Ethionine (BioDeep_00000003453)

   

natural product


代谢物信息卡片


L-2-Amino-4-(ethylthio)butyric acid

化学式: C6H13NO2S (163.0666958)
中文名称: L-乙硫胺酸, DL-乙硫氨酸
谱图信息: 最多检出来源 Viridiplantae(plant) 23.08%

分子结构信息

SMILES: CCSCCC(C(=O)O)N
InChI: InChI=1S/C6H13NO2S/c1-2-10-4-3-5(7)6(8)9/h5H,2-4,7H2,1H3,(H,8,9)

描述信息

An S-ethylhomocysteine that has S-configuration at the chiral centre.
D009676 - Noxae > D000963 - Antimetabolites
Acquisition and generation of the data is financially supported in part by CREST/JST.
KEIO_ID E056

同义名列表

4 个代谢物同义名

L-Ethionine; Ethionine; L-2-Amino-4-(ethylthio)butyric acid; DL-ETHIONINE



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Robin D Tucker, Victor Ciofoaia, Sandeep Nadella, Martha D Gay, Hong Cao, Matthew Huber, Anita Safronenka, Narayan Shivapurkar, Bhaskar Kallakury, Annie J Kruger, Alexander H K Kroemer, Jill P Smith. A Cholecystokinin Receptor Antagonist Halts Nonalcoholic Steatohepatitis and Prevents Hepatocellular Carcinoma. Digestive diseases and sciences. 2020 01; 65(1):189-203. doi: 10.1007/s10620-019-05722-3. [PMID: 31297627]
  • Gyorgy Biczo, Eszter T Vegh, Natalia Shalbueva, Olga A Mareninova, Jason Elperin, Ethan Lotshaw, Sophie Gretler, Aurelia Lugea, Sudarshan R Malla, David Dawson, Piotr Ruchala, Julian Whitelegge, Samuel W French, Li Wen, Sohail Z Husain, Fred S Gorelick, Peter Hegyi, Zoltan Rakonczay, Ilya Gukovsky, Anna S Gukovskaya. Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models. Gastroenterology. 2018 Feb; 154(3):689-703. doi: 10.1053/j.gastro.2017.10.012. [PMID: 29074451]
  • Sun-Bok Choi, Gi-Sang Bae, Il-Joo Jo, Ho-Joon Song, Sung-Joo Park. Effects of Berberine on Acute Necrotizing Pancreatitis and Associated Lung Injury. Pancreas. 2017 09; 46(8):1046-1055. doi: 10.1097/mpa.0000000000000877. [PMID: 28797013]
  • Sapna Iyer, Min-Jung Park, David Moons, Raymond Kwan, Jian Liao, Li Liu, M Bishr Omary. Clusterin and Pycr1 alterations associate with strain and model differences in susceptibility to experimental pancreatitis. Biochemical and biophysical research communications. 2017 Jan; 482(4):1346-1352. doi: 10.1016/j.bbrc.2016.12.039. [PMID: 27939882]
  • Angel L Pey, Tomas Majtan, Jan P Kraus. The role of surface electrostatics on the stability, function and regulation of human cystathionine β-synthase, a complex multidomain and oligomeric protein. Biochimica et biophysica acta. 2014 Sep; 1844(9):1453-62. doi: 10.1016/j.bbapap.2014.04.015. [PMID: 24780582]
  • Chad McKee, Junpei Soeda, Esra Asilmaz, Barbara Sigalla, Maelle Morgan, Nicoletta Sinelli, Tania Roskams, Jude A Oben. Propranolol, a β-adrenoceptor antagonist, worsens liver injury in a model of non-alcoholic steatohepatitis. Biochemical and biophysical research communications. 2013 Aug; 437(4):597-602. doi: 10.1016/j.bbrc.2013.07.005. [PMID: 23850676]
  • Zoltan Erdos, Kara Pearson, Michael Goedken, Karsten Menzel, Frank D Sistare, Warren E Glaab, Louise Parks Saldutti. Inhibin B response to testicular toxicants hexachlorophene, ethane dimethane sulfonate, di-(n-butyl)-phthalate, nitrofurazone, DL-ethionine, 17-alpha ethinylestradiol, 2,5-hexanedione, or carbendazim following short-term dosing in male rats. Birth defects research. Part B, Developmental and reproductive toxicology. 2013 Feb; 98(1):41-53. doi: 10.1002/bdrb.21035. [PMID: 23348767]
  • Kjetil H Løland, Oyvind Bleie, Heidi Borgeraas, Elin Strand, Per M Ueland, Asbjørn Svardal, Jan E Nordrehaug, Ottar Nygård. The association between progression of atherosclerosis and the methylated amino acids asymmetric dimethylarginine and trimethyllysine. PloS one. 2013; 8(5):e64774. doi: 10.1371/journal.pone.0064774. [PMID: 23734218]
  • Jin Hwan Lee, Chun San An, Bok Sun Yun, Kum Suk Kang, Young Ae Lee, Sun Mi Won, Byoung Joo Gwag, Sung Ig Cho, Ki-Baik Hahm. Prevention effects of ND-07, a novel drug candidate with a potent antioxidative action and anti-inflammatory action, in animal models of severe acute pancreatitis. European journal of pharmacology. 2012 Jul; 687(1-3):28-38. doi: 10.1016/j.ejphar.2012.04.048. [PMID: 22575522]
