Glycitein (BioDeep_00000384946)

Main id: BioDeep_00000001345

 

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-

化学式: C16H12O5 (284.0685)
中文名称: 黄豆黄素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C=C2C(=C1)C(=O)C(=CO2)C3=CC=C(C=C3)O)O
InChI: InChI=1S/C16H12O5/c1-20-15-6-11-14(7-13(15)18)21-8-12(16(11)19)9-2-4-10(17)5-3-9/h2-8,17-18H,1H3

描述信息

A natural product found in Cordyceps sinensis.
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D004967 - Estrogens
Glycitein is a soy isoflavone used to study apoptosis and antioxidant.
Glycitein is a soy isoflavone used to study apoptosis and antioxidant.

同义名列表

13 个代谢物同义名

Glycitein; 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-; 7-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one; 7-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-chromen-4-one; 7-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-4-chromenone; 7-hydroxy-3-(4-hydroxyphenyl)-6-methoxychromen-4-one; 7-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-chromone; 7,4-Dihydroxy-6-methoxyisoflavone; 40957-83-3; ST5331727; C14536; Glycetein; Glycitein



数据库引用编号

50 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(3)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

61 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AKT1, BCL2, CASP3, CAT, ESR1, MAPK14, NFKB1, PIK3CA, PTGS2, RELA, TNK1, TP53
Peripheral membrane protein 4 CYP1B1, ESR1, PTGS2, TNK1
Endoplasmic reticulum membrane 4 BCL2, CYP19A1, CYP1B1, PTGS2
Nucleus 10 AKT1, BCL2, CASP3, ESR1, ESR2, JUND, MAPK14, NFKB1, RELA, TP53
cytosol 10 AKT1, BCL2, CASP3, CAT, ESR1, MAPK14, NFKB1, PIK3CA, RELA, TP53
centrosome 1 TP53
nucleoplasm 9 AKT1, CASP3, ESR1, ESR2, JUND, MAPK14, NFKB1, RELA, TP53
RNA polymerase II transcription regulator complex 1 JUND
Cell membrane 3 AKT1, ESR1, TNF
Cytoplasmic side 1 ESR1
lamellipodium 2 AKT1, PIK3CA
Multi-pass membrane protein 1 CYP19A1
cell cortex 1 AKT1
cell surface 1 TNF
glutamatergic synapse 4 AKT1, CASP3, MAPK14, RELA
Golgi apparatus 1 ESR1
Golgi membrane 1 INS
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
plasma membrane 5 AKT1, ESR1, PIK3CA, TNF, TNK1
Membrane 8 AKT1, BCL2, CAT, CYP19A1, CYP1B1, ESR1, TNK1, TP53
caveola 1 PTGS2
extracellular exosome 2 CAT, SHBG
endoplasmic reticulum 4 BCL2, CYP19A1, PTGS2, TP53
extracellular space 3 IL6, INS, TNF
perinuclear region of cytoplasm 1 PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 7 BCL2, CAT, CYP1B1, ESR2, MAPK14, NFKB1, TP53
protein-containing complex 6 AKT1, BCL2, CAT, ESR1, PTGS2, TP53
intracellular membrane-bounded organelle 3 CAT, CYP1B1, ESR2
Microsome membrane 3 CYP19A1, CYP1B1, PTGS2
postsynaptic density 1 CASP3
Secreted 3 IL6, INS, SHBG
extracellular region 7 CAT, IL6, INS, MAPK14, NFKB1, SHBG, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
Mitochondrion matrix 1 TP53
mitochondrial matrix 2 CAT, TP53
transcription regulator complex 5 ESR1, JUND, NFKB1, RELA, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
microtubule cytoskeleton 1 AKT1
nucleolus 1 TP53
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 CAT
spindle 1 AKT1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 TP53
PML body 1 TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 6 ESR1, ESR2, JUND, NFKB1, RELA, TP53
phagocytic cup 1 TNF
spindle pole 1 MAPK14
site of double-strand break 1 TP53
endosome lumen 1 INS
euchromatin 1 ESR1
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 4 CAT, INS, MAPK14, NFKB1
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 2 JUND, TP53
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
specific granule lumen 1 NFKB1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
