alpha-Allocryptopine (BioDeep_00000000340)

 

Secondary id: BioDeep_00000332557, BioDeep_00000410576

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


7,8-dimethoxy-11-methyl-17,19-dioxa-11-azatetracyclo[12.7.0.04,9.016,20]henicosa-1(21),4(9),5,7,14,16(20)-hexaen-2-one

化学式: C21H23NO5 (369.1576148)
中文名称: 别隐品碱, A-别隐品碱
谱图信息: 最多检出来源 Viridiplantae(plant) 0.15%

Reviewed

Last reviewed on 2024-09-04.

Cite this Page

alpha-Allocryptopine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/alpha-allocryptopine (retrieved 2024-11-03) (BioDeep RN: BioDeep_00000000340). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: c12c(cc3c(c1)CCN(Cc1c(CC3=O)ccc(c1OC)OC)C)OCO2
InChI: InChI=1S/C21H23NO5/c1-22-7-6-14-9-19-20(27-12-26-19)10-15(14)17(23)8-13-4-5-18(24-2)21(25-3)16(13)11-22/h4-5,9-10H,6-8,11-12H2,1-3H3

描述信息

Alpha-allocryptopine, also known as alpha-fagarine or beta-homochelidonine, is a member of the class of compounds known as protopine alkaloids. Protopine alkaloids are alkaloids with a structure based on a tricyclic protopine formed by oxidative ring fission of protoberberine N-metho salts. Alpha-allocryptopine is practically insoluble (in water) and an extremely weak acidic compound (based on its pKa). Alpha-allocryptopine can be found in barley, which makes alpha-allocryptopine a potential biomarker for the consumption of this food product.
Allocryptopine is a dibenzazecine alkaloid, an organic heterotetracyclic compound, a tertiary amino compound, a cyclic ketone, a cyclic acetal and an aromatic ether.
Allocryptopine is a natural product found in Zanthoxylum beecheyanum, Berberis integerrima, and other organisms with data available.
See also: Sanguinaria canadensis root (part of).
KEIO_ID A137; [MS2] KO008812
KEIO_ID A137; [MS3] KO008813
KEIO_ID A137
Allocryptopine, a derivative of tetrahydropalmatine, is extracted from Macleaya cordata (Thunb.) Pers. Papaveraceae. Allocryptopine has antiarrhythmic effects and potently blocks human ether-a-go-go related gene (hERG) current[1][2].
Allocryptopine, a derivative of tetrahydropalmatine, is extracted from Macleaya cordata (Thunb.) Pers. Papaveraceae. Allocryptopine has antiarrhythmic effects and potently blocks human ether-a-go-go related gene (hERG) current[1][2].