  • Erik Alm, Tove Slagbrand, K Magnus Aberg, Erik Wahlström, Ingela Gustafsson, Johan Lindberg. Automated annotation and quantification of metabolites in 1H NMR data of biological origin. Analytical and bioanalytical chemistry. 2012 Apr; 403(2):443-55. doi: 10.1007/s00216-012-5789-x. [PMID: 22362275]
  • Jessie Fernandez, Janet D Wright, David Hartline, Cristian F Quispe, Nandakumar Madayiputhiya, Richard A Wilson. Principles of carbon catabolite repression in the rice blast fungus: Tps1, Nmr1-3, and a MATE-family pump regulate glucose metabolism during infection. PLoS genetics. 2012; 8(5):e1002673. doi: 10.1371/journal.pgen.1002673. [PMID: 22570632]
  • Soo-Jung Lee, Myung-Hee Kang, Hyesun Min. Folic acid supplementation reduces oxidative stress and hepatic toxicity in rats treated chronically with ethanol. Nutrition research and practice. 2011 Dec; 5(6):520-6. doi: 10.4162/nrp.2011.5.6.520. [PMID: 22259676]
  • Suzanne Geenen, Cristina Guallar-Hoyas, Filippos Michopoulos, J Gerry Kenna, Kyle L Kolaja, Hans V Westerhoff, Paul Thomas, Ian D Wilson. HPLC-MS/MS methods for the quantitative analysis of 5-oxoproline (pyroglutamate) in rat plasma and hepatic cell line culture medium. Journal of pharmaceutical and biomedical analysis. 2011 Nov; 56(3):655-63. doi: 10.1016/j.jpba.2011.06.001. [PMID: 21752568]
  • Agnès Fourcot, Dominique Couchie, Marie-Noele Chobert, Elie-Serge Zafrani, Philippe Mavier, Yannick Laperche, Arthur Brouillet. Gas6 deficiency prevents liver inflammation, steatohepatitis, and fibrosis in mice. American journal of physiology. Gastrointestinal and liver physiology. 2011 Jun; 300(6):G1043-53. doi: 10.1152/ajpgi.00311.2010. [PMID: 21350191]
  • Mahmoud Rushdi Abd Ellah. The role of liver biopsy in detection of hepatic oxidative stress. Veterinary medicine international. 2011 Feb; 2011(?):613602. doi: 10.4061/2011/613602. [PMID: 21403828]
  • Abbass Ghanbari-Niaki, Rahelah Soltani, Afsaneh Shemshaki, Robert R Kraemer. Effects of acute ethionine injection on plasma ghrelin and obestatin levels in trained male rats. Metabolism: clinical and experimental. 2010 Jul; 59(7):982-7. doi: 10.1016/j.metabol.2009.10.020. [PMID: 20045146]
  • Schonna R Manning, John W La Claire. Prymnesins: toxic metabolites of the golden alga, Prymnesium parvum Carter (Haptophyta). Marine drugs. 2010 Mar; 8(3):678-704. doi: 10.3390/md8030678. [PMID: 20411121]
  • Erik Alm, Ralf J O Torgrip, K Magnus Aberg, Ina Schuppe-Koistinen, Johan Lindberg. Time-resolved biomarker discovery in 1H-NMR data using generalized fuzzy Hough transform alignment and parallel factor analysis. Analytical and bioanalytical chemistry. 2010 Mar; 396(5):1681-9. doi: 10.1007/s00216-009-3421-5. [PMID: 20087727]
  • Tuncay Baubec, Huy Q Dinh, Ales Pecinka, Branislava Rakic, Wilfried Rozhon, Bonnie Wohlrab, Arndt von Haeseler, Ortrun Mittelsten Scheid. Cooperation of multiple chromatin modifications can generate unanticipated stability of epigenetic States in Arabidopsis. The Plant cell. 2010 Jan; 22(1):34-47. doi: 10.1105/tpc.109.072819. [PMID: 20097869]
  • Chiaki Kondo, Yohsuke Minowa, Takeki Uehara, Yasushi Okuno, Noriyuki Nakatsu, Atsushi Ono, Toshiyuki Maruyama, Ikuo Kato, Jyoji Yamate, Hiroshi Yamada, Yasuo Ohno, Tetsuro Urushidani. Identification of genomic biomarkers for concurrent diagnosis of drug-induced renal tubular injury using a large-scale toxicogenomics database. Toxicology. 2009 Nov; 265(1-2):15-26. doi: 10.1016/j.tox.2009.09.003. [PMID: 19761811]
  • Mahmoud R Abd Ellah, Keiji Okada, Masanobu Goryo, Akihiro Oishi, Jun Yasuda. Superoxide dismutase activity as a measure of hepatic oxidative stress in cattle following ethionine administration. Veterinary journal (London, England : 1997). 2009 Nov; 182(2):336-41. doi: 10.1016/j.tvjl.2008.05.013. [PMID: 18585936]
