Semicarbazide (BioDeep_00000003483)
Secondary id: BioDeep_00001868234
human metabolite blood metabolite Volatile Flavor Compounds
代谢物信息卡片
化学式: CH5N3O (75.04326)
中文名称: 氨基脲
谱图信息:
最多检出来源 Homo sapiens(blood) 96.67%
分子结构信息
SMILES: C(=O)(N)NN
InChI: InChI=1S/CH5N3O/c2-1(5)4-3/h3H2,(H3,2,4,5)
描述信息
D009676 - Noxae > D002273 - Carcinogens
KEIO_ID S034
同义名列表
数据库引用编号
22 个数据库交叉引用编号
- ChEBI: CHEBI:28306
- KEGG: C02077
- KEGGdrug: D95915
- PubChem: 5196
- HMDB: HMDB0258225
- Metlin: METLIN65708
- ChEMBL: CHEMBL903
- Wikipedia: Semicarbazide
- MetaCyc: SEMICARBAZIDE
- chemspider: 5008
- CAS: 57-56-7
- MoNA: KO004007
- MoNA: KO004008
- MoNA: KO004010
- MoNA: KO004011
- MoNA: KO004009
- PMhub: MS000009743
- PubChem: 5163
- NIKKAJI: J4.582I
- RefMet: Semicarbazide
- KNApSAcK: 28306
- CAS: 4426-72-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(9)
- trans-4-hydroxy-L-proline degradation II
- L-arginine degradation VIII (arginine oxidase pathway)
- methanol and methylamine oxidation to formaldehyde
- superpathway of C1 compounds oxidation to CO2
- formaldehyde assimilation I (serine pathway)
- methylamine degradation I
- CMP-N-acetylneuraminate biosynthesis II (bacteria)
- superpathway of CMP-sialic acids biosynthesis
- spermidine biosynthesis I
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
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International journal of biological macromolecules.
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. [PMID: 32334390] - Michael J Reid, Russell Eyre, Terry Podoll. Oxidative Deamination of Emixustat by Human Vascular Adhesion Protein-1/Semicarbazide-Sensitive Amine Oxidase.
Drug metabolism and disposition: the biological fate of chemicals.
2019 05; 47(5):504-515. doi:
10.1124/dmd.118.085811
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Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
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. [PMID: 29729480] - Zonghao Yue, Miao Yu, Haifeng Zhao, Jun Wang, Xiaona Zhang, Hua Tian, Wei Wang, Shaoguo Ru. The anti-estrogenicity of chronic exposure to semicarbazide in female Japanese flounders (Paralichthys olivaceus), and its potential mechanisms.
Marine pollution bulletin.
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Reproductive toxicology (Elmsford, N.Y.).
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Pancreas.
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Pakistan journal of pharmaceutical sciences.
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Laboratory animals.
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Human & experimental toxicology.
2012 Oct; 31(10):1035-49. doi:
10.1177/0960327112444475
. [PMID: 22549094] - Eduardo Paredes-Andrade, Craig A Solid, Sarah B Rockswold, Rick M Odland, Gaylan L Rockswold. Hypertonic saline reduces intracranial hypertension in the presence of high serum and cerebrospinal fluid osmolalities.
Neurocritical care.
2012 Oct; 17(2):204-10. doi:
10.1007/s12028-011-9574-z
. [PMID: 21725694] - David A Spector, Jie Deng, Kerry J Stewart. Dietary protein affects urea transport across rat urothelia.
American journal of physiology. Renal physiology.
2012 Oct; 303(7):F944-53. doi:
10.1152/ajprenal.00238.2012
. [PMID: 22832927] - Thulasingam Senthilkumar, Nagarajan Sangeetha, Natarajan Ashokkumar. Antihyperglycemic, antihyperlipidemic, and renoprotective effects of Chlorella pyrenoidosa in diabetic rats exposed to cadmium.
Toxicology mechanisms and methods.
2012 Oct; 22(8):617-24. doi:
10.3109/15376516.2012.714007
. [PMID: 22827700] - Sanyog Jain, Pankaj U Valvi, Nitin K Swarnakar, Kaushik Thanki. Gelatin coated hybrid lipid nanoparticles for oral delivery of amphotericin B.
Molecular pharmaceutics.
2012 Sep; 9(9):2542-53. doi:
10.1021/mp300320d
. [PMID: 22845020] - Timothy K Cooper, Qing Zhong, Mary Nabity, Gerson Rosenberg, William J Weiss. Use of urinary biomarkers of renal ischemia in a lamb preclinical left ventricular assist device model.
Artificial organs.