同义名列表

50 个代谢物同义名

7,8-DIMETHOXY-11-METHYL-17,19-DIOXA-11-AZATETRACYCLO[12.7.0.0?,?.0(1)?,(2)?]HENICOSA-1(14),4(9),5,7,15,20-HEXAEN-2-ONE; 7,8-dimethoxy-11-methyl-17,19-dioxa-11-azatetracyclo[12.7.0.04,9.016,20]henicosa-1(21),4(9),5,7,14,16(20)-hexaen-2-one; 7,8-dimethoxy-11-methyl-17,19-dioxa-11-azatetracyclo[12.7.0.0⁴,⁹.0¹⁶,²⁰]henicosa-1(14),4(9),5,7,15,20-hexaen-2-one; 7,8-dimethoxy-11-methyl-17,19-dioxa-11-azatetracyclo[12.7.0.0 , .0 , ]henicosa-1(14),4(9),5,7,15,20-hexaen-2-one; Benzo(e)(1,3)dioxolo(4,5-k)(3)benzazecin-14(6H)-one, 5,7,8,15-tetrahydro-3,4-dimethoxy-6-methyl-(VAN) (8CI); Benzo(e)(1,3)dioxolo(4,5-k)(3)benzazecin-14(6H)-one, 5,7,8,15-tetrahydro-3,4-dimethoxy-6-methyl- (VAN); 3,4-dimethoxy-6-methyl-5,7,8,15-tetrahydro-[1,3]dioxolo[4,5:4,5]benzo[1,2-g]benzo[c]azecin-14(6H)-one; Benzo(e)(1,3)dioxolo(4,5-k)(3)benzazecin-14(6H)-one, 5,7,8,15-tetrahydro-3,4-dimethoxy-6-methyl-; [1,3]Benzodioxolo[5,6-e][2]benzazecin-14(6H)-one, 5,7,8,15-tetrahydro-3,4-dimethoxy-6-methyl-; 3,4-Dimethoxy-6-methyl-5,7,8,15-tetrahydrobenzo[c][1,3]benzodioxolo[5,6-g]azecin-14(6H)-one #; 5,7,8,15-Tetrahydro-3,4-dimethoxy-6-methylbenzo(e)(1,3)dioxolo(4,5-k)(3)benzazecin-14(6H)-one; 3,4-dimethoxy-6-methyl-5,7,8,15-tetrahydrobenzo(c)(1,3)benzodioxolo(5,6-g)azecin-14(6H)-one; 3,4-Dimethoxy-6-methyl-5,7,8,15-tetrahydrobenzo[c][1,3]benzodioxolo[5,6-g]azecin-14(6H)-one; Benzo[e][1,5-k][3]benzazecin-14(6H)-one, 5,7,8,15-tetrahydro-3,4-dimethoxy-6-methyl- (VAN8C; 5,7,8,15-Tetrahydro-3,4-dimethoxy-6-methyl(1,3)benzodioxolo(5,6-e)(2)benzazecin-14(6H)-one; Allocryptopine; Alpha-Allocryptopine; HYBRYAPKQCZIAE-UHFFFAOYSA-N; Taliktrimin (thalictrimine); .gamma.-Homochelidonine; .beta.-Homochelidonine; .alpha.-Allocryptopine; gamma-Homochelidonine; .beta.-Allocryptopine; alpha-Allocryptopine; beta-Homochelidonine; beta-Allocryptopine; ALLOCRYPTOPINE [MI]; |A-Homochelidonine; Β-homochelidonine; b-Homochelidonine; a-allocryptopine; Α-allocryptopine; β-allocryptopine; .alpha.-Fagarine; UNII-EK27J8ROYB; allo-cryptopine; Allocryptopine; alpha-Fagarine; Allocrytopine; Allocryptopin; Thalictrimine; Oprea1_700961; MEGxp0_001784; Oprea1_535693; ACon1_000293; Taliktrimin; Fagarine I; EK27J8ROYB; Α-fagarine; a-Fagarine



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

3 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(2)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

