Dimethylamine (BioDeep_00000003447)

 

Secondary id: BioDeep_00000268063

human metabolite Endogenous blood metabolite Toxin


代谢物信息卡片


N-Methylmethanamine (acd/name 4.0)

化学式: C2H7N (45.0578)
中文名称: 二甲胺
谱图信息: 最多检出来源 Homo sapiens(blood) 86.81%

分子结构信息

SMILES: CNC
InChI: InChI=1S/C2H7N/c1-3-2/h3H,1-2H3

描述信息

Dimethylamine (DMA) is an organic secondary amine. It is a colorless, liquefied and flammable gas with an ammonia and fish-like odor. Dimethylamine is abundantly present in human urine. Main sources of urinary DMA have been reported to include trimethylamine N-oxide, a common food component, and asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide (NO) synthesis. ADMA is excreted in the urine in part unmetabolized and in part after hydrolysis to DMA by dimethylarginine dimethylaminohydrolase (DDAH). Statistically significant increases in urinary DMA have been found in individuals after the consumption of fish and seafoods. The highest values were obtained for individuals that consumed coley, squid and whiting with cod, haddock, sardine, skate and swordfish (PMID: 18282650). It has also been identified as a uremic toxin according to the European Uremic Toxin Working Group (PMID: 22626821). As a pure chemical substance Dimethylamine is used as dehairing agent in tanning, in dyes, in rubber accelerators, in soaps and cleaning compounds and as an agricultural fungicide. In the body, DMA also undergoes nitrosation under weak acid conditions to give dimethlynitrosamine. Study has shown that DMA is a metabolite of Arthrobacter and Micrococcus (PMID: 11422368 ; PMID: 7191).
Aminating agent in the manuf. of ion-exchange resins for food processing
KEIO_ID D103

同义名列表

27 个代谢物同义名

N-Methylmethanamine (acd/name 4.0); Dimethylamine aqueous solution; Dimethylamine anhydrous (dot); Dimethylamine, conjugate acid; Dimethylamine phosphate (3:1); Dimethylamine hydrochloride; Dimethylamine sulfate (1:1); Dimethylamine hydrobromide; Dimethylamine monosulfate; Dimethylammonium chloride; Dimethylamine perchlorate; Dimethylammonium formate; Dimethylamine anhydrous; Dimethylamine solution; Dimethylamine nitrate; Dimethylamine sulfate; N-Methyl-methanamine; N-Methylmethanamine; N,N-Dimethylamine; dimethylamine; (CH3)2nh; HNMe2; Me2nh; DMA; Dimethylamine; Dimethylamine; Dimethylamine



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

41 个相关的代谢反应过程信息。

Reactome(38)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

PharmGKB(0)

