1-Pyrroline-5-carboxylic acid (BioDeep_00000003702)
Secondary id: BioDeep_00001869326
human metabolite Endogenous natural product
代谢物信息卡片
delta-1-Pyrroline-5-carboxylate, 14C-labeled, (+-)-isomer
化学式: C5H7NO2 (113.0477)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(feces) 15.86%
分子结构信息
SMILES: C1CC(N=C1)C(=O)O
InChI: InChI=1S/C5H7NO2/c7-5(8)4-2-1-3-6-4/h3-4H,1-2H2,(H,7,8)/t4-/m0/s1
描述信息
1-Pyrroline-5-carboxylic acid (CAS: 2906-39-0) is an enamine or an imino acid that forms upon the spontaneous dehydration of L-glutamate gamma-semialdehyde in aqueous solutions. The stereoisomer (S)-1-pyrroline-5-carboxylate is an intermediate in glutamate metabolism, arginine degradation, and proline biosynthesis and degradation. It can also be converted into or be formed from three amino acids: L-glutamate, L-ornithine, and L-proline. In particular, it is synthesized via the oxidation of proline by pyrroline-5-carboxylate reductase 1 (PYCR1) (EC 1.5.1.2) or by proline dehydrogenase (PRODH) (EC 1.5.99.8). It is hydrolyzed into L-glutamate by delta-1-pyrroline-5-carboxylate dehydrogenase (ALDH4A1) (EC 1.5.1.12). It is also one of the few metabolites that can act as a precursor to other metabolites of both the urea cycle and the tricarboxylic acid (TCA) cycle. Under certain conditions, pyrroline-5-carboxylate can act as a neurotoxin and a metabotoxin. A neurotoxin causes damage to nerve cells and nerve tissues. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Chronically high levels of pyrroline-5-carboxylate are associated with at least five inborn errors of metabolism, including hyperprolinemia type I, hyperprolinemia type II, iminoglycinuria, prolinemia type II, and pyruvate carboxylase deficiency. Hyperprolinemia type II results in high levels of pyrroline-5-carboxylate. People with hyperprolinemia type II have signs and symptoms that vary in severity, but they are more likely than type I to have seizures or intellectual disability. Pyrroline-5-carboxylate is highly reactive and excess quantities have been shown to cause cell death and apoptosis (PMID: 15548746).
(s)-1-pyrroline-5-carboxylate, also known as delta-1-pyrroline-5-carboxylate, (+-)-isomer, belongs to alpha amino acids and derivatives class of compounds. Those are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof (s)-1-pyrroline-5-carboxylate is soluble (in water) and a moderately acidic compound (based on its pKa). (s)-1-pyrroline-5-carboxylate can be found in a number of food items such as beech nut, mango, oyster mushroom, and other bread, which makes (s)-1-pyrroline-5-carboxylate a potential biomarker for the consumption of these food products (s)-1-pyrroline-5-carboxylate may be a unique E.coli metabolite.
同义名列表
16 个代谢物同义名
delta-1-Pyrroline-5-carboxylate, 14C-labeled, (+-)-isomer; (2S)-3,4-Dihydro-2H-pyrrole-2-carboxylic acid; delta-1-Pyrroline-5-carboxylate, (+-)-isomer; 3,4-dihydro-2H-pyrrole-2-carboxylic acid; delta-1-Pyrroline-5-carboxylic acid; delta1-Pyrroline-5-carboxylic acid; (S)-1-Pyrroline-5-carboxylic acid; delta-1-Pyrroline-5-carboxylate; L-1-Pyrroline-5-carboxylic acid; delta(1)Pyrroline-5-carboxylate; Δ1-Pyrroline-5-carboxylic acid; (S)-1-Pyrroline-5-carboxylate; 1-Pyrroline-5-carboxylic acid; L-1-Pyrroline-5-carboxylate; 1-Pyrroline-5-carboxylate; Pyrroline-5-carboxylate
数据库引用编号
21 个数据库交叉引用编号
- ChEBI: CHEBI:371
- KEGG: C03912
- PubChem: 440162
- PubChem: 1196
- HMDB: HMDB0001301
- Metlin: METLIN63418
- Wikipedia: 1-Pyrroline-5-carboxylic acid
- MetaCyc: L-DELTA1-PYRROLINE_5-CARBOXYLATE
- KNApSAcK: C00007606
- foodb: FDB030153
- chemspider: 389153
- CAS: 64199-88-8
- PMhub: MS000011023
- ChEBI: CHEBI:17388
- PubChem: 6642
- 3DMET: B01698
- NIKKAJI: J654.872E
- RefMet: 1-Pyrroline-5-carboxylic acid
- LOTUS: LTS0069041
- LOTUS: LTS0078321
- wikidata: Q27105294
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
67 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(1)
- Urea cycle and metabolism of amino groups:
(S)-1-Pyrroline-5-carboxylate ⟶ L-Proline
Plant Reactome(0)
INOH(2)
- Arginine and Proline metabolism ( Arginine and Proline metabolism ):
