1-Hydroxy-2-naphthoic acid (BioDeep_00000003197)

 

Secondary id: BioDeep_00000419009

human metabolite PANOMIX_OTCML-2023 blood metabolite BioNovoGene_Lab2019 natural product


代谢物信息卡片


1-Hydroxy-2-naphthoic acid, monosodium salt

化学式: C11H8O3 (188.0473)
中文名称: 1-羟基-2-萘甲酸
谱图信息: 最多检出来源 Homo sapiens(blood) 13.99%

分子结构信息

SMILES: C1=CC=C2C(=C1)C=CC(=C2O)C(=O)O
InChI: InChI=1S/C11H8O3/c12-10-8-4-2-1-3-7(8)5-6-9(10)11(13)14/h1-6,12H,(H,13,14)

描述信息

1-Hydroxy-2-naphthoic acid is an endogenous metabolite.

同义名列表

11 个代谢物同义名

1-Hydroxy-2-naphthoic acid, monosodium salt; 1-hydroxynaphthalene-2-carboxylic acid; 1-Hydroxy-2-naphthalenecarboxylic acid; 1-Hydroxy-2-naphthalenecarboxylate; 1-Naphthol-2-carboxylic acid; 1-Hydroxy-2-naphthoic acid; 1-Naphthol-2-carboxylate; 1-Hydroxy-2-naphthoate; 2-carboxy-1-naphthol; 1-Hydroxy-2-naphthoate; 1-Hydroxy-2-naphthoate



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ALB, BCL2, BCL2L1, BLVRB, EIF2AK2, ERN1, MCL1, PTGS1, PTGS2, THNSL1, XBP1
Peripheral membrane protein 5 FDXR, HSD17B6, PTGS1, PTGS2, XBP1
Endoplasmic reticulum membrane 6 BCL2, ERN1, PANX1, PTGS1, PTGS2, XBP1
Mitochondrion membrane 1 BCL2L1
Nucleus 6 ALB, BCL2, EIF2AK2, ITGB3, MCL1, XBP1
cytosol 9 ALB, BCL2, BCL2L1, BLVRB, ECI2, EIF2AK2, GSR, MCL1, XBP1
centrosome 2 ALB, BCL2L1
nucleoplasm 5 BLVRB, EIF2AK2, ITGB3, MCL1, XBP1
RNA polymerase II transcription regulator complex 1 XBP1
Cell membrane 2 ITGB3, PANX1
Cytoplasmic side 1 BCL2L1
ruffle membrane 1 ITGB3
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 1 PANX1
Synapse 1 ITGB3
cell surface 2 ITGB3, TNR
glutamatergic synapse 2 ITGB3, TNR
Golgi apparatus 2 ALB, PTGS1
mitochondrial inner membrane 2 BCL2L1, FDXR
Cytoplasm, cytosol 1 BCL2L1
plasma membrane 4 BLVRB, ITGB3, ME3, PANX1
synaptic vesicle membrane 1 BCL2L1
Membrane 8 BCL2, ECI2, EIF2AK2, ITGB3, MCL1, ME3, PANX1, XBP1
apical plasma membrane 1 ITGB3
caveola 1 PTGS2
extracellular exosome 5 ALB, BLVRB, GSR, ITGB3, PTGS1
Lumenal side 1 HSD17B6
endoplasmic reticulum 8 ALB, BCL2, BCL2L1, ERN1, HSD17B6, PANX1, PTGS2, XBP1
extracellular space 2 ALB, TNR
perinuclear region of cytoplasm 1 EIF2AK2
Schaffer collateral - CA1 synapse 1 TNR
gap junction 1 PANX1
mitochondrion 9 BCL2, BCL2L1, ECI2, ERN1, FDXR, GSR, MCL1, ME3, THNSL1
protein-containing complex 5 ALB, BCL2, ITGB3, PANX1, PTGS2
intracellular membrane-bounded organelle 4 BLVRB, ECI2, HSD17B6, PTGS1
Microsome membrane 3 HSD17B6, PTGS1, PTGS2
Single-pass type I membrane protein 2 ERN1, ITGB3
Secreted 1 ALB
extracellular region 2 ALB, TNR
Mitochondrion outer membrane 2 BCL2, BCL2L1
Single-pass membrane protein 4 BCL2, BCL2L1, MCL1, ME3
mitochondrial outer membrane 3 BCL2, BCL2L1, MCL1
Mitochondrion matrix 1 BCL2L1
mitochondrial matrix 4 BCL2L1, FDXR, GSR, ME3
anchoring junction 1 ALB
photoreceptor outer segment 1 PTGS1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 BCL2L1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 BCL2L1
Nucleus membrane 2 BCL2, BCL2L1
Bcl-2 family protein complex 3 BCL2, BCL2L1, MCL1
nuclear membrane 2 BCL2, BCL2L1
external side of plasma membrane 2 GSR, ITGB3
Secreted, extracellular space, extracellular matrix 1 TNR
cell-cell junction 1 ITGB3
Single-pass type II membrane protein 1 XBP1
postsynaptic membrane 1 ITGB3
Cytoplasm, perinuclear region 1 EIF2AK2
Mitochondrion inner membrane 1 FDXR
Membrane raft 1 TNR
pore complex 1 BCL2
Cell junction, focal adhesion 1 ITGB3
focal adhesion 1 ITGB3
Peroxisome 1 ECI2
peroxisomal matrix 1 ECI2
collagen-containing extracellular matrix 1 TNR
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 2 ERN1, PTGS2
nuclear outer membrane 1 PTGS2
Postsynaptic cell membrane 1 ITGB3
receptor complex 1 ITGB3
neuron projection 2 PTGS1, PTGS2
ciliary basal body 1 ALB
centriole 1 ALB
[Isoform 1]: Mitochondrion 1 ECI2
spindle pole 1 ALB
blood microparticle 1 ALB
microvillus membrane 1 ITGB3
Endomembrane system 1 PTGS1
myosin complex 1 MCL1
Nucleus, nucleoplasm 1 MCL1
Melanosome 1 ITGB3
myelin sheath 1 BCL2
filopodium membrane 1 ITGB3
endoplasmic reticulum lumen 2 ALB, PTGS2
platelet alpha granule lumen 1 ALB
perineuronal net 1 TNR
[Isoform 2]: Nucleus 1 XBP1
[Isoform 1]: Nucleus 1 XBP1
platelet alpha granule membrane 1 ITGB3
AIP1-IRE1 complex 1 ERN1
Ire1 complex 1 ERN1
IRE1-RACK1-PP2A complex 1 ERN1
IRE1-TRAF2-ASK1 complex 1 ERN1
[Isoform 2]: Peroxisome matrix 1 ECI2
integrin complex 1 ITGB3
bleb 1 PANX1
lamellipodium membrane 1 ITGB3
ribosome 1 EIF2AK2
alphav-beta3 integrin-vitronectin complex 1 ITGB3
alphav-beta3 integrin-IGF-1-IGF1R complex 1 ITGB3
Cell projection, lamellipodium membrane 1 ITGB3
alpha9-beta1 integrin-ADAM8 complex 1 ITGB3
alphav-beta3 integrin-HMGB1 complex 1 ITGB3
alphav-beta3 integrin-PKCalpha complex 1 ITGB3
glycinergic synapse 1 ITGB3
integrin alphaIIb-beta3 complex 1 ITGB3
integrin alphav-beta3 complex 1 ITGB3
BAD-BCL-2 complex 1 BCL2
[X-box-binding protein 1, cytoplasmic form]: Cytoplasm 1 XBP1
tenascin complex 1 TNR
ciliary transition fiber 1 ALB
[Isoform Bcl-X(L)]: Mitochondrion inner membrane 1 BCL2L1