7 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ALB, AOC3, AXIN2, CYP3A4, EGFR, NOS2, NOS3, PMP2, PNMA1
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 2 CYP3A4, EGFR
Nucleus 6 ALB, AXIN2, EGFR, NOS2, NOS3, PMP2
cytosol 7 ALB, AXIN2, DDAH1, GPT, NOS2, NOS3, PMP2
centrosome 2 ALB, AXIN2
nucleoplasm 3 CD2, NOS2, NOS3
Cell membrane 4 AOC3, CD2, CNGA1, EGFR
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 2 CNGA1, TMEM11
cell junction 1 EGFR
cell surface 4 AOC3, CD2, EGFR, TNFRSF10B
glutamatergic synapse 1 EGFR
Golgi apparatus 5 ALB, AOC3, ATRN, CD2, NOS3
Golgi membrane 3 EGFR, INS, NOS3
mitochondrial inner membrane 1 TMEM11
Cytoplasm, cytosol 1 NOS2
endosome 1 EGFR
plasma membrane 12 AOC3, ATRN, AXIN2, BCHE, CD2, CNGA1, EGFR, ME2, NOS2, NOS3, TMEM11, TNFRSF10B
Membrane 5 AOC3, CYP3A4, EGFR, ME2, TNFRSF10B
apical plasma membrane 1 EGFR
basolateral plasma membrane 1 EGFR
caveola 1 NOS3
extracellular exosome 5 ALB, ATRN, DDAH1, GPT, PMP2
endoplasmic reticulum 2 ALB, AOC3
extracellular space 6 ALB, ATRN, BCHE, EGFR, GAST, INS
perinuclear region of cytoplasm 3 EGFR, NOS2, NOS3
mitochondrion 2 ME2, TMEM11
protein-containing complex 3 ALB, CD2, EGFR
intracellular membrane-bounded organelle 2 CYP3A4, ME2
Microsome membrane 1 CYP3A4
Single-pass type I membrane protein 3 ATRN, CD2, EGFR
Secreted 4 ALB, BCHE, GAST, INS
extracellular region 5 ALB, BCHE, CD2, GAST, INS
cytoplasmic side of plasma membrane 1 CD2
Single-pass membrane protein 1 ME2
[Isoform 2]: Secreted 1 ATRN
Mitochondrion matrix 1 ME2
mitochondrial matrix 1 ME2
anchoring junction 1 ALB
nuclear membrane 1 EGFR
external side of plasma membrane 1 CD2
beta-catenin destruction complex 1 AXIN2
nucleolus 1 PNMA1
Cytoplasm, P-body 2 NOS2, NOS3
P-body 2 NOS2, NOS3
Early endosome 1 AOC3
cell-cell junction 1 CD2
Single-pass type II membrane protein 1 AOC3
Cytoplasm, perinuclear region 1 NOS2
Mitochondrion inner membrane 1 TMEM11
Membrane raft 1 EGFR
focal adhesion 1 EGFR
Peroxisome 1 NOS2
intracellular vesicle 1 EGFR
peroxisomal matrix 1 NOS2
receptor complex 1 EGFR
ciliary basal body 1 ALB
cytoskeleton 1 NOS3
centriole 1 ALB
Nucleus, nucleolus 1 PNMA1
spindle pole 1 ALB
blood microparticle 2 ALB, BCHE
[Isoform 3]: Secreted 1 ATRN
endosome lumen 1 INS
microvillus 1 AOC3
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
myelin sheath 1 PMP2
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, BCHE, INS
platelet alpha granule lumen 1 ALB
endocytic vesicle membrane 1 NOS3
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
nuclear envelope lumen 1 BCHE
clathrin-coated endocytic vesicle membrane 1 EGFR
[Isoform 1]: Cell membrane 1 ATRN
photoreceptor outer segment membrane 1 CNGA1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
cortical cytoskeleton 1 NOS2
rod photoreceptor outer segment 1 CNGA1
intracellular cyclic nucleotide activated cation channel complex 1 CNGA1
ciliary transition fiber 1 ALB


文献列表

  • Yongning Gao, Jingyu Zhang, Hui Chen, Zhu Wang, Jingjing Hou, Lihua Wang. Dimethylamine enhances platelet hyperactivity in chronic kidney disease model. Journal of bioenergetics and biomembranes. 2021 10; 53(5):585-595. doi: 10.1007/s10863-021-09913-4. [PMID: 34327565]
  • Peter Neyer, Luca Bernasconi, Jens A Fuchs, Martina D Allenspach, Christian Steuer. Derivatization-free determination of short-chain volatile amines in human plasma and urine by headspace gas chromatography-mass spectrometry. Journal of clinical laboratory analysis. 2020 Feb; 34(2):e23062. doi: 10.1002/jcla.23062. [PMID: 31595561]
  • Xiaofei Yin, Helena Gibbons, Milena Rundle, Gary Frost, Breige A McNulty, Anne P Nugent, Janette Walton, Albert Flynn, Lorraine Brennan. The Relationship between Fish Intake and Urinary Trimethylamine-N-Oxide. Molecular nutrition & food research. 2020 02; 64(3):e1900799. doi: 10.1002/mnfr.201900799. [PMID: 31863680]
  • Yu-Jie Liang, Pan Wang, Hui-Ping Wang, Ding-Xin Long, Ying-Jian Sun, Yi-Jun Wu. Time-Course Changes in Urine Metabolic Profiles of Rats Following 90-Day Exposure to Propoxur. Scientific reports. 2019 11; 9(1):16989. doi: 10.1038/s41598-019-52787-1. [PMID: 31740703]
  • Qiu Wu, Yan Zhao, Xiangnan Zhang, Xingbin Yang. A faster and simpler UPLC-MS/MS method for the simultaneous determination of trimethylamine N-oxide, trimethylamine and dimethylamine in different types of biological samples. Food & function. 2019 Oct; 10(10):6484-6491. doi: 10.1039/c9fo00954j. [PMID: 31532423]
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