79 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Fatma M El-Demerdash, Manal M Ahmed, Raghda A El-Sayed, Tarek M Mohemed, Marian N Gerges. Nephroprotective effects of silymarin and its fabricated nanoparticles against aluminum-induced oxidative stress, hyperlipidemia, and genotoxicity. Environmental toxicology. 2024 Jun; 39(6):3746-3759. doi: 10.1002/tox.24223. [PMID: 38546352]
  • J Anupama Sekar, Shiny Velayudhan, M Senthilkumar, P R Anil Kumar. Silymarin enriched gelatin methacrylamide bioink imparts hepatoprotectivity to 3D bioprinted liver construct against carbon tetrachloride induced toxicity. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2024 May; 198(?):114272. doi: 10.1016/j.ejpb.2024.114272. [PMID: 38537909]
  • Xin Wang, Yufeng Jin, Can Di, Yupeng Zeng, Yuqing Zhou, Yu Chen, Zhijun Pan, Zhongxia Li, Wenhua Ling. Supplementation of Silymarin Alone or in Combination with Salvianolic Acids B and Puerarin Regulates Gut Microbiota and Its Metabolism to Improve High-Fat Diet-Induced NAFLD in Mice. Nutrients. 2024 Apr; 16(8):. doi: 10.3390/nu16081169. [PMID: 38674860]
  • Zoe D. Draelos, Martina Kerscher, Stephen Lynch, Stacy White, Hina Choudhary. A Silymarin Antioxidant Serum Improves Facial Acne Alone and as Part of a Treatment Regimen. Journal of drugs in dermatology : JDD. 2024 04; 23(4):233-238. doi: 10.36849/jdd.8120. [PMID: 38564394]
  • Lucia-Maria Ciovicescu, Simona Valeria Clichici, Ramona-Ariana Simedrea, Felix Ciovicescu, Simona Corina Lupan, Lavinia Ioana Sabău, Alina Mihaela Toader, Teodora Mocan. Innovative prophylactic and therapeutic approaches in liver cirrhosis. Physiology international. 2024 Mar; 111(1):1-18. doi: 10.1556/2060.2024.00339. [PMID: 38421387]
  • Rajeev K Singla, Digvijay Singh, Ravinder Verma, Deepak Kaushik, Javier Echeverría, Vandana Garg, Pankaj Gupta, Mohammad Akhlaquer Rahman, Ajay Sharma, Vineet Mittal, Bairong Shen. Fermented formulation of Silybum marianum seeds: Optimization, heavy metal analysis, and hepatoprotective assessment. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Feb; 124(?):155286. doi: 10.1016/j.phymed.2023.155286. [PMID: 38241906]
  • Hebatallah Husseini Atteia. A combination of silymarin and garlic extract enhances thyroid hormone activation and body metabolism in orally intoxicated male rats with atrazine: Impact on hepatic iodothyronine deiodinase type 1. Pesticide biochemistry and physiology. 2024 Feb; 199(?):105801. doi: 10.1016/j.pestbp.2024.105801. [PMID: 38458692]
  • Xin Zhang, Yuhan Jiang, Na Guo, Yifan Ding, Jingting Feng, Chenyang Miao, Yanni Lv. Application of SNAP-tag-EGFR cell membrane chromatography model in screening antitumor active components of Silybum marianum (L.) Gaertn. Journal of pharmaceutical and biomedical analysis. 2024 Jan; 238(?):115816. doi: 10.1016/j.jpba.2023.115816. [PMID: 37976988]
  • Mohammad Reza Karimzadeh, Afsane Masoudi Chelegahi, Shahrzad Shahbazi, Somayeh Reiisi. Co-treatment of silymarin and cisplatin inhibited cell proliferation, induced apoptosis in ovarian cancer. Molecular biology reports. 2024 Jan; 51(1):118. doi: 10.1007/s11033-023-09026-8. [PMID: 38227082]
  • Jyoti Rani, Sanju Bala Dhull, Pawan Kumar Rose, Mohd Kashif Kidwai. Drug-induced liver injury and anti-hepatotoxic effect of herbal compounds: a metabolic mechanism perspective. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 122(?):155142. doi: 10.1016/j.phymed.2023.155142. [PMID: 37913641]
  • Zheyuan Ren, Yang Yu, Zhongyao Ji, Huitao Li, Xiaoheng Li, Han Lin, Renshan Ge, Qiqi Zhu. Structure-activity relationship and docking analysis of nature flavonoids as inhibitors of human and rat gonadal 3β-hydroxysteroid dehydrogenases for therapeutic purposes. The Journal of steroid biochemistry and molecular biology. 2023 Dec; 238(?):106450. doi: 10.1016/j.jsbmb.2023.106450. [PMID: 38143010]
