Masoprocol (BioDeep_00000003596)

 

Secondary id: BioDeep_00000395795, BioDeep_00000398544, BioDeep_00000858484, BioDeep_00000866934

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Chemicals and Drugs


代谢物信息卡片


4-[(2S,3R)-3-[(3,4-dihydroxyphenyl)methyl]-2-methylbutyl]benzene-1,2-diol

化学式: C18H22O4 (302.1518012)
中文名称: 去甲二氢愈创木酸, 马索罗酚, 去甲二氢愈创木酸
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 7.5%

分子结构信息

SMILES: c1(c(ccc(c1)C[C@@H]([C@@H](Cc1ccc(c(c1)O)O)C)C)O)O
InChI: InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3

描述信息

Masoprocol is the meso-form of nordihydroguaiaretic acid. An antioxidant found in the creosote bush, Larrea divaricata, it is a potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. It also inhibits (though to a lesser extent) formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase. It has a role as an antineoplastic agent, a lipoxygenase inhibitor, a hypoglycemic agent and a metabolite.
Masoprocol is a natural product found in Larrea divaricata, Schisandra chinensis, and Larrea tridentata with data available.
Masoprocol is a naturally occurring antioxidant dicatechol originally derived from the creosote bush Larrea divaricatta with antipromoter, anti-inflammatory, and antineoplastic activities. Masoprocol directly inhibits activation of two receptor tyrosine kinases (RTKs), the insulin-like growth factor receptor (IGF-1R) and the c-erbB2/HER2/neu receptor, resulting in decreased proliferation of susceptible tumor cell populations. This agent may induce apoptosis in susceptible tumor cell populations as a result of disruption of the actin cytoskeleton in association with the activation of stress activated protein kinases (SAPKs). In addition, masoprocol inhibits arachidonic acid 5-lipoxygenase (5LOX), resulting in diminished synthesis of inflammatory mediators such as prostaglandins and leukotrienes. It may prevent leukocyte infiltration into tissues and the release of reactive oxygen species.
A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils.
A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils.
Masoprocol, also known as actinex or meso-ndga, belongs to the class of organic compounds known as dibenzylbutane lignans. These are lignan compounds containing a 2,3-dibenzylbutane moiety. Symptoms of overdose or allergic reaction include bluish coloration of skin, dizziness, or feeling faint, wheezing or trouble in breathing. Masoprocol also inhibits prostaglandins but the significance of this action is not yet known. Masoprocol is a drug which is used for the treatment of actinic keratoses (precancerous skin growths that can become malignant if left untreated). It also serves as an antioxidant in fats and oils. Masoprocol is a potentially toxic compound. It is not known exactly how masoprocol works. Although the exact mechanism of action is not known, studies have shown that masoprocol is a potent 5-lipoxygenase inhibitor and has antiproliferative activity against keratinocytes in tissue culture, but the relationship between this activity and its effectiveness in actinic keratoses is unknown. A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism.
