Tromethamine (BioDeep_00000003435)
Secondary id: BioDeep_00001867738
human metabolite Chemicals and Drugs
代谢物信息卡片
Tris-magnesium(II)-potassium chloride buffer
化学式: C4H11NO3 (121.0739)
中文名称: 三(羟甲基)氨基甲烷, 氨丁三醇
谱图信息:
最多检出来源 Homo sapiens(plant) 4.14%
分子结构信息
SMILES: C(C(CO)(CO)N)O
InChI: InChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
描述信息
Tromethamine, also known as trometamol or tham, belongs to the class of organic compounds known as 1,2-aminoalcohols. These are organic compounds containing an alkyl chain with an amine group bound to the C1 atom and an alcohol group bound to the C2 atom. Tromethamine is a drug which is used for the prevention and correction of metabolic acidosis. Tromethamine exists as a solid, soluble (in water), and a very weakly acidic compound (based on its pKa). Tromethamine is also a parent compound for other transformation products, including but not limited to, bis-tris, bis-tris propane, and N-tris(hydroxymethyl)methylglycine.
B - Blood and blood forming organs > B05 - Blood substitutes and perfusion solutions > B05B - I.v. solutions > B05BB - Solutions affecting the electrolyte balance
B - Blood and blood forming organs > B05 - Blood substitutes and perfusion solutions > B05X - I.v. solution additives
D010592 - Pharmaceutic Aids > D014677 - Pharmaceutical Vehicles > D005079 - Excipients
D019995 - Laboratory Chemicals > D002021 - Buffers
KEIO_ID A194
同义名列表
21 个代谢物同义名
Tris-magnesium(II)-potassium chloride buffer; 2-Amino-2-(hydroxymethyl)-1,3-propanediol; 2-amino-2-(hydroxymethyl)propane-1,3-diol; 1,1,1-Tris(hydroxymethyl)methanamine; Aminotris(hydroxymethyl)methane; Tris(hydroxymethyl)aminomethane; Tri(hydroxymethyl)aminomethane; Abbott brand OF trometamol; Trometamol abbott brand; Tris-MG(II)-KCL buffer; tromethamine; Tris buffer; Tris amino; Trometamol; Trisamine; Tris base; Tris-base; Trizma; THAM; Tromethamine; Tromethamine
数据库引用编号
28 个数据库交叉引用编号
- ChEBI: CHEBI:9754
- KEGG: C07182
- KEGGdrug: D00396
- PubChem: 6503
- HMDB: HMDB0240288
- Metlin: METLIN43366
- DrugBank: DB03754
- ChEMBL: CHEMBL1200391
- Wikipedia: Tris
- MeSH: Tromethamine
- chemspider: 6257
- CAS: 126850-03-1
- CAS: 126850-05-3
- CAS: 136760-04-8
- CAS: 126850-08-6
- CAS: 207802-44-6
- CAS: 126850-06-4
- CAS: 77-86-1
- MoNA: KO002369
- MoNA: KO002371
- MoNA: KO002370
- MoNA: KO002372
- MoNA: KO002368
- PMhub: MS000009676
- PubChem: 9391
- PDB-CCD: TRS
- NIKKAJI: J4.214E
- KNApSAcK: 9754
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Maria Eberhardt, Sylwia Prochowska, Agnieszka Partyka, Wiesław Bielas, Ann Van Soom, Wanda Olech, Wojciech Niżański. The morphology, morphometry and functionality of fresh and cryopreserved wisent (Bison bonasus) epididymal spermatozoa.
Scientific reports.
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2023 May; 71(18):7131-7139. doi:
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The journal of physical chemistry. B.
2022 10; 126(39):7651-7663. doi:
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Journal of helminthology.
2021 Dec; 95(?):e72. doi:
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Nursing.
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Applied biochemistry and biotechnology.
2021 Sep; 193(9):2843-2857. doi:
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Animal biotechnology.
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Veterinary medicine and science.
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Cryobiology.
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2020 Mar; 41(2):106-114. doi:
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Cryobiology.
2020 02; 92(?):117-123. doi:
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Molecular pharmacology.
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Journal of biomolecular structure & dynamics.
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Andrologia.
2019 Sep; 51(8):e13322. doi:
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Explore (New York, N.Y.).
2019 Mar; 15(2):165-167. doi:
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2019 03; 67(1):106-114. doi:
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2018 Dec; ?(6):70-75. doi:
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Veterinary anaesthesia and analgesia.