  • Helena Pluháčková, Barbora Kudláčková, Lenka Svojanovská, Michal Roth, Marta Bradáčová, Marie Bjelková. Effect of Field Trial on Silymarin Complex Composition and Antioxidant Assessment of Milk Thistle (Silybum marianum L. Gaertner). Plant foods for human nutrition (Dordrecht, Netherlands). 2023 Dec; 78(4):691-697. doi: 10.1007/s11130-023-01101-6. [PMID: 37668769]
  • Zhenzhen Chen, Wenhao Gao, Xianquan Feng, Guizhi Zhou, Minxin Zhang, Lingjun Zeng, Xiaomu Hu, Zhihong Liu, Hongtao Song. A comparative study on the preparation and evaluation of solubilizing systems for silymarin. Drug delivery and translational research. 2023 Nov; ?(?):. doi: 10.1007/s13346-023-01476-8. [PMID: 37964172]
  • Rasool Haddadi, Shahla Eyvari-Brooshghalan, Sajjad Makhdoomi, Ahmad Fadaiie, Alireza Komaki, Afsoon Daneshvar. Neuroprotective effects of silymarin in 3-nitropropionic acid-induced neurotoxicity in male mice: improving behavioral deficits by attenuating oxidative stress and neuroinflammation. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Oct; ?(?):. doi: 10.1007/s00210-023-02776-z. [PMID: 37847410]
  • Salah A Sheweita, Ahmed Abd El Rafea, Sabah G Elbana. The deleterious effects of cadmium on oxidative stress markers, drug-metabolizing, and antioxidant enzyme activities: Role of Silymarin and Garlic as Antioxidants. Environmental science and pollution research international. 2023 Oct; ?(?):. doi: 10.1007/s11356-023-30197-1. [PMID: 37831250]
  • Hanaa S S Gazwi, Osama I A Soltan, Sanaa M Abdel-Hameed. Cakes fortified with papaya seeds effectively protects against CCl4-induced immunotoxicity. Environmental science and pollution research international. 2023 Oct; ?(?):. doi: 10.1007/s11356-023-30172-w. [PMID: 37815681]
  • Pei-Ling Yen, Ting-An Lin, Wei Lin Chuah, Chih-Yi Chang, Yen-Hsueh Tseng, Chia-Yin Huang, Jeng-Chuann Yang, Fu-Lan Hsu, Vivian Hsiu-Chuan Liao. Methanol Extracts from Cirsium japonicum DC. var. australe Kitam. and Their Active Components Reduce Intracellular Oxidative Stress in Caenorhabditis elegans. Molecules (Basel, Switzerland). 2023 Oct; 28(19):. doi: 10.3390/molecules28196923. [PMID: 37836767]
  • Ahmed H Sherif, Adel E Toulan, Naglaa El-Kalamwi, Enas A H Farag, Abeer E Mahmoud. Silymarin enhances the response to oxytetracycline treatment in Oreochromis niloticus experimentally infected with Aeromonas hydrophila. Scientific reports. 2023 Sep; 13(1):16235. doi: 10.1038/s41598-023-43270-z. [PMID: 37758826]
  • Sajida Sumaiya, Aisha Siddiqui, Shahid Shah Chaudhary, Mohd Aslam, Sayeed Ahmad, Mairaj Ahmed Ansari. Isolation and characterization of bioactive components from hydroalcoholic extract of Cymbopogon jwarancusa (Jones) Schult. To evaluate its hepatoprotective activity. Journal of ethnopharmacology. 2023 Sep; ?(?):117185. doi: 10.1016/j.jep.2023.117185. [PMID: 37714225]
  • Fatemeh Gheybi, Fatemeh Rajabian, Zahra Tayarani-Najaran, Amir Reza Adibi, Seyedeh Hoda Alavizadeh, Prashant Kesharwani, Amirhossein Sahebkar. Liposomal silymarin anti-oxidative and anti-apoptotic features in lung cells: An implication in cadmium toxicity. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2023 Aug; 80(?):127291. doi: 10.1016/j.jtemb.2023.127291. [PMID: 37672872]
  • Hossein Abbasinia, Masoumeh Heshmati, Mohammad Yousefi, Nabaa Najjar, Hanieh Sadeghi. Silymarin-Loaded Tin(IV) Nanoparticles Exhibit Enhanced Bioavailability and Antiproliferative Effects on Colorectal Cancer Cells. ACS applied bio materials. 2023 Aug; ?(?):. doi: 10.1021/acsabm.3c00434. [PMID: 37608575]