The meso-form of nordihydroguaiaretic acid. An antioxidant found in the creosote bush, Larrea divaricata, it is a potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. It also inhibits (though to a lesser extent) formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase.
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents
D004791 - Enzyme Inhibitors > D016859 - Lipoxygenase Inhibitors
D002491 - Central Nervous System Agents > D000700 - Analgesics
C471 - Enzyme Inhibitor > C1322 - Lipooxygenase Inhibitor
D020011 - Protective Agents > D000975 - Antioxidants
C26170 - Protective Agent > C275 - Antioxidant
D000893 - Anti-Inflammatory Agents
CONFIDENCE standard compound; INTERNAL_ID 611; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4658; ORIGINAL_PRECURSOR_SCAN_NO 4657
CONFIDENCE standard compound; INTERNAL_ID 611; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4580; ORIGINAL_PRECURSOR_SCAN_NO 4576
CONFIDENCE standard compound; INTERNAL_ID 611; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4551; ORIGINAL_PRECURSOR_SCAN_NO 4548
CONFIDENCE standard compound; INTERNAL_ID 611; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4643; ORIGINAL_PRECURSOR_SCAN_NO 4642
CONFIDENCE standard compound; INTERNAL_ID 611; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4651; ORIGINAL_PRECURSOR_SCAN_NO 4650
CONFIDENCE standard compound; INTERNAL_ID 611; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4591; ORIGINAL_PRECURSOR_SCAN_NO 4587
Masoprocol (meso-Nordihydroguaiaretic acid) is a potent and orally active lipoxygenase inhibitor. Masoprocol shows antihyperglycemic activity. Masoprocol decreases the glucose concentration and hepatic triglyceride in vivo. Masoprocol has the potential for the research of type II diabetes[1][2][3].
Masoprocol (meso-Nordihydroguaiaretic acid) is a potent and orally active lipoxygenase inhibitor. Masoprocol shows antihyperglycemic activity. Masoprocol decreases the glucose concentration and hepatic triglyceride in vivo. Masoprocol has the potential for the research of type II diabetes[1][2][3].
Masoprocol (meso-Nordihydroguaiaretic acid) is a potent and orally active lipoxygenase inhibitor. Masoprocol shows antihyperglycemic activity. Masoprocol decreases the glucose concentration and hepatic triglyceride in vivo. Masoprocol has the potential for the research of type II diabetes[1][2][3].
Nordihydroguaiaretic acid is a 5-lipoxygenase (5LOX) (IC50=8 μM) and tyrosine kinase inhibitor.
Nordihydroguaiaretic acid is a 5-lipoxygenase (5LOX) (IC50=8 μM) and tyrosine kinase inhibitor.
Nordihydroguaiaretic acid is a 5-lipoxygenase (5LOX) (IC50=8 μM) and tyrosine kinase inhibitor.