ATP + Creatine ⟶ ADP + N-Phospho-creatine - NADH + (S)-1-Pyrroline-5-carboxylic acid = NAD+ + L-Proline ( Arginine and Proline metabolism ):
(S)-1-Pyrroline-5-carboxylic acid + NADH ⟶ L-Proline + NAD+
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(64)
- Proline Metabolism:
Adenosine triphosphate + L-Glutamic acid + Water ⟶ Adenosine diphosphate + Hydrogen Ion + L-Glutamic acid + Phosphate - Arginine and Proline Metabolism:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Prolidase Deficiency (PD):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Hyperprolinemia Type II:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Hyperprolinemia Type I:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Prolinemia Type II:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Ornithine Aminotransferase Deficiency (OAT Deficiency):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Hyperornithinemia with Gyrate Atrophy (HOGA):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome]:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - L-Arginine:Glycine Amidinotransferase Deficiency:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Arginine Metabolism:
N-Acetylornithine + Water ⟶ Acetic acid + Ornithine - Proline Metabolism:
N-Acetylornithine + Water ⟶ Acetic acid + Ornithine - Arginine and Proline Metabolism:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Arginine and Proline Metabolism:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Hyperprolinemia Type I:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Hyperprolinemia Type II:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Ornithine Aminotransferase Deficiency (OAT Deficiency):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Prolinemia Type II:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Prolidase Deficiency (PD):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Hyperornithinemia with Gyrate Atrophy (HOGA):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome]:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - L-Arginine:Glycine Amidinotransferase Deficiency:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Arginine and Proline Metabolism:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Arginine and Proline Metabolism:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Hyperprolinemia Type I:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Hyperprolinemia Type II:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Ornithine Aminotransferase Deficiency (OAT Deficiency):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Prolinemia Type II:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Prolidase Deficiency (PD):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Hyperornithinemia with Gyrate Atrophy (HOGA):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome]:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - L-Arginine:Glycine Amidinotransferase Deficiency:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Glutamate Metabolism:
Adenosine triphosphate + L-Glutamine + Nicotinic acid adenine dinucleotide + Water ⟶ Adenosine monophosphate + L-Glutamic acid + NAD + Pyrophosphate - 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency:
Adenosine triphosphate + L-Glutamine + Nicotinic acid adenine dinucleotide + Water ⟶ Adenosine monophosphate + L-Glutamic acid + NAD + Pyrophosphate - Homocarnosinosis:
Adenosine triphosphate + L-Glutamine + Nicotinic acid adenine dinucleotide + Water ⟶ Adenosine monophosphate + L-Glutamic acid + NAD + Pyrophosphate - Hyperinsulinism-Hyperammonemia Syndrome:
Adenosine triphosphate + L-Glutamine + Nicotinic acid adenine dinucleotide + Water ⟶ Adenosine monophosphate + L-Glutamic acid + NAD + Pyrophosphate - 2-Hydroxyglutric Aciduria (D and L Form):
Adenosine triphosphate + L-Glutamine + Nicotinic acid adenine dinucleotide + Water ⟶ Adenosine monophosphate + L-Glutamic acid + NAD + Pyrophosphate - Succinic Semialdehyde Dehydrogenase Deficiency:
Adenosine triphosphate + L-Glutamine + Nicotinic acid adenine dinucleotide + Water ⟶ Adenosine monophosphate + L-Glutamic acid + NAD + Pyrophosphate - Proline Metabolism:
Adenosine triphosphate + L-Glutamic acid + Water ⟶ Adenosine diphosphate + Hydrogen Ion + L-Glutamic acid + Phosphate - 2-Hydroxyglutric Aciduria (D and L Form):
Adenosine triphosphate + L-Glutamine + Water + Xanthylic acid ⟶ Adenosine monophosphate + Guanosine monophosphate + L-Glutamic acid + Pyrophosphate - 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency:
Adenosine triphosphate + L-Glutamine + Water + Xanthylic acid ⟶ Adenosine monophosphate + Guanosine monophosphate + L-Glutamic acid + Pyrophosphate - Homocarnosinosis:
Adenosine triphosphate + L-Glutamine + Water + Xanthylic acid ⟶ Adenosine monophosphate + Guanosine monophosphate + L-Glutamic acid + Pyrophosphate - Hyperinsulinism-Hyperammonemia Syndrome:
Adenosine triphosphate + L-Glutamine + Water + Xanthylic acid ⟶ Adenosine monophosphate + Guanosine monophosphate + L-Glutamic acid + Pyrophosphate - Succinic Semialdehyde Dehydrogenase Deficiency:
Adenosine triphosphate + L-Glutamine + Water + Xanthylic acid ⟶ Adenosine monophosphate + Guanosine monophosphate + L-Glutamic acid + Pyrophosphate - Glutamate Metabolism:
Adenosine triphosphate + L-Glutamine + Water + Xanthylic acid ⟶ Adenosine monophosphate + Guanosine monophosphate + L-Glutamic acid + Pyrophosphate - Glutamate Metabolism:
Adenosine triphosphate + L-Glutamine + Water + Xanthylic acid ⟶ Adenosine monophosphate + Guanosine monophosphate + L-Glutamic acid + Pyrophosphate - Glutamate Metabolism:
Adenosine triphosphate + L-Glutamine ⟶ Adenosine monophosphate + Pyrophosphate - Glutamate Metabolism:
Adenosine triphosphate + L-Glutamine + Water + Xanthylic acid ⟶ Adenosine monophosphate + Guanosine monophosphate + L-Glutamic acid + Pyrophosphate - 2-Hydroxyglutric Aciduria (D and L Form):
Adenosine triphosphate + L-Glutamine ⟶ Adenosine monophosphate + Pyrophosphate - 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency:
Adenosine triphosphate + L-Glutamine ⟶ Adenosine monophosphate + Pyrophosphate - Homocarnosinosis:
Adenosine triphosphate + L-Glutamine ⟶ Adenosine monophosphate + Pyrophosphate - Hyperinsulinism-Hyperammonemia Syndrome:
Adenosine triphosphate + L-Glutamine ⟶ Adenosine monophosphate + Pyrophosphate - Succinic Semialdehyde Dehydrogenase Deficiency:
Adenosine triphosphate + L-Glutamine ⟶ Adenosine monophosphate + Pyrophosphate - Proline Metabolism:
Adenosine triphosphate + L-Glutamic acid + Water ⟶ Adenosine diphosphate + Hydrogen Ion + L-Glutamic acid + Phosphate - Glutamate Metabolism:
Adenosine triphosphate + L-Glutamine + Water + Xanthylic acid ⟶ Adenosine monophosphate + Guanosine monophosphate + L-Glutamic acid + Pyrophosphate
PharmGKB(0)
23 个相关的物种来源信息
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 6656 - Arthropoda: LTS0069041
- 2 - Bacteria: LTS0069041
- 6658 - Branchiopoda: LTS0069041
- 6668 - Daphnia: LTS0069041
- 6669 - Daphnia pulex: 10.1038/SREP25125
- 6669 - Daphnia pulex: LTS0069041
- 77658 - Daphniidae: LTS0069041
- 33682 - Euglenozoa: LTS0069041
- 2759 - Eukaryota: LTS0069041
- 1236 - Gammaproteobacteria: LTS0069041
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
- 5653 - Kinetoplastea: LTS0069041
- 33208 - Metazoa: LTS0069041
- 135621 - Pseudomonadaceae: LTS0069041
- 286 - Pseudomonas: LTS0069041
- 287 - Pseudomonas aeruginosa: LTS0069041
- 5690 - Trypanosoma: LTS0069041
- 5691 - Trypanosoma brucei:
- 5691 - Trypanosoma brucei: 10.1128/AAC.00044-13
- 5691 - Trypanosoma brucei: LTS0069041
- 5654 - Trypanosomatidae: LTS0069041
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Giuseppe Forlani, Giuseppe Sabbioni, Simone Barera, Dietmar Funck. A complex array of factors regulate the activity of Arabidopsis thaliana δ1 -pyrroline-5-carboxylate synthetase isoenzymes to ensure their specific role in plant cell metabolism.
Plant, cell & environment.
2024 Apr; 47(4):1348-1362. doi:
10.1111/pce.14817. [PMID: 38223941] - Yao Zheng, Cécile Cabassa-Hourton, Holger Eubel, Guillaume Chevreux, Laurent Lignieres, Emilie Crilat, Hans-Peter Braun, Sandrine Lebreton, Arnould Savouré. Pyrroline-5-carboxylate metabolism protein complex detected in Arabidopsis thaliana leaf mitochondria.
Journal of experimental botany.
