Iridin (BioDeep_00000003828)

   

natural product PANOMIX_OTCML-2023


代谢物信息卡片


5-hydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one

化学式: C24H26O13 (522.1373)
中文名称: 野鹫尾苷, 野鸢尾苷
谱图信息: 最多检出来源 Viridiplantae(plant) 45.17%

分子结构信息

SMILES: COC1=CC(=CC(=C1OC)O)C2=COC3=CC(=C(C(=C3C2=O)O)OC)OC4C(C(C(C(O4)CO)O)O)O
InChI: InChI=1S/C24H26O13/c1-32-13-5-9(4-11(26)22(13)33-2)10-8-35-12-6-14(23(34-3)19(29)16(12)17(10)27)36-24-21(31)20(30)18(28)15(7-25)37-24/h4-6,8,15,18,20-21,24-26,28-31H,7H2,1-3H3/t15-,18+,20-,21-,24+/m0/s1

描述信息

Iridin is a glycosyloxyisoflavone that is irigenin substituted by a beta-D-glucopyranosyl residue at position 7 via a glycosidic linkage. It has a role as a plant metabolite. It is a hydroxyisoflavone, a monosaccharide derivative, a member of 4-methoxyisoflavones and a 7-hydroxyisoflavones 7-O-beta-D-glucoside. It is functionally related to an irigenin.
Iridin is a natural product found in Iris milesii, Iris tectorum, and other organisms with data available.
See also: Iris versicolor root (part of).
A glycosyloxyisoflavone that is irigenin substituted by a beta-D-glucopyranosyl residue at position 7 via a glycosidic linkage.
Iridin is an isoflavone isolated from Iris milesii[1].
Iridin is an isoflavone isolated from Iris milesii[1].

同义名列表

40 个代谢物同义名

5-hydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one; 5-hydroxy-3-(3-hydroxy-4,5-dimethoxy-phenyl)-6-methoxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-chromen-4-one; 5-hydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4H-chromen-4-one; 5-hydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one; 5-hydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-7-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxychromen-4-one; 4H-1-Benzopyran-4-one, 7-(beta-D-glucopyranosyloxy)-5-hydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-; 5-hydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-4-oxo-4H-1-benzopyran-7-yl beta-D-glucopyranoside; irigenin 7-O-beta-D-glucopyranoside; Irigenin 7-O-glucoside; Spectrum3_000192; Spectrum4_001510; Spectrum2_000198; Spectrum5_000279; UNII-6NTS007OHQ; DivK1c_006239; KBio3_001243; KBio2_003667; KBio2_006235; KBio2_001099; KBio1_001183; 6NTS007OHQ; Lridin; Irisin; Iridin; 5-hydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxy-7-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]-4-chromenone; 5-hydroxy-3-(3-hydroxy-4,5-dimethoxy-phenyl)-6-methoxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-chromone; 5-hydroxy-3-(3-hydroxy-4,5-dimethoxy-phenyl)-6-methoxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-chromen-4-one; SDCCGMLS-0066463.P001; Spectrum_000619; SpecPlus_000143; SPECTRUM200793; KBioGR_002179; BSPBio_001743; KBioSS_001099; SPBio_000155; 491-74-7; C10465; 7- (beta-D-Glucopyranosyloxy) -5-hydroxy-3- (3-hydroxy-4,5-dimethoxyphenyl) -6-methoxy-4H-1-benzopyran-4-one; AKOS037514696; Iridin