文献列表

  • Jong Cheol Shon, Young Ji Noh, Young Sang Kwon, Jong-Hwan Kim, Zhexue Wu, Jong-Su Seo. The impact of phenanthrene on membrane phospholipids and its biodegradation by Sphingopyxis soli. Ecotoxicology and environmental safety. 2020 Apr; 192(?):110254. doi: 10.1016/j.ecoenv.2020.110254. [PMID: 32007746]
  • Ekaterina Dubrovskaya, Natalia Pozdnyakova, Sergey Golubev, Anna Muratova, Vyacheslav Grinev, Anastasiya Bondarenkova, Olga Turkovskaya. Peroxidases from root exudates of Medicago sativa and Sorghum bicolor: Catalytic properties and involvement in PAH degradation. Chemosphere. 2017 Feb; 169(?):224-232. doi: 10.1016/j.chemosphere.2016.11.027. [PMID: 27880920]
  • Anna Muratova, Natalya Pozdnyakova, Oleg Makarov, Mikhail Baboshin, Boris Baskunov, Nina Myasoedova, Ludmila Golovleva, Olga Turkovskaya. Degradation of phenanthrene by the rhizobacterium Ensifer meliloti. Biodegradation. 2014 Nov; 25(6):787-95. doi: 10.1007/s10532-014-9699-9. [PMID: 25052918]
  • A A Ovchinnikova, A A Vetrova, A E Filonov, A M Boronin. [Phenanthren biodegradation and interaction of Pseudomonas putida BS3701 and Burkholderia sp.BS3702 in plant rhizosphere]. Mikrobiologiia. 2009 Jul; 78(4):484-90. doi: ". [PMID: 19827713]
  • Suja Shrestha, Bharat Raj Bhattarai, Keun-Hyeung Lee, Hyeongjin Cho. Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs. Bioorganic & medicinal chemistry. 2007 Oct; 15(20):6535-48. doi: 10.1016/j.bmc.2007.07.010. [PMID: 17692525]
  • Gerd Ohlenbusch, Christian Zwiener, Rainer U Meckenstock, Fritz H Frimmel. Identification and quantification of polar naphthalene derivatives in contaminated groundwater of a former gas plant site by liquid chromatography-electrospray ionization tandem mass spectrometry. Journal of chromatography. A. 2002 Aug; 967(2):201-7. doi: 10.1016/s0021-9673(02)00785-9. [PMID: 12685567]
  • Mario Cazzola, Renato Testi, Maria Gabriella Matera. Clinical pharmacokinetics of salmeterol. Clinical pharmacokinetics. 2002; 41(1):19-30. doi: 10.2165/00003088-200241010-00003. [PMID: 11825095]
  • A S Chilton, R E Godward, P F Carey. The determination in human plasma of 1-hydroxy-2-naphthoic acid following administration of salmeterol xinafoate. Journal of pharmaceutical and biomedical analysis. 1995 Feb; 13(2):165-9. doi: 10.1016/0731-7085(94)00122-i. [PMID: 7766724]