  • Iman H Hasan, Amirah Badr, Haneen Almalki, Alanoud Alhindi, Hesham S Mostafa. Podocin, mTOR, and CHOP dysregulation contributes to nephrotoxicity induced of lipopolysaccharide/diclofenac combination in rats: Curcumin and silymarin could afford protective effect. Life sciences. 2023 Aug; 330(?):121996. doi: 10.1016/j.lfs.2023.121996. [PMID: 37536613]
  • Hamed Baharara, Sara Rahsepar, Seyyed Ahmad Emami, Sepideh Elyasi, Amir Hooshang Mohammadpour, Vahid Ghavami, Rajkumar Rajendram, Amirhossein Sahebkar, Omid Arasteh. The efficacy of medicinal plant preparations in the alleviation of radiodermatitis in patients with breast cancer: A systematic review of clinical trials. Phytotherapy research : PTR. 2023 Aug; 37(8):3275-3295. doi: 10.1002/ptr.7894. [PMID: 37211432]
  • A Jabbari, B Alani, A Arjmand, T Mazoochi, N Kheiripour, A Ardjmand. Silymarin pretreatment protects against ethanol-induced memory impairment: Biochemical and histopathological evidence. Journal of chemical neuroanatomy. 2023 Jul; 132(?):102310. doi: 10.1016/j.jchemneu.2023.102310. [PMID: 37429530]
  • Elnaz Golestaneh, Abolfazl Aslani, Mahmoud Aghaei, Mohammad Hashemnia, Mohammad Hosein Aarabi. Preparation and characterisation of a new form of silymarin as a potential antidiabetic agent in the adult male rat. Archives of physiology and biochemistry. 2023 Jun; 129(3):799-809. doi: 10.1080/13813455.2021.1874018. [PMID: 33529090]
  • Paolo Bellavite, Serafino Fazio, Flora Affuso. A Descriptive Review of the Action Mechanisms of Berberine, Quercetin and Silymarin on Insulin Resistance/Hyperinsulinemia and Cardiovascular Prevention. Molecules (Basel, Switzerland). 2023 Jun; 28(11):. doi: 10.3390/molecules28114491. [PMID: 37298967]
  • Leila Parsa, Rouhollah Motafakkerazad, Sarvin Taleb Soheyli, Amin Haratian, Morteza Kosari-Nasab, Majid Mahdavi. Silymarin in combination with ATRA enhances apoptosis induction in human acute promyelocytic NB4 cells. Toxicon : official journal of the International Society on Toxinology. 2023 Jun; 228(?):107127. doi: 10.1016/j.toxicon.2023.107127. [PMID: 37085055]
  • Peichen Wang, Ning Yang, Ying Luo, Gan Wang, Shuaizhen Zhou, Shuai Huang, Li Chen, Yiping Zhao. Silymarin modified polysulfone hollow fiber membranes with antioxidant, anti-M1 macrophage polarization and hemocompatibility for blood purification. Journal of biomedical materials research. Part B, Applied biomaterials. 2023 May; ?(?):. doi: 10.1002/jbm.b.35285. [PMID: 37255001]
  • Doriana Eurosia Angela Tedesco, Alessandro Guerrini. Use of Milk Thistle in Farm and Companion Animals: A Review. Planta medica. 2023 May; 89(6):584-607. doi: 10.1055/a-1969-2440. [PMID: 36302565]
  • Mehran Ebrahimi Shah-Abadi, Armin Ariaei, Fatemeh Moradi, Auob Rustamzadeh, Rastegar Rahmani Tanha, Nader Sadigh, Mohsen Marzban, Mahdi Heydari, Vahid Tavakolian Ferdousie. In Silico Interactions of Natural and Synthetic Compounds with Key Proteins Involved in Alzheimer's Disease: Prospects for Designing New Therapeutics Compound. Neurotoxicity research. 2023 Apr; ?(?):. doi: 10.1007/s12640-023-00648-1. [PMID: 37086338]
  • D Shah, N Mahurkar, D Gadhave, R Nikhate, K Kakad. Hepatoprotective activity of Balsamodendron mukul extract against Paracetamol-induced liver toxicity in rats: In vivo pharmacological and toxicological evaluation. Annales pharmaceutiques francaises. 2023 Apr; ?(?):. doi: 10.1016/j.pharma.2023.04.003. [PMID: 37060939]
  • Yingwen Bai, Lulu Wang, TingYang, Lingyun Wang, Weihong Ge. Silymarin ameliorates peritoneal fibrosis by inhibiting the TGF-β/Smad signaling pathway. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Apr; ?(?):. doi: 10.1007/s00210-023-02450-4. [PMID: 37052642]
  • Meghanath B Shete, Ashwini S Deshpande, Pravin Shende. Enhancement of in-vitro anti-oral cancer activities of silymarin using dispersion of nanostructured lipid carrier in mucoadhesive in-situ gel. International journal of pharmaceutics. 2023 Apr; 636(?):122860. doi: 10.1016/j.ijpharm.2023.122860. [PMID: 36933584]