  • Takanari Nakano, Ikuo Inoue, Shigehiro Katayama, Makoto Seo, Seiichiro Takahashi, Shigeru Hokari, Rina Shinozaki, Kazuhisa Hatayama, Tsugikazu Komoda. Lysophosphatidylcholine for efficient intestinal lipid absorption and lipoprotein secretion in caco-2 cells. Journal of clinical biochemistry and nutrition. 2009 Sep; 45(2):227-34. doi: 10.3164/jcbn.09-25. [PMID: 19794933]
  • Mitsuhiro Hirode, Ko Omura, Naoki Kiyosawa, Takeki Uehara, Toshinobu Shimuzu, Atsushi Ono, Toshikazu Miyagishima, Taku Nagao, Yasuo Ohno, Tetsuro Urushidani. Gene expression profiling in rat liver treated with various hepatotoxic-compounds inducing coagulopathy. The Journal of toxicological sciences. 2009 Jun; 34(3):281-93. doi: 10.2131/jts.34.281. [PMID: 19483382]
  • Runkuan Yang, Angel L Shaufl, Meaghan E Killeen, Mitchell P Fink. Ethyl pyruvate ameliorates liver injury secondary to severe acute pancreatitis. The Journal of surgical research. 2009 May; 153(2):302-9. doi: 10.1016/j.jss.2008.04.004. [PMID: 19027919]
  • Jiankun Duan, Bin Hu. Separation and determination of seleno amino acids using gas chromatography hyphenated with inductively coupled plasma mass spectrometry after hollow fiber liquid phase microextraction. Journal of mass spectrometry : JMS. 2009 May; 44(5):605-12. doi: 10.1002/jms.1533. [PMID: 19053158]
  • Hyesun Min. Effects of dietary supplementation of high-dose folic acid on biomarkers of methylating reaction in vitamin B(12)-deficient rats. Nutrition research and practice. 2009; 3(2):122-7. doi: 10.4162/nrp.2009.3.2.122. [PMID: 20016712]
  • Emey Suhana Mohd Azamai, Suhaniza Sulaiman, Shafina Hanim Mohd Habib, Mee Lee Looi, Srijit Das, Nor Aini Abdul Hamid, Wan Zurinah Wan Ngah, Yasmin Anum Mohd Yusof. Chlorella vulgaris triggers apoptosis in hepatocarcinogenesis-induced rats. Journal of Zhejiang University. Science. B. 2009 Jan; 10(1):14-21. doi: 10.1631/jzus.b0820168. [PMID: 19198018]
  • Isamu Yamaguchi, Kentaro Hamada, Masanori Yoshida, Hiroyuki Isayama, Shuichi Kanazashi, Koji Takeuchi. Risperidone attenuates local and systemic inflammatory responses to ameliorate diet-induced severe necrotic pancreatitis in mice: it may provide a new therapy for acute pancreatitis. The Journal of pharmacology and experimental therapeutics. 2009 Jan; 328(1):256-62. doi: 10.1124/jpet.108.141895. [PMID: 18832108]
  • Shafina Hanim Mohd Habib, Suzana Makpol, Noor Aini Abdul Hamid, Srijit Das, Wan Zurinah Wan Ngah, Yasmin Anum Mohd Yusof. Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory effects on ethionine-induced hepatoma rats. Clinics (Sao Paulo, Brazil). 2008 Dec; 63(6):807-13. doi: 10.1590/s1807-59322008000600017. [PMID: 19061005]
  • Yasmin Anum Mohd Yusof, Norliza Ahmad, Srijit Das, Suhaniza Sulaiman, Nor Azian Murad. Chemopreventive efficacy of ginger (Zingiber officinale) in ethionine induced rat hepatocarcinogenesis. African journal of traditional, complementary, and alternative medicines : AJTCAM. 2008 Oct; 6(1):87-93. doi: 10.4314/ajtcam.v6i1.57078. [PMID: 20162046]
  • Muhammad K Saeed, Yulin Deng, Rongji Dai. Attenuation of Biochemical Parameters in Streptozotocin-induced Diabetic Rats by Oral Administration of Extracts and Fractions of Cephalotaxus sinensis. Journal of clinical biochemistry and nutrition. 2008 Jan; 42(?):21-8. doi: 10.3164/jcbn2008004. [PMID: 18231626]
  • Eleni Skordi, Ivan K S Yap, Sandrine P Claus, François-Pierre J Martin, Olivier Cloarec, Johan Lindberg, Ina Schuppe-Koistinen, Elaine Holmes, Jeremy K Nicholson. Analysis of time-related metabolic fluctuations induced by ethionine in the rat. Journal of proteome research. 2007 Dec; 6(12):4572-81. doi: 10.1021/pr070268q. [PMID: 17966971]
  • Percy Ho, K F Kong, Y H Chan, Jimmy S H Tsang, Joseph T Y Wong. An unusual S-adenosylmethionine synthetase gene from dinoflagellate is methylated. BMC molecular biology. 2007 Oct; 8(?):87. doi: 10.1186/1471-2199-8-87. [PMID: 17915037]