2012 Sep; 36(9):820-4. doi:
10.1111/j.1525-1594.2011.01436.x
. [PMID: 22428807] - Ileana Mackinney-Novelo, Josué Barahona-Garrido, Fátima Castillo-Albarran, Jean J Santiago-Hernández, Nahum Méndez-Sánchez, Misael Uribe, Norberto Chávez-Tapia. Clinical course and management of acute hepatitis A infection in adults.
Annals of hepatology.
2012 Sep; 11(5):652-7. doi:
10.1016/s1665-2681(19)31438-3
. [PMID: 22947525] - Xi-Xin Wu. [Clinical comparison study of Chinese adult serum cystatin C based estimated glomerular filtration rate equations].
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue.
2012 Sep; 24(9):530-3. doi:
NULL
. [PMID: 22938660] - Shin Ahn, Yoon-Seon Lee, Yeon Hee Chun, Kyung Soo Lim, Won Kim, Jae-Lyun Lee. Predictive factors of bacteraemia in low-risk patients with febrile neutropenia.
Emergency medicine journal : EMJ.
2012 Sep; 29(9):715-9. doi:
10.1136/emermed-2011-200012
. [PMID: 22011971] - Farzaneh Ashrafi, Mehdi Nematbakhsh, Tahereh Safari, Ardeshir Talebi, Hamid Nasri, Mehdi Khazaei, Mohammad-Mehdi Baradaran-Mahdavi, Amir Jafapisheh, Behrooz Olia, Omid Pirhaji, Sayyed-Javad Hashemi-Nia, Fatemeh Eshraghi, Zahra Pezeshki, Mojgan Mortazavi. A combination of vitamin C and losartan for cisplatin-induced nephrotoxicity in rats.
Iranian journal of kidney diseases.
2012 Sep; 6(5):361-5. doi:
NULL
. [PMID: 22976262] - Selvinaz Dalaklioglu, Pinar Sahin, Ece Gungor Ordueri, Ciler Celik-Ozenci, Arda Tasatargil. Potential role of poly(ADP-ribose) polymerase (PARP) activation in methotrexate-induced nephrotoxicity and tubular apoptosis.
International journal of toxicology.
2012 Sep; 31(5):430-40. doi:
10.1177/1091581812457430
. [PMID: 22914891] - Ming Li, Nanfu Luo, Zhixuan Bai, Shuren Wang, Yingkang Shi, Xian'en Fa. A canine model of multiple organ dysfunction following acute type-A aortic dissection.
Surgery today.
2012 Sep; 42(9):876-83. doi:
10.1007/s00595-011-0073-9
. [PMID: 22120508] - Wei Li, Hong Jiang, Jiang-Min Feng. Isogenic mesenchymal stem cells transplantation improves a rat model of chronic aristolochic acid nephropathy via upregulation of hepatic growth factor and downregulation of transforming growth factor β1.
Molecular and cellular biochemistry.
2012 Sep; 368(1-2):137-45. doi:
10.1007/s11010-012-1352-5
. [PMID: 22661380] - Emi Yamamato, Takeshi Izawa, Osamu Sawamoto, Vetnizah Juniantito, Mitsuru Kuwamura, Jyoji Yamate. Amelioration of cisplatin-induced rat renal lesions by a cyclooxygenase (COX)-2 selective inhibitor.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2012 Sep; 64(6):625-31. doi:
10.1016/j.etp.2010.12.005
. [PMID: 21256724] - Matthias Dupont, Yuping Wu, Stanley L Hazen, W H Wilson Tang. Cystatin C identifies patients with stable chronic heart failure at increased risk for adverse cardiovascular events.
Circulation. Heart failure.
2012 Sep; 5(5):602-9. doi:
10.1161/circheartfailure.112.966960
. [PMID: 22899766] - Talib Hussain, Ramesh K Gupta, K Sweety, Bavani Eswaran, M Vijayakumar, Chandana Venkateswara Rao. Nephroprotective activity of Solanum xanthocarpum fruit extract against gentamicin-induced nephrotoxicity and renal dysfunction in experimental rodents.
Asian Pacific journal of tropical medicine.
2012 Sep; 5(9):686-91. doi:
10.1016/s1995-7645(12)60107-2
. [PMID: 22805718] - Juan-Pablo Idrovo, Weng-Lang Yang, Jeffrey Nicastro, Gene F Coppa, Ping Wang. Stimulation of carnitine palmitoyltransferase 1 improves renal function and attenuates tissue damage after ischemia/reperfusion.
The Journal of surgical research.
2012 Sep; 177(1):157-64. doi:
10.1016/j.jss.2012.05.053
. [PMID: 22698429] - Mohammed Ahmed Saad Almansob, Bo Xu, Li Zhou, Xiao-Xia Hu, Wen Chen, Feng-Jun Chang, Hong-Bo Ci, Jian-Ping Yao, Ying-Qi Xu, Feng-Juan Yao, Dong-Hong Liu, Wen-Bo Zhang, Bai-Yun Tang, Zhi-Ping Wang, Jing-Song Ou. Simvastatin reduces myocardial injury undergoing noncoronary artery cardiac surgery: a randomized controlled trial.