2023 Oct; ?(?):. doi:
10.1093/jxb/erad406. [PMID: 37843921] - Yao Zheng, Cécile Cabassa-Hourton, Séverine Planchais, Emilie Crilat, Gilles Clément, Matthieu Dacher, Nina Durand, Marianne Bordenave-Jacquemin, Anne Guivarc'h, Corentin Dourmap, Pierre Carol, Sandrine Lebreton, Arnould Savouré. Pyrroline-5-carboxylate dehydrogenase is an essential enzyme for proline dehydrogenase function during dark-induced senescence in Arabidopsis thaliana.
Plant, cell & environment.
2023 03; 46(3):901-917. doi:
10.1111/pce.14529. [PMID: 36583533] - Chengcheng Chen, Xiaoyue Cui, Pingying Zhang, Zheng Wang, Jianxia Zhang. Expression of the pyrroline-5-carboxylate reductase (P5CR) gene from the wild grapevine Vitis yeshanensis promotes drought resistance in transgenic Arabidopsis.
Plant physiology and biochemistry : PPB.
2021 Nov; 168(?):188-201. doi:
10.1016/j.plaphy.2021.10.004. [PMID: 34649022] - Xuwei Liu, Zhuoli Huang, Yuzhan Li, Wenjun Xie, Wu Li, Xiangru Tang, Umair Ashraf, Leilei Kong, Longmei Wu, Shuli Wang, Zhaowen Mo. Selenium-silicon (Se-Si) induced modulations in physio-biochemical responses, grain yield, quality, aroma formation and lodging in fragrant rice.
Ecotoxicology and environmental safety.
2020 Jun; 196(?):110525. doi:
10.1016/j.ecoenv.2020.110525. [PMID: 32224370] - Débora Bublitz Anton, Frank Lino Guzman, Nicole Moreira Vetö, Felipe Augusto Krause, Franceli Rodrigues Kulcheski, Ana Paula Durand Coelho, Guilherme Leitão Duarte, Rogério Margis, Lúcia Rebello Dillenburg, Andreia Carina Turchetto-Zolet. Characterization and expression analysis of P5CS (Δ1-pyrroline-5-carboxylate synthase) gene in two distinct populations of the Atlantic Forest native species Eugenia uniflora L.
Molecular biology reports.
2020 Feb; 47(2):1033-1043. doi:
10.1007/s11033-019-05195-7. [PMID: 31749121] - Cong Guan, Yan-Hua Huang, Hui-Fang Cen, Xin Cui, Dan-Yang Tian, Yun-Wei Zhang. Overexpression of the Lolium perenne L. delta1-pyrroline 5-carboxylate synthase (LpP5CS) gene results in morphological alterations and salinity tolerance in switchgrass (Panicum virgatum L.).
PloS one.
2019; 14(7):e0219669. doi:
10.1371/journal.pone.0219669. [PMID: 31310632] - Christian Blume, Julia Ost, Marco Mühlenbruch, Christoph Peterhänsel, Miriam Laxa. Low CO2 induces urea cycle intermediate accumulation in Arabidopsis thaliana.
PloS one.
2019; 14(1):e0210342. doi:
10.1371/journal.pone.0210342. [PMID: 30650113] - Shumaila Muzammil, Asis Shrestha, Said Dadshani, Klaus Pillen, Shahid Siddique, Jens Léon, Ali Ahmad Naz. An Ancestral Allele of Pyrroline-5-carboxylate synthase1 Promotes Proline Accumulation and Drought Adaptation in Cultivated Barley.
Plant physiology.
2018 10; 178(2):771-782. doi:
10.1104/pp.18.00169. [PMID: 30131422] - Dávid Aleksza, Gábor V Horváth, Györgyi Sándor, László Szabados. Proline Accumulation Is Regulated by Transcription Factors Associated with Phosphate Starvation.
Plant physiology.
2017 Sep; 175(1):555-567. doi:
10.1104/pp.17.00791. [PMID: 28765275] - Pasqualina Woodrow, Loredana F Ciarmiello, Maria Grazia Annunziata, Severina Pacifico, Federica Iannuzzi, Antonio Mirto, Luisa D'Amelia, Emilia Dell'Aversana, Simona Piccolella, Amodio Fuggi, Petronia Carillo. Durum wheat seedling responses to simultaneous high light and salinity involve a fine reconfiguration of amino acids and carbohydrate metabolism.
Physiologia plantarum.
2017 Mar; 159(3):290-312. doi:
10.1111/ppl.12513. [PMID: 27653956] - Xuan Jun Feng, Jing Rui Li, Shi Lian Qi, Qing Fang Lin, Jing Bo Jin, Xue Jun Hua. Light affects salt stress-induced transcriptional memory of P5CS1 in Arabidopsis.