  • R Mota, F Sánchez-Bueno, J J Berenguer-Pina, D Hernández-Espinosa, P Parrilla, J Yélamos. Therapeutic treatment with poly(ADP-ribose) polymerase inhibitors attenuates the severity of acute pancreatitis and associated liver and lung injury. British journal of pharmacology. 2007 Aug; 151(7):998-1005. doi: 10.1038/sj.bjp.0707310. [PMID: 17533414]
  • Aymeric Goyer, Eva Collakova, Yair Shachar-Hill, Andrew D Hanson. Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway. Plant & cell physiology. 2007 Feb; 48(2):232-42. doi: 10.1093/pcp/pcl055. [PMID: 17169919]
  • Keith D Gray, Misho O Simovic, Timothy S Blackwell, John W Christman, Addison K May, Kelly S Parman, William C Chapman, Steven C Stain. Activation of nuclear factor kappa B and severe hepatic necrosis may mediate systemic inflammation in choline-deficient/ethionine-supplemented diet-induced pancreatitis. Pancreas. 2006 Oct; 33(3):260-7. doi: 10.1097/01.mpa.0000240599.95817.34. [PMID: 17003648]
  • Taketoshi Ogawa, Atsuhiro Sugidachi, Naoki Tanaka, Koichi Fujimoto, Jun-ichiro Fukushige, Yoshiro Tani, Fumitoshi Asai. Effects of R-102444 and its active metabolite R-96544, selective 5-HT2A receptor antagonists, on experimental acute and chronic pancreatitis: Additional evidence for possible involvement of 5-HT2A receptors in the development of experimental pancreatitis. European journal of pharmacology. 2005 Oct; 521(1-3):156-63. doi: 10.1016/j.ejphar.2005.08.033. [PMID: 16183055]
  • Yasuyuki Kihara, Hiroyuki Yoshikawa, Hidekazu Honda, Ken-ichirou Fukumitsu, Taizou Yamaguchi, Makoto Otsuki. Natural disruption of group 2 phospholipase A2 gene protects against choline-deficient ethionine-supplemented diet-induced acute pancreatitis and lung injury. Pancreas. 2005 Jul; 31(1):48-53. doi: 10.1097/01.mpa.0000168223.43709.28. [PMID: 15968247]
  • Jongwon Choi, Jung-Kwan Park, Kyung-Tae Lee, Kwang-Kyun Park, Won-Bae Kim, Jin-Ha Lee, Hyun-Ju Jung, Hee-Juhn Park. In vivo antihepatotoxic effects of Ligularia fischeri var. spiciformis and the identification of the active component, 3,4-dicaffeoylquinic acid. Journal of medicinal food. 2005; 8(3):348-52. doi: 10.1089/jmf.2005.8.348. [PMID: 16176146]
  • Lena Trulsson, Per Sandström, Tommy Sundqvist, Staffan Smeds, Thomas Gasslander, Joar Svanvik. The Influence of a load of L-arginine on serum amino acids and pancreatic apoptosis/proliferation and ATP levels in the rat. Pancreas. 2004 Nov; 29(4):e113-20. doi: 10.1097/00006676-200411000-00165. [PMID: 15502637]
  • Vance B Matthews, Elizabeth Klinken, George C T Yeoh. Direct effects of interleukin-6 on liver progenitor oval cells in culture. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 2004 Nov; 12(6):650-6. doi: 10.1111/j.1067-1927.2004.12605.x. [PMID: 15555057]
  • Atsushi Nitanai, Norio Katoh, Shin Oikawa, Masakazu Saitoh, Masaomi Hamada, Akihito Kutsuzawa, Tharwat Mohamed, Eiji Uchida, Daiji Endoh, Takashi Kurosawa, Hiroshi Sato. Decreases in serum apolipoprotein C-III concentration in cows with ethionine-induced fatty liver. The Journal of veterinary medical science. 2004 Sep; 66(9):1113-8. doi: 10.1292/jvms.66.1113. [PMID: 15472476]
  • Runkuan Yang, Takashi Uchiyama, Sean M Alber, Xiaonan Han, Simon K Watkins, Russell L Delude, Mitchell P Fink. Ethyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitis. Critical care medicine. 2004 Jul; 32(7):1453-9. doi: 10.1097/01.ccm.0000130835.65462.06. [PMID: 15241088]
  • Fatma Aiad, Basiouny El-Gamal, Jehan Al-Meer, Zinab El-Kerdasy, Nadia Zakhary, Abdelbaset El-Aaser. Protective effect of soybean against hepatocarcinogenesis induced by DL-ethionine. Journal of biochemistry and molecular biology. 2004 May; 37(3):370-5. doi: 10.5483/bmbrep.2004.37.3.370. [PMID: 15469721]