同义名列表

82 个代谢物同义名

4-[(2S,3R)-3-[(3,4-dihydroxyphenyl)methyl]-2-methylbutyl]benzene-1,2-diol; 4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]benzene-1,2-diol; 4-((2R,3S)-4-(3,4-DIHYDROXYPHENYL)-2,3-DIMETHYLBUTYL)BENZENE-1,2-DIOL; 4-[(2S,3R)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol; 4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol; 1,2-Benzenediol, 4,4-((2R,3S)-2,3-dimethyl-1,4-butanediyl)bis-, rel-; 1,2-Benzenediol, 4,4-[(2R,3S)-2,3-dimethyl-1,4-butanediyl]bis-, rel-; meso-beta,gamma-dimethyl-alpha,delta-bis(3,4-dihydroxyphenyl)butan; meso-4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol; meso-4-(4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl)benzene-1,2-diol; rel-4,4-((2R,3S)-2,3-Dimethylbutane-1,4-diyl)bis(benzene-1,2-diol); 1,2-Benzenediol, 4,4-(2,3-dimethyl-1,4-butanediyl)bis-, (R*,S*)-; Nordihydroguaiaretic acid from Larrea divaricata (creosote bush); 4,4-((2R,3S)-2,3-Dimethylbutane-1,4-diyl)bis(benzene-1,2-diol); 4,4-((2R,3S)-2,3-dimethylbutane-1,4-diyl)dibenzene-1,2-diol; (R*,S*)-4,4-(2,3-Dimethylbutane-1,4-diyl)bispyrocatechol; meso-4,4-(2,3-dimethyl-1,4-butanediyl)bis(pyrocatechol); Meso-b,g-dimethyl-a,delta-bis(3,4-dihydroxyphenyl)butan; 4,4-(2,3-Dimethyl-1,4-butanediyl)bis(1,2-benzenediol); meso-1,4-bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane; Meso-β,γ-dimethyl-α,δ-bis(3,4-dihydroxyphenyl)butan; meso-4,4-(2,3-Dimethyltetramethylene)dipyrocatechol; Meso-b,g-dimethyl-a,δ-bis(3,4-dihydroxyphenyl)butan; meso-2,3-bis(3,4-dihydroxyphenylmethyl)butane; Nordihydroguaiaretic Acid, (R*,S*)-Isomer; Nordihydroguaiaretic acid (meso-form); NORDIHYDROGUAIARETIC ACID [WHO-DD]; erythro-nordihydroguaiaretic acid; NORDIHYDROGUAIARETIC ACID [INCI]; Acid, meso-Nordihydroguaiaretic; meso Nordihydroguaiaretic Acid; meso-Nordihydroguaiaretic acid; NORDIHYDROGUAIARETIC ACID [MI]; Erythro-nordihydroguaiaretate; Meso-nordihydroguaiaretate; Nordihydroguairaretic acid; Dihydronorguaiaretic Acid; Nordihydroguaiaretic Acid; nordihydroguiaretic acid; Masoprocolum (INN-Latin); Masoprocolum [INN-Latin]; MASOPROCOL [ORANGE BOOK]; Nordihydroguaiaretsaure; Masoprocol [USAN:INN]; nordihydroguaiaretate; Masoprocol (USAN/INN); MASOPROCOL [WHO-DD]; MASOPROCOL (MART.); MASOPROCOL [MART.]; MASOPROCOL [VANDF]; MASOPROCOL [USAN]; MASOPROCOL [INN]; UNII-7BO8G1BYQU; Lopac0_000877; Masoprocolum; Tox21_500877; ORISTAR NHGA; Tox21_110210; Actinex (TN); Masoprocol; 7BO8G1BYQU; meso-NDGA; C18H22O4; CHX-100; CHX 100; INSM-18; L01XX10; Actinex; INSM18; NDHGA; NDGA; 4,4-(2,3-dimethyl-1,4-butanediyl)bis-1, 2-Benzenediol; 4,4-(2,3-Dimethyl-1,4-butanediyl)bis-1,2-benzenediol; 4, 4-(2,3-Dimethyl-1,4-butanediyl)bis(pyrocatechol); 4,4-(2,3-Dimethyl-1,4-butanediyl)bis(pyrocatechol); 1,4-bis(3,4-dihydroxyphenyl)-2,3-dimethyl-Butane; 4,4- (2,3-diemthyltetramethylene)-diPyrocatechol; 4,4-(2, 3-Dimethyltetramethylene)dipyrocatechol; 4,4-(2,3-Dimethyltetramethylene)dipyrocatechol; 2,3-Bis(3,4-dihydroxyphenylmethyl)butane; dihydro-Dinorguaiaretic acid; dihydro-Norguaiaretic acid