2018 Nov; 45(6):820-830. doi:
10.1016/j.vaa.2018.06.016. [PMID: 30316696] - Nimisha Singh, Jyotsnamayee Nayak, Khushbu Patel, Suban K Sahoo, Rajender Kumar. Electrochemical impedance spectroscopy reveals a new mechanism based on competitive binding between Tris and protein on a conductive biomimetic polydopamine surface.
Physical chemistry chemical physics : PCCP.
2018 Oct; 20(40):25812-25821. doi:
10.1039/c8cp05391j. [PMID: 30283960] - José A B Bezerra, Andréia M Silva, Patrícia C Sousa, Lívia B Campos, Érica C G Praxedes, Luana G P Bezerra, Thibério S Castelo, Ana L P Souza, Alexandre R Silva. Cryopreservation of collared peccary (Pecari tajacu L., 1758) epididymal sperm using extenders based on Tris and powdered coconut water (ACP®-116c).
Zygote (Cambridge, England).
2018 Aug; 26(4):301-307. doi:
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Reproduction in domestic animals = Zuchthygiene.
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Bratislavske lekarske listy.
2015; 116(3):191-5. doi:
10.4149/bll_2015_038. [PMID: 25869569] - Sema Avcı, Selim Genç, Macit Aydın, Fatih Büyükcam, Seda Özkan. Ataxia caused by a single dose of dexketoprofen trometamol.
Acta bio-medica : Atenei Parmensis.
2014 Dec; 85(3):269-70. doi:
NULL. [PMID: 25567464] - Antônio Cavalcante Mota Filho, Herlon Victor Rodrigues Silva, Thalles Gothardo Pereira Nunes, Mírley Barbosa de Souza, Luana Azevedo de Freitas, Airton Alencar de Araújo, Lúcia Daniel Machado da Silva. Cryopreservation of canine epididymal sperm using ACP-106c and TRIS.
Cryobiology.
2014 Aug; 69(1):17-21. doi:
10.1016/j.cryobiol.2014.04.013. [PMID: 24824725] - A M Crespilho, M Nichi, P N Guasti, C P Freitas-Dell'Aqua, M F Sá Filho, R R Maziero, J A Dell'aqua, F O Papa. Sperm fertility and viability following 48h of refrigeration: evaluation of different extenders for the preservation of bull semen in liquid state.
Animal reproduction science.
2014 May; 146(3-4):126-33. doi:
10.1016/j.anireprosci.2014.02.020. [PMID: 24685263] - Pramod Kadaba Srinivasan, Ngwi Fet, Christian Bleilevens, Mamdouh Afify, Benedict Doorschodt, Shintaro Yagi, Gerhild van Echten-Deckert, René Hany Tolba. Hydroxyectoine ameliorates preservation injury in deceased after cardiac death donors in experimental liver grafts.
Annals of transplantation.
2014 Apr; 19(?):165-73. doi:
10.12659/aot.889958. [PMID: 24727658] - Federico Mainardi, Ferdinando Maggioni, Deborha Pezzola, Dario Zava, Giorgio Zanchin. Dexketoprofen trometamol in the acute treatment of migraine attack: a phase II, randomized, double-blind, crossover, placebo-controlled, dose optimization study.
The journal of pain.
2014 Apr; 15(4):388-94. doi:
10.1016/j.jpain.2013.12.006. [PMID: 24412801] - Saki Matsumoto, Nozomi Gotoh, Saori Hishinuma, Yohei Abe, Yoshimi Shimizu, Yumi Katano, Akira Ishihata. The role of hypertriglyceridemia in the development of atherosclerosis and endothelial dysfunction.
Nutrients.
2014 Mar; 6(3):1236-50. doi:
10.3390/nu6031236. [PMID: 24667131] - Sermet Inal, Sahin Kabay, M Kasim Cayci, H Isa Kuru, Sayit Altikat, Gizem Akkas, Aysenur Deger. Comparison of the effects of dexketoprofen trometamol, meloxicam and diclofenac sodium on fibular fracture healing, kidney and liver: an experimental rat model.
Injury.
2014 Mar; 45(3):494-500. doi:
10.1016/j.injury.2013.10.002. [PMID: 24246878] - Bei Lai, Bo Zheng, Yun Li, Sainan Zhu, Zhaohui Tong. In vitro susceptibility of Escherichia coli strains isolated from urine samples obtained in mainland China to fosfomycin trometamol and other antibiotics: a 9-year surveillance study (2004-2012).
BMC infectious diseases.