Arteriosclerosis, thrombosis, and vascular biology.
2012 Sep; 32(9):2304-13. doi:
10.1161/atvbaha.112.252098
. [PMID: 22796581] - Kubra Kaynar, Rezzan Aliyazioglu, Safak Ersoz, Sukru Ulusoy, Sait Al, Gulsum Ozkan, Muammer Cansiz. Role of erythropoietin in prevention of amikacin-induced nephropathy.
Journal of nephrology.
2012 Sep; 25(5):744-9. doi:
10.5301/jn.5000054
. [PMID: 22322815] - Li-li Deng, Ling Zhong, Jian-rong Lei, Lin Tang, Ling Liu, Shu-qin Xie, Xiao-hui Liao. [Protective effect of lipoxin A4 against rhabdomyolysis-induced acute kidney injury in rats].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2012 Sep; 28(9):907-10. doi:
NULL
. [PMID: 22980651] - Guangzhi Chen, Renfan Xu, Yinna Wang, Peihua Wang, Gang Zhao, Xizhen Xu, Artiom Gruzdev, Darryl C Zeldin, Dao Wen Wang. Genetic disruption of soluble epoxide hydrolase is protective against streptozotocin-induced diabetic nephropathy.
American journal of physiology. Endocrinology and metabolism.
2012 Sep; 303(5):E563-75. doi:
10.1152/ajpendo.00591.2011
. [PMID: 22739108] - Shanshan Chen, Junbao Du, Yinfang Liang, Rongyuan Zhang, Chaoshu Tang, Hongfang Jin. Sulfur dioxide restores calcium homeostasis disturbance in rat with isoproterenol-induced myocardial injury.
Histology and histopathology.
2012 09; 27(9):1219-26. doi:
10.14670/hh-27.1219
. [PMID: 22806909] - Chia-Yu Lin, Chia-Yun Lin, Mei-Chin Yin. Renal protective effects of extracts from guava fruit (Psidium guajava L.) in diabetic mice.
Plant foods for human nutrition (Dordrecht, Netherlands).
2012 Sep; 67(3):303-8. doi:
10.1007/s11130-012-0294-0
. [PMID: 22581156] - Peng Hu, Jing Wang, Bo Hu, Ling Lu, Qiang Xuan, Yuan Han Qin. Increased urinary C-type natriuretic peptide excretion may be an early marker of renal tubulointerstitial fibrosis.
Peptides.
2012 Sep; 37(1):98-105. doi:
10.1016/j.peptides.2012.06.009
. [PMID: 22743139] - Alsayed Ahmed Alnahal, Usama Ahmed Khalil, Magada Alsayed Diab, Ali Fahmy Zanaty. Expression of angiotensin-converting enzyme mRNA gene in the kidneys of patients with glomerulonephrites.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.
2012 Sep; 23(5):993-9. doi:
10.4103/1319-2442.100881
. [PMID: 22982912] - Y F Jiang, B He, J Ma, N-P Li, G-Z Gong, D Cheng. Comparison of the antiviral effects of entecavir and adefovir dipivoxil in chronic HBV infection: a randomized control trial.
Acta gastro-enterologica Belgica.
2012 Sep; 75(3):316-21. doi:
NULL
. [PMID: 23082701] - Kubra Kaynar, Safak Ersoz, Rezzan Aliyazicioglu, Aysegul Uzun, Sukru Ulusoy, Sait Al, Gulsum Ozkan, Muammer Cansız. Is there any way to protect from tacrolimus-induced renal and pancreas injury?.
Clinical transplantation.
2012 Sep; 26(5):722-8. doi:
10.1111/j.1399-0012.2012.01603.x
. [PMID: 22428934] - Yun-Wei Shi, Cai-Ping Wang, Lei Liu, Yang-Liu Liu, Xing Wang, Ye Hong, Zhen Li, Ling-Dong Kong. Antihyperuricemic and nephroprotective effects of resveratrol and its analogues in hyperuricemic mice.
Molecular nutrition & food research.
2012 Sep; 56(9):1433-44. doi:
10.1002/mnfr.201100828
. [PMID: 22865646] - Farzaneh Ashrafi, Sara Haghshenas, Mehdi Nematbakhsh, Hamid Nasri, Ardeshir Talebi, Fatemeh Eshraghi-Jazi, Zahra Pezeshki, Tahereh Safari. The Role of Magnesium Supplementation in Cisplatin-induced Nephrotoxicity in a Rat Model: No Nephroprotectant Effect.