数据库引用编号

34 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

16 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Stephen A Banse, Christine A Sedore, Erik Johnson, Anna L Coleman-Hulbert, Brian Onken, David Hall, E Grace Jackson, Phu Huynh, Anna C Foulger, Suzhen Guo, Theo Garrett, Jian Xue, Delaney Inman, Mackenzie L Morshead, W Todd Plummer, Esteban Chen, Dipa Bhaumik, Michelle K Chen, Girish Harinath, Manish Chamoli, Rose P Quinn, Ron Falkowski, Daniel Edgar, Madeline O Schmidt, Mark Lucanic, Max Guo, Monica Driscoll, Gordon J Lithgow, Patrick C Phillips. Antioxidants green tea extract and nordihydroguaiaretic acid confer species and strain-specific lifespan and health effects in Caenorhabditis nematodes. GeroScience. 2024 Apr; 46(2):2239-2251. doi: 10.1007/s11357-023-00978-0. [PMID: 37923874]
  • Qiong Wu, Yanan He, Chunxiao Cui, Xiaoya Tao, Dongdong Zhang, Yurong Zhang, Tiejin Ying, Li Li. Quantitative proteomic analysis of tomato fruit ripening behavior in response to exogenous abscisic acid. Journal of the science of food and agriculture. 2023 Dec; 103(15):7469-7483. doi: 10.1002/jsfa.12838. [PMID: 37421609]
  • Joshua A Visser, Deborah Yager, Schuyler A Chambers, Ji Youn Lim, Xujun Cao, Lynette Cegelski. Nordihydroguaiaretic Acid (NDGA) Inhibits CsgA Polymerization, Bacterial Amyloid Biogenesis, and Biofilm Formation. Chembiochem : a European journal of chemical biology. 2023 May; ?(?):e202300266. doi: 10.1002/cbic.202300266. [PMID: 37195016]
  • Narasimham L Parinandi, Alex Liaugminas, Patrick J Oliver, Saradhadevi Varadharaj, Anita Yenigalla, Austin C Elliott, Sukruthi Arutla, Steven J Campbell, Sainath R Kotha, Shariq I Sherwani, Vijay K Kutala, Jodi C McDaniel, Krishna Rao Maddipati, Periannan Kuppusamy, Thomas J Hund. Classic Phytochemical Antioxidant and Lipoxygenase Inhibitor, Nordihydroguaiaretic Acid, Activates Phospholipase D through Oxidant Signaling and Tyrosine Phosphorylation Leading to Cytotoxicity in Lung Vascular Endothelial Cells. Cell biochemistry and biophysics. 2023 Feb; ?(?):. doi: 10.1007/s12013-023-01128-1. [PMID: 36820994]
  • Tamara Sipka, Seol Ah Park, Resul Ozbilgic, Laurence Balas, Thierry Durand, Karol Mikula, Georges Lutfalla, Mai Nguyen-Chi. Macrophages undergo a behavioural switch during wound healing in zebrafish. Free radical biology & medicine. 2022 11; 192(?):200-212. doi: 10.1016/j.freeradbiomed.2022.09.021. [PMID: 36162743]
  • Florencia Martinez, Lucia Maria Ghietto, Giuliana Lingua, M Laura Mugas, J Javier Aguilar, Pedro Gil, M Belén Pisano, Juliana Marioni, María Gabriela Paglini, Marta S Contigiani, Susana C Núñez-Montoya, Brenda S Konigheim. New insights into the antiviral activity of nordihydroguaiaretic acid: Inhibition of dengue virus serotype 1 replication. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Nov; 106(?):154424. doi: 10.1016/j.phymed.2022.154424. [PMID: 36126544]
  • Nor Azrini Nadiha Azmi, Amal A M Elgharbawy, Hamzah Mohd Salleh, Muhammad Moniruzzaman. Preparation, Characterization and Biological Activities of an Oil-in-Water Nanoemulsion from Fish By-Products and Lemon Oil by Ultrasonication Method. Molecules (Basel, Switzerland). 2022 Oct; 27(19):. doi: 10.3390/molecules27196725. [PMID: 36235261]
  • Ignacio Peralta, Carla Marrassini, Malen Saint Martin, Yanina Santander Plantamura, Laura Cogoi, Néstor Pellegrino, María Rosario Alonso, Claudia Anesini. Anti-hyperglycaemic effect and nutritional properties of an aqueous extract of Larrea divaricata Cav. (jarilla) in streptozotocin-induced diabetes in mice. Journal of ethnopharmacology. 2022 Oct; 296(?):115429. doi: 10.1016/j.jep.2022.115429. [PMID: 35659916]