2014 Feb; 14(?):66. doi:
10.1186/1471-2334-14-66. [PMID: 24502648] - Ali Ghaffarian-Bahraman, Ibrahim Shahroozian, Abbas Jafari, Mahmoud Ghazi-Khansari. Protective effect of magnesium and selenium on cadmium toxicity in the isolated perfused rat liver system.
Acta medica Iranica.
2014; 52(12):872-8. doi:
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Bratislavske lekarske listy.
2014; 115(12):753-6. doi:
10.4149/bll_2014_145. [PMID: 25520222] - Ozlem Sagir, Fatma Bahar Sunay, Hatice Yildirim, Elif Aksoz, Sabri Ozaslan, Ahmet Koroglu, Tugsen Aydemir, Ali Engin Ulusal, Feray Kockar. Evaluation of the effects of dexketoprofen trometamol on knee joınt: an in vivo & in vitro study.
The Indian journal of medical research.
2013 Dec; 138(6):912-8. doi:
NULL. [PMID: 24521635] - Hamid Darvishnia, Niknam Lakpour, Maryam Shams Lahijani, Hamed Heidari-Vala, Mohammad A Akhondi, Hojjat Zeraati, Mohammad Reza Sadeghi. Effects of very rapid versus vapor phase freezing on human sperm parameters.
Cell and tissue banking.
2013 Dec; 14(4):679-85. doi:
10.1007/s10561-012-9351-z. [PMID: 23184170] - Vikas Agarwal, Alaadin Alayoubi, Akhtar Siddiqui, Sami Nazzal. Powdered self-emulsified lipid formulations of meloxicam as solid dosage forms for oral administration.
Drug development and industrial pharmacy.
2013 Nov; 39(11):1681-9. doi:
10.3109/03639045.2012.729594. [PMID: 23072611] - Bushra A Rakha, Iftikhar Hussain, Shamim Akhter, Nemat Ullah, Syed M H Andrabi, Muhammad S Ansari. Evaluation of Tris-citric acid, skim milk and sodium citrate extenders for liquid storage of Punjab Urial (Ovis vignei punjabiensis) spermatozoa.
Reproductive biology.
2013 Sep; 13(3):238-42. doi:
10.1016/j.repbio.2013.06.004. [PMID: 24011195] - A-Peng Lin, Guang-Ce Wang, Wen-Qin Zhou. Simultaneous measurements of H+ and O2 fluxes in Zostera marina and its physiological implications.
Physiologia plantarum.
2013 Aug; 148(4):582-9. doi:
10.1111/ppl.12008. [PMID: 23163246] - S Höstman, J Engström, G Hedenstierna, A Larsson. Intensive buffering can keep pH above 7.2 for over 4 h during apnea: an experimental porcine study.
Acta anaesthesiologica Scandinavica.
2013 Jan; 57(1):63-70. doi:
10.1111/aas.12012. [PMID: 23167283] - Fernando Antonio Simas Vaz, Patrícia Aparecida da Silva, Leônidas Paixão Passos, Melina Heller, Gustavo Amadeu Micke, Ana Carolina Oliveira Costa, Marcone Augusto Leal de Oliveira. Optimisation of a capillary zone electrophoresis methodology for simultaneous analysis of organic aliphatic acids in extracts of Brachiaria brizantha.
Phytochemical analysis : PCA.
2012 Nov; 23(6):569-75. doi:
10.1002/pca.2355. [PMID: 22407535] - Jin-Quan Zhang, Yong-Sheng Wang, Jin-Hua Xue, Yan He, Hui-Xian Yang, Jun Liang, Lin-Fei Shi, Xi-Lin Xiao. A gold nanoparticles-modified aptamer beacon for urinary adenosine detection based on structure-switching/fluorescence-'turning on' mechanism.
Journal of pharmaceutical and biomedical analysis.
2012 Nov; 70(?):362-8. doi:
10.1016/j.jpba.2012.05.032. [PMID: 22717140] - Tansu Sav, Aydin Unal, Abdulsamet Erden, Ali Ihsan Gunal. Single-dose-dexketoprofen-induced acute kidney injury due to massive rhabdomyolysis.
International urology and nephrology.
2012 Oct; 44(5):1581-3. doi:
10.1007/s11255-011-9982-1. [PMID: 21553112] - Susann Schaller, Christian Wilhelm, Kazimierz Strzałka, Reimund Goss. Investigating the interaction between the violaxanthin cycle enzyme zeaxanthin epoxidase and the thylakoid membrane.
Journal of photochemistry and photobiology. B, Biology.