数据库引用编号

40 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

93 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ANG, ANXA5, BCL2, BCL2L1, CCNB1, CDC25C, CDK1, JAK1, MAPK8, PIK3CA, PKM, STAT1, STAT3
Peripheral membrane protein 2 ANXA5, GORASP1
Endoplasmic reticulum membrane 2 BCL2, CDK1
Mitochondrion membrane 1 BCL2L1
Nucleus 11 ANG, BCL2, CCNB1, CDC25C, CDK1, JAK1, MAPK8, MMP2, PKM, STAT1, STAT3
cytosol 13 ANG, ANXA5, BCL2, BCL2L1, CCNB1, CDC25C, CDK1, JAK1, MAPK8, PIK3CA, PKM, STAT1, STAT3
dendrite 1 STAT1
centrosome 3 BCL2L1, CCNB1, CDK1
nucleoplasm 6 CCNB1, CDC25C, CDK1, MAPK8, STAT1, STAT3
RNA polymerase II transcription regulator complex 2 STAT1, STAT3
Cell membrane 1 TNF
Cytoplasmic side 2 BCL2L1, GORASP1
lamellipodium 1 PIK3CA
Golgi apparatus membrane 1 GORASP1
Synapse 1 MAPK8
cell surface 1 TNF
Golgi apparatus 1 GORASP1
Golgi membrane 1 GORASP1
growth cone 1 ANG
mitochondrial inner membrane 1 BCL2L1
neuronal cell body 2 ANG, TNF
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 BCL2L1
endosome 1 JAK1
plasma membrane 5 JAK1, MMP2, PIK3CA, STAT3, TNF
synaptic vesicle membrane 1 BCL2L1
Membrane 5 ANXA5, BCL2, CCNB1, CDK1, JAK1
axon 2 MAPK8, STAT1
extracellular exosome 3 ANXA5, CDK1, PKM
endoplasmic reticulum 2 BCL2, BCL2L1
extracellular space 3 ANG, MMP2, TNF
perinuclear region of cytoplasm 3 CDC25C, PIK3CA, STAT1
intercalated disc 1 PIK3CA
mitochondrion 5 BCL2, BCL2L1, CDK1, MMP2, PKM
protein-containing complex 2 BCL2, STAT1
Secreted 1 ANG
extracellular region 5 ANG, ANXA5, MMP2, PKM, TNF
cytoplasmic side of plasma membrane 1 JAK1
Mitochondrion outer membrane 2 BCL2, BCL2L1
Single-pass membrane protein 2 BCL2, BCL2L1
mitochondrial outer membrane 2 BCL2, BCL2L1
Mitochondrion matrix 1 BCL2L1
mitochondrial matrix 3 BCL2L1, CCNB1, CDK1
transcription regulator complex 1 STAT3
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 BCL2L1, CDK1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 BCL2L1
Nucleus membrane 2 BCL2, BCL2L1
Bcl-2 family protein complex 2 BCL2, BCL2L1
nuclear membrane 2 BCL2, BCL2L1
external side of plasma membrane 2 ANXA5, TNF
Extracellular vesicle 1 PKM
actin cytoskeleton 1 ANG
nucleolus 2 ANG, STAT1
midbody 1 CDK1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 PKM
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 2 ANXA5, JAK1
cis-Golgi network 1 GORASP1
extracellular matrix 1 MMP2
basement membrane 1 ANG
mitochondrial intermembrane space 1 CDC25C
collagen-containing extracellular matrix 3 ANXA5, MMP2, PKM
sarcomere 1 MMP2
Zymogen granule membrane 1 ANXA5
cilium 1 PKM
chromatin 2 STAT1, STAT3
phagocytic cup 1 TNF
mitotic spindle 1 CDK1
Chromosome 1 ANG
cytoskeleton 1 JAK1
Nucleus, nucleolus 1 ANG
spindle pole 1 CCNB1
chromosome, telomeric region 1 CDK1
Endomembrane system 1 JAK1
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 PKM
secretory granule lumen 1 PKM
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endocytic vesicle 1 ANG
[Isoform 1]: Secreted, extracellular space, extracellular matrix 1 MMP2
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
outer kinetochore 1 CCNB1
vesicle membrane 1 ANXA5
extrinsic component of cytoplasmic side of plasma membrane 1 JAK1
spindle microtubule 1 CDK1
basal dendrite 1 MAPK8
Rough endoplasmic reticulum 1 PKM
cyclin-dependent protein kinase holoenzyme complex 1 CDK1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
angiogenin-PRI complex 1 ANG
cyclin A1-CDK1 complex 1 CDK1
cyclin A2-CDK1 complex 1 CDK1
cyclin B1-CDK1 complex 2 CCNB1, CDK1
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
[Isoform M2]: Cytoplasm 1 PKM
[Isoform M1]: Cytoplasm 1 PKM
ISGF3 complex 1 STAT1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[Isoform Bcl-X(L)]: Mitochondrion inner membrane 1 BCL2L1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Zehua Jin, Hongda Sheng, Shufang Wang, Yi Wang, Yiyu Cheng. Network pharmacology study to reveal active compounds of Qinggan Yin formula against pulmonary inflammation by inhibiting MAPK activation. Journal of ethnopharmacology. 2022 Oct; 296(?):115513. doi: 10.1016/j.jep.2022.115513. [PMID: 35779819]
  • Tao Hu, Xinyu Ge, Junyang Wang, Ning Zhang, Xingxing Diao, Lihong Hu, Xiachang Wang. Metabolite identification of iridin in rats by using UHPLC-MS/MS and pharmacokinetic study of its metabolite irigenin. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 Sep; 1181(?):122914. doi: 10.1016/j.jchromb.2021.122914. [PMID: 34492510]
  • Orawan Monthakantirat, Wanchai De-Eknamkul, Kaoru Umehara, Yohko Yoshinaga, Toshio Miyase, Tsutomu Warashina, Hiroshi Noguchi. Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines. Journal of natural products. 2005 Mar; 68(3):361-4. doi: 10.1021/np040175c. [PMID: 15787436]