[Isoform 1]: Nucleus 2 ESR1, TP53
death-inducing signaling complex 1 CASP3
transcription factor AP-1 complex 1 JUND
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 2 NFKB1, RELA
NF-kappaB complex 1 RELA
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Tao Xiang, Weibiao Jin. Mechanism of glycitein in the treatment of colon cancer based on network pharmacology and molecular docking. Lifestyle genomics. 2022 Sep; ?(?):. doi: 10.1159/000527124. [PMID: 36183698]
  • Na Dong, Zhilong Yang. Glycitein exerts neuroprotective effects in Rotenone-triggered oxidative stress and apoptotic cell death in the cellular model of Parkinson's disease. Acta biochimica Polonica. 2022 Jun; 69(2):447-452. doi: 10.18388/abp.2020_5963. [PMID: 35691030]
  • Sarah M Jung, Ella H Haddad, Amandeep Kaur, Rawiwan Sirirat, Alice Y Kim, Keiji Oda, Sujatha Rajaram, Joan Sabaté. A Non-Probiotic Fermented Soy Product Reduces Total and LDL Cholesterol: A Randomized Controlled Crossover Trial. Nutrients. 2021 Feb; 13(2):. doi: 10.3390/nu13020535. [PMID: 33562090]
  • Kai Uchida, Yuji Sawada, Koji Ochiai, Muneo Sato, Jun Inaba, Masami Yokota Hirai. Identification of a Unique Type of Isoflavone O-Methyltransferase, GmIOMT1, Based on Multi-Omics Analysis of Soybean under Biotic Stress. Plant & cell physiology. 2020 Dec; 61(11):1974-1985. doi: 10.1093/pcp/pcaa112. [PMID: 32894761]
  • Minsu Kim, Seowoo Im, Yoon Keun Cho, Cheoljun Choi, Yeonho Son, Doyoung Kwon, Young-Suk Jung, Yun-Hee Lee. Anti-Obesity Effects of Soybean Embryo Extract and Enzymatically-Modified Isoquercitrin. Biomolecules. 2020 09; 10(10):. doi: 10.3390/biom10101394. [PMID: 33008006]
  • Amritha Johny, Lada Ivanova, Tone-Kari Knutsdatter Østbye, Christiane Kruse Fæste. Biotransformation of phytoestrogens from soy in enzymatically characterized liver microsomes and primary hepatocytes of Atlantic salmon. Ecotoxicology and environmental safety. 2020 Jul; 197(?):110611. doi: 10.1016/j.ecoenv.2020.110611. [PMID: 32294595]
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  • You Jin Lim, Bora Lim, Hae Yeong Kim, Soon-Jae Kwon, Seok Hyun Eom. Deglycosylation patterns of isoflavones in soybean extracts inoculated with two enzymatically different strains of lactobacillus species. Enzyme and microbial technology. 2020 Jan; 132(?):109394. doi: 10.1016/j.enzmictec.2019.109394. [PMID: 31731960]
  • Vikas Kumar, A Aneesh Kumar, Vinod Joseph, Vipin Mohan Dan, Abdul Jaleel, T R Santhosh Kumar, Chandrasekharan C Kartha. Untargeted metabolomics reveals alterations in metabolites of lipid metabolism and immune pathways in the serum of rats after long-term oral administration of Amalaki rasayana. Molecular and cellular biochemistry. 2020 Jan; 463(1-2):147-160. doi: 10.1007/s11010-019-03637-1. [PMID: 31595424]
  • Shuhong Dai, Mingfang Pan, Hani S El-Nezami, Jennifer M F Wan, M F Wang, Olivier Habimana, Jetty C Y Lee, Jimmy C Y Louie, Nagendra P Shah. Effects of Lactic Acid Bacteria-Fermented Soymilk on Isoflavone Metabolites and Short-Chain Fatty Acids Excretion and Their Modulating Effects on Gut Microbiota. Journal of food science. 2019 Jul; 84(7):1854-1863. doi: 10.1111/1750-3841.14661. [PMID: 31206699]
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  • Michaela Kopečná-Zapletalová, Kristýna Krasulová, Pavel Anzenbacher, Petr Hodek, Eva Anzenbacherová. Interaction of isoflavonoids with human liver microsomal cytochromes P450: inhibition of CYP enzyme activities. Xenobiotica; the fate of foreign compounds in biological systems. 2017 Apr; 47(4):324-331. doi: 10.1080/00498254.2016.1195028. [PMID: 27312150]
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