Homocarnosine (BioDeep_00000003393)

 

Secondary id: BioDeep_00000400413

natural product human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


(2S)-2-(4-aminobutanamido)-3-(1H-imidazol-4-yl)propanoic acid

化学式: C10H16N4O3 (240.12223459999998)
中文名称: L-高肌肽, L-高肌肽
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 0.16%

分子结构信息

SMILES: C(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O)CN
InChI: InChI=1S/C10H16N4O3/c11-3-1-2-9(15)14-8(10(16)17)4-7-5-12-6-13-7/h5-6,8H,1-4,11H2,(H,12,13)(H,14,15)(H,16,17)

描述信息

Homocarnosine is a normal human metabolite, the brain-specific dipeptide of gamma-aminobutyric acid (GABA) and histidine. (PMID 1266573). Increased concentration of CSF homocarnosine has been found in familial spastic paraplegia. (PMID 842287). Homocarnosinosis (an inherited disorder, OMIM 236130) is characterized by an elevated level of the dipeptide homocarnosine (Hca) in the Cerebrospinal fluid (CSF) and the brain and by carnosinuria and serum carnosinase deficiency, and can co-exist with paraplegia, retinitis pigmentosa, and a progressive mental deficiency. (PMID 3736769). In glial tumors of human brain the content of homocarnosine has been found to be lower than in brain tissue (PMID 1032224), while an increase in content of homocarnosine was observed in brain tissue of animals under experimental trauma of cranium. (PMID 1025883).
Homocarnosine is a normal human metabolite, the brain-specific dipeptide of gamma-aminobutyric acid (GABA) and histidine. (PMID 1266573)
Acquisition and generation of the data is financially supported in part by CREST/JST.
KEIO_ID H013; [MS3] KO008992
KEIO_ID H013; [MS2] KO008991
KEIO_ID H013

同义名列表

24 个代谢物同义名

(2S)-2-(4-aminobutanamido)-3-(1H-imidazol-4-yl)propanoic acid; N(alpha)-(4-Aminobutyryl)-L-histidine; N-(4-amino-1-oxobutyl)-L-Histidine; N(a)-(4-Aminobutyryl)-L-histidine; N-(4-Amino-1-oxobutyryl)histidine; N-(4-Aminobutanoyl)-(S)-histidine; N(Α)-(4-aminobutyryl)-L-histidine; N-(4-Aminobutyryl)-L-histidine; gamma-Aminobutyryl-L-histidine; gamma-Aminobutyryl histidine; N-(4-Aminobutyryl)-histidine; gamma-Aminobutyrylhistidine; g-Aminobutyryl-L-histidine; g-Aminobutyryl histidine; Γ-aminobutyryl histidine; gamma-Aminobutyryl-L-his; g-Aminobutyrylhistidine; Homocarnosine sulfate; Γ-aminobutyryl-L-his; g-Aminobutyryl-L-his; (2S)-Homocarnosine; (S)-Homocarnosine; L-Homocarnosine; Homocarnosine



数据库引用编号

37 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

  • Inner Membrane Transport: Adenosine triphosphate + Water + Zinc ⟶ Adenosine diphosphate + Hydrogen Ion + Phosphate + Zinc
  • Inner Membrane Transport: Adenosine triphosphate + Water + Zinc ⟶ Adenosine diphosphate + Hydrogen Ion + Phosphate + Zinc

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

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  • Panyu Zhou, Demeng Xia, Yan Xia, Hongyue Zhang, Yang Wang, Tao Tang, Shuogui Xu. Synergistic effect of vancomycin and l-homocarnosine alleviates Staphylococcus aureus-induced osteomyelitis in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Mar; 111(?):31-35. doi: 10.1016/j.biopha.2018.11.102. [PMID: 30572244]
  • Jing Huang, Tao Wang, Daorui Yu, Xingyue Fang, Haofei Fan, Qiang Liu, Guohui Yi, Xinan Yi, Qibing Liu. l-Homocarnosine attenuates inflammation in cerebral ischemia-reperfusion injury through inhibition of nod-like receptor protein 3 inflammasome. International journal of biological macromolecules. 2018 Oct; 118(Pt A):357-364. doi: 10.1016/j.ijbiomac.2018.06.032. [PMID: 29890246]
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