2012 Sep; 114(?):119-25. doi:
10.1016/j.jphotobiol.2012.05.019. [PMID: 22705077] - R T Padilha, D M Magalhães-Padilha, M M Cavalcante, A P Almeida, K T Haag, M O Gastal, J F Nunes, A P R Rodrigues, J R Figueiredo, M A L Oliveira. Effect of insulin-like growth factor-I on some quality traits and fertility of cryopreserved ovine semen.
Theriogenology.
2012 Sep; 78(4):907-13. doi:
10.1016/j.theriogenology.2012.04.005. [PMID: 22541171] - V P Avdoshin, M I Andriukhin, A V Annenkov, M N Israfilov. [Treatment and metaphylaxis of gout complicated by nephropathy and urolithiasis].
Urologiia (Moscow, Russia : 1999).
2012 Sep; ?(5):18-20. doi:
NULL. [PMID: 23342610] - Stephen D Johnston, Yeng Peng Zee, Carmen López-Fernández, Jamie Gosálvez. The effect of chilled storage and cryopreservation on the sperm DNA fragmentation dynamics of a captive population of koalas.
Journal of andrology.
2012 Sep; 33(5):1007-15. doi:
10.2164/jandrol.111.015248. [PMID: 22282436] - Karina Mastropasqua Rebello, Caroline Reis de Siqueira, Erika Louise Ribeiro, Richard Hemmi Valente, Ester Maria Mota, Jonas Perales, Ana Gisele da Costa Neves-Ferreira, Henrique Leonel Lenzi. Proteolytic activity in the adult and larval stages of the human roundworm parasite Angiostrongylus costaricensis.
Memorias do Instituto Oswaldo Cruz.
2012 Sep; 107(6):752-9. doi:
10.1590/s0074-02762012000600008. [PMID: 22990964] - S Beuck, G Sigmund, A Koch, W Schänzer, A Pokrywka, D Kwiatkowska, M Thevis. Identification and characterization of urinary prenylamine metabolites by means of liquid chromatography-tandem mass spectrometry.
Drug testing and analysis.
2012 Sep; 4(9):701-16. doi:
10.1002/dta.1388. [PMID: 22786790] - Daniel J Kutscher, Alfredo Sanz-Medel, Jörg Bettmer. Metallomics investigations on potential binding partners of methylmercury in tuna fish muscle tissue using complementary mass spectrometric techniques.
Metallomics : integrated biometal science.
2012 Aug; 4(8):807-13. doi:
10.1039/c2mt20055d. [PMID: 22699869] - Young-Seob Lee, Sin-Hee Han, Su-Hwan Lee, Young-Guk Kim, Chung-Berm Park, Ok-Hwa Kang, Joon-Ho Keum, Sung-Bae Kim, Su-Hyun Mun, Yun-Soo Seo, Noh-Yil Myung, Dong-Yeul Kwon. The mechanism of antibacterial activity of tetrandrine against Staphylococcus aureus.
Foodborne pathogens and disease.
2012 Aug; 9(8):686-91. doi:
10.1089/fpd.2011.1119. [PMID: 22845553] - Djemil Bencharif, Lamia Amirat-Briand, Annabelle Garand, Marc Anton, Eric Schmitt, Serge Desherces, Guy Delhomme, Marie-Laure Langlois, Paul Barrière, Sandrine Destrumelle, Oscar Vera-Munoz, Daniel Tainturier. The advantages of using a combination of LDL and glutamine in comparison with TRIS egg yolk and Equex® STAMP extenders in the cryopreservation of canine semen.
Research in veterinary science.
2012 Aug; 93(1):440-7. doi:
10.1016/j.rvsc.2011.06.027. [PMID: 21824633] - Vicki S Blazer, Luke R Iwanowicz, Holly Henderson, Patricia M Mazik, Jill A Jenkins, David A Alvarez, John A Young. Reproductive endocrine disruption in smallmouth bass (Micropterus dolomieu) in the Potomac River basin: spatial and temporal comparisons of biological effects.
Environmental monitoring and assessment.
2012 Jul; 184(7):4309-34. doi:
10.1007/s10661-011-2266-5. [PMID: 21814719] - Shao-Yun Wei, Li-Fang Wang, Yuan-Han Yang, Hsin-Hua Yeh, Yi-Chin Chen, Su-Hwei Chen. Sample stacking by field-amplified sample injection and sweeping for simultaneous analysis of acidic and basic components in clinic application.
Electrophoresis.
2012 Jun; 33(11):1571-81. doi:
10.1002/elps.201100716. [PMID: 22736359] - Hugo F Miranda, Maria Asunción Romero, Margarita M Puig. Antinociceptive and anti-exudative synergism between dexketoprofen and tramadol in a model of inflammatory pain in mice.