  • D Jayabal, S Jayanthi, R Thirumalaisamy, R Karthika, Muhammad Nasir Iqbal. Comparative anti-Diabetic potential of phytocompounds from Dr. Duke's phytochemical and ethnobotanical database and standard antidiabetic drugs against diabetes hyperglycemic target proteins: an in silico validation. Journal of biomolecular structure & dynamics. 2023 Apr; ?(?):1-13. doi: 10.1080/07391102.2023.2187231. [PMID: 37011006]
  • Kassahun Dires Ayenew, Yared Wasihun. Hepatoprotective effect of methanol extract of Agave americana leaves on paracetamol induced hepatotoxicity in Wistar albino rats. BMC complementary medicine and therapies. 2023 Apr; 23(1):99. doi: 10.1186/s12906-023-03931-y. [PMID: 37005601]
  • Arwa A Elsheikh, Sulaiman Mohammed Alnasser, Amany Mohamed Shalaby, Mohamed Ali Alabiad, Noha Ali Abd-Almotaleb, Mohammed Alorini, Fatima A Jaber, Eman El-Sayed Khayal. Polystyrene microplastic particles induced hepatotoxic injury via pyroptosis, oxidative stress, and fibrotic changes in adult male albino rats; the therapeutic role of silymarin. Toxicology mechanisms and methods. 2023 Mar; ?(?):1-17. doi: 10.1080/15376516.2023.2191270. [PMID: 36970996]
  • Subhasish Sahoo, Diptirani Rath, Durga Madhab Kar, Sovan Pattanaik. Hepatoprotective potency of Litsea glutinosa (L.) C.B. Rob. leaf methanol extract on H2O2-induced toxicity in HepG2 cells. Journal of ethnopharmacology. 2023 Mar; 304(?):116076. doi: 10.1016/j.jep.2022.116076. [PMID: 36567040]
  • Longlong Liu, Hua Zhang. Milk Thistle Oil Extracted by Enzyme-Mediated Assisted Solvent Extraction Compared with n-Hexane and Cold-Pressed Extraction. Molecules (Basel, Switzerland). 2023 Mar; 28(6):. doi: 10.3390/molecules28062591. [PMID: 36985564]
  • Sreevarsha Gali, Swati Sharma, Amit Kundu, Eunah Lee, Joo Hee Han, Joo Kyung Shin, Ji Soo Choi, So Young Kyung, Jae-Sung Kim, Hyung Sik Kim. Protective effect of dendropanoxide against cadmium-induced hepatotoxicity via anti-inflammatory activities in Sprague-Dawley rats. Toxicology mechanisms and methods. 2023 Jan; ?(?):1-15. doi: 10.1080/15376516.2023.2171824. [PMID: 36718047]
  • Wen-Long Sun, Sha Hua, Xin-Yu Li, Liang Shen, Hao Wu, Hong-Fang Ji. Microbially produced vitamin B12 contributes to the lipid-lowering effect of silymarin. Nature communications. 2023 01; 14(1):477. doi: 10.1038/s41467-023-36079-x. [PMID: 36717576]
  • Hosny Abd El Fadil, Amany Behairy, Lamiaa L M Ebraheim, Yasmina M Abd-Elhakim, Heba Hussein Fathy. The palliative effect of mulberry leaf and olive leaf ethanolic extracts on hepatic CYP2E1 and caspase-3 immunoexpression and oxidative damage induced by paracetamol in male rats. Environmental science and pollution research international. 2023 Jan; ?(?):. doi: 10.1007/s11356-023-25152-z. [PMID: 36637651]
  • Vijay Kumar Shankar, Anitha Police, Srinivas Ajjarapu, S Narasimha Murthy. Development of silymarin topical formulation: In vitro and ex vivo dermal kinetics of silymarin. International journal of pharmaceutics. 2023 Jan; 630(?):122431. doi: 10.1016/j.ijpharm.2022.122431. [PMID: 36436747]
  • Ali Hanafi, Kazem D Safa, Shamsali Rezazadeh. Neural Network-based Optimization of Silybum Marianum Extract-loaded Chitosan Particles: Modeling, Preparation and Antioxidant Evaluation. Current computer-aided drug design. 2023; 19(1):2-12. doi: 10.2174/1573409918666221010101036. [PMID: 36221887]
  • Garima Singh, Namrata Mittra, Chetna Singh. Tempol and silymarin rescue from zinc-induced degeneration of dopaminergic neurons through modulation of oxidative stress and inflammation. Molecular and cellular biochemistry. 2022 Dec; ?(?):. doi: 10.1007/s11010-022-04620-z. [PMID: 36562918]
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