  • Felicia S Manciu, Jose Guerrero, Kevin E Bennet, Su-Youne Chang, Masum Rahman, Lizbeth V Martinez Lopez, Siobhan Chantigian, Mariana Castellanos, Marian Manciu. Assessing Nordihydroguaiaretic Acid Therapeutic Effect for Glioblastoma Multiforme. Sensors (Basel, Switzerland). 2022 Mar; 22(7):. doi: 10.3390/s22072643. [PMID: 35408257]
  • Nicole M Anders, Carlos G Romo, Avelina Hemingway, Manmeet S Ahluwalia, Michelle A Rudek. Quantitation of terameprocol in human plasma by liquid chromatography-tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2022 Feb; 209(?):114525. doi: 10.1016/j.jpba.2021.114525. [PMID: 34906921]
  • Leyla Polat Kose, İlhami Gulcin. Evaluation of the Antioxidant and Antiradical Properties of Some Phyto and Mammalian Lignans. Molecules (Basel, Switzerland). 2021 Nov; 26(23):. doi: 10.3390/molecules26237099. [PMID: 34885681]
  • Maria N de Lira, Lukas Bolini, Natália R T Amorim, Hercules A Silva-Souza, Bruno L Diaz, Claudio Canetti, Pedro M Persechini, Christianne Bandeira-Melo. Acute catabolism of leukocyte lipid bodies: Characterization of a nordihydroguaiaretic acid (NDGA)-induced proteasomal-dependent model. Prostaglandins, leukotrienes, and essential fatty acids. 2021 08; 171(?):102320. doi: 10.1016/j.plefa.2021.102320. [PMID: 34303171]
  • Florencia Martinez, María Laura Mugas, Juan Javier Aguilar, Juliana Marioni, Marta Silvia Contigiani, Susana C Núñez Montoya, Brenda S Konigheim. First report of antiviral activity of nordihydroguaiaretic acid against Fort Sherman virus (Orthobunyavirus). Antiviral research. 2021 03; 187(?):104976. doi: 10.1016/j.antiviral.2020.104976. [PMID: 33444704]
  • Kumar Lama, Guy Harlev, Hadas Shafran, Reut Peer, Moshe A Flaishman. Anthocyanin accumulation is initiated by abscisic acid to enhance fruit color during fig (Ficus carica L.) ripening. Journal of plant physiology. 2020 Aug; 251(?):153192. doi: 10.1016/j.jplph.2020.153192. [PMID: 32554070]
  • Nathaniel C Gilbert, Jana Gerstmeier, Erin E Schexnaydre, Friedemann Börner, Ulrike Garscha, David B Neau, Oliver Werz, Marcia E Newcomer. Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products. Nature chemical biology. 2020 07; 16(7):783-790. doi: 10.1038/s41589-020-0544-7. [PMID: 32393899]
  • Geraldine Sandana Mala John, Veena Kumari Vuttaradhi, Satoru Takeuchi, Ravi Shankar Pitani, Ganesh Venkatraman, Suresh Kumar Rayala. Facile synthesis and nanoscale features of a nanostructured nordihydroguaiaretic acid analog for therapeutic applications. Journal of nanobiotechnology. 2020 May; 18(1):74. doi: 10.1186/s12951-020-00628-z. [PMID: 32410712]
  • Qinghua Cui, Ruikun Du, Miaomiao Liu, Lijun Rong. Lignans and Their Derivatives from Plants as Antivirals. Molecules (Basel, Switzerland). 2020 Jan; 25(1):. doi: 10.3390/molecules25010183. [PMID: 31906391]
  • Geraldine Sandana Mala John, Satoru Takeuchi, Ganesh Venkatraman, Suresh Kumar Rayala. Nordihydroguaiaretic Acid in Therapeutics: Beneficial to Toxicity Profiles and the Search for its Analogs. Current cancer drug targets. 2020; 20(2):86-103. doi: 10.2174/1568009619666191022141547. [PMID: 31642411]
  • Michael E Zubrow, Susan S Margulies, Nadir Yehya. Nordihydroguaiaretic acid reduces secondary organ injury in septic rats after cecal ligation and puncture. PloS one. 2020; 15(8):e0237613. doi: 10.1371/journal.pone.0237613. [PMID: 32790786]