  • T Andrew Clayton, John C Lindon, Jeremy R Everett, Claude Charuel, Gilles Hanton, Jean-Loic Le Net, Jean-Pierre Provost, Jeremy K Nicholson. Hepatotoxin-induced hypercreatinaemia and hypercreatinuria: their relationship to one another, to liver damage and to weakened nutritional status. Archives of toxicology. 2004 Feb; 78(2):86-96. doi: 10.1007/s00204-003-0515-2. [PMID: 14520508]
  • P Chowdhury. An exploratory study on the development of an animal model of acute pancreatitis following nicotine exposure. Tobacco induced diseases. 2003 Sep; 1(3):213-7. doi: 10.1186/1617-9625-1-3-213. [PMID: 19570262]
  • Rong Di, Jungsup Kim, Melinda N Martin, Tom Leustek, Jinwoo Jhoo, Chi-Tang Ho, Nilgun E Tumer. Enhancement of the primary flavor compound methional in potato by increasing the level of soluble methionine. Journal of agricultural and food chemistry. 2003 Sep; 51(19):5695-702. doi: 10.1021/jf030148c. [PMID: 12952421]
  • T Andrew Clayton, John C Lindon, Jeremy R Everett, Claude Charuel, Gilles Hanton, Jean-Loic Le Net, Jean-Pierre Provost, Jeremy K Nicholson. An hypothesis for a mechanism underlying hepatotoxin-induced hypercreatinuria. Archives of toxicology. 2003 Apr; 77(4):208-17. doi: 10.1007/s00204-002-0431-x. [PMID: 12698236]
  • Yoshitaka Sakai, Atsushi Masamune, Akihiko Satoh, Jun Nishihira, Tetsuya Yamagiwa, Tooru Shimosegawa. Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitis. Gastroenterology. 2003 Mar; 124(3):725-36. doi: 10.1053/gast.2003.50099. [PMID: 12612911]
  • D Papagoras, E J Giamarellos-Bourboulis, M Kanara, G Douridas, I Paraskevopoulos, G Antzaklis, P Karayannacos, H Giamarellou. Pancreatic concentrations of cefepime in experimental necrotizing pancreatitis. Journal of chemotherapy (Florence, Italy). 2003 Feb; 15(1):43-6. doi: 10.1179/joc.2003.15.1.43. [PMID: 12678413]
  • Tsunao Imamura, Junichi Niikawa, Katsuya Kitamura, Akira Takahashi, Akitoshi Ikegami, Hitoshi Yoshida, Shigeki Tanaka, Keiji Mitamura. Effect of IS-741 on ethionine-induced acute pancreatitis in rats: relation to pancreatic acinar cell regeneration. Journal of gastroenterology. 2003; 38(3):260-7. doi: 10.1007/s005350300045. [PMID: 12673449]
  • Takaya Sato, Junichi Niikawa, Ichiro Usui, Tsunao Imamura, Hitoshi Yoshida, Shigeki Tanaka, Keiji Mitamura. Pancreatic regeneration after ethionine-induced acute pancreatitis in rats lacking pancreatic CCK-A receptor gene expression. Journal of gastroenterology. 2003; 38(7):672-80. doi: 10.1007/s00535-003-1120-0. [PMID: 12898360]
  • Kimihiro Ominato, Hiroshi Akita, Akinori Suzuki, Fumiko Kijima, Takashi Yoshino, Michiko Yoshino, Yukako Chiba, Hitoshi Onouchi, Satoshi Naito. Identification of a short highly conserved amino acid sequence as the functional region required for posttranscriptional autoregulation of the cystathionine gamma-synthase gene in Arabidopsis. The Journal of biological chemistry. 2002 Sep; 277(39):36380-6. doi: 10.1074/jbc.m204645200. [PMID: 12121993]
  • Martina Wein, Noa Lavid, Stefan Lunkenbein, Efraim Lewinsohn, Wilfried Schwab, Ralf Kaldenhoff. Isolation, cloning and expression of a multifunctional O-methyltransferase capable of forming 2,5-dimethyl-4-methoxy-3(2H)-furanone, one of the key aroma compounds in strawberry fruits. The Plant journal : for cell and molecular biology. 2002 Sep; 31(6):755-65. doi: 10.1046/j.1365-313x.2002.01396.x. [PMID: 12220266]
  • Derek B Goto, Makoto Ogi, Fumiko Kijima, Tomoko Kumagai, Folkert van Werven, Hitoshi Onouchi, Satoshi Naito. A single-nucleotide mutation in a gene encoding S-adenosylmethionine synthetase is associated with methionine over-accumulation phenotype in Arabidopsis thaliana. Genes & genetic systems. 2002 Apr; 77(2):89-95. doi: 10.1266/ggs.77.89. [PMID: 12087191]
  • Bo Shen, Changjiang Li, Mitchell C Tarczynski. High free-methionine and decreased lignin content result from a mutation in the Arabidopsis S-adenosyl-L-methionine synthetase 3 gene. The Plant journal : for cell and molecular biology. 2002 Feb; 29(3):371-80. doi: 10.1046/j.1365-313x.2002.01221.x. [PMID: 11844113]