Proceedings of the National Academy of Sciences of the United States of America.
2016 12; 113(51):E8335-E8343. doi:
10.1073/pnas.1610670114. [PMID: 27930298] - Benjamin W Arentson, Erin L Hayes, Weidong Zhu, Harkewal Singh, John J Tanner, Donald F Becker. Engineering a trifunctional proline utilization A chimaera by fusing a DNA-binding domain to a bifunctional PutA.
Bioscience reports.
2016 12; 36(6):. doi:
10.1042/bsr20160435. [PMID: 27742866] - Meijuan Li, Umair Ashraf, Hua Tian, Zhaowen Mo, Shenggang Pan, Shakeel Ahmad Anjum, Meiyang Duan, Xiangru Tang. Manganese-induced regulations in growth, yield formation, quality characters, rice aroma and enzyme involved in 2-acetyl-1-pyrroline biosynthesis in fragrant rice.
Plant physiology and biochemistry : PPB.
2016 Jun; 103(?):167-75. doi:
10.1016/j.plaphy.2016.03.009. [PMID: 26995311] - Vijeta Singh, Bhumi Nath Tripathi, Vinay Sharma. Interaction of Mg with heavy metals (Cu, Cd) in T. aestivum with special reference to oxidative and proline metabolism.
Journal of plant research.
2016 May; 129(3):487-97. doi:
10.1007/s10265-015-0767-y. [PMID: 26547559] - Hamada AbdElgawad, Dirk De Vos, Gaurav Zinta, Malgorzata A Domagalska, Gerrit T S Beemster, Han Asard. Grassland species differentially regulate proline concentrations under future climate conditions: an integrated biochemical and modelling approach.
The New phytologist.
2015 Oct; 208(2):354-69. doi:
10.1111/nph.13481. [PMID: 26037253] - Madhulika Singh, Vijay Pratap Singh, Gunjan Dubey, Sheo Mohan Prasad. Exogenous proline application ameliorates toxic effects of arsenate in Solanum melongena L. seedlings.
Ecotoxicology and environmental safety.
2015 Jul; 117(?):164-73. doi:
10.1016/j.ecoenv.2015.03.021. [PMID: 25881134] - Mariela Inés Monteoliva, Yanina Soledad Rizzi, Nicolás Miguel Cecchini, Mohammad-Reza Hajirezaei, María Elena Alvarez. Context of action of proline dehydrogenase (ProDH) in the Hypersensitive Response of Arabidopsis.
BMC plant biology.
2014 Jan; 14(?):21. doi:
10.1186/1471-2229-14-21. [PMID: 24410747] - Milena Cvikrová, Lenka Gemperlová, Olga Martincová, Radomira Vanková. Effect of drought and combined drought and heat stress on polyamine metabolism in proline-over-producing tobacco plants.
Plant physiology and biochemistry : PPB.
2013 Dec; 73(?):7-15. doi:
10.1016/j.plaphy.2013.08.005. [PMID: 24029075] - Goon-Bo Kim, Young-Woo Nam. A novel Δ(1)-pyrroline-5-carboxylate synthetase gene of Medicago truncatula plays a predominant role in stress-induced proline accumulation during symbiotic nitrogen fixation.
Journal of plant physiology.
2013 Feb; 170(3):291-302. doi:
10.1016/j.jplph.2012.10.004. [PMID: 23158502] - M Nagaraj Kumar, Wann-Neng Jane, Paul E Verslues. Role of the putative osmosensor Arabidopsis histidine kinase1 in dehydration avoidance and low-water-potential response.
Plant physiology.
2013 Feb; 161(2):942-53. doi:
10.1104/pp.112.209791. [PMID: 23184230] - Ziting Yao, Chengwu Zou, Hui Zhou, Jinzi Wang, Lidan Lu, Yang Li, Baoshan Chen. Δ(1)-pyrroline-5-carboxylate/glutamate biogenesis is required for fungal virulence and sporulation.
PloS one.
2013; 8(9):e73483. doi:
10.1371/journal.pone.0073483. [PMID: 24039956] - Ji Huang, Shujing Sun, Dongqing Xu, Hongxia Lan, Hui Sun, Zhoufei Wang, Yongmei Bao, Jianfei Wang, Haijuan Tang, Hongsheng Zhang. A TFIIIA-type zinc finger protein confers multiple abiotic stress tolerances in transgenic rice (Oryza sativa L.).
Plant molecular biology.
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Amino acids.
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