  • Ignacio Peralta, Carla Marrassini, María Laura Barreiro Arcos, Graciela Cremaschi, María Rosario Alonso, Claudia Anesini. Larrea divaricata Cav. aqueous extract and nordihydroguariaretic acid modulate oxidative stress in submandibular glands of diabetic rats: a buccal protective in diabetes. BMC complementary and alternative medicine. 2019 Aug; 19(1):227. doi: 10.1186/s12906-019-2636-z. [PMID: 31438933]
  • Zhong Zhang, Chenxuan Kang, Shuyi Zhang, Xingang Li. Transcript analyses reveal a comprehensive role of abscisic acid in modulating fruit ripening in Chinese jujube. BMC plant biology. 2019 May; 19(1):189. doi: 10.1186/s12870-019-1802-2. [PMID: 31068143]
  • Mourad Chioua, Emma Martínez-Alonso, Rafael Gonzalo-Gobernado, Maria I Ayuso, Alejandro Escobar-Peso, Lourdes Infantes, Dimitra Hadjipavlou-Litina, Juan J Montoya, Joan Montaner, Alberto Alcázar, José Marco-Contelles. New Quinolylnitrones for Stroke Therapy: Antioxidant and Neuroprotective ( Z)- N- tert-Butyl-1-(2-chloro-6-methoxyquinolin-3-yl)methanimine Oxide as a New Lead-Compound for Ischemic Stroke Treatment. Journal of medicinal chemistry. 2019 02; 62(4):2184-2201. doi: 10.1021/acs.jmedchem.8b01987. [PMID: 30715875]
  • Gustavo Tomás Díaz-Gerevini, Alejandro Daín, María Eugenia Pasqualini, Cristina B López, Aldo R Eynard, Gastón Repossi. Diabetic encephalopathy: beneficial effects of supplementation with fatty acids ω3 and nordihydroguaiaretic acid in a spontaneous diabetes rat model. Lipids in health and disease. 2019 Feb; 18(1):43. doi: 10.1186/s12944-018-0938-7. [PMID: 30736810]
  • Nitin Mundhe, Parveen Kumar, Ishan Arora, Sahabuddin Ahmed, Mangala Lahkar. Differential effect of NDGA on cisplatin-induced nephrotoxicity in Spargue-Dawley rats. Immunopharmacology and immunotoxicology. 2019 Feb; 41(1):68-75. doi: 10.1080/08923973.2018.1547741. [PMID: 30604648]
  • Madhurima Singh, Stefanie Bittner, Yihang Li, Alex Bittner, Lu Han, Yuan Cortez, Mohammed Inayathullah, Zeeshan Arif, Ramakrishnan Parthasarathi, Jayakumar Rajadas, Wen-Jun Shen, Mark R Nicolls, Fredric B Kraemer, Salman Azhar. Anti-hyperlipidaemic effects of synthetic analogues of nordihydroguaiaretic acid in dyslipidaemic rats. British journal of pharmacology. 2019 02; 176(3):369-385. doi: 10.1111/bph.14528. [PMID: 30374952]
  • Saurabh Awasthi, R Preethy, N T Saraswathi. Nordihydroguaiaretic acid prevents glycation induced structural alterations and aggregation of albumin. International journal of biological macromolecules. 2019 Feb; 122(?):479-484. doi: 10.1016/j.ijbiomac.2018.10.173. [PMID: 30416092]
  • Kumar Lama, Sharawan Yadav, Yogev Rosianski, Felix Shaya, Amnon Lichter, Lijuan Chai, Yardena Dahan, Zohar Freiman, Reut Peer, Moshe A Flaishman. The distinct ripening processes in the reproductive and non-reproductive parts of the fig syconium are driven by ABA. Journal of experimental botany. 2019 01; 70(1):115-131. doi: 10.1093/jxb/ery333. [PMID: 30239815]
  • Jackie K W Chan, Stefanie Bittner, Alex Bittner, Suman Atwal, Wen-Jun Shen, Mohammed Inayathullah, Jayakumar Rajada, Mark R Nicolls, Fredric B Kraemer, Salman Azhar. Nordihydroguaiaretic Acid, a Lignan from Larrea tridentata (Creosote Bush), Protects Against American Lifestyle-Induced Obesity Syndrome Diet-Induced Metabolic Dysfunction in Mice. The Journal of pharmacology and experimental therapeutics. 2018 05; 365(2):281-290. doi: 10.1124/jpet.117.243733. [PMID: 29472517]
  • María Rosario Alonso, Ignacio Peralta, Demian Monti, Renzo Martino, Claudia Anesini. Stability of an Aqueous Extract of Larrea divaricata Cav. during a Simulated Digestion Process. Phytotherapy research : PTR. 2017 Nov; 31(11):1708-1714. doi: 10.1002/ptr.5897. [PMID: 28857321]
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