International journal of preventive medicine.
2012 Sep; 3(9):637-43. doi:
NULL
. [PMID: 23024853] - Rieko Katayama, Jun Saito, Masaaki Katayama, Norio Yamagishi, Tetsuro Yamashita, Masaki Kato, Kazuhisa Furuhama. Simplified procedure for the estimation of glomerular filtration rate following intravenous administration of iodixanol in cats.
American journal of veterinary research.
2012 Sep; 73(9):1344-9. doi:
10.2460/ajvr.73.9.1344
. [PMID: 22924714] - Qin Zhang, Gonçalo Gamboa da Costa, Linda S Von Tungeln, Cristina C Jacob, Ronald P Brown, Peter L Goering. Urinary biomarker detection of melamine- and cyanuric acid-induced kidney injury in rats.
Toxicological sciences : an official journal of the Society of Toxicology.
2012 Sep; 129(1):1-8. doi:
10.1093/toxsci/kfs182
. [PMID: 22610612] - Chia-Hung Yen, Kun-Chen Lin, Steve Leu, Cheuk-Kwan Sun, Li-Teh Chang, Han-Tan Chai, Sheng-Ying Chung, Hsueh-Wen Chang, Sheung-Fat Ko, Yen-Ta Chen, Hon-Kan Yip. Chronic exposure to environmental contaminant nonylphenol exacerbates adenine-induced chronic renal insufficiency: role of signaling pathways and therapeutic impact of rosuvastatin.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2012 Aug; 46(5):455-67. doi:
10.1016/j.ejps.2012.03.009
. [PMID: 22484332] - Gaoming Wang, Hairong Huang, Haiwei Wu, Chen Wu, Yanhui Xu, Lian Wang, Xiaolong Liu, Changtian Wang, Yi Shen, Demin Li, Hua Jing. Erythropoietin attenuates cardiopulmonary bypass-induced renal inflammatory injury by inhibiting nuclear factor-κB p65 expression.
European journal of pharmacology.
2012 Aug; 689(1-3):154-9. doi:
10.1016/j.ejphar.2012.05.027
. [PMID: 22659586] - Yi Li, Xi Tang, Juqian Zhang, Taixiang Wu. Nutritional support for acute kidney injury.
The Cochrane database of systematic reviews.
2012 Aug; ?(8):CD005426. doi:
10.1002/14651858.cd005426.pub3
. [PMID: 22895948] - Ho-Jeong Lee, Hyun-Kyung Yu, Jin-Hyung Ahn, Yong-Keun Park, Yeup Yoon, Jang-Seong Kim, Sun-Jin Kim. Repeated intravenous infusion of human apolipoprotein(a) kringle V is associated with reversible dose-dependent acute tubulointerstitial nephritis without affecting glomerular filtration function.
Toxicology letters.
2012 Aug; 212(3):298-306. doi:
10.1016/j.toxlet.2012.05.019
. [PMID: 22659101] - Hiroyuki Terawaki, Yukie Matsuyama, Nanae Matsuo, Makoto Ogura, Jun Mitome, Akihiko Hamaguchi, Tomoyoshi Terada, Seiichi Era, Tatsuo Hosoya. A lower level of reduced albumin induces serious cardiovascular incidence among peritoneal dialysis patients.
Clinical and experimental nephrology.
2012 Aug; 16(4):629-35. doi:
10.1007/s10157-012-0610-x
. [PMID: 22358613] - Seung-Min Lee, Yoonsu Cho, Hye-Kyung Chung, Dong-Hyuk Shin, Woel-Kyu Ha, Sang-Chul Lee, Min-Jeong Shin. Effects of kimchi supplementation on blood pressure and cardiac hypertrophy with varying sodium content in spontaneously hypertensive rats.
Nutrition research and practice.
2012 Aug; 6(4):315-21. doi:
10.4162/nrp.2012.6.4.315
. [PMID: 22977685] - Wen-Hung Huang, Cheng-Chieh Hung, Chih-Wei Yang, Jeng-Yi Huang. High correlation between clearance of renal protein-bound uremic toxins (indoxyl sulfate and p-cresyl sulfate) and renal water-soluble toxins in peritoneal dialysis patients.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.
2012 Aug; 16(4):361-7. doi:
10.1111/j.1744-9987.2012.01068.x
. [PMID: 22817125] - Caitlin C O'Meara, Matthew Hoffman, William E Sweeney, Shirng-Wern Tsaih, Bing Xiao, Howard J Jacob, Ellis D Avner, Carol Moreno. Role of genetic modifiers in an orthologous rat model of ARPKD.
Physiological genomics.
2012 Aug; 44(15):741-53. doi:
10.1152/physiolgenomics.00187.2011
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