  • M Govendir, P J Canfield, D R Emslie, A D J Watson, D B Church. Evaluation of d,l-ethionine as a mechanism for pancreatic islet regeneration in dogs. Australian veterinary journal. 2002 Jan; 80(1-2):75-82; discussion 82. doi: . [PMID: 12180885]
  • M K McMillian, E R Grant, Z Zhong, J B Parker, L Li, R A Zivin, M E Burczynski, M D Johnson. Nile Red binding to HepG2 cells: an improved assay for in vitro studies of hepatosteatosis. In vitro & molecular toxicology. 2001; 14(3):177-90. doi: 10.1089/109793301753407948. [PMID: 11846991]
  • J Maa, E F Grady, S K Yoshimi, T E Drasin, E H Kim, M M Hutter, N W Bunnett, K S Kirkwood. Substance P is a determinant of lethality in diet-induced hemorrhagic pancreatitis in mice. Surgery. 2000 Aug; 128(2):232-9. doi: 10.1067/msy.2000.107378. [PMID: 10922997]
  • J L Frossard, A Saluja, L Bhagat, H S Lee, M Bhatia, B Hofbauer, M L Steer. The role of intercellular adhesion molecule 1 and neutrophils in acute pancreatitis and pancreatitis-associated lung injury. Gastroenterology. 1999 Mar; 116(3):694-701. doi: 10.1016/s0016-5085(99)70192-7. [PMID: 10029629]
  • M Bhatia, A K Saluja, B Hofbauer, H S Lee, J L Frossard, M L Steer. The effects of neutrophil depletion on a completely noninvasive model of acute pancreatitis-associated lung injury. International journal of pancreatology : official journal of the International Association of Pancreatology. 1998 Oct; 24(2):77-83. doi: 10.1007/bf02788564. [PMID: 9816540]
  • K Furuhama, K Yabe. Application of hepatic tolerance tests to the functional reserve assessment in rat models of fatty liver. The Journal of veterinary medical science. 1998 May; 60(5):635-7. doi: 10.1292/jvms.60.635. [PMID: 9637301]
  • T Yoshino, I Yamaguchi. Possible involvement of 5-HT2 receptor activation in aggravation of diet-induced acute pancreatitis in mice. The Journal of pharmacology and experimental therapeutics. 1997 Dec; 283(3):1495-502. doi: NULL. [PMID: 9400026]
  • K E Todd, M P Lewis, B Gloor, J S Lane, S W Ashley, H A Reber. An ETa/ETb endothelin antagonist ameliorates systemic inflammation in a murine model of acute hemorrhagic pancreatitis. Surgery. 1997 Aug; 122(2):443-9; discussion 449. doi: 10.1016/s0039-6060(97)90038-6. [PMID: 9288152]
  • A Bergman, A Sundin, F Karpe, A Magnusson. CT with the hepatocyte-specific contrast medium FP 736-04 in an experimental model of liver steatosis. Acta radiologica (Stockholm, Sweden : 1987). 1997 May; 38(3):405-9. doi: 10.1080/02841859709172091. [PMID: 9191431]
  • P Padma, O H Setty. Protective effect of vitamin E against ethionine toxicity. Biochemistry and molecular biology international. 1997 Apr; 41(4):785-95. doi: 10.1080/15216549700201821. [PMID: 9111939]
  • J Cai, W M Sun, J J Hwang, S C Stain, S C Lu. Changes in S-adenosylmethionine synthetase in human liver cancer: molecular characterization and significance. Hepatology (Baltimore, Md.). 1996 Nov; 24(5):1090-7. doi: 10.1002/hep.510240519. [PMID: 8903381]
  • J G Norman, G W Fink, C Sexton, G Carter. Transgenic animals demonstrate a role for the IL-1 receptor in regulating IL-1beta gene expression at steady-state and during the systemic stress induced by acute pancreatitis. The Journal of surgical research. 1996 Jun; 63(1):231-6. doi: 10.1006/jsre.1996.0253. [PMID: 8661203]
  • D Kanduc. Modulation of in vitro kidney cell growth by hepatic transfer RNAs. Biochemical and biophysical research communications. 1996 Apr; 221(3):735-8. doi: 10.1006/bbrc.1996.0665. [PMID: 8630030]
  • M A Manso, A I Rodriguez, A C Garcia-Montero, I De Dios. Effects of the cholecystokinin receptor antagonist L-364,718 on pancreatitis induced by a deficient in choline and supplemented with ethionine (CDE) diet in the rat. Archives of physiology and biochemistry. 1995 Aug; 103(4):410-5. doi: 10.3109/13813459509047130. [PMID: 8548474]