Fundamental & clinical pharmacology.
2012 Jun; 26(3):373-82. doi:
10.1111/j.1472-8206.2010.00922.x. [PMID: 22081874] - Christina Elliott, Maren Lindner, Ariel Arthur, Kathryn Brennan, Sven Jarius, John Hussey, Andrew Chan, Anke Stroet, Tomas Olsson, Hugh Willison, Susan C Barnett, Edgar Meinl, Christopher Linington. Functional identification of pathogenic autoantibody responses in patients with multiple sclerosis.
Brain : a journal of neurology.
2012 Jun; 135(Pt 6):1819-33. doi:
10.1093/brain/aws105. [PMID: 22561643] - Bin Zhang, Ye Wang, Min Gao, Ming Gu, Changhai Wang. Tris(hydroxymethyl)aminomethane-functionalized agarose particles: parameters affecting the binding of bovine serum albumin.
Journal of separation science.
2012 Jun; 35(12):1406-10. doi:
10.1002/jssc.201200118. [PMID: 22740250] - Min Kyong Moon, Min Joo Kim, In Kyung Jung, Young Do Koo, Hwa Young Ann, Kwan Jae Lee, Soon Hee Kim, Yeo Cho Yoon, Bong-Jun Cho, Kyong Soo Park, Hak C Jang, Young Joo Park. Bisphenol A impairs mitochondrial function in the liver at doses below the no observed adverse effect level.
Journal of Korean medical science.
2012 Jun; 27(6):644-52. doi:
10.3346/jkms.2012.27.6.644. [PMID: 22690096] - Margaret R Cunningham, Kathryn A McIntosh, John D Pediani, Joris Robben, Alexandra E Cooke, Mary Nilsson, Gwyn W Gould, Stuart Mundell, Graeme Milligan, Robin Plevin. Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4).
The Journal of biological chemistry.
2012 May; 287(20):16656-69. doi:
10.1074/jbc.m111.315911. [PMID: 22411985] - Fredrik Persson, Joachim Fritzsche, Kalim U Mir, Mauro Modesti, Fredrik Westerlund, Jonas O Tegenfeldt. Lipid-based passivation in nanofluidics.
Nano letters.
2012 May; 12(5):2260-5. doi:
10.1021/nl204535h. [PMID: 22432814] - Hunter K C Laidlaw, Jelle Lahnstein, Rachel A Burton, Geoffrey B Fincher, Stephen A Jobling. Analysis of the arabinoxylan arabinofuranohydrolase gene family in barley does not support their involvement in the remodelling of endosperm cell walls during development.
Journal of experimental botany.
2012 May; 63(8):3031-45. doi:
10.1093/jxb/ers019. [PMID: 22378943] - Shu-Xiao Zheng, Shi Xiao, Mee-Len Chye. The gene encoding Arabidopsis acyl-CoA-binding protein 3 is pathogen inducible and subject to circadian regulation.
Journal of experimental botany.
2012 May; 63(8):2985-3000. doi:
10.1093/jxb/ers009. [PMID: 22345636] - Anna Dietrich-Muszalska, Joanna Malinowska, Beata Olas, Rafal Głowacki, Edward Bald, Barbara Wachowicz, Jolanta Rabe-Jabłońska. The oxidative stress may be induced by the elevated homocysteine in schizophrenic patients.
Neurochemical research.
2012 May; 37(5):1057-62. doi:
10.1007/s11064-012-0707-3. [PMID: 22270909] - Elżbieta Miller, Łukasz Markiewicz, Joanna Saluk, Ireneusz Majsterek. Effect of short-term cryostimulation on antioxidative status and its clinical applications in humans.
European journal of applied physiology.
2012 May; 112(5):1645-52. doi:
10.1007/s00421-011-2122-x. [PMID: 21874554] - Gadham Setty Saayi Krushna, Mohammed Abdul Kareem, Vaddi Damodara Reddy, Pannuru Padmavathi, Shaik Althaf Hussain, Lakshmi Devi Kodidhela. Aegle marmelos fruit extract attenuates isoproterenol-induced oxidative stress in rats.
Journal of clinical biochemistry and nutrition.
2012 May; 50(3):199-204. doi:
10.3164/jcbn.11-69. [PMID: 22573921] - Arghya Biswas, Syed Imam Rabbani, Kshama Devi. Influence of pioglitazone on experimental heart failure and hyperlipidemia in rats.
Indian journal of pharmacology.
2012 May; 44(3):333-9. doi:
10.4103/0253-7613.96305. [PMID: 22701242]
