity of standardized platycodi radix.
Advances in therapy.
2011 Oct; 28(10):857-65. doi:
10.1007/s12325-011-0061-x. [PMID: 21975926] - Haeyong Lee, Sungmin Bae, Yeong Shik Kim, Yoosik Yoon. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D, a natural compound found in Platycodon grandiflorum.
Life sciences.
2011 Sep; 89(11-12):388-94. doi:
10.1016/j.lfs.2011.07.006. [PMID: 21798269] - Chuan-shan Jin, Li Huang, Su-liang Li. [Study on industrialization production technology of decoction pieces shuangfei of Platycodon grandiflorum].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2011 Jun; 34(6):968-71. doi:
". [PMID: 22017014] - Yi Qiu, Lei-guang Wang, Yi-fang Jia, Dan-tong Yang, Ai-dong Zhang, Yan-ping Zhang, Li-hong Zhang. [Mechanism for sperm immobilization activity of extract from Platycodon grandiflorum in vitro].
Zhonghua yi xue za zhi.
2010 Nov; 90(44):3107-11. doi:
". [PMID: 21211338] - Yeon Hee Choi, Dae Seok Yoo, Mi-Ran Cha, Chun Whan Choi, Young Sup Kim, Sang-Un Choi, Kang Ro Lee, Shi Yong Ryu. Antiproliferative effects of saponins from the roots of Platycodon grandiflorum on cultured human tumor cells.
Journal of natural products.
2010 Nov; 73(11):1863-7. doi:
10.1021/np100496p. [PMID: 20939516] - Haeyong Lee, Ryunhwa Kang, Yeong Shik Kim, Sang-In Chung, Yoosik Yoon. Platycodin D inhibits adipogenesis of 3T3-L1 cells by modulating Kruppel-like factor 2 and peroxisome proliferator-activated receptor gamma.
Phytotherapy research : PTR.
2010 Jun; 24 Suppl 2(?):S161-7. doi:
10.1002/ptr.3054. [PMID: 20024897] - Ji Sun Yu, An Keun Kim. Platycodin D induces apoptosis in MCF-7 human breast cancer cells.
Journal of medicinal food.
2010 Apr; 13(2):298-305. doi:
10.1089/jmf.2009.1226. [PMID: 20412017] - Yong Xie, Hong-Xiang Sun, Duo Li. Platycodin d improves the immunogenicity of newcastle disease virus-based recombinant avian influenza vaccine in mice.
Chemistry & biodiversity.
2010 Mar; 7(3):677-89. doi:
10.1002/cbdv.200900183. [PMID: 20232336] - Yong Xie, Shu-Wang He, Hong-Xiang Sun, Duo Li. Platycodin D2 improves specific cellular and humoral responses to hepatitis B surface antigen in mice.
Chemistry & biodiversity.
2010 Jan; 7(1):178-85. doi:
10.1002/cbdv.200900002. [PMID: 20087984] - Jung Hoon Choi, Ki-Yeon Yoo, Ok Kyu Park, Choong Hyun Lee, Moo-Ho Won, In Koo Hwang, Shi Yong Ryu, Young Sup Kim, Jae-Seon Yi, Young-Soo Bae, Il-Jun Kang. Platycodin D and 2''-O-acetyl-polygalacin D2 isolated from Platycodon grandiflorum protect ischemia/reperfusion injury in the gerbil hippocampus.
Brain research.
2009 Jul; 1279(?):197-208. doi:
10.1016/j.brainres.2009.05.005. [PMID: 19433075] - Dong Yeok Shin, Gi Young Kim, Wei Li, Byung Tae Choi, Nam Deuk Kim, Ho Sung Kang, Yung Hyun Choi. Implication of intracellular ROS formation, caspase-3 activation and Egr-1 induction in platycodon D-induced apoptosis of U937 human leukemia cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2009 Feb; 63(2):86-94. doi:
10.1016/j.biopha.2008.08.001. [PMID: 18804340] - Huiyun Geng, Jianhua Wang, Aimin Cai, Hongying Zhou, Qiting Dong, Yinshi Sun, Yongfeng Xue, Xiaochong Ma, Sha Liu. [Dynamic research of density on Platycodon grandiflorum dry material accumulation and platycodin D content in Platycodon grandiflorum].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2009 Jan; 34(1):22-5. doi:
". [PMID: 19382443] - Yong Xie, Wen Deng, Hongxiang Sun, Duo Li. Platycodin D2 is a potential less hemolytic saponin adjuvant eliciting Th1 and Th2 immune responses.
International immunopharmacology.
2008 Aug; 8(8):1143-50. doi:
10.1016/j.intimp.2008.04.006. [PMID: 18550019] - Hye Jeong Wie, Hai Lin Zhao, Jeong Hwa Chang, Yeong Shik Kim, In Kyeong Hwang, Geun Eog Ji. Enzymatic modification of saponins from Platycodon grandiflorum with Aspergillus niger.
Journal of agricultural and food chemistry.
2007 Oct; 55(22):8908-13. doi:
10.1021/jf0716937. [PMID: 17927135] - Li Guo, Cun Zhang, Li Li, Yong-qing Xiao. [Advances in studies on Platycodon grandiflorum].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2007 Feb; 32(3):181-6. doi:
". [PMID: 17432133] - Hai Lin Zhao, Kyung-Hyun Cho, Young Wan Ha, Tae-Sook Jeong, Woo Song Lee, Yeong Shik Kim. Cholesterol-lowering effect of platycodin D in hypercholesterolemic ICR mice.
European journal of pharmacology.
2006 May; 537(1-3):166-73. doi:
10.1016/j.ejphar.2006.03.032. [PMID: 16626693] - Kwang Seok Ahn, Eun Jung Noh, Hai Lin Zhao, Sang Hoon Jung, Sam Sik Kang, Yeong Shik Kim. Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-kappaB activation in RAW 264.7 cells.
Life sciences.
2005 Apr; 76(20):2315-28. doi:
10.1016/j.lfs.2004.10.042. [PMID: 15748625] - Bao Jun Xu, Li Kun Han, Yi Nan Zheng, Jeong Hyun Lee, Chang Keun Sung. In vitro inhibitory effect of triterpenoidal saponins from Platycodi Radix on pancreatic lipase.
Archives of pharmacal research.
2005 Feb; 28(2):180-5. doi:
10.1007/bf02977712. [PMID: 15789748] - Hai Lin Zhao, Yeong Shik Kim. Determination of the kinetic properties of platycodin D for the inhibition of pancreatic lipase using a 1,2-diglyceride-based colorimetric assay.
Archives of pharmacal research.
2004 Oct; 27(10):1048-52. doi:
10.1007/bf02975430. [PMID: 15554263]