  • F Takabayashi, N Harada, Y Hara. The effects of green tea catechins (Polyphenon) on DL-ethionine-induced acute pancreatitis. Pancreas. 1995 Aug; 11(2):127-31. doi: 10.1097/00006676-199508000-00003. [PMID: 7479668]
  • M A Manso, A Rebollo, R Pescador, I de Dios. Action of CCK on CDE diet-induced acute pancreatitis in rats treated with hydrocortisone. Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology. 1995 Jun; 111(2):257-63. doi: 10.1016/0742-8413(95)00045-p. [PMID: 8521247]
  • J G Norman, M G Franz, G S Fink, J Messina, P J Fabri, W R Gower, L C Carey. Decreased mortality of severe acute pancreatitis after proximal cytokine blockade. Annals of surgery. 1995 Jun; 221(6):625-31; discussion 631. doi: 10.1097/00000658-199506000-00002. [PMID: 7794067]
  • L Tessitore, E Sesca, M Greco, P Pani, M U Dianzani. Sexually differentiated response to choline in choline deficiency and ethionine intoxication. International journal of experimental pathology. 1995 Apr; 76(2):125-9. doi: NULL. [PMID: 7786762]
  • S Oikawa, N Katoh. Enzyme-linked immunosorbent assay for apolipoprotein A-I in the serum of cattle. American journal of veterinary research. 1995 Apr; 56(4):409-14. doi: . [PMID: 7785812]
  • G J Enderle, U Delabar, H Krell. Different pathomechanisms of altered biliary leukotriene C4 elimination in isolated perfused rat livers. Biochemical pharmacology. 1995 Jan; 49(3):297-304. doi: 10.1016/0006-2952(94)00461-t. [PMID: 7857316]
  • Y Echigo, K Inoue, M Kogire, R Doi, S Higashide, S Sumi, H Kaji, M Imamura. Effects of cyclosporine and tacrolimus (FK 506) on acute pancreatitis in mice. Archives of surgery (Chicago, Ill. : 1960). 1995 Jan; 130(1):64-8. doi: 10.1001/archsurg.1995.01430010066013. [PMID: 7528496]
  • E Uchida, N Katoh, K Takahashi. The activity of lecithin:cholesterol acyltransferase in the serum of cows at parturition or with fatty liver. Veterinary research communications. 1995; 19(5):343-51. doi: 10.1007/bf01839316. [PMID: 8560751]
  • M Noguchi, T Fujitsuka, K Honda, Y Kawai. Effects of phenobarbital on drug metabolizing enzyme activities and other biochemical parameters in rats with DL-ethionine-induced liver injury. The Journal of toxicological sciences. 1994 Nov; 19(4):203-12. doi: 10.2131/jts.19.4_203. [PMID: 7884831]
  • A Kovarík, B Koukalová, A Holý, M Bezdĕk. Sequence-specific hypomethylation of the tobacco genome induced with dihydroxypropyladenine, ethionine and 5-azacytidine. FEBS letters. 1994 Oct; 353(3):309-11. doi: 10.1016/0014-5793(94)01048-x. [PMID: 7525347]
  • T Foitzik, K B Lewandrowski, C Fernández-del Castillo, D W Rattner, A L Warshaw. Evidence for extraluminal trypsinogen activation in three different models of acute pancreatitis. Surgery. 1994 Jun; 115(6):698-702. doi: . [PMID: 8197561]
  • J W Miller, M R Nadeau, J Smith, D Smith, J Selhub. Folate-deficiency-induced homocysteinaemia in rats: disruption of S-adenosylmethionine's co-ordinate regulation of homocysteine metabolism. The Biochemical journal. 1994 Mar; 298 ( Pt 2)(?):415-9. doi: 10.1042/bj2980415. [PMID: 8135750]
  • M Noguchi, K Tanaka, Y Kuwamura, T Fukushima, Y Kawai. Toxicokinetics of phenobarbital in rats with DL-ethionine-induced liver injury. The Journal of toxicological sciences. 1993 Nov; 18(4):245-55. doi: 10.2131/jts.18.4_245. [PMID: 8295228]
  • K L Schalinske, R D Steele. 13-cis-retinoic acid and hepatic steatosis in rats. Biochemical pharmacology. 1993 Jul; 46(2):319-25. doi: 10.1016/0006-2952(93)90421-r. [PMID: 8347155]
  • E Uchida, N Katoh, K Takahashi. Induction of serum haptoglobin by administration of ethionine to cows. The Journal of veterinary medical science. 1993 Jun; 55(3):501-2. doi: 10.1292/jvms.55.501. [PMID: 8357931]
  • W W Barrow, E L Wright, K S Goh, N Rastogi. Activities of fluoroquinolone, macrolide, and aminoglycoside drugs combined with inhibitors of glycosylation and fatty acid and peptide biosynthesis against Mycobacterium avium. Antimicrobial agents and chemotherapy. 1993 Apr; 37(4):652-61. doi: 10.1128/aac.37.4.652. [PMID: 8494359]
  • A Hagiwara, H Tanaka, K Imaida, S Tamano, S Fukushima, N Ito. Correlation between medium-term multi-organ carcinogenesis bioassay data and long-term observation results in rats. Japanese journal of cancer research : Gann. 1993 Mar; 84(3):237-45. doi: 10.1111/j.1349-7006.1993.tb02862.x. [PMID: 8486526]
  • L S Yoshida, T Miyazawa, I Hatayama, K Sato, K Fujimoto, T Kaneda. Phosphatidylcholine peroxidation and liver cancer in mice fed a choline-deficient diet with ethionine. Free radical biology & medicine. 1993 Feb; 14(2):191-9. doi: 10.1016/0891-5849(93)90010-r. [PMID: 8425721]
  • J L de Camargo, H Tsuda, M Asamoto, Y Tagawa, S Wada, S Nagase, N Ito. Modifying effects of chemicals on the development of liver preneoplastic placental glutathione S-transferase positive foci in analbuminemic and Sprague-Dawley rats. Toxicologic pathology. 1993; 21(4):409-16. doi: 10.1177/019262339302100410. [PMID: 8290874]
  • E Uchida, N Katoh, K Takahashi. Induction of fatty liver in cows by ethionine administration and concomitant decreases of serum apolipoproteins B-100 and A-I concentrations. American journal of veterinary research. 1992 Nov; 53(11):2035-42. doi: . [PMID: 1466499]
  • R W Peace, G Sarwar, H G Botting, S P Touchburn. Influence of dietary soybean trypsin inhibitors and DL-ethionine on sulfur amino acid adequacy of diets for young rats. Plant foods for human nutrition (Dordrecht, Netherlands). 1992 Oct; 42(4):337-49. doi: 10.1007/bf02194095. [PMID: 1438078]
  • T Hirano, T Manabe, G Ohshio, Y Nio. Improved survival in mice with diet-induced pancreatitis treated with new potent protease inhibitor, E-3123 and a broad spectrum antibiotic, cefmetazole. Nihon geka hokan. Archiv fur japanische Chirurgie. 1992 May; 61(3):213-23. doi: NULL. [PMID: 1444701]
  • M Bezdĕk, B Koukalová, V Kuhrová, B Vyskot. Differential sensitivity of CG and CCG DNA sequences to ethionine-induced hypomethylation of the Nicotiana tabacum genome. FEBS letters. 1992 Apr; 300(3):268-70. doi: 10.1016/0014-5793(92)80860-j. [PMID: 1372869]
  • M Suzuki, S Isaji, R Stanten, C F Frey, B Ruebner. Effect of protease inhibitor FUT-175 on acute hemorrhagic pancreatitis in mice. International journal of pancreatology : official journal of the International Association of Pancreatology. 1992 Feb; 11(1):59-65. doi: NULL. [PMID: 1374785]
  • C Niederau, M Niederau, F Borchard, K Ude, R Lüthen, G Strohmeyer, L D Ferrell, J H Grendell. Effects of antioxidants and free radical scavengers in three different models of acute pancreatitis. Pancreas. 1992; 7(4):486-96. doi: 10.1097/00006676-199207000-00011. [PMID: 1641391]
  • P M Novikoff, T Ikeda, D C Hixson, A Yam. Characterizations of and interactions between bile ductule cells and hepatocytes in early stages of rat hepatocarcinogenesis induced by ethionine. The American journal of pathology. 1991 Dec; 139(6):1351-68. doi: . [PMID: 1750508]
  • I Yoshitake, E Ohishi, K Kubo. Hepatoprotective effects of 1-[(2-thiazolin-2-yl)-amino]acetyl-4-(1,3-dithiol-2-ylidene)-2,3,4,5- tetrahydro-1H-1-benzazepin-3,5-dione hydrochloride (KF-14363) in various experimental liver injuries. Japanese journal of pharmacology. 1991 Oct; 57(2):127-36. doi: 10.1254/jjp.57.127. [PMID: 1812294]
  • A Nonaka, T Manabe, T Tobe. Effect of a new synthetic ascorbic acid derivative as a free radical scavenger on the development of acute pancreatitis in mice. Gut. 1991 May; 32(5):528-32. doi: 10.1136/gut.32.5.528. [PMID: 1710198]
  • C Niederau, K Ude, M Niederau, R Lüthen, G Strohmeyer, L D Ferrell, J H Grendell. Effects of the seleno-organic substance Ebselen in two different models of acute pancreatitis. Pancreas. 1991 May; 6(3):282-90. doi: 10.1097/00006676-199105000-00005. [